The aetiology of OAL is undefined, although much attention has been recently focused on determining whether OAL is caused by an autoimmune disorder, chronic antigenic stimulation or both. It is becoming evident that i...The aetiology of OAL is undefined, although much attention has been recently focused on determining whether OAL is caused by an autoimmune disorder, chronic antigenic stimulation or both. It is becoming evident that infectious agents underlying chronic eye infection, as Chlamydia, may play a role in ocular lymphomagenesis. The high prevalence of Chlamydophila psittaci in patients with OAL has suggested a potential oncogenic role for its tendency to cause chronic and persistent infections, although it has been documented an evident geographical variability and response to antibiotic treatment. For C. pneumoniae, the findings so far obtained are very limited not only for identification in OAL but also for the specific treatment with antibiotics. The recent molecular and cultural evidence of C. trachomatis in patients with OAL, seems to suggest that also this pathogen may contribute to pathogenesis of such lymphoma. The potential application of bacteria-eradicating therapy at local and systemic level may ultimately result in safer and more efficient therapeutic option for patients affected by these malignancies. Moreover, a close collaboration between experts in ophthalmology, infectious diseases and hematology will help, in the future, to effectively manage this disease. This review attempts to weigh the currently available evidence regarding the role that Chlamydia play in development of OAL and focuses on patients with OAL observed at our Institution.展开更多
本研究对基于MRI的附件肿物评分系统研究进展进行综述。首先分别回顾ADNEX MR评分系统和O-RADS MRI评分系统的提出背景及其对超声下不确定的附件肿物的诊断性能和临床价值。其次,整理两大MRI评分系统的分类标准以及相关的MRI特征术语。...本研究对基于MRI的附件肿物评分系统研究进展进行综述。首先分别回顾ADNEX MR评分系统和O-RADS MRI评分系统的提出背景及其对超声下不确定的附件肿物的诊断性能和临床价值。其次,整理两大MRI评分系统的分类标准以及相关的MRI特征术语。再总结近年来两大评分系统的临床应用进展及局限性。最后,进一步讨论MRI评分系统未来的可能发展方向。本综述旨在为后续研究附件肿物的术前评估及准确分类方面提供一些可行的思路和建议。The present review examines the current landscape and emerging developments of MRI-derived scoring systems for characterizing adnexal masses. Firstly, the background of the ADNEX MR SCORING system and the O-RADS MRI scoring system were reviewed, and their diagnostic performance and clinical value for indeterminate adnexal masses under ultrasound were reviewed, respectively. Secondly, the classification criteria of the two MRI scoring systems and the related descriptive terms of MRI signs are organized. The clinical progress and limitations of the two scoring systems in recent years are then summarized, and finally, the possible future directions of MRI scoring systems are further explored and discussed. The aim of this study is to provide some feasible ideas and suggestions for subsequent studies on the preoperative evaluation and accurate classification of adnexal masses.展开更多
目的 探讨眼附属器黏膜相关淋巴组织结外边缘区(extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue, MALT)淋巴瘤伴显著浆细胞分化(plasmacytic differentiation, PCD)的临床病理特征。方法 收集3例眼附属器...目的 探讨眼附属器黏膜相关淋巴组织结外边缘区(extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue, MALT)淋巴瘤伴显著浆细胞分化(plasmacytic differentiation, PCD)的临床病理特征。方法 收集3例眼附属器MALT淋巴瘤伴显著PCD临床病理资料,采用MaxVision两步法进行免疫组化检测、BIOMED-2方法进行基因重排检测,并复习文献。结果 3例眼附属器MALT淋巴瘤伴显著PCD患者为1例男性,2例女性,中位年龄56岁,组织学表现为肿瘤性小B细胞成分少,主要局限在边缘区,单克隆性PCD细胞数量众多,在扩张的滤泡间区弥漫浸润、融合成片。免疫组化染色显示PCD细胞MUM1、CD38和(或)CD138阳性,Kappa或Lambda轻链限制性表达。基因重排结果显示IGH、IGK基因克隆性重排阳性。结论 眼附属器MALT淋巴瘤伴显著PCD罕见,与多种浆细胞众多的良恶性病变鉴别时有一定困难,诊断时需要综合判断。展开更多
文摘The aetiology of OAL is undefined, although much attention has been recently focused on determining whether OAL is caused by an autoimmune disorder, chronic antigenic stimulation or both. It is becoming evident that infectious agents underlying chronic eye infection, as Chlamydia, may play a role in ocular lymphomagenesis. The high prevalence of Chlamydophila psittaci in patients with OAL has suggested a potential oncogenic role for its tendency to cause chronic and persistent infections, although it has been documented an evident geographical variability and response to antibiotic treatment. For C. pneumoniae, the findings so far obtained are very limited not only for identification in OAL but also for the specific treatment with antibiotics. The recent molecular and cultural evidence of C. trachomatis in patients with OAL, seems to suggest that also this pathogen may contribute to pathogenesis of such lymphoma. The potential application of bacteria-eradicating therapy at local and systemic level may ultimately result in safer and more efficient therapeutic option for patients affected by these malignancies. Moreover, a close collaboration between experts in ophthalmology, infectious diseases and hematology will help, in the future, to effectively manage this disease. This review attempts to weigh the currently available evidence regarding the role that Chlamydia play in development of OAL and focuses on patients with OAL observed at our Institution.
文摘本研究对基于MRI的附件肿物评分系统研究进展进行综述。首先分别回顾ADNEX MR评分系统和O-RADS MRI评分系统的提出背景及其对超声下不确定的附件肿物的诊断性能和临床价值。其次,整理两大MRI评分系统的分类标准以及相关的MRI特征术语。再总结近年来两大评分系统的临床应用进展及局限性。最后,进一步讨论MRI评分系统未来的可能发展方向。本综述旨在为后续研究附件肿物的术前评估及准确分类方面提供一些可行的思路和建议。The present review examines the current landscape and emerging developments of MRI-derived scoring systems for characterizing adnexal masses. Firstly, the background of the ADNEX MR SCORING system and the O-RADS MRI scoring system were reviewed, and their diagnostic performance and clinical value for indeterminate adnexal masses under ultrasound were reviewed, respectively. Secondly, the classification criteria of the two MRI scoring systems and the related descriptive terms of MRI signs are organized. The clinical progress and limitations of the two scoring systems in recent years are then summarized, and finally, the possible future directions of MRI scoring systems are further explored and discussed. The aim of this study is to provide some feasible ideas and suggestions for subsequent studies on the preoperative evaluation and accurate classification of adnexal masses.
