Objective:To investigate the relationship betweenp16INK4a and primary hepatocellular carcinoma (HCC),especially hepatitis B-related HCC. Methods: p16INK4a andits protein in HCC were analyzed with PCR-SSCP and theimmun...Objective:To investigate the relationship betweenp16INK4a and primary hepatocellular carcinoma (HCC),especially hepatitis B-related HCC. Methods: p16INK4a andits protein in HCC were analyzed with PCR-SSCP and theimmunohistochemistry methods respectively. Results: Thepositive incidence of p16INK4 protein expressing in HCC waslower than that of normal liver tissue (P<0.05), and theabsence of p16INK4 protein was associated with HCCmetastasis (P<0.05). The low frequency of mutation ofp16INK4 exonl and exon2 upstream fragment was found inHCC. Conclusion: Absence of p16INK4 protein in HCC wasnot associated with HBV-infection.展开更多
对转基因作物的怀疑缺乏科学依据,因为转基因作物从未有过伤害人体或破坏生态系统的记录去年8月,在菲律宾国际水稻研究所(International Rice Research Institute),一伙激进分子大肆破坏黄金大米试验田。其中一些人甚至得到了瑞典政府...对转基因作物的怀疑缺乏科学依据,因为转基因作物从未有过伤害人体或破坏生态系统的记录去年8月,在菲律宾国际水稻研究所(International Rice Research Institute),一伙激进分子大肆破坏黄金大米试验田。其中一些人甚至得到了瑞典政府的国际发展合作局(International Development Cooperation Agency)的支持,后者为菲律宾基金组织MASIPAG提供资金。大米富含碳水化合物,但缺少维生素。展开更多
Gastric cancer is the fourth commonest cancer and the second leading cause of cancer-related death worldwide[1].Its incidence ranks no.2 and its mortality rate ranks no.3 among all malignant tumors in China according ...Gastric cancer is the fourth commonest cancer and the second leading cause of cancer-related death worldwide[1].Its incidence ranks no.2 and its mortality rate ranks no.3 among all malignant tumors in China according to the latest cancer disease spectrum[2].The gastric cancer prognosis is very poor with 5-year survivals below 24%[3].Early gastric cancer can be cured with surgery;advanced gastric cancer often needs multidisciplinary combined therapy.Gastric cancer seems insensitive to current chemotherapy agents,which may be closely related to stomach cancer stem cells[4].Early gastric cancer refers to the in situ gastric cancer which locates only in stomach mucous membraneand does not infiltrate into thin submucosa.In China,early gastric cancer diagnosis rate is less than 20%,while the diagnosis rate of early gastric cancer in Japan and South Korea has reached 30%-50%[5,6].It is definite to classify H.pylori as the class I carcinogen by the World Health Organization.Approximately 75%of the global gastric cancer are attributable to H.pylori-induced inflammation and injury[7].To date,the precise mechanism of H.pylori-associated gastric carcinogenesis has not been well clarified.To develop prewarning and early theranostic system of gastric cancer can save a lot of patients with gastric cancer and can also reduce the cost of treatment and even cure or significantly prolong the lifespan of patients.展开更多
文摘Objective:To investigate the relationship betweenp16INK4a and primary hepatocellular carcinoma (HCC),especially hepatitis B-related HCC. Methods: p16INK4a andits protein in HCC were analyzed with PCR-SSCP and theimmunohistochemistry methods respectively. Results: Thepositive incidence of p16INK4 protein expressing in HCC waslower than that of normal liver tissue (P<0.05), and theabsence of p16INK4 protein was associated with HCCmetastasis (P<0.05). The low frequency of mutation ofp16INK4 exonl and exon2 upstream fragment was found inHCC. Conclusion: Absence of p16INK4 protein in HCC wasnot associated with HBV-infection.
文摘对转基因作物的怀疑缺乏科学依据,因为转基因作物从未有过伤害人体或破坏生态系统的记录去年8月,在菲律宾国际水稻研究所(International Rice Research Institute),一伙激进分子大肆破坏黄金大米试验田。其中一些人甚至得到了瑞典政府的国际发展合作局(International Development Cooperation Agency)的支持,后者为菲律宾基金组织MASIPAG提供资金。大米富含碳水化合物,但缺少维生素。
文摘Gastric cancer is the fourth commonest cancer and the second leading cause of cancer-related death worldwide[1].Its incidence ranks no.2 and its mortality rate ranks no.3 among all malignant tumors in China according to the latest cancer disease spectrum[2].The gastric cancer prognosis is very poor with 5-year survivals below 24%[3].Early gastric cancer can be cured with surgery;advanced gastric cancer often needs multidisciplinary combined therapy.Gastric cancer seems insensitive to current chemotherapy agents,which may be closely related to stomach cancer stem cells[4].Early gastric cancer refers to the in situ gastric cancer which locates only in stomach mucous membraneand does not infiltrate into thin submucosa.In China,early gastric cancer diagnosis rate is less than 20%,while the diagnosis rate of early gastric cancer in Japan and South Korea has reached 30%-50%[5,6].It is definite to classify H.pylori as the class I carcinogen by the World Health Organization.Approximately 75%of the global gastric cancer are attributable to H.pylori-induced inflammation and injury[7].To date,the precise mechanism of H.pylori-associated gastric carcinogenesis has not been well clarified.To develop prewarning and early theranostic system of gastric cancer can save a lot of patients with gastric cancer and can also reduce the cost of treatment and even cure or significantly prolong the lifespan of patients.
