《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准...《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。展开更多
State Administration for Market Regulation and National Standardization Administration of China have approved the foreign language versions of the following 41 national standards in foreign language versions.
State Administration for Market Regulation and National Standardization Administration of China have approved the foreign language versions of the following 60 national standards in foreign language version.
State Administration for Market Regulation and National Standardization Administration of China have approved the following 261 voluntary national standards.
The thoracic duct(TD),the largest lymphatic vessel in the human body,plays a critical role in returning lymph to the circulatory system.However,its dynamic,distensible nature and concealed anatomical location make int...The thoracic duct(TD),the largest lymphatic vessel in the human body,plays a critical role in returning lymph to the circulatory system.However,its dynamic,distensible nature and concealed anatomical location make intraoperative visualization critically challenging and increase the risk of injury.Real-time,high-resolution assessment of TD leaks remains an urgent clinical need.Here,we present a breakthrough molecular engineering strategy that leverages an intestinally lipophilic fluorescent formulation for dynamic in vivo TD imaging.Our rationally designed cyanine derivative IR790+,known for its rapid membrane permeability and endoplasmic reticulum(ER)targeting localization,demonstrates unprecedented chylomicron affinity,which subsequently transports the dye through the lymphatic system to the TD.Notably,dynamic,high-contrast intraoperative TD imaging is achieved from rat models to swine models.Administered orally as near-infrared(NIR)fluorescent contrast agent,this ultra-stable IR790+@oil formulation,engineered via flash nanoprecipitation,surpasses conventional counterparts by enabling non-invasive,real-time identification of TD.Intriguingly,this first-reported ER-targeting NIR formulation,delivered orally,represents a paradigm shift in fluorescence-guided surgery,significantly improving intraoperative accuracy.展开更多
State Administration for Market Regulation and National Standardization Administration of China have approved the following 76 national standards as guiding technical docoments.
State Administration for Market Regulation and National Standardization Administration of China have approved the following 3 voluntary national standards.
The story tells how a Chinese village hit a home run by building its future around baseball,transforming the sport into a powerful engine for rural revitalization.XUJIADAI is an administrative village in Lindai Town o...The story tells how a Chinese village hit a home run by building its future around baseball,transforming the sport into a powerful engine for rural revitalization.XUJIADAI is an administrative village in Lindai Town of Jiaxing City,east China’s Zhejiang Province.It is in this small village that over 100 baseball and softball tournaments have been held,a record that has crowned it China’s top baseball village.展开更多
State Administration for Market Regulation and National Standardization Administration of China have approved the following 758 voluntary national standards and 6 voluntary national standards with amendment.
Recently,the Standardization Administration of China issued Announcement No.1 of 2026,officially approving the establishment of the Subcommittee 1 on Nonwoven Material of National Technical Committee 606 on Technical ...Recently,the Standardization Administration of China issued Announcement No.1 of 2026,officially approving the establishment of the Subcommittee 1 on Nonwoven Material of National Technical Committee 606 on Technical Textiles of Standardization Administration of China(SAC/TC606/SC1)and the Subcommittee 2 on Filtration and Separation Textiles of National Technical Committee 606 on Technical Textiles of Standardization Administration of China(SAC/TC606/SC2).The formation of these two subcommittees marks a crucial step in the standardization development of China's industrial textiles sector in specialized fields.展开更多
Type 1 diabetes(T1D)is defined by autoimmune-mediated destruction of the insulin-producing pancreatic β-cells.Impaired insulin secretion due to β-cell apoptosis and islet massloss is the main feature of T1D[1].Curre...Type 1 diabetes(T1D)is defined by autoimmune-mediated destruction of the insulin-producing pancreatic β-cells.Impaired insulin secretion due to β-cell apoptosis and islet massloss is the main feature of T1D[1].Current therapeutic strategies for T1D are mainly through subcutaneous administration of insulin or islet/pancreas transplantation.展开更多
《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准...《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。展开更多
《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准...《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。展开更多
《公共行政评论》(Journal of Public Administration, JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标...《公共行政评论》(Journal of Public Administration, JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。展开更多
《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准...《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。展开更多
OBJECTIVE:To investigate whether Jiegeng(Radix Platycodi,RP)has a Yin-Jing potentiating effect on Jingjie(Herba Schizonepetae Tenuifoliae,ST).We investigated the pharmacokinetics and tissue distribution of pulegone,th...OBJECTIVE:To investigate whether Jiegeng(Radix Platycodi,RP)has a Yin-Jing potentiating effect on Jingjie(Herba Schizonepetae Tenuifoliae,ST).We investigated the pharmacokinetics and tissue distribution of pulegone,the active ingredient in ST volatile oil,in rats to verify the scientific validity of the Yin-Jing doctrine,the basic theory of Traditional Chinese Medicine(TCM).METHODS:The volatile oil and aqueous extract of ST were extracted by hydrodistillation.RP's aqueous extract underwent aqueous extraction.After individual and co-administration,we conducted pharmacokinetic and tissue distribution studies on Sprague-Dawley male rats.RESULTS:Peak concentration(Cmax),mean retention time from 0 to∞(MRT0→∞),and area under the curve(AUC0→10),(AUC0→∞)were 1.51,1.14,2.34,and 3.86 times higher in the co-administration group than in the individual administration group,respectively(P<0.05).In addition,half-life(T1/2)was significantly prolonged in the co-administration group(P<0.05).Meanwhile,the clearance and elimination rate constant(Ke)in the co-administration group were significantly lower than those in the individual administration group,just 50%of those in the individual administration group(P<0.05).After co-administration of the drug,the pulegone content in all tissues of the rats was elevated to varying degrees,especially a significant increase in the drug content in lung tissues(P<0.05).CONCLUSION:After co-administration,the retention of pulegone in the body was prolonged,the elimination of pulegone from the body was delayed,and the accumulation of pulegone in the lungs was facilitated.Therefore,using RP as a Yin-Jing drug concoction has a significant cumulative effect of inducing upward mobilization and targeting lung tissues.展开更多
Background:Whether lactated Ringer's solution is clinically superior to normal saline for routine intravenous administration of fluids is uncertain.Methods:In an open-label,two-period,two-sequence,cross-sectional,...Background:Whether lactated Ringer's solution is clinically superior to normal saline for routine intravenous administration of fluids is uncertain.Methods:In an open-label,two-period,two-sequence,cross-sectional,cluster-randomized,crossover trial,we assigned hospitals in Ontario,Canada,to use either lactated Ringer's solution or normal saline hospital-wide for a period of 12 weeks.展开更多
Aims and Scope Asian Journal of Social Pharmacy(AJSP)is peer-reviewed quarterly English journal jointly hosted by Herbal Font Pharmaceutical Limited and Shenyang Pharmaceutical University.AJSP is dedicated to providin...Aims and Scope Asian Journal of Social Pharmacy(AJSP)is peer-reviewed quarterly English journal jointly hosted by Herbal Font Pharmaceutical Limited and Shenyang Pharmaceutical University.AJSP is dedicated to providing researchers,pharmacists,administrators,and educators working within the field of pharmacy worldwide with a platform of communication in the advancement and development in social pharmacy.The journal welcomes original contributions in pharmacy-related research including policies,regulations and laws,administration,monitoring,inspection,surveillance,utilization,formulary analysis,drug manufacturing,drug marketing,drug R&D,pharmacy practice,clinical pharmacy,pharmacoeconomics,and modernization of traditional Chinese medicine.To expedite the dissemination of findings from latest research,the journal receives rapid research report.Rapid research reports can be published within 3 months on submission,which does not preclude publication of full length reports of the research work in other journals.展开更多
Lipid nanoparticles(LNPs)have emerged as versatile carriers for the delivery of genetic medicines and small-molecule drugs,offering desired benefits for therapeutic applications.Optimization of the treatment efficacy ...Lipid nanoparticles(LNPs)have emerged as versatile carriers for the delivery of genetic medicines and small-molecule drugs,offering desired benefits for therapeutic applications.Optimization of the treatment efficacy of nanocarriers necessitates a thorough understanding of the connection between pharmacokinetics and physicochemical properties.This review consolidates scientific efforts to elucidate how LNP’s physicochemical attributes influence their in vivo fate,emphasizing particle size and shape,surface electric potential and ligand-binding chemistry.By examining the interplay between LNPs and biological barriers across various administration routes,this review provides insights into tailoring LNP properties for optimal delivery and reduced off-target effects.Recommendations for future research are provided to advance the study of LNP in vivo behaviors and offer a practical framework for optimizing in vivo performance through product design parameters.展开更多
文摘《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。
文摘State Administration for Market Regulation and National Standardization Administration of China have approved the foreign language versions of the following 41 national standards in foreign language versions.
文摘State Administration for Market Regulation and National Standardization Administration of China have approved the foreign language versions of the following 60 national standards in foreign language version.
文摘State Administration for Market Regulation and National Standardization Administration of China have approved the following 261 voluntary national standards.
基金supported by the National Natural Science Foundation of China(22225805,81400681,32394001,32121005)the Shanghai Science and Technology Innovation Action Plan(22Y11907200,23J21901600)the Innovation Program of Shanghai Municipal Education Commission,Shanghai Municipal Health Commission(2024ZZ2025)。
文摘The thoracic duct(TD),the largest lymphatic vessel in the human body,plays a critical role in returning lymph to the circulatory system.However,its dynamic,distensible nature and concealed anatomical location make intraoperative visualization critically challenging and increase the risk of injury.Real-time,high-resolution assessment of TD leaks remains an urgent clinical need.Here,we present a breakthrough molecular engineering strategy that leverages an intestinally lipophilic fluorescent formulation for dynamic in vivo TD imaging.Our rationally designed cyanine derivative IR790+,known for its rapid membrane permeability and endoplasmic reticulum(ER)targeting localization,demonstrates unprecedented chylomicron affinity,which subsequently transports the dye through the lymphatic system to the TD.Notably,dynamic,high-contrast intraoperative TD imaging is achieved from rat models to swine models.Administered orally as near-infrared(NIR)fluorescent contrast agent,this ultra-stable IR790+@oil formulation,engineered via flash nanoprecipitation,surpasses conventional counterparts by enabling non-invasive,real-time identification of TD.Intriguingly,this first-reported ER-targeting NIR formulation,delivered orally,represents a paradigm shift in fluorescence-guided surgery,significantly improving intraoperative accuracy.
文摘State Administration for Market Regulation and National Standardization Administration of China have approved the following 76 national standards as guiding technical docoments.
文摘State Administration for Market Regulation and National Standardization Administration of China have approved the following 3 voluntary national standards.
文摘The story tells how a Chinese village hit a home run by building its future around baseball,transforming the sport into a powerful engine for rural revitalization.XUJIADAI is an administrative village in Lindai Town of Jiaxing City,east China’s Zhejiang Province.It is in this small village that over 100 baseball and softball tournaments have been held,a record that has crowned it China’s top baseball village.
文摘State Administration for Market Regulation and National Standardization Administration of China have approved the following 758 voluntary national standards and 6 voluntary national standards with amendment.
文摘Recently,the Standardization Administration of China issued Announcement No.1 of 2026,officially approving the establishment of the Subcommittee 1 on Nonwoven Material of National Technical Committee 606 on Technical Textiles of Standardization Administration of China(SAC/TC606/SC1)and the Subcommittee 2 on Filtration and Separation Textiles of National Technical Committee 606 on Technical Textiles of Standardization Administration of China(SAC/TC606/SC2).The formation of these two subcommittees marks a crucial step in the standardization development of China's industrial textiles sector in specialized fields.
基金supported by the National Natural Science Foundation of China(32325024,32400981,32222024,32271224,32471228,and 82270891)the National Key Research and Development Program of China(2023YFA1800400)+3 种基金the Shuguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission(23SG22)the Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0507300)the ECNU public platform for Innovation(011)the instruments sharing platform of School of Life Sciences.
文摘Type 1 diabetes(T1D)is defined by autoimmune-mediated destruction of the insulin-producing pancreatic β-cells.Impaired insulin secretion due to β-cell apoptosis and islet massloss is the main feature of T1D[1].Current therapeutic strategies for T1D are mainly through subcutaneous administration of insulin or islet/pancreas transplantation.
文摘《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。
文摘《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。
文摘《公共行政评论》(Journal of Public Administration, JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。
文摘《公共行政评论》(Journal of Public Administration,JPA)采用严格的匿名评审制度,致力于为国内外所有有志于公共管理研究的人士构建平等的交流平台,营造一个温暖的精神家园。现不拘作者专业、身份与地域,以聚焦公共管理领域为征稿标准,以学术品质为用稿标准,向国内外学术界、实务界热忱征集言之有物、论之有据、符合学术规范、遵守学术道德的论文、理论综述、书评、评论和博士学位论文摘要。
基金Supported by Key Laboratory of Xin’an Medicine Open Project Fund(Anhui University of Chinese Medicine)Ministry of Education:Study on the Material Basis and Mechanism of the Buoyance of Jingjie(Herba Schizonepetae Tenuifoliae)Loaded with Jiegeng(Radix Platycodi)of Traditional Chinese Medicine(2020xayx02)Drug Regulatory Scientific Research Key Project:Establishment of a New Dissolution Method Based on Drug Absorption and its Application in Drug Quality Monitoring(AHYJ-KJ-202206,Central of Regulatory Science for Medical Products,Anhui Province)Anhui Provincial Natural Science Foundation of Anhui Province of China:to Explore the Effect and Mechanism of Immune Escape Nanopreparation Based on"Dont eat me"Signal on Tumor Photodynamic Therapy(2308085MH308)。
文摘OBJECTIVE:To investigate whether Jiegeng(Radix Platycodi,RP)has a Yin-Jing potentiating effect on Jingjie(Herba Schizonepetae Tenuifoliae,ST).We investigated the pharmacokinetics and tissue distribution of pulegone,the active ingredient in ST volatile oil,in rats to verify the scientific validity of the Yin-Jing doctrine,the basic theory of Traditional Chinese Medicine(TCM).METHODS:The volatile oil and aqueous extract of ST were extracted by hydrodistillation.RP's aqueous extract underwent aqueous extraction.After individual and co-administration,we conducted pharmacokinetic and tissue distribution studies on Sprague-Dawley male rats.RESULTS:Peak concentration(Cmax),mean retention time from 0 to∞(MRT0→∞),and area under the curve(AUC0→10),(AUC0→∞)were 1.51,1.14,2.34,and 3.86 times higher in the co-administration group than in the individual administration group,respectively(P<0.05).In addition,half-life(T1/2)was significantly prolonged in the co-administration group(P<0.05).Meanwhile,the clearance and elimination rate constant(Ke)in the co-administration group were significantly lower than those in the individual administration group,just 50%of those in the individual administration group(P<0.05).After co-administration of the drug,the pulegone content in all tissues of the rats was elevated to varying degrees,especially a significant increase in the drug content in lung tissues(P<0.05).CONCLUSION:After co-administration,the retention of pulegone in the body was prolonged,the elimination of pulegone from the body was delayed,and the accumulation of pulegone in the lungs was facilitated.Therefore,using RP as a Yin-Jing drug concoction has a significant cumulative effect of inducing upward mobilization and targeting lung tissues.
文摘Background:Whether lactated Ringer's solution is clinically superior to normal saline for routine intravenous administration of fluids is uncertain.Methods:In an open-label,two-period,two-sequence,cross-sectional,cluster-randomized,crossover trial,we assigned hospitals in Ontario,Canada,to use either lactated Ringer's solution or normal saline hospital-wide for a period of 12 weeks.
文摘Aims and Scope Asian Journal of Social Pharmacy(AJSP)is peer-reviewed quarterly English journal jointly hosted by Herbal Font Pharmaceutical Limited and Shenyang Pharmaceutical University.AJSP is dedicated to providing researchers,pharmacists,administrators,and educators working within the field of pharmacy worldwide with a platform of communication in the advancement and development in social pharmacy.The journal welcomes original contributions in pharmacy-related research including policies,regulations and laws,administration,monitoring,inspection,surveillance,utilization,formulary analysis,drug manufacturing,drug marketing,drug R&D,pharmacy practice,clinical pharmacy,pharmacoeconomics,and modernization of traditional Chinese medicine.To expedite the dissemination of findings from latest research,the journal receives rapid research report.Rapid research reports can be published within 3 months on submission,which does not preclude publication of full length reports of the research work in other journals.
文摘Lipid nanoparticles(LNPs)have emerged as versatile carriers for the delivery of genetic medicines and small-molecule drugs,offering desired benefits for therapeutic applications.Optimization of the treatment efficacy of nanocarriers necessitates a thorough understanding of the connection between pharmacokinetics and physicochemical properties.This review consolidates scientific efforts to elucidate how LNP’s physicochemical attributes influence their in vivo fate,emphasizing particle size and shape,surface electric potential and ligand-binding chemistry.By examining the interplay between LNPs and biological barriers across various administration routes,this review provides insights into tailoring LNP properties for optimal delivery and reduced off-target effects.Recommendations for future research are provided to advance the study of LNP in vivo behaviors and offer a practical framework for optimizing in vivo performance through product design parameters.
