Foxtail millet(Setaria italica)is an important crop and an emerging model plant.Photoperiodic flowering is a key determinant of its production and geographic expansion.In this study,we found that SiPRR37 is responsibl...Foxtail millet(Setaria italica)is an important crop and an emerging model plant.Photoperiodic flowering is a key determinant of its production and geographic expansion.In this study,we found that SiPRR37 is responsible for the major quantitative trait locus(QTL)Heading date 2(Hd2)identified in 680 foxtail millets using a genome-wide association study.Overexpression of SiPRR37 in foxtail millet significantly delayed the heading date under both natural long-day and short-day conditions.CRISPR/Cas9-induced Siprr37 mutants exhibited earlier flowering in long-day conditions but later flowering in short-day conditions.The critical day length(CDL)for the reversal of Siprr37’s function was around 14.3 h.Haplotype analysis revealed that accessions with the Tc1-Mariner transposon insertion in SiPRR37(Hap 1)flowered significantly earlier at higher latitudes,and later at lower latitudes,indicating that natural variants of SiPRR37 exert dual functions in flowering regulation according to geographic latitude.The gradual,successive decrease in the frequency of Hap 2 from low to high latitudes,with the concurrent increase of Hap 1,demonstrates that these haplotypes have undergone artificial selection.Further FST analysis demonstrated that SiPRR37 has contributed to the ecological adaption of foxtail millet.Additionally,we reveal that OsPRR37 promotes flowering in rice,while GmPRR37 may only inhibit flowering in soybean.Further diurnal expression and transgenic analyses suggest that the dual function of SiPRR37 might depend on SiHd1.Our study uncovered the distinct functional reversal of SiPRR37 and functional diversification of PRR37 homologs in SD crops.These findings not only enrich knowledge about the regulation of photoperiodic flowering,but also contribute to genetic improvement of crops’regional adaptability.展开更多
This work presents an adaptive tracking guidance method for robotic fishes. The scheme enables robots to suppress external interference and eliminate motion jitter. An adaptive integral surge line-of-sight guidance ru...This work presents an adaptive tracking guidance method for robotic fishes. The scheme enables robots to suppress external interference and eliminate motion jitter. An adaptive integral surge line-of-sight guidance rule is designed to eliminate dynamics interference and sideslip issues. Limited-time yaw and surge speed observers are reported to fit disturbance variables in the model. The approximation values can compensate for the system's control input and improve the robots' tracking accuracy.Moreover, this work develops a terminal sliding mode controller and third-order differential processor to determine the rotational torque and reduce the robots' run jitter. Then, Lyapunov's theory proves the uniform ultimate boundedness of the proposed method. Simulation and physical experiments confirm that the technology improves the tracking error convergence speed and stability of robotic fishes.展开更多
News is an important medium to transmit social information and reflect social reality. Its effects are irreplaceable and the news language which is a carrier to spread information is in fact influenced by many factors...News is an important medium to transmit social information and reflect social reality. Its effects are irreplaceable and the news language which is a carrier to spread information is in fact influenced by many factors such as society, economy and culture. In order to exert its function to gain different social ends, the presentation of news language owns distinguishing features. This article starts from Verschueren's Adaption Theory to have the final conclusion that the adaption to the social, mental and physical world is the key element for the determination of the originality in news language.展开更多
Based on specimens collected in Yinggehai, Hainan, China from 2013 to 2016, a stable epiphytic taxon is found on the surface of the individual of marine green alga Cladophora aokii Yamada. According to the morphologic...Based on specimens collected in Yinggehai, Hainan, China from 2013 to 2016, a stable epiphytic taxon is found on the surface of the individual of marine green alga Cladophora aokii Yamada. According to the morphological characteristics, the taxonomy of Cl. aokii and its epiphytes is carried out. There are some epiphytes attached on Cl. aokii Yamada including Cl. fascicularis （Mertens ex C. Agardh） Kfitzing, Chaetomorpha pachynerna （Montagne） Kiitzing, Cerarniurn carnouii Dawson, Licmophora abbreviata Agardh, Lyngbya sp. and Chattonella sp.. The formation of the individual of Cl. aokii is dissected and explained, which can help to analyze the adaption in details among this species, its epiphytes and native marine environment. The results reveal the marine macroepiphytic taxonomy in Ha/nan, China, and preliminarily explain the adaptive relationship between macroalgae and environment.展开更多
We designed two types of pre-adaption plans for this study. One was a pre-adaption training with progressive intermittent hypoxia, with a constant lower pressure oxygen tank used in the plain before arriving at the pl...We designed two types of pre-adaption plans for this study. One was a pre-adaption training with progressive intermittent hypoxia, with a constant lower pressure oxygen tank used in the plain before arriving at the plateau （PG）. The other was by progressively increasing the time of exposure to hypoxia with oxygen supplied in stages after radical plateau （RG）. By testing the blood oxygen saturation （SpO2）, heart rate （HR）, and quality of sleep after arriving at the 3800 m high plateau, results showed that the pre-acclimatization and radical groups performed better than the control group （CG）. Both strategies were equivalent in terms of effects and principles in providing more flexible choices for acclimatization.展开更多
Neurodegenerative disease is a condition in which subpopulations of neuronal cells of the brain and spinal cord are selectively lost. A common event in many neurodegenerative diseases, such as Parkinson＇s disease （P...Neurodegenerative disease is a condition in which subpopulations of neuronal cells of the brain and spinal cord are selectively lost. A common event in many neurodegenerative diseases, such as Parkinson＇s disease （PD）, Alzheimer＇s disease （AD）, amyotrophic lateral sclerosis （ALS）, multiple sclerosis and prion diseases, is the increased level of endoplasmic reticulum （ER） stress caused by accumulation and deposits of inclusion bodies that contain abnormal aggregated proteins. However, the exact contributions to and causal effects of ER stress in neuron degeneration are not clear （Lindholm et al., 2006）.展开更多
Based on physiological properties of synapse, soma and axon, this paper presents and analyses a model of neural circuit which can approximately simulate input-output relation, strength-duration curve, adaption and non...Based on physiological properties of synapse, soma and axon, this paper presents and analyses a model of neural circuit which can approximately simulate input-output relation, strength-duration curve, adaption and nonlinear connection of real neuron. The obtained results show that the model approximates to realistic principles of neural computation better than the available neural networks. The impulse-coded WTA(winner takes all) networks constructed with the above model find the winner more effectively than the analog WTA. Finally, the two important concepts: time competition and strength competition are introduced, which illustrate that the model has abilities to perform series and parallel information processing.展开更多
Dynamic adaptive streaming over HTTP （DASH） has been widely deployed. However, large latency in HTTP/1.1 cannot meet the requirements of live streaming. Data- pushing in HTFP/2 is emerging as a promising technology....Dynamic adaptive streaming over HTTP （DASH） has been widely deployed. However, large latency in HTTP/1.1 cannot meet the requirements of live streaming. Data- pushing in HTFP/2 is emerging as a promising technology. For video live over HTTP/2, new challenges arise due to both low-delay and small buffer constraints. In this paper, we study the rate adaption problem over HTFP/2 with the aim to improve the quality of experience （QoE） of live streaming. To track the dynamic characteristics of the streaming system, a Markov-theoretical approach is employed. System variables are taken into account to describe the system state, by which the system transi- tion probability is derived. Moreover, we design a dynamic reward function considering both the quality of user experience and dynamic system variables. Therefore, the rate adaption problem is formulated into a Markov decision based optimization problem and the best streaming policy is obtained. At last, the effectiveness of our proposed rate adaption scheme is demonstrated by numerous experiment results.展开更多
As the rapid development of Internet, the film is an effective way to transmit Chinese culture through the language adaption. And the film title can catch people's eyes more quickly. Some scholars think that the t...As the rapid development of Internet, the film is an effective way to transmit Chinese culture through the language adaption. And the film title can catch people's eyes more quickly. Some scholars think that the translation of Chinese film titles should from the Functional Perspective. Some scholars think that it should do from the perspective of Skopos Theory. However, there are not enough scholars try to do it from the Perspective of the Contextual Adaption Theory. It is important to find an idea to translate the Chinese film titles to achieve that. So, this thesis try to find a effective way to translate the Chinese film titles. According to the contextual adaption theory, this thesis draws a conclusion that the translators can directly use the Chinese images in the film titles.展开更多
Under the development of the modern media,the adaption of literary works to films has been developed into a new trend.It is true enough to say that there are both advantages and disadvantages of film-making.However,to...Under the development of the modern media,the adaption of literary works to films has been developed into a new trend.It is true enough to say that there are both advantages and disadvantages of film-making.However,to some extent,the film Henry VI is an appropriate adaption toward the original text.展开更多
The cavitating flow around a Delft Twist-11 hydrofoil is simulated using the large eddy simulation approach.The volume-of-fluid method incorporated with the Schnerr-Sauer cavitation model is utilized to track the wate...The cavitating flow around a Delft Twist-11 hydrofoil is simulated using the large eddy simulation approach.The volume-of-fluid method incorporated with the Schnerr-Sauer cavitation model is utilized to track the water-vapor interface.Adaptive mesh refinement(AMR)is also applied to improve the simulation accuracy automatically.Two refinement levels are conducted to verify the dominance of AMR in predicting cavitating flows.Results show that cavitation features,including the U-type structure of shedding clouds,are consistent with experimental observations.Even a coarse mesh can precisely capture the phase field without increasing the total cell number significantly using mesh adaption.The predicted shedding frequency agrees fairly well with the experimental data under refinement level 2.This study illustrates that AMR is a promising approach to achieve accurate simulations for multiscale cavitating flows within limited computational costs.Finally,the force element method is currently adopted to investigate the lift and drag fluctuations during the evolution of cavitation structure.The mechanisms of lift and drag fluctuations due to cavitation and the interaction between vorticity forces and cavitation are explicitly revealed.展开更多
Climate change adaptation is the process of preparing and actively adjusting to meet the climate change (negative effects and potential opportunities). Urban adaptation is aimed at the sensitivity level of risks and s...Climate change adaptation is the process of preparing and actively adjusting to meet the climate change (negative effects and potential opportunities). Urban adaptation is aimed at the sensitivity level of risks and specific impacts of cities under the impact of climate change, and to develop policies and investment programs to reduce the vulnerability of cities to climate change risk. Urban adaptive action provides the basis and direction for the construction of urban resilience and sustainable development. Identifying the demand of adaption technologies, promoting the practical implementation of international technology transfer and reducing domestic emissions have important significance for the global response to climate change and improvement of the ability of urban adaptation. In this paper, through in-depth analysis on the concept and connotation of climate change, climate disasters and urban adaptation to climate change, the evaluation framework and steps of urban adaptation to climate change technology are determined, and six priority application technologies which can maximize the overall efficiency of sustainable development, improve the ability to adapt to climate change and at the same time reduce the cost at the greatest extent are identified.展开更多
The purpose of this paper is to study effect factors of adaptation to university life of Chinese International Students in Korea. 374 Korean language trainees are chosen as investigation objects by means of random clu...The purpose of this paper is to study effect factors of adaptation to university life of Chinese International Students in Korea. 374 Korean language trainees are chosen as investigation objects by means of random cluster sampling. Questionnaire data are collected by using the survey form and then paths of effect factors on adaption to university life of Korean training Chinese students in Korea are analyzed. The results indicate that Korean language proficiency, physical symptoms, loneliness, self-efficacy, acculturation stress are direct effect factors on Chinese students adapting to university life in Korea. Besides, Korean language proficiency, physical symptoms, loneliness are not only direct effect factors on self-efficacy and acculturation stress but also indirect effect factors on Chinese students adapting to university life in Korea. In order to improve ability of Korean training Chinese students adapting to university life in Korea, Korean language proficiency and self-efficacy should be improved. And, some effective interventions should be given to reducing physical symptoms, loneliness and acculturation stress.展开更多
Background: An essential condition to improve patient safety is considered to ensure a supportive patient safety culture. Measuring the culture of patient safety in all health care institutions may be a first step to ...Background: An essential condition to improve patient safety is considered to ensure a supportive patient safety culture. Measuring the culture of patient safety in all health care institutions may be a first step to target improvements. Creating a culture of safety requires eliminating the culture of blame. In order to formulate actions for improvement, it is important for hospitals to assess their baseline scores for the existing safety culture and to determine the areas of priority. Aim: The aim of this study was first to measure the use, translation in Albanian and adaptation of the Hospital Survey on Patient Safety Culture (HSOPSC) assessment as a tool for improving patient safety in Kosovo Hospitals. The second aim was to measure the level of patient safety culture in Kosovo, in seven hospitals and one University Clinical Center (hospitals with over 50 beds, including psychiatric hospitals). Method: The questionnaire (HSOPSC) was translated into Albanian for use in the Kosovo. It was used forward-backward translation: the questions were translated into Albanian by one translator and then translated back into English by an independent translator who was blinded to the original questionnaire. Results: In the eight-factor model, the internal consistency of the factors and the construct validity of the HSOPSC questionnaire were mostly satisfactory. The construct validity was sufficient for all subscales, except for the 4 other subscale regarding intention to report incidents which correlated poorly with other subscales. In total, HSOPSC has 12 dimensions. Cronbach’s α showed that in Kosovarian society, we could use only 8 dimensions model. Conclusion: The hypothesis that HSOPSC would be a suitable instrument to provide important indicators for the improvement of patient safety culture was tested and it was confirmed, that HSOPSC could be used as 8 dimension model. HSOPSC is suitable to improve patient safety culture and provide each hospital with a basic profile on patient safety culture and recommendations for an oriented intervention plan.展开更多
A novel particle filter bandwidth adaption for kernel particle filter(BAKPF)is proposed.Selection of the kernel bandwidth is a critical issue in kernel density estimation(KDE).The plug-in method is adopted to get the ...A novel particle filter bandwidth adaption for kernel particle filter(BAKPF)is proposed.Selection of the kernel bandwidth is a critical issue in kernel density estimation(KDE).The plug-in method is adopted to get the global fixed bandwidth by optimizing the asymptotic mean integrated squared error(AMISE)firstly.Then,particle-driven bandwidth selection is invoked in the KDE.To get a more effective allocation of the particles,the KDE with adap-tive bandwidth in the BAKPF is used to approximate the posterior probability density function(PDF)by moving particles toward the posterior.A closed-form expression of the true distribution is given.The simulation results show that the proposed BAKPF performs better than the standard particle filter(PF),unscented particle filter(UPF)and the kernel particle filter(KPF)both in efficiency and estimation precision.展开更多
The Tibetan antelope(Pantholops hodgsonii),blue sheep(Pseudois nayaur),and Tibetan sheep(Ovis aries)are the dominant small ruminants in the Three-River-Source National Park(TRSNP).However,knowledge about the associati...The Tibetan antelope(Pantholops hodgsonii),blue sheep(Pseudois nayaur),and Tibetan sheep(Ovis aries)are the dominant small ruminants in the Three-River-Source National Park(TRSNP).However,knowledge about the association between gut microbiota and host adaptability remains poorly understood.Herein,multi-omics sequencing approaches were employed to investigate the gut microbiota-mediated forage adaption in these ruminants.The results revealed that although wild ruminants(WR)of P.hodgsoni and P.nayaur were faced with severe foraging environments with significantly low vegetation coverage and nutrition,the apparent forage digestibility of dry matter,crude protein,and acid detergent fiber was significantly higher than that of O.aries.The 16s rRNA sequencing showed that the gut microbiota in WR underwent convergent evolution,and alpha diversity in these two groups was significantly higher than that in O.aries.Moreover,indicator species,including Bacteroidetes and Firmicutes,exhibited positive relationships with apparent forage digestibility,and their relative abundances were enriched in the gut of WR.Enterotype analysis further revealed that enterotype 1 belonged to WR,and the abundance of fatty acid synthesis metabolic pathway-related enzyme genes was significantly higher than enterotype 2,represented by O.aries.Besides,the metagenomic analysis identified 14 pathogenic bacterial species,among which 10 potentially pathogenic bacteria were significantly enriched in the gut microbiota of O.aries.Furthermore,the cellulolytic strains and genes encoding cellulase and hemicellulase were significantly enriched in WR.In conclusion,our results provide new evidence of gut microbiota to facilitate wildlife adaption in severe foraging environments of the TRSNP,China.展开更多
Self-care behavior plays a major role in diabetic management. However, in China, a satisfactory instrument has not yet been developed to evaluate the compliance of self-care behavior for young patients with type 1 dia...Self-care behavior plays a major role in diabetic management. However, in China, a satisfactory instrument has not yet been developed to evaluate the compliance of self-care behavior for young patients with type 1 diabetes mellitus （T 1DM）. The Diabetes Behavior Rating Scale （DBRS） has a potential to be the first mature instrument. The purpose of this study is to cross-culturally adapt the DBRS, and preliminarily evaluate its psychometric properties. The instrument translation included translation, back translation and culture adaptation. Psychometric properties were assessed in a sample of 116 young patients with T1DM adapting insulin injection therapy. The Chinese version of the DBRS was divided to four subscales. Cronbaeh＇s α for the total scale was 0.92. The mean inter-item and item-total correlations were 0.35 and 0.54 respectively. Test-retest reliability showed good temporal stability （r=0.81, P=0.001）. Negative correlations were found between DBRS scores with the Diabetes Distress Scale scores （r=-0.32, P=-0.003） and hemoglobin Ale （HbAlc） levels （r=-0.36, P=0.002）. Higher DBRS scores correlated with better glycemic control. The Chinese insulin injection therapy version of the DBRS is well translated and culturally adapted. It shows good overall reliability and validity and appears to be a valuable tool for assessing the diabetic self-care behaviors for young patients with T 1DM.展开更多
Diabetic cardiomyopathy is defined as abnormal structure and function of the heart in the setting of diabetes,which could eventually develop heart failure and leads to the death of the patients.Although blood glucose ...Diabetic cardiomyopathy is defined as abnormal structure and function of the heart in the setting of diabetes,which could eventually develop heart failure and leads to the death of the patients.Although blood glucose control and medications to heart failure show beneficial effects on this disease,there is currently no specific treatment for diabetic cardiomyopathy.Over the past few decades,the pathophysiology of diabetic cardiomyopathy has been extensively studied,and an increasing number of studies pinpoint that impaired mitochondrial energy metabolism is a key mediator as well as a therapeutic target.In this review,we summarize the latest research in the field of diabetic cardiomyopathy,focusing on mitochondrial damage and adaptation,altered energy substrates,and potential therapeutic targets.A better understanding of the mitochondrial energy metabolism in diabetic cardiomyopathy may help to gain more mechanistic insights and generate more precise mitochondria-oriented therapies to treat this disease.展开更多
For soil liquefaction prediction from multiple data sources,this study designs a hierarchical machine learning model based on deep feature extraction and Gaussian Process with integrated domain adaption techniques.The...For soil liquefaction prediction from multiple data sources,this study designs a hierarchical machine learning model based on deep feature extraction and Gaussian Process with integrated domain adaption techniques.The proposed model first combines deep fisher discriminant analysis(DDA)and Gaussian Process(GP)in a unified framework,so as to extract deep discriminant features and enhance the model performance for classification.To deliver fair evalu-ation,the classifier is validated in the approach of repeated stratified K-fold cross validation.Then,five different data resources are presented to further verify the model’s robustness and generality.To reuse the gained knowledge from the existing data sources and enhance the generality of the predictive model,a domain adaption approach is formu-lated by combing a deep Autoencoder with TrAdaboost,to achieve good performance over different data records from both the in-situ and laboratory observations.After comparing the proposed model with classical machine learn-ing models,such as supported vector machine,as well as with the state-of-art ensemble learning models,it is found that,regarding seismic-induced liquefaction prediction,the predicted results of this model show high accuracy on all datasets both in the repeated cross validation and Wilcoxon signed rank test.Finally,a sensitivity analysis is made on the DDA-GP model to reveal the features that may significantly affect the liquefaction.展开更多
基金supported by the National Natural Science Foundation of China(32101759,32241042)the National Key Research and Development Program of China(2023YFD1200700 and 2023YFD1200704).
文摘Foxtail millet(Setaria italica)is an important crop and an emerging model plant.Photoperiodic flowering is a key determinant of its production and geographic expansion.In this study,we found that SiPRR37 is responsible for the major quantitative trait locus(QTL)Heading date 2(Hd2)identified in 680 foxtail millets using a genome-wide association study.Overexpression of SiPRR37 in foxtail millet significantly delayed the heading date under both natural long-day and short-day conditions.CRISPR/Cas9-induced Siprr37 mutants exhibited earlier flowering in long-day conditions but later flowering in short-day conditions.The critical day length(CDL)for the reversal of Siprr37’s function was around 14.3 h.Haplotype analysis revealed that accessions with the Tc1-Mariner transposon insertion in SiPRR37(Hap 1)flowered significantly earlier at higher latitudes,and later at lower latitudes,indicating that natural variants of SiPRR37 exert dual functions in flowering regulation according to geographic latitude.The gradual,successive decrease in the frequency of Hap 2 from low to high latitudes,with the concurrent increase of Hap 1,demonstrates that these haplotypes have undergone artificial selection.Further FST analysis demonstrated that SiPRR37 has contributed to the ecological adaption of foxtail millet.Additionally,we reveal that OsPRR37 promotes flowering in rice,while GmPRR37 may only inhibit flowering in soybean.Further diurnal expression and transgenic analyses suggest that the dual function of SiPRR37 might depend on SiHd1.Our study uncovered the distinct functional reversal of SiPRR37 and functional diversification of PRR37 homologs in SD crops.These findings not only enrich knowledge about the regulation of photoperiodic flowering,but also contribute to genetic improvement of crops’regional adaptability.
基金supported in part by the National Natural Science Foundation of China(62303117,T2325018,92367109)the Xiangjiang Scholar Program(XJ2023018)+2 种基金the Key Laboratory of System Control and Information Processing(Scip20240108)the Aeronautical Science Foundation of China(20230001144001)Fujian Provincial Natural Science Foundation(2024J01130098)
文摘This work presents an adaptive tracking guidance method for robotic fishes. The scheme enables robots to suppress external interference and eliminate motion jitter. An adaptive integral surge line-of-sight guidance rule is designed to eliminate dynamics interference and sideslip issues. Limited-time yaw and surge speed observers are reported to fit disturbance variables in the model. The approximation values can compensate for the system's control input and improve the robots' tracking accuracy.Moreover, this work develops a terminal sliding mode controller and third-order differential processor to determine the rotational torque and reduce the robots' run jitter. Then, Lyapunov's theory proves the uniform ultimate boundedness of the proposed method. Simulation and physical experiments confirm that the technology improves the tracking error convergence speed and stability of robotic fishes.
文摘News is an important medium to transmit social information and reflect social reality. Its effects are irreplaceable and the news language which is a carrier to spread information is in fact influenced by many factors such as society, economy and culture. In order to exert its function to gain different social ends, the presentation of news language owns distinguishing features. This article starts from Verschueren's Adaption Theory to have the final conclusion that the adaption to the social, mental and physical world is the key element for the determination of the originality in news language.
基金The National Natural Science Foundation of China under contract Nos 31400186 and 31670199the Scientific Research Plan of Tianjin Municipal Education Committee under contract No.JW1705the Research Fund for Talented Scholars of Tianjin Normal University(2016)
文摘Based on specimens collected in Yinggehai, Hainan, China from 2013 to 2016, a stable epiphytic taxon is found on the surface of the individual of marine green alga Cladophora aokii Yamada. According to the morphological characteristics, the taxonomy of Cl. aokii and its epiphytes is carried out. There are some epiphytes attached on Cl. aokii Yamada including Cl. fascicularis （Mertens ex C. Agardh） Kfitzing, Chaetomorpha pachynerna （Montagne） Kiitzing, Cerarniurn carnouii Dawson, Licmophora abbreviata Agardh, Lyngbya sp. and Chattonella sp.. The formation of the individual of Cl. aokii is dissected and explained, which can help to analyze the adaption in details among this species, its epiphytes and native marine environment. The results reveal the marine macroepiphytic taxonomy in Ha/nan, China, and preliminarily explain the adaptive relationship between macroalgae and environment.
基金supported in part by the national basic research program of China 973 program(NO.2012CB518200-G)Army major issue of comprehensive medical security research of flight crew in the plateau(N0.AKJ11J005)
文摘We designed two types of pre-adaption plans for this study. One was a pre-adaption training with progressive intermittent hypoxia, with a constant lower pressure oxygen tank used in the plain before arriving at the plateau （PG）. The other was by progressively increasing the time of exposure to hypoxia with oxygen supplied in stages after radical plateau （RG）. By testing the blood oxygen saturation （SpO2）, heart rate （HR）, and quality of sleep after arriving at the 3800 m high plateau, results showed that the pre-acclimatization and radical groups performed better than the control group （CG）. Both strategies were equivalent in terms of effects and principles in providing more flexible choices for acclimatization.
基金supported by the Paul and Harriett Campbell Fund for ALS Researchthe Zimmerman Family Love Fundthe Judith&Jean Pape Adams Charitable Foundation
文摘Neurodegenerative disease is a condition in which subpopulations of neuronal cells of the brain and spinal cord are selectively lost. A common event in many neurodegenerative diseases, such as Parkinson＇s disease （PD）, Alzheimer＇s disease （AD）, amyotrophic lateral sclerosis （ALS）, multiple sclerosis and prion diseases, is the increased level of endoplasmic reticulum （ER） stress caused by accumulation and deposits of inclusion bodies that contain abnormal aggregated proteins. However, the exact contributions to and causal effects of ER stress in neuron degeneration are not clear （Lindholm et al., 2006）.
文摘Based on physiological properties of synapse, soma and axon, this paper presents and analyses a model of neural circuit which can approximately simulate input-output relation, strength-duration curve, adaption and nonlinear connection of real neuron. The obtained results show that the model approximates to realistic principles of neural computation better than the available neural networks. The impulse-coded WTA(winner takes all) networks constructed with the above model find the winner more effectively than the analog WTA. Finally, the two important concepts: time competition and strength competition are introduced, which illustrate that the model has abilities to perform series and parallel information processing.
基金supported in part by China“973”Program under Grant No.2014CB340303”ZTE Industry-Academia-Research Cooperation Funds
文摘Dynamic adaptive streaming over HTTP （DASH） has been widely deployed. However, large latency in HTTP/1.1 cannot meet the requirements of live streaming. Data- pushing in HTFP/2 is emerging as a promising technology. For video live over HTTP/2, new challenges arise due to both low-delay and small buffer constraints. In this paper, we study the rate adaption problem over HTFP/2 with the aim to improve the quality of experience （QoE） of live streaming. To track the dynamic characteristics of the streaming system, a Markov-theoretical approach is employed. System variables are taken into account to describe the system state, by which the system transi- tion probability is derived. Moreover, we design a dynamic reward function considering both the quality of user experience and dynamic system variables. Therefore, the rate adaption problem is formulated into a Markov decision based optimization problem and the best streaming policy is obtained. At last, the effectiveness of our proposed rate adaption scheme is demonstrated by numerous experiment results.
文摘As the rapid development of Internet, the film is an effective way to transmit Chinese culture through the language adaption. And the film title can catch people's eyes more quickly. Some scholars think that the translation of Chinese film titles should from the Functional Perspective. Some scholars think that it should do from the perspective of Skopos Theory. However, there are not enough scholars try to do it from the Perspective of the Contextual Adaption Theory. It is important to find an idea to translate the Chinese film titles to achieve that. So, this thesis try to find a effective way to translate the Chinese film titles. According to the contextual adaption theory, this thesis draws a conclusion that the translators can directly use the Chinese images in the film titles.
文摘Under the development of the modern media,the adaption of literary works to films has been developed into a new trend.It is true enough to say that there are both advantages and disadvantages of film-making.However,to some extent,the film Henry VI is an appropriate adaption toward the original text.
基金financially supported by the National Natural Science Foundation of China(Nos.U21A20126 and 52006197)the National Science Foundation of Zhejiang Province(Nos.LQ21E060012 and LR20E090001)the Key Research and Development Program of Zhejiang Province(No.2021C05006)。
文摘The cavitating flow around a Delft Twist-11 hydrofoil is simulated using the large eddy simulation approach.The volume-of-fluid method incorporated with the Schnerr-Sauer cavitation model is utilized to track the water-vapor interface.Adaptive mesh refinement(AMR)is also applied to improve the simulation accuracy automatically.Two refinement levels are conducted to verify the dominance of AMR in predicting cavitating flows.Results show that cavitation features,including the U-type structure of shedding clouds,are consistent with experimental observations.Even a coarse mesh can precisely capture the phase field without increasing the total cell number significantly using mesh adaption.The predicted shedding frequency agrees fairly well with the experimental data under refinement level 2.This study illustrates that AMR is a promising approach to achieve accurate simulations for multiscale cavitating flows within limited computational costs.Finally,the force element method is currently adopted to investigate the lift and drag fluctuations during the evolution of cavitation structure.The mechanisms of lift and drag fluctuations due to cavitation and the interaction between vorticity forces and cavitation are explicitly revealed.
文摘Climate change adaptation is the process of preparing and actively adjusting to meet the climate change (negative effects and potential opportunities). Urban adaptation is aimed at the sensitivity level of risks and specific impacts of cities under the impact of climate change, and to develop policies and investment programs to reduce the vulnerability of cities to climate change risk. Urban adaptive action provides the basis and direction for the construction of urban resilience and sustainable development. Identifying the demand of adaption technologies, promoting the practical implementation of international technology transfer and reducing domestic emissions have important significance for the global response to climate change and improvement of the ability of urban adaptation. In this paper, through in-depth analysis on the concept and connotation of climate change, climate disasters and urban adaptation to climate change, the evaluation framework and steps of urban adaptation to climate change technology are determined, and six priority application technologies which can maximize the overall efficiency of sustainable development, improve the ability to adapt to climate change and at the same time reduce the cost at the greatest extent are identified.
文摘The purpose of this paper is to study effect factors of adaptation to university life of Chinese International Students in Korea. 374 Korean language trainees are chosen as investigation objects by means of random cluster sampling. Questionnaire data are collected by using the survey form and then paths of effect factors on adaption to university life of Korean training Chinese students in Korea are analyzed. The results indicate that Korean language proficiency, physical symptoms, loneliness, self-efficacy, acculturation stress are direct effect factors on Chinese students adapting to university life in Korea. Besides, Korean language proficiency, physical symptoms, loneliness are not only direct effect factors on self-efficacy and acculturation stress but also indirect effect factors on Chinese students adapting to university life in Korea. In order to improve ability of Korean training Chinese students adapting to university life in Korea, Korean language proficiency and self-efficacy should be improved. And, some effective interventions should be given to reducing physical symptoms, loneliness and acculturation stress.
文摘Background: An essential condition to improve patient safety is considered to ensure a supportive patient safety culture. Measuring the culture of patient safety in all health care institutions may be a first step to target improvements. Creating a culture of safety requires eliminating the culture of blame. In order to formulate actions for improvement, it is important for hospitals to assess their baseline scores for the existing safety culture and to determine the areas of priority. Aim: The aim of this study was first to measure the use, translation in Albanian and adaptation of the Hospital Survey on Patient Safety Culture (HSOPSC) assessment as a tool for improving patient safety in Kosovo Hospitals. The second aim was to measure the level of patient safety culture in Kosovo, in seven hospitals and one University Clinical Center (hospitals with over 50 beds, including psychiatric hospitals). Method: The questionnaire (HSOPSC) was translated into Albanian for use in the Kosovo. It was used forward-backward translation: the questions were translated into Albanian by one translator and then translated back into English by an independent translator who was blinded to the original questionnaire. Results: In the eight-factor model, the internal consistency of the factors and the construct validity of the HSOPSC questionnaire were mostly satisfactory. The construct validity was sufficient for all subscales, except for the 4 other subscale regarding intention to report incidents which correlated poorly with other subscales. In total, HSOPSC has 12 dimensions. Cronbach’s α showed that in Kosovarian society, we could use only 8 dimensions model. Conclusion: The hypothesis that HSOPSC would be a suitable instrument to provide important indicators for the improvement of patient safety culture was tested and it was confirmed, that HSOPSC could be used as 8 dimension model. HSOPSC is suitable to improve patient safety culture and provide each hospital with a basic profile on patient safety culture and recommendations for an oriented intervention plan.
基金supported by the National Natural Science Foundation of China(60736043,60805012)the Fundamental Research Funds for the Central Universities(K50510020032)
文摘A novel particle filter bandwidth adaption for kernel particle filter(BAKPF)is proposed.Selection of the kernel bandwidth is a critical issue in kernel density estimation(KDE).The plug-in method is adopted to get the global fixed bandwidth by optimizing the asymptotic mean integrated squared error(AMISE)firstly.Then,particle-driven bandwidth selection is invoked in the KDE.To get a more effective allocation of the particles,the KDE with adap-tive bandwidth in the BAKPF is used to approximate the posterior probability density function(PDF)by moving particles toward the posterior.A closed-form expression of the true distribution is given.The simulation results show that the proposed BAKPF performs better than the standard particle filter(PF),unscented particle filter(UPF)and the kernel particle filter(KPF)both in efficiency and estimation precision.
基金supported by the Youth Fund Project of the National Natural Science Foundation of China(32100100)the Joint Grant from the Chinese Academy of Sciences-People’s Government of Qinghai Province on Sanjiangyuan National Park(LHZX-2022-02)+1 种基金the Youth Innovation Promotion Association,Chinese Academy of Sciencesthe National Science Foundation of Qinghai Province(2022-ZJ-943Q).
文摘The Tibetan antelope(Pantholops hodgsonii),blue sheep(Pseudois nayaur),and Tibetan sheep(Ovis aries)are the dominant small ruminants in the Three-River-Source National Park(TRSNP).However,knowledge about the association between gut microbiota and host adaptability remains poorly understood.Herein,multi-omics sequencing approaches were employed to investigate the gut microbiota-mediated forage adaption in these ruminants.The results revealed that although wild ruminants(WR)of P.hodgsoni and P.nayaur were faced with severe foraging environments with significantly low vegetation coverage and nutrition,the apparent forage digestibility of dry matter,crude protein,and acid detergent fiber was significantly higher than that of O.aries.The 16s rRNA sequencing showed that the gut microbiota in WR underwent convergent evolution,and alpha diversity in these two groups was significantly higher than that in O.aries.Moreover,indicator species,including Bacteroidetes and Firmicutes,exhibited positive relationships with apparent forage digestibility,and their relative abundances were enriched in the gut of WR.Enterotype analysis further revealed that enterotype 1 belonged to WR,and the abundance of fatty acid synthesis metabolic pathway-related enzyme genes was significantly higher than enterotype 2,represented by O.aries.Besides,the metagenomic analysis identified 14 pathogenic bacterial species,among which 10 potentially pathogenic bacteria were significantly enriched in the gut microbiota of O.aries.Furthermore,the cellulolytic strains and genes encoding cellulase and hemicellulase were significantly enriched in WR.In conclusion,our results provide new evidence of gut microbiota to facilitate wildlife adaption in severe foraging environments of the TRSNP,China.
基金supported by the National Natural Science Foundation of China(81530026)the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education
文摘Self-care behavior plays a major role in diabetic management. However, in China, a satisfactory instrument has not yet been developed to evaluate the compliance of self-care behavior for young patients with type 1 diabetes mellitus （T 1DM）. The Diabetes Behavior Rating Scale （DBRS） has a potential to be the first mature instrument. The purpose of this study is to cross-culturally adapt the DBRS, and preliminarily evaluate its psychometric properties. The instrument translation included translation, back translation and culture adaptation. Psychometric properties were assessed in a sample of 116 young patients with T1DM adapting insulin injection therapy. The Chinese version of the DBRS was divided to four subscales. Cronbaeh＇s α for the total scale was 0.92. The mean inter-item and item-total correlations were 0.35 and 0.54 respectively. Test-retest reliability showed good temporal stability （r=0.81, P=0.001）. Negative correlations were found between DBRS scores with the Diabetes Distress Scale scores （r=-0.32, P=-0.003） and hemoglobin Ale （HbAlc） levels （r=-0.36, P=0.002）. Higher DBRS scores correlated with better glycemic control. The Chinese insulin injection therapy version of the DBRS is well translated and culturally adapted. It shows good overall reliability and validity and appears to be a valuable tool for assessing the diabetic self-care behaviors for young patients with T 1DM.
基金Yunnan Provincial Cardiovascular Disease Clinical Medical Center Project(Nos.FZX2019-06-01,2022YFKY078)Key Research and Development Program of Sichuan Province(Nos.2022YFS0132,2022YFS0198 and 2023YFS0295)National Natural Science Foundation of China(Nos.81970715 and 82370260)
文摘Diabetic cardiomyopathy is defined as abnormal structure and function of the heart in the setting of diabetes,which could eventually develop heart failure and leads to the death of the patients.Although blood glucose control and medications to heart failure show beneficial effects on this disease,there is currently no specific treatment for diabetic cardiomyopathy.Over the past few decades,the pathophysiology of diabetic cardiomyopathy has been extensively studied,and an increasing number of studies pinpoint that impaired mitochondrial energy metabolism is a key mediator as well as a therapeutic target.In this review,we summarize the latest research in the field of diabetic cardiomyopathy,focusing on mitochondrial damage and adaptation,altered energy substrates,and potential therapeutic targets.A better understanding of the mitochondrial energy metabolism in diabetic cardiomyopathy may help to gain more mechanistic insights and generate more precise mitochondria-oriented therapies to treat this disease.
文摘For soil liquefaction prediction from multiple data sources,this study designs a hierarchical machine learning model based on deep feature extraction and Gaussian Process with integrated domain adaption techniques.The proposed model first combines deep fisher discriminant analysis(DDA)and Gaussian Process(GP)in a unified framework,so as to extract deep discriminant features and enhance the model performance for classification.To deliver fair evalu-ation,the classifier is validated in the approach of repeated stratified K-fold cross validation.Then,five different data resources are presented to further verify the model’s robustness and generality.To reuse the gained knowledge from the existing data sources and enhance the generality of the predictive model,a domain adaption approach is formu-lated by combing a deep Autoencoder with TrAdaboost,to achieve good performance over different data records from both the in-situ and laboratory observations.After comparing the proposed model with classical machine learn-ing models,such as supported vector machine,as well as with the state-of-art ensemble learning models,it is found that,regarding seismic-induced liquefaction prediction,the predicted results of this model show high accuracy on all datasets both in the repeated cross validation and Wilcoxon signed rank test.Finally,a sensitivity analysis is made on the DDA-GP model to reveal the features that may significantly affect the liquefaction.
