The coronavirus disease 2019(COVID-19)caused a large number of deaths and serious economic losses.Safety precautions and effective measures are urgently demanded to control the virus spread in public places.Owing to t...The coronavirus disease 2019(COVID-19)caused a large number of deaths and serious economic losses.Safety precautions and effective measures are urgently demanded to control the virus spread in public places.Owing to the longevity of the viruses in the aerosols and surfaces,sustained nanomaterials with efficient antiviral abilities during both daytime and night appear to be a promising way to control virus spread.Here,AgCu nanocomposites,which are outstanding antibacterial and antiviral elements,including Ag_(2)Cu_(2)O_(3)and AgCuO_(2),have been successfully prepared via a simple co-precipitation method for inactivation of model Qbeta(Qβ)bacteriophage.Notably,Ag_(2)Cu_(2)O_(3)has uniform nanorods morphol-ogy with a width of 50-100 nm and a length of 200-500 nm,regular elemental states of Cu^(2+)and Ag^(+),and good visible light response.Instead,AgCuO_(2)has more complex elemental states of Cu^(2+),Ag^(+),and Ag^(3+),including morphology with large particles of 500-1000 nm surrounded by small nanorods and nanoplates.Density functional theory(DFT)calculations showed that Ag_(2)Cu_(2)O_(3)has a lower work function than AgCuO_(2),indicating the charges can be better released from the surface.The accumulated surface charge can bind to the virus to inactivate it.As a result,Ag_(2)Cu_(2)O_(3)shows outstanding antiviral properties with a 6-log reduction(99.9999%)of Qβphage after 45 min contact under dark condition,and the activity can be further promoted to 7.5-log inactivation of Qβphage after the same time contact under visible light irradiation,revealing its potential to sustainably prevent viruses spread in indoor environments.展开更多
基金supported by the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University(No.BJ202205)the National Natural Science Foundation of China(Grant No.22376222)+1 种基金the Central South University Research Programme of Advanced Interdisciplinary Studies(Grant No.2023QYJC012)the Natural Science Foundation of Hunan Province(Grant No.2021JJ30864).
文摘The coronavirus disease 2019(COVID-19)caused a large number of deaths and serious economic losses.Safety precautions and effective measures are urgently demanded to control the virus spread in public places.Owing to the longevity of the viruses in the aerosols and surfaces,sustained nanomaterials with efficient antiviral abilities during both daytime and night appear to be a promising way to control virus spread.Here,AgCu nanocomposites,which are outstanding antibacterial and antiviral elements,including Ag_(2)Cu_(2)O_(3)and AgCuO_(2),have been successfully prepared via a simple co-precipitation method for inactivation of model Qbeta(Qβ)bacteriophage.Notably,Ag_(2)Cu_(2)O_(3)has uniform nanorods morphol-ogy with a width of 50-100 nm and a length of 200-500 nm,regular elemental states of Cu^(2+)and Ag^(+),and good visible light response.Instead,AgCuO_(2)has more complex elemental states of Cu^(2+),Ag^(+),and Ag^(3+),including morphology with large particles of 500-1000 nm surrounded by small nanorods and nanoplates.Density functional theory(DFT)calculations showed that Ag_(2)Cu_(2)O_(3)has a lower work function than AgCuO_(2),indicating the charges can be better released from the surface.The accumulated surface charge can bind to the virus to inactivate it.As a result,Ag_(2)Cu_(2)O_(3)shows outstanding antiviral properties with a 6-log reduction(99.9999%)of Qβphage after 45 min contact under dark condition,and the activity can be further promoted to 7.5-log inactivation of Qβphage after the same time contact under visible light irradiation,revealing its potential to sustainably prevent viruses spread in indoor environments.
