Agitation is a neuropsychiatric syndrome characterized by excessive motor and/or verbal behaviors,with or without aggressive behaviors.The prevalence of agitation in Alzheimer’s disease varies from 5%to over 50%.Mult...Agitation is a neuropsychiatric syndrome characterized by excessive motor and/or verbal behaviors,with or without aggressive behaviors.The prevalence of agitation in Alzheimer’s disease varies from 5%to over 50%.Multiple factors have been implicated in its pathophysiology,including disease stage,comorbidity with other symptoms(e.g.,psychosis,anxiety/depression),and psychosocial factors.Ruling out delirium and identifying environmental triggers are fundamental steps in the management of agitation in Alzheimer’s disease.For establishing an effective therapeutic plan,it is important to define duration,severity,and potential for harm.While non-pharmacological approaches are considered the first line of intervention,pharmacological agents are frequently used in the treatment of agitation.Antipsychotics are commonly used in acute agitation.For chronic agitation,serotonin-selective reuptake inhibitors,especially citalopram and escitalopram,are often preferred due to safety concerns associated with the longterm use of antipsychotics.Promising novel strategies,such as new compounds and neuromodulation,are likely to be incorporated into agitation therapeutics in the next few years.展开更多
Unintended dural tear(DT)is not an infrequent complication of biportal percutaneous endoscopic spinal surgery(BESS).DT manifests in neurological deficits,including seizure,headache,and intracranial hemorrhage.Meanwhil...Unintended dural tear(DT)is not an infrequent complication of biportal percutaneous endoscopic spinal surgery(BESS).DT manifests in neurological deficits,including seizure,headache,and intracranial hemorrhage.Meanwhile,DT may be a risk of emergence agitation(EA)after BESS,which has not yet been reported.We presented a case of a 55-year-old man with L5-S1 intervertebral disc herniation receiving BESS under general anesthesia.A DT about 3-4 mm occurred during the operation,and was repaired immediately.The patient presented EA shouting for a headache after the surgery in post anesthesia care unit(PACU).Sedative agents(midazolam,propofol and dexmedetomidine)were used,only continuously infusion of dexmedetomidine for about 4 h successfully improved EA in PACU.He had no neurologic deficits in following 3 months.This case report highlights the risk of EA when a DT occurs during BESS.Adequate sedation in early phase is critical to resolve the mass effect caused by EA.展开更多
The agitated thin-film evaporator(ATFE)plays a crucial role in evaporation and concentration processes.The design of the scraper for processing high-viscosity non-Newtonian fluids in the ATFE is complex.The intricate ...The agitated thin-film evaporator(ATFE)plays a crucial role in evaporation and concentration processes.The design of the scraper for processing high-viscosity non-Newtonian fluids in the ATFE is complex.The intricate scraping action of the scraper introduces gas into the liquid film,leading to the formation of a gas ring along the wall.This process subsequently reduces wall heat flow,thereby affecting heat transfer.Computational fluid dynamics(CFD)is used to simulate the flow field of the non-Newtonian fluid in the ATFE.The investigation focuses on understanding the mechanism behind the formation of gas rings in the liquid film and proposes methods to prevent their formation.The results demonstrate a transition of the gas from a gas ring suspended in the liquid to a gas ring attached to the wall after entering the liquid film.The scraping action around the circumference of the scraper helps to expel gas rings,indicating the necessity of adjusting the scraper arrangement and increasing the frequency of scraping to enhance gas ring expulsion.The spiral motion of the bow wave serves as the source of gas entry into the liquid film.Therefore,the rotation speed can appropriately increase to reduce the size of the bow wave,thereby inhibiting the formation of the gas ring from the source.This research investigates the mechanism of gas ring generation and expulsion,offering theoretical guidance for processing high-viscosity non-Newtonian materials in the flow field of the ATFE.展开更多
The aim of this paper is to study the effect of agitator’s types on the turbulent flows in stirred tanks without and with baffles.The hydrodynamics behavior induced by four different agitator’s types:a Rushton turbi...The aim of this paper is to study the effect of agitator’s types on the turbulent flows in stirred tanks without and with baffles.The hydrodynamics behavior induced by four different agitator’s types:a Rushton turbine(RT),a circular blade turbine(CBT),a diverging triangular blade turbine(DTBT)and converging triangular blade turbine(CTBT)are numerically predicted by solving the Navier-Stokes equations and RNGκ–εturbulent model.The simulations are carried out using the Multi Reference Frame(MRF)approach.The numerical results showed good agreement with experiment.We find that the agitator CTBT gives an important profit on the power consumption per report/ratio the others and DTBT give a good reduction of the vortex size of the impeller angles.展开更多
In accordance to the anisotropic feature of turbulent flow, ananisotropic algebraic stress model is adopted to predict theturbulent flow field and turbulent characteristics generated by aRushton disc turbine with the ...In accordance to the anisotropic feature of turbulent flow, ananisotropic algebraic stress model is adopted to predict theturbulent flow field and turbulent characteristics generated by aRushton disc turbine with the improved inner-outer iterativeprocedure. The predicted turbulent flow is compared with experimentaldata and the simulation by the standard k-ε turbulence model. Theanisotropic algebraic stress model is found to give better predictionthan the standard k-ε turbulence model. The predicted turbulent flowfield is in accordance to experimental data and the trend of theturbulence intensity can be effectively reflected in the simulation.展开更多
The spatial structure of the velocity field in a stirred vessel with water has been measured and analyzed using the laser Doppler velocimeter technique, with the immersing depth and agitation speed of the impeller re-...The spatial structure of the velocity field in a stirred vessel with water has been measured and analyzed using the laser Doppler velocimeter technique, with the immersing depth and agitation speed of the impeller re-maining approximately constant. The experimental results were provided such as the mean velocity field, fluctuat-ing velocities, turbulent kinetic energy, Reynolds shear stress and time series of the velocity in the stirred tank. These results probably provided the valuable basis to further optimize and enlarge the stirred tank in the industrial process.展开更多
AIM To evaluate the safety and efficacy of agitation thrombolysis(AT) combined with catheter-directed thrombolysis(CDT) for the treatment of non-cirrhotic acute portal vein thrombosis(PVT). METHODS Nine patients with ...AIM To evaluate the safety and efficacy of agitation thrombolysis(AT) combined with catheter-directed thrombolysis(CDT) for the treatment of non-cirrhotic acute portal vein thrombosis(PVT). METHODS Nine patients with non-cirrhotic acute PVT who underwent AT combined with CDT were analyzed retrospectively. Portography was carried out via the transjugular intrahepatic portosystemic(commonly known as TIP) or percutaneous transhepatic(commonly known as PT) route, followed by AT combined with CDT. Complications of the procedure, and the changes in clinical symptoms, hemodynamics of the portal vein and liver function were recorded. Follow-up was scheduled at1, 3 and 6 mo after treatment, and every 6 mo thereafter, or when the patients developed clinical symptoms related to PVT. Color Doppler ultrasound and contrast-enhanced computed tomography/magnetic resonance imaging were performed during the follow-up period to determine the condition of the portal vein.RESULTS AT combined with CDT was successfully performed. The portal vein was reached via the TIP route in 6 patients, and via the PT route in 3 patients. All clinical symptoms were relieved or disappeared, with the exception of 1 patient who died of intestinal necrosis 9 d after treatment. Significant differences in the changes in portal vein hemodynamics were observed, including the maximum lumen occupancy of PVT, portal vein pressure and flow velocity between pre-and posttreatment(P < 0.05). During the follow-up period, recurrence was observed in 1 patient at 19 mo after the procedure, and the portal vein was patent in the remaining patients.CONCLUSION AT combined with CDT is a safe and effective method for the treatment of non-cirrhotic acute PVT.展开更多
Pneumatically agitated slurry reactors,including bubble column reactors and airlift loop reactors(ALRs),are important gas-liquid-solid multiphase reactors.These reactors have been widely applied in many processes,espe...Pneumatically agitated slurry reactors,including bubble column reactors and airlift loop reactors(ALRs),are important gas-liquid-solid multiphase reactors.These reactors have been widely applied in many processes,especially in the biological fermentation and energy chemical industry,due to their low shear stress,good mixing,perfect mass-/heat-transfer properties,and relatively low costs.To further improve the performance of slurry reactors(i.e.,mixing and mass/heat transfer)and to satisfy industrial require-ments(e.g.,temperature control,reduction of back-mixing,and product separation),the process intensi-fication of slurry reactors is essential.This article starts by reviewing the latest advancements in the intensification of mixing and mass/heat transfer in these two types of reactors.It then summarizes process-intensification methods for mixing and separation that allow continuous production in these slurry reactors.Process-intensification technology that integrates directional flow in an ALR with simple solid-liquid separation in a hydrocyclone is recommended for its high efficiency and low costs.This arti-cle also systematically addresses vital considerations and challenges,including flow regime discrimina-tion,gas spargers,solid particle effects,and other concerns in slurry reactors.It introduces the progress of numerical simulation using computational fluid dynamics(CFD)for the rational design of slurry reactors and discusses difficulties in modeling.Finally,it presents conclusions and perspectives on the design of industrial slurry reactors.展开更多
A laboratory-scale reaction-crystallization process of struvite synthesis from diluted water solution of Mg^2＋, NH^＋ 4 and PO3- ions was studied. The research covered the tests of two original constructions of conti...A laboratory-scale reaction-crystallization process of struvite synthesis from diluted water solution of Mg^2＋, NH^＋ 4 and PO3- ions was studied. The research covered the tests of two original constructions of continuous jet-pump Draft Tube Magma （DTM）-type crystallizers with internal circulation of suspension （upward/downward）. Interactions between constructional, hydrodynamic and kinetic factors were established and discussed. Nucleation and linear growth rates of struvite crystals were calculated on the basis of population density distribution. Kinetic model of idealized Mixed Suspension Mixed Product Removal （MSMPR） crystallizer considering the size-dependent growth mechanism was applied （Rojkowski hyperbolic equation）. For comparison purposes the kinetic data corre- sponded to a simpler, continuous draft tube-type crystallizer equipped with propeller agitator were analyzed. It was concluded that crystal product of larger size was withdrawn from the jet-pump DTM crystallizer of the descending flow of suspension in a mixing chamber.展开更多
This paper presents the heat transfer characteristics of A1203-water nanofluid in a coiled agitated vessel with propeller agitator. The experimental study was conducted using 0.10%, 0.20% and 0.30% volume concentra ti...This paper presents the heat transfer characteristics of A1203-water nanofluid in a coiled agitated vessel with propeller agitator. The experimental study was conducted using 0.10%, 0.20% and 0.30% volume concentra tion of A1203-water nanofluids. The results showed considerable enhancement of convective heat transfer using the nanofluids. The empirical correlations developed for Nusselt number in terms of Reynolds number, Prandtl number, viscosity ratio and volume concentration fit with the experimental data within ±10%. The heat transfer characteris tics were also simulated using computational fluid dynamics using FLUENT software with the standard ke model and multiple reference frame were adopted. The computational fluid dynamics （CFD） predicted Nusselt number agrees well with the experimental value and the discrepancy is found to be less than ＋8%.展开更多
A new kind of nano-crysta cellulose (NCC) prepared from natural cotton fiber has been obtained by the method ofacid hydrolysis. Compared to most other nanophase materials that derive from inorganic materials, our prod...A new kind of nano-crysta cellulose (NCC) prepared from natural cotton fiber has been obtained by the method ofacid hydrolysis. Compared to most other nanophase materials that derive from inorganic materials, our products are preparedfrom natural cotton fibers. The products are of spherical shape with mixed crystal forms of cellulose I and II. The preparationconditions determine the properties of the products. Prior treatment is a critical procedure. The properties of the products arealso strongly affected by such conditions as the kinds of acids used, the ratio of the acid mixture, the acid concentration, theultrasonic agitation time and hydrolysis temperature. The number average molecular weight of NCC is determined by gelpermeation chromatography (GPC). The particle size and shape were determined by transmission electron microscopy(TEM). X-ray diffraction was used to detect the crystallinity and average crystallite size of the panicle.展开更多
A number of dry bridges have been built to substitute for the roadbed on the Qinghai-Tibet Railway,China.The aim of this study was to investigate the exothermic process of cast-in-place (CIP) pile foundation of a dry ...A number of dry bridges have been built to substitute for the roadbed on the Qinghai-Tibet Railway,China.The aim of this study was to investigate the exothermic process of cast-in-place (CIP) pile foundation of a dry bridge and its harm to the stability of nearby frozen ground.We present 3D heat conduction functions of a concrete pile and of frozen ground with related boundaries.Our analysis is based on the theory of heat conduction and the exponent law describing the adiabatic temperature rise caused by hydration heat.Results under continuous and initial conditions were combined to establish a finite element model of a CIP pile-frozen ground system for a dry bridge under actual field conditions in cold regions.Numerical results indicated that the process could effectively simulate the exothermic process of CIP pile foundation.Thermal disturbance to frozen ground under a long dry bridge caused by the casting temperature and hydration heat of CIP piles was substantial and long-lasting.The simulated thermal analysis results agreed with field measurements and some significant rules relating to the problem were deduced and conclusions reached.展开更多
The flow field of liquid phase (water) of agitated extraction columns is simulated with the help of computational fluid dynamics (CFD). Four kinds of Reynolds-averaged turbulence models, i.e. the standard k-ε model, ...The flow field of liquid phase (water) of agitated extraction columns is simulated with the help of computational fluid dynamics (CFD). Four kinds of Reynolds-averaged turbulence models, i.e. the standard k-ε model, the RNG (renormalization group) k-s model, the realizable k-ε model and the Reynolds stress model, are compared in detail in order to judge which is the best model in terms of the accuracy, less CPU time and memory required. The performance of the realizable k-s model is obviously improved by reducing the model constant from C2 = 1.90 to C2 = 1.61. It is concluded that the improved realizable k-e model is the optimal model.展开更多
AIM: To investigate the impact of agitation speed on pectinase production and morphological changing of Aspergillus niger(A. niger) HFD5A-1 in submerged fermentation. METHODS: A. niger HFM5A-1 was isolated from a rott...AIM: To investigate the impact of agitation speed on pectinase production and morphological changing of Aspergillus niger(A. niger) HFD5A-1 in submerged fermentation. METHODS: A. niger HFM5A-1 was isolated from a rotted pomelo. The inoculum preparation was performed by adding 5.0 m L of sterile distilled water containing 0.1% Tween 80 to a sporulated culture. Cultivation was carried out with inoculated 1 × 107 spores/m L suspension and incubated at 30 ℃ with different agitation speed for 6 d. The samples were withdrawn after 6 d cultivation time and were assayed for pectinase activity and fungal growth determination. The culture broth was filtered through filter paper(Whatman No. 1, London) to separate the fungal mycelium. The cell-free culture filtrate containing the crude enzyme was then assayed for pectinase activity. The biomass was dried at 80 ℃ until constant weight. The fungal cell dry weight was then expressed as g/L. The 6 d old fungal mycelia were harvested from various agitation speed, 0, 50, 100, 150, 200 and 250 rpm. The morphological changing of samples was then viewed under the light microscope and scanning electron microscope.RESULTS: In the present study, agitation speed was found to influence pectinase production in a batch cultivation system. However, higher agitation speeds than the optimal speed(150 rpm) reduced pectinase production which due to shear forces and also collision among the suspended fungal cells in the cultivation medium. Enzyme activity increased with the increasing of agitation speed up to 150 rpm, where it achieved its maximal pectinase activity of 1.559 U/m L. There were significant different(Duncan, P < 0.05) of the pectinase production with the agitation speed at static, 50, 100, 200 and 250 rpm. At the static condition, a well growth mycelial mat was observed on the surface of the cultivation medium and sporulation occurred all over the fungal mycelial mat. However with the increased in agitation speed, the mycelial mat turned slowly to become a single circular pellet. Thus, it was found that agitation speed affected the morphological characteristics of the fungal hyphae/mycelia of A. niger HFD5A-1 by altering their external as well as internal cell structures.CONCLUSION: Exposure to higher shear stress with an increasing agitation speed could result in lower biomass yields as well as pectinase production by A. niger HFD5A-1.展开更多
In order to increase the contact area and promote the mass transfer process of gas and liquid,the process of the bubble refine-ment in a metallurgical reactor with mechanical agitation was studied by physical simulati...In order to increase the contact area and promote the mass transfer process of gas and liquid,the process of the bubble refine-ment in a metallurgical reactor with mechanical agitation was studied by physical simulation.Based on the capillary number,a prediction equation for the bubble refinement was established.The effects of the gas flow rate,the stirring speed and thestirring depth on the bubble refinement in the reactor were discussed in detail.The distribution of the bubble diameter in thereactor was obtained under different conditions.The results show that when the stirring speed reaches 300 r/min,the bubblediamcter mainly distributes in the range of 1-2 mm.A higher gas flow rate may increase the number of bubbles in the meltand promote the bubble refinement process.The mechanism of bubble refinement under mechanical agitation was analyzed.and the results indicated that the stirring speed.,the blade area and the blade inclination are the main influencing factors.展开更多
The fine scheelite flotation using garnet and glass beads as agitation medium was investigated through slurry rheology and froth property analysis. The apparent viscosity of fine scheelite, calcite and quartz(-20 μm)...The fine scheelite flotation using garnet and glass beads as agitation medium was investigated through slurry rheology and froth property analysis. The apparent viscosity of fine scheelite, calcite and quartz(-20 μm) slurry were measured and the corresponding scheelite flotation behaviours, froth water recovery and froth height were studied. It was found that calcite slurry could aggregate into network structures and exhibit much higher apparent viscosity at the vicinity of pH 8.5–9.0 than scheelite and quartz(scheelite, calcite, and quartz slurry at 20.34, 38.66, and 14.58 mPa·s, respectively). Agitation medium containing garnet and glass beads could reduce the slurry apparent viscosity by effectively dispersing the calcite network structures in flotation slurry, and improve the fine scheelite flotation selectivity. As the apparent viscosity was reduced, the froth water recovery decreased from 24.33% to 6.37% and initial froth height of the flotation froth decreased from 69.6 to 8.7 mm, and finally results in increase in separation efficiency from 23.10% to 31.96%. The results could be potentially used in flotation of fine minerals by applying agitation medium to improve the process selectivity.展开更多
BACKGROUND:Agitation occurs frequently among critically ill patients admitted to the intensive care unit(ICU).We aimed to evaluate the frequency,predisposing factors and outcomes of agitation in trauma ICU.METHODS:A r...BACKGROUND:Agitation occurs frequently among critically ill patients admitted to the intensive care unit(ICU).We aimed to evaluate the frequency,predisposing factors and outcomes of agitation in trauma ICU.METHODS:A retrospective analysis was conducted to include patients who were admitted to the trauma ICU between April 2014 and March 2015.Data included patient's demographics,initial vitals,associated injuries,Ramsey Sedation Scale,Glasgow Coma Scale,head injury lesions,use of sedatives and analgesics,head interventions,ventilator days,and ICU length of stay.Patients were divided into two groups based on the agitation status.RESULTS:A total of 102 intubated patients were enrolled;of which 46(45%)experienced agitation.Patients in the agitation group were 7 years younger,had significantly lower GCS and sustained higher frequency of head injuries(P<0.05).Patients who developed agitation were more likely to be prescribed propofol alone or in combination with midazolam and to have frequent ICP catheter insertion,longer ventilatory days and higher incidence of pneumonia(P<0.05).On multivariate analysis,use of propofol alone(OR=4.97;95%CI=1.35–18.27),subarachnoid hemorrhage(OR=5.11;95%CI=1.38–18.91)and ICP catheter insertion for severe head injury(OR=4.23;95%CI=1.16–15.35)were independent predictors for agitation(P<0.01).CONCLUSION:Agitation is a frequent problem in trauma ICU and is mainly related to the type of sedation and poor outcomes in terms of prolonged mechanical ventilation and development of nosocomial pneumonia.Therefore,understanding the main predictors of agitation facilitates early risk-stratification and development of better therapeutic strategies in trauma patients.展开更多
Three approaches based on computational fluid dynamics(CFD) techniques have been assessed for their ability to describe the engineering flow environment in a miniaturized mechanically agitated bioreactor. The three a...Three approaches based on computational fluid dynamics(CFD) techniques have been assessed for their ability to describe the engineering flow environment in a miniaturized mechanically agitated bioreactor. The three approaches tested were the source-sink(SS), the multiple reference frames(MRF) and the sliding grids(SG). In all the cases, the predictions of the velocity components agree with reported experimental data. However, the analysis of the results of the turbulent intensities predicted by the three approaches indicates the MRF and the SG techniques under predicted turbulent intensities are comparable to both experimental measurements and the SS method. The predicted power number and pumping number based on the SS approach are closer to typical reported experimental values compared to those obtained from the MRF and SG methods.展开更多
This work focuses on drop breakage for liquid-liquid system with an adoption of numerical simulation by using computational fluid dynamics and population balance model (PBM) coupled with two-fluid model (TFM). Two dif...This work focuses on drop breakage for liquid-liquid system with an adoption of numerical simulation by using computational fluid dynamics and population balance model (PBM) coupled with two-fluid model (TFM). Two different breakage kernels based on identical breakage mechanism but different descriptions of breaking time are take n into account in this work. Eight cases corresp on ding to distinct configurations of agitator are carried out to validate numerical predictions, namely agitators with different porosity and hole diameters, respectively implemented in Cases 1 to 5 and Cases 6 to 8. The results are compared with experimental data for testing the applicability of both kernels. Simulations are implemented, in this work, with an approach of class method for the solution of population balance model by the special-purpose computational fluid dynamics solver Fluent 16.1 based on finite volume method, and the grids used for meshing the solution domain are accomplished in a commercial software Gambit 2.4.6. The effects of configurations of agitator corresponding to different parameters mentioned above on final Sauter mean diameter are equally concentrated in this work. Analysis of both kernels and comparisons with experimental results reveal that, the second kernel has more decent agreement with experiments, and the results of investigations on effects of agitator configurations show that the in fluences of these parameters on Sauter mean diameter are marginal, but appropriate porosity and hole diameter are actually able to decrease Sauter mean diameter. These outcomes allow us to draw general conclusions and help investigate performances of liquid-liquid system.展开更多
基金Supported by the National Institutes of Health/National Institute on Aging,No.1R21AG091282.
文摘Agitation is a neuropsychiatric syndrome characterized by excessive motor and/or verbal behaviors,with or without aggressive behaviors.The prevalence of agitation in Alzheimer’s disease varies from 5%to over 50%.Multiple factors have been implicated in its pathophysiology,including disease stage,comorbidity with other symptoms(e.g.,psychosis,anxiety/depression),and psychosocial factors.Ruling out delirium and identifying environmental triggers are fundamental steps in the management of agitation in Alzheimer’s disease.For establishing an effective therapeutic plan,it is important to define duration,severity,and potential for harm.While non-pharmacological approaches are considered the first line of intervention,pharmacological agents are frequently used in the treatment of agitation.Antipsychotics are commonly used in acute agitation.For chronic agitation,serotonin-selective reuptake inhibitors,especially citalopram and escitalopram,are often preferred due to safety concerns associated with the longterm use of antipsychotics.Promising novel strategies,such as new compounds and neuromodulation,are likely to be incorporated into agitation therapeutics in the next few years.
文摘Unintended dural tear(DT)is not an infrequent complication of biportal percutaneous endoscopic spinal surgery(BESS).DT manifests in neurological deficits,including seizure,headache,and intracranial hemorrhage.Meanwhile,DT may be a risk of emergence agitation(EA)after BESS,which has not yet been reported.We presented a case of a 55-year-old man with L5-S1 intervertebral disc herniation receiving BESS under general anesthesia.A DT about 3-4 mm occurred during the operation,and was repaired immediately.The patient presented EA shouting for a headache after the surgery in post anesthesia care unit(PACU).Sedative agents(midazolam,propofol and dexmedetomidine)were used,only continuously infusion of dexmedetomidine for about 4 h successfully improved EA in PACU.He had no neurologic deficits in following 3 months.This case report highlights the risk of EA when a DT occurs during BESS.Adequate sedation in early phase is critical to resolve the mass effect caused by EA.
基金National Natural Science Foundation of China(No.51905089)Fundamental Research Funds for the Central Universities,China(No.2232020D-31)。
文摘The agitated thin-film evaporator(ATFE)plays a crucial role in evaporation and concentration processes.The design of the scraper for processing high-viscosity non-Newtonian fluids in the ATFE is complex.The intricate scraping action of the scraper introduces gas into the liquid film,leading to the formation of a gas ring along the wall.This process subsequently reduces wall heat flow,thereby affecting heat transfer.Computational fluid dynamics(CFD)is used to simulate the flow field of the non-Newtonian fluid in the ATFE.The investigation focuses on understanding the mechanism behind the formation of gas rings in the liquid film and proposes methods to prevent their formation.The results demonstrate a transition of the gas from a gas ring suspended in the liquid to a gas ring attached to the wall after entering the liquid film.The scraping action around the circumference of the scraper helps to expel gas rings,indicating the necessity of adjusting the scraper arrangement and increasing the frequency of scraping to enhance gas ring expulsion.The spiral motion of the bow wave serves as the source of gas entry into the liquid film.Therefore,the rotation speed can appropriately increase to reduce the size of the bow wave,thereby inhibiting the formation of the gas ring from the source.This research investigates the mechanism of gas ring generation and expulsion,offering theoretical guidance for processing high-viscosity non-Newtonian materials in the flow field of the ATFE.
文摘The aim of this paper is to study the effect of agitator’s types on the turbulent flows in stirred tanks without and with baffles.The hydrodynamics behavior induced by four different agitator’s types:a Rushton turbine(RT),a circular blade turbine(CBT),a diverging triangular blade turbine(DTBT)and converging triangular blade turbine(CTBT)are numerically predicted by solving the Navier-Stokes equations and RNGκ–εturbulent model.The simulations are carried out using the Multi Reference Frame(MRF)approach.The numerical results showed good agreement with experiment.We find that the agitator CTBT gives an important profit on the power consumption per report/ratio the others and DTBT give a good reduction of the vortex size of the impeller angles.
基金the National Natural Science Foundation of China (No. 29792074).
文摘In accordance to the anisotropic feature of turbulent flow, ananisotropic algebraic stress model is adopted to predict theturbulent flow field and turbulent characteristics generated by aRushton disc turbine with the improved inner-outer iterativeprocedure. The predicted turbulent flow is compared with experimentaldata and the simulation by the standard k-ε turbulence model. Theanisotropic algebraic stress model is found to give better predictionthan the standard k-ε turbulence model. The predicted turbulent flowfield is in accordance to experimental data and the trend of theturbulence intensity can be effectively reflected in the simulation.
基金Supported by the Natural Science Foundation of Inner Mongolia (No.200408020715).
文摘The spatial structure of the velocity field in a stirred vessel with water has been measured and analyzed using the laser Doppler velocimeter technique, with the immersing depth and agitation speed of the impeller re-maining approximately constant. The experimental results were provided such as the mean velocity field, fluctuat-ing velocities, turbulent kinetic energy, Reynolds shear stress and time series of the velocity in the stirred tank. These results probably provided the valuable basis to further optimize and enlarge the stirred tank in the industrial process.
文摘AIM To evaluate the safety and efficacy of agitation thrombolysis(AT) combined with catheter-directed thrombolysis(CDT) for the treatment of non-cirrhotic acute portal vein thrombosis(PVT). METHODS Nine patients with non-cirrhotic acute PVT who underwent AT combined with CDT were analyzed retrospectively. Portography was carried out via the transjugular intrahepatic portosystemic(commonly known as TIP) or percutaneous transhepatic(commonly known as PT) route, followed by AT combined with CDT. Complications of the procedure, and the changes in clinical symptoms, hemodynamics of the portal vein and liver function were recorded. Follow-up was scheduled at1, 3 and 6 mo after treatment, and every 6 mo thereafter, or when the patients developed clinical symptoms related to PVT. Color Doppler ultrasound and contrast-enhanced computed tomography/magnetic resonance imaging were performed during the follow-up period to determine the condition of the portal vein.RESULTS AT combined with CDT was successfully performed. The portal vein was reached via the TIP route in 6 patients, and via the PT route in 3 patients. All clinical symptoms were relieved or disappeared, with the exception of 1 patient who died of intestinal necrosis 9 d after treatment. Significant differences in the changes in portal vein hemodynamics were observed, including the maximum lumen occupancy of PVT, portal vein pressure and flow velocity between pre-and posttreatment(P < 0.05). During the follow-up period, recurrence was observed in 1 patient at 19 mo after the procedure, and the portal vein was patent in the remaining patients.CONCLUSION AT combined with CDT is a safe and effective method for the treatment of non-cirrhotic acute PVT.
基金supported by the National Key Research and Development Program of China(2016YFB0301701)the National Natural Science Foundation of China(21808234,21878318,and 21938009)+3 种基金the DNL Cooperation Fund,Chinese Academy of Sciences(CAS)(DNL201902)the Strategic Priority Research Program of the CAS(XDA21060400)the QIBEBT and Dalian National Laboratory for Clean Energy of the CAS(QIBEBT ZZBS201803 and QIBEBT I201907)the CAS Key Technology Talent Program.
文摘Pneumatically agitated slurry reactors,including bubble column reactors and airlift loop reactors(ALRs),are important gas-liquid-solid multiphase reactors.These reactors have been widely applied in many processes,especially in the biological fermentation and energy chemical industry,due to their low shear stress,good mixing,perfect mass-/heat-transfer properties,and relatively low costs.To further improve the performance of slurry reactors(i.e.,mixing and mass/heat transfer)and to satisfy industrial require-ments(e.g.,temperature control,reduction of back-mixing,and product separation),the process intensi-fication of slurry reactors is essential.This article starts by reviewing the latest advancements in the intensification of mixing and mass/heat transfer in these two types of reactors.It then summarizes process-intensification methods for mixing and separation that allow continuous production in these slurry reactors.Process-intensification technology that integrates directional flow in an ALR with simple solid-liquid separation in a hydrocyclone is recommended for its high efficiency and low costs.This arti-cle also systematically addresses vital considerations and challenges,including flow regime discrimina-tion,gas spargers,solid particle effects,and other concerns in slurry reactors.It introduces the progress of numerical simulation using computational fluid dynamics(CFD)for the rational design of slurry reactors and discusses difficulties in modeling.Finally,it presents conclusions and perspectives on the design of industrial slurry reactors.
文摘A laboratory-scale reaction-crystallization process of struvite synthesis from diluted water solution of Mg^2＋, NH^＋ 4 and PO3- ions was studied. The research covered the tests of two original constructions of continuous jet-pump Draft Tube Magma （DTM）-type crystallizers with internal circulation of suspension （upward/downward）. Interactions between constructional, hydrodynamic and kinetic factors were established and discussed. Nucleation and linear growth rates of struvite crystals were calculated on the basis of population density distribution. Kinetic model of idealized Mixed Suspension Mixed Product Removal （MSMPR） crystallizer considering the size-dependent growth mechanism was applied （Rojkowski hyperbolic equation）. For comparison purposes the kinetic data corre- sponded to a simpler, continuous draft tube-type crystallizer equipped with propeller agitator were analyzed. It was concluded that crystal product of larger size was withdrawn from the jet-pump DTM crystallizer of the descending flow of suspension in a mixing chamber.
文摘This paper presents the heat transfer characteristics of A1203-water nanofluid in a coiled agitated vessel with propeller agitator. The experimental study was conducted using 0.10%, 0.20% and 0.30% volume concentra tion of A1203-water nanofluids. The results showed considerable enhancement of convective heat transfer using the nanofluids. The empirical correlations developed for Nusselt number in terms of Reynolds number, Prandtl number, viscosity ratio and volume concentration fit with the experimental data within ±10%. The heat transfer characteris tics were also simulated using computational fluid dynamics using FLUENT software with the standard ke model and multiple reference frame were adopted. The computational fluid dynamics （CFD） predicted Nusselt number agrees well with the experimental value and the discrepancy is found to be less than ＋8%.
基金This work was supported by the Special Funds for Major State Basic Research Projects (95-12 and G1999064800).
文摘A new kind of nano-crysta cellulose (NCC) prepared from natural cotton fiber has been obtained by the method ofacid hydrolysis. Compared to most other nanophase materials that derive from inorganic materials, our products are preparedfrom natural cotton fibers. The products are of spherical shape with mixed crystal forms of cellulose I and II. The preparationconditions determine the properties of the products. Prior treatment is a critical procedure. The properties of the products arealso strongly affected by such conditions as the kinds of acids used, the ratio of the acid mixture, the acid concentration, theultrasonic agitation time and hydrolysis temperature. The number average molecular weight of NCC is determined by gelpermeation chromatography (GPC). The particle size and shape were determined by transmission electron microscopy(TEM). X-ray diffraction was used to detect the crystallinity and average crystallite size of the panicle.
基金Project supported by the National Natural Science Foundation of China (No.50678076)the Opening Foundation of the State Key Laboratory of Frozen Soil Engineering (No.SKLFSE200603),China
文摘A number of dry bridges have been built to substitute for the roadbed on the Qinghai-Tibet Railway,China.The aim of this study was to investigate the exothermic process of cast-in-place (CIP) pile foundation of a dry bridge and its harm to the stability of nearby frozen ground.We present 3D heat conduction functions of a concrete pile and of frozen ground with related boundaries.Our analysis is based on the theory of heat conduction and the exponent law describing the adiabatic temperature rise caused by hydration heat.Results under continuous and initial conditions were combined to establish a finite element model of a CIP pile-frozen ground system for a dry bridge under actual field conditions in cold regions.Numerical results indicated that the process could effectively simulate the exothermic process of CIP pile foundation.Thermal disturbance to frozen ground under a long dry bridge caused by the casting temperature and hydration heat of CIP piles was substantial and long-lasting.The simulated thermal analysis results agreed with field measurements and some significant rules relating to the problem were deduced and conclusions reached.
文摘The flow field of liquid phase (water) of agitated extraction columns is simulated with the help of computational fluid dynamics (CFD). Four kinds of Reynolds-averaged turbulence models, i.e. the standard k-ε model, the RNG (renormalization group) k-s model, the realizable k-ε model and the Reynolds stress model, are compared in detail in order to judge which is the best model in terms of the accuracy, less CPU time and memory required. The performance of the realizable k-s model is obviously improved by reducing the model constant from C2 = 1.90 to C2 = 1.61. It is concluded that the improved realizable k-e model is the optimal model.
基金Supported by Universiti Sains Malaysia Scientific Research Fund
文摘AIM: To investigate the impact of agitation speed on pectinase production and morphological changing of Aspergillus niger(A. niger) HFD5A-1 in submerged fermentation. METHODS: A. niger HFM5A-1 was isolated from a rotted pomelo. The inoculum preparation was performed by adding 5.0 m L of sterile distilled water containing 0.1% Tween 80 to a sporulated culture. Cultivation was carried out with inoculated 1 × 107 spores/m L suspension and incubated at 30 ℃ with different agitation speed for 6 d. The samples were withdrawn after 6 d cultivation time and were assayed for pectinase activity and fungal growth determination. The culture broth was filtered through filter paper(Whatman No. 1, London) to separate the fungal mycelium. The cell-free culture filtrate containing the crude enzyme was then assayed for pectinase activity. The biomass was dried at 80 ℃ until constant weight. The fungal cell dry weight was then expressed as g/L. The 6 d old fungal mycelia were harvested from various agitation speed, 0, 50, 100, 150, 200 and 250 rpm. The morphological changing of samples was then viewed under the light microscope and scanning electron microscope.RESULTS: In the present study, agitation speed was found to influence pectinase production in a batch cultivation system. However, higher agitation speeds than the optimal speed(150 rpm) reduced pectinase production which due to shear forces and also collision among the suspended fungal cells in the cultivation medium. Enzyme activity increased with the increasing of agitation speed up to 150 rpm, where it achieved its maximal pectinase activity of 1.559 U/m L. There were significant different(Duncan, P < 0.05) of the pectinase production with the agitation speed at static, 50, 100, 200 and 250 rpm. At the static condition, a well growth mycelial mat was observed on the surface of the cultivation medium and sporulation occurred all over the fungal mycelial mat. However with the increased in agitation speed, the mycelial mat turned slowly to become a single circular pellet. Thus, it was found that agitation speed affected the morphological characteristics of the fungal hyphae/mycelia of A. niger HFD5A-1 by altering their external as well as internal cell structures.CONCLUSION: Exposure to higher shear stress with an increasing agitation speed could result in lower biomass yields as well as pectinase production by A. niger HFD5A-1.
基金supported by the National Natural Science Foundation of China(U1508217,U1702253 and 51774078)the Fundamental Research Funds for the Central Universities(N172506009 and N170908001).
文摘In order to increase the contact area and promote the mass transfer process of gas and liquid,the process of the bubble refine-ment in a metallurgical reactor with mechanical agitation was studied by physical simulation.Based on the capillary number,a prediction equation for the bubble refinement was established.The effects of the gas flow rate,the stirring speed and thestirring depth on the bubble refinement in the reactor were discussed in detail.The distribution of the bubble diameter in thereactor was obtained under different conditions.The results show that when the stirring speed reaches 300 r/min,the bubblediamcter mainly distributes in the range of 1-2 mm.A higher gas flow rate may increase the number of bubbles in the meltand promote the bubble refinement process.The mechanism of bubble refinement under mechanical agitation was analyzed.and the results indicated that the stirring speed.,the blade area and the blade inclination are the main influencing factors.
基金support of the National Natural Science Foundation of China(Nos.51904221 and 51774041)the Natural Science Foundation of Hunan Province,China(No.2022JJ40594).
文摘The fine scheelite flotation using garnet and glass beads as agitation medium was investigated through slurry rheology and froth property analysis. The apparent viscosity of fine scheelite, calcite and quartz(-20 μm) slurry were measured and the corresponding scheelite flotation behaviours, froth water recovery and froth height were studied. It was found that calcite slurry could aggregate into network structures and exhibit much higher apparent viscosity at the vicinity of pH 8.5–9.0 than scheelite and quartz(scheelite, calcite, and quartz slurry at 20.34, 38.66, and 14.58 mPa·s, respectively). Agitation medium containing garnet and glass beads could reduce the slurry apparent viscosity by effectively dispersing the calcite network structures in flotation slurry, and improve the fine scheelite flotation selectivity. As the apparent viscosity was reduced, the froth water recovery decreased from 24.33% to 6.37% and initial froth height of the flotation froth decreased from 69.6 to 8.7 mm, and finally results in increase in separation efficiency from 23.10% to 31.96%. The results could be potentially used in flotation of fine minerals by applying agitation medium to improve the process selectivity.
文摘BACKGROUND:Agitation occurs frequently among critically ill patients admitted to the intensive care unit(ICU).We aimed to evaluate the frequency,predisposing factors and outcomes of agitation in trauma ICU.METHODS:A retrospective analysis was conducted to include patients who were admitted to the trauma ICU between April 2014 and March 2015.Data included patient's demographics,initial vitals,associated injuries,Ramsey Sedation Scale,Glasgow Coma Scale,head injury lesions,use of sedatives and analgesics,head interventions,ventilator days,and ICU length of stay.Patients were divided into two groups based on the agitation status.RESULTS:A total of 102 intubated patients were enrolled;of which 46(45%)experienced agitation.Patients in the agitation group were 7 years younger,had significantly lower GCS and sustained higher frequency of head injuries(P<0.05).Patients who developed agitation were more likely to be prescribed propofol alone or in combination with midazolam and to have frequent ICP catheter insertion,longer ventilatory days and higher incidence of pneumonia(P<0.05).On multivariate analysis,use of propofol alone(OR=4.97;95%CI=1.35–18.27),subarachnoid hemorrhage(OR=5.11;95%CI=1.38–18.91)and ICP catheter insertion for severe head injury(OR=4.23;95%CI=1.16–15.35)were independent predictors for agitation(P<0.01).CONCLUSION:Agitation is a frequent problem in trauma ICU and is mainly related to the type of sedation and poor outcomes in terms of prolonged mechanical ventilation and development of nosocomial pneumonia.Therefore,understanding the main predictors of agitation facilitates early risk-stratification and development of better therapeutic strategies in trauma patients.
基金Supported by the U CL ORS Award and KC Wong Scholarshi
文摘Three approaches based on computational fluid dynamics(CFD) techniques have been assessed for their ability to describe the engineering flow environment in a miniaturized mechanically agitated bioreactor. The three approaches tested were the source-sink(SS), the multiple reference frames(MRF) and the sliding grids(SG). In all the cases, the predictions of the velocity components agree with reported experimental data. However, the analysis of the results of the turbulent intensities predicted by the three approaches indicates the MRF and the SG techniques under predicted turbulent intensities are comparable to both experimental measurements and the SS method. The predicted power number and pumping number based on the SS approach are closer to typical reported experimental values compared to those obtained from the MRF and SG methods.
基金Supported by the National Natural Science Foundation of China(21776180,21306116)
文摘This work focuses on drop breakage for liquid-liquid system with an adoption of numerical simulation by using computational fluid dynamics and population balance model (PBM) coupled with two-fluid model (TFM). Two different breakage kernels based on identical breakage mechanism but different descriptions of breaking time are take n into account in this work. Eight cases corresp on ding to distinct configurations of agitator are carried out to validate numerical predictions, namely agitators with different porosity and hole diameters, respectively implemented in Cases 1 to 5 and Cases 6 to 8. The results are compared with experimental data for testing the applicability of both kernels. Simulations are implemented, in this work, with an approach of class method for the solution of population balance model by the special-purpose computational fluid dynamics solver Fluent 16.1 based on finite volume method, and the grids used for meshing the solution domain are accomplished in a commercial software Gambit 2.4.6. The effects of configurations of agitator corresponding to different parameters mentioned above on final Sauter mean diameter are equally concentrated in this work. Analysis of both kernels and comparisons with experimental results reveal that, the second kernel has more decent agreement with experiments, and the results of investigations on effects of agitator configurations show that the in fluences of these parameters on Sauter mean diameter are marginal, but appropriate porosity and hole diameter are actually able to decrease Sauter mean diameter. These outcomes allow us to draw general conclusions and help investigate performances of liquid-liquid system.
