This article discusses the various blood interactions that may occur with various types of nano drug-loading systems. Nanoparticles enter the blood circulation as foreign objects. On the one hand, they may cause a ser...This article discusses the various blood interactions that may occur with various types of nano drug-loading systems. Nanoparticles enter the blood circulation as foreign objects. On the one hand, they may cause a series of inflammatory reactions and immune reactions, resulting in the rapid elimination of immune cells and the reticuloendothelial system, affecting their durability in the blood circulation. On the other hand, the premise of the drug-carrying system to play a therapeutic role depends on whether they cause coagulation and platelet activation, the absence of hemolysis and the elimination of immune cells. For different forms of nano drug-carrying systems, we can find the characteristics, elements and coping strategies of adverse blood reactions that we can find in previous researches. These adverse reactions may include destruction of blood cells, abnormal coagulation system, abnormal effects of plasma proteins, abnormal blood cell behavior, adverse immune and inflammatory reactions, and excessive vascular stimulation. In order to provide help for future research and formulation work on the blood compatibility of nano drug carriers.展开更多
Objective:To relate physiologic changes and presence of illnesses in older adults,with the risk of appearance of adverse reactions and pharmacological interactions as consequence of the use of medicinal plants.Methods...Objective:To relate physiologic changes and presence of illnesses in older adults,with the risk of appearance of adverse reactions and pharmacological interactions as consequence of the use of medicinal plants.Methods:To carry out a search in the last 5 years and to present a general vision about what have been published related to the use of medicinal plants with risk of appearance of adverse reactions and interactions in older adults.Conclusions:Technological prevision based on the search of articles in the Virtual Library in Health(BVS)and using the words key“medicinal plants”,“older adult”,“pharmacokinetics”,“adverse reactions”,“elderly”,“pharmacological interactions”,and the association among them.展开更多
1 Introduction For patients with complex diseases or co-existing conditions,polypharmacy-defined as the concurrent use of multiple medications-can be a promising strategy.However,this approach significantly increases ...1 Introduction For patients with complex diseases or co-existing conditions,polypharmacy-defined as the concurrent use of multiple medications-can be a promising strategy.However,this approach significantly increases the risk of side effects due to drug-drug interactions(DDIs).Adverse DDIs are a leading cause of morbidity and mortality,with drug-induced fatalities accounting for approximately 100,000 deaths annually in the U.S.,making them the fourth leading cause of death after lung disease[1,2].展开更多
文摘This article discusses the various blood interactions that may occur with various types of nano drug-loading systems. Nanoparticles enter the blood circulation as foreign objects. On the one hand, they may cause a series of inflammatory reactions and immune reactions, resulting in the rapid elimination of immune cells and the reticuloendothelial system, affecting their durability in the blood circulation. On the other hand, the premise of the drug-carrying system to play a therapeutic role depends on whether they cause coagulation and platelet activation, the absence of hemolysis and the elimination of immune cells. For different forms of nano drug-carrying systems, we can find the characteristics, elements and coping strategies of adverse blood reactions that we can find in previous researches. These adverse reactions may include destruction of blood cells, abnormal coagulation system, abnormal effects of plasma proteins, abnormal blood cell behavior, adverse immune and inflammatory reactions, and excessive vascular stimulation. In order to provide help for future research and formulation work on the blood compatibility of nano drug carriers.
文摘Objective:To relate physiologic changes and presence of illnesses in older adults,with the risk of appearance of adverse reactions and pharmacological interactions as consequence of the use of medicinal plants.Methods:To carry out a search in the last 5 years and to present a general vision about what have been published related to the use of medicinal plants with risk of appearance of adverse reactions and interactions in older adults.Conclusions:Technological prevision based on the search of articles in the Virtual Library in Health(BVS)and using the words key“medicinal plants”,“older adult”,“pharmacokinetics”,“adverse reactions”,“elderly”,“pharmacological interactions”,and the association among them.
基金supported by the Key Program of Jiangsu Science Foundation(BK20243012)the Fundamental Research Funds for the Central Universities(022114380023).
文摘1 Introduction For patients with complex diseases or co-existing conditions,polypharmacy-defined as the concurrent use of multiple medications-can be a promising strategy.However,this approach significantly increases the risk of side effects due to drug-drug interactions(DDIs).Adverse DDIs are a leading cause of morbidity and mortality,with drug-induced fatalities accounting for approximately 100,000 deaths annually in the U.S.,making them the fourth leading cause of death after lung disease[1,2].
