AIM: To detect lymph nodes micrometastases and analyze its correlation with clinicopathological parameters in Dukes' A and B colorectal cancer patients.METHODS: One hundred and fourteen patients with colorectal ca...AIM: To detect lymph nodes micrometastases and analyze its correlation with clinicopathological parameters in Dukes' A and B colorectal cancer patients.METHODS: One hundred and fourteen patients with colorectal cancer (Dukes' A 16; Dukes' B 98) undergoing curative operation without histological lymph nodes metastases were studied between 2001 and 2003. A total of 2 481 lymph nodes were analyzed using monoclonal cytokeratin antibody AE1/AE3 (DAKO, Carpinteria, CA) for immunohistochemistry.RESULTS: In total, 33 (29%) patients were positive forcancer cell by immunohistochemistry. In 31 (94%) patientsof them positive nodes showed single tumor cell or small groups of tumor cells; and tumor deposits measuring 0.2and 0.37 mm in diameter in another 2 (6%) patients.Micrometastases were mainly located in the subcapsular sinus or paracortical sinus. There was no correlation between the positive lymph nodes and gender, age, tumor site, tumor size, histological type, histological grade, invasion depth, Dukes' staging and microsatellite instability (P＞0.05).CONCLUSION: Our findings suggest that immunohistochemical technique using monoclonal cytokeratin antibody AE1/AE3 may be a sensitive and reliable method for detecting lymph nodes micrometastases in Dukes' A and B colorectal cancer. The clinical significance of lymph nodes micrometastases is still not confirmed.展开更多
随着广播行业对安全播出、智能化和融合媒体需求的不断提升,传统音频工程协会标准3(Audio Engineering Society Standard 3,AES3)、多通道音频数字接口(Multi-channel Audio Digital Interface,MADI)传输架构已难以满足要求。对此,采用...随着广播行业对安全播出、智能化和融合媒体需求的不断提升,传统音频工程协会标准3(Audio Engineering Society Standard 3,AES3)、多通道音频数字接口(Multi-channel Audio Digital Interface,MADI)传输架构已难以满足要求。对此,采用基于网际互连协议的音频(Audio over Internet Protocol,AoIP)传输技术构建传输架构,采用双平面冗余设计方案打造智能广播总控系统。通过搭建冗余AoIP网络、智能化信号路由与监测系统,实现高精度精确时间协议(Precision Time Protocol,PTP)时钟同步,并引入人工智能(Artificial Intelligence,AI)驱动的故障预测算法,有效实现全广播信号的统一管理、智能调度以及安全播出保障。展开更多
文摘AIM: To detect lymph nodes micrometastases and analyze its correlation with clinicopathological parameters in Dukes' A and B colorectal cancer patients.METHODS: One hundred and fourteen patients with colorectal cancer (Dukes' A 16; Dukes' B 98) undergoing curative operation without histological lymph nodes metastases were studied between 2001 and 2003. A total of 2 481 lymph nodes were analyzed using monoclonal cytokeratin antibody AE1/AE3 (DAKO, Carpinteria, CA) for immunohistochemistry.RESULTS: In total, 33 (29%) patients were positive forcancer cell by immunohistochemistry. In 31 (94%) patientsof them positive nodes showed single tumor cell or small groups of tumor cells; and tumor deposits measuring 0.2and 0.37 mm in diameter in another 2 (6%) patients.Micrometastases were mainly located in the subcapsular sinus or paracortical sinus. There was no correlation between the positive lymph nodes and gender, age, tumor site, tumor size, histological type, histological grade, invasion depth, Dukes' staging and microsatellite instability (P＞0.05).CONCLUSION: Our findings suggest that immunohistochemical technique using monoclonal cytokeratin antibody AE1/AE3 may be a sensitive and reliable method for detecting lymph nodes micrometastases in Dukes' A and B colorectal cancer. The clinical significance of lymph nodes micrometastases is still not confirmed.
文摘随着广播行业对安全播出、智能化和融合媒体需求的不断提升,传统音频工程协会标准3(Audio Engineering Society Standard 3,AES3)、多通道音频数字接口(Multi-channel Audio Digital Interface,MADI)传输架构已难以满足要求。对此,采用基于网际互连协议的音频(Audio over Internet Protocol,AoIP)传输技术构建传输架构,采用双平面冗余设计方案打造智能广播总控系统。通过搭建冗余AoIP网络、智能化信号路由与监测系统,实现高精度精确时间协议(Precision Time Protocol,PTP)时钟同步,并引入人工智能(Artificial Intelligence,AI)驱动的故障预测算法,有效实现全广播信号的统一管理、智能调度以及安全播出保障。
