An ultra-wideband mixing component cascaded by a mixing multi-function chip and a frequency multiplier multi-function chip was demonstrated and implemented using 3D heterogeneous integration based on the silicon adapt...An ultra-wideband mixing component cascaded by a mixing multi-function chip and a frequency multiplier multi-function chip was demonstrated and implemented using 3D heterogeneous integration based on the silicon adapter board technology.Four layers of high-resistance silicon substrate stack packaging are implemented based on the wafer-level gold-gold bonding process.Each layer adopts though silicon via(TSV)technology to realize signal interconnection.A core monolithic integrated microwave chip(MMIC)is embedded in the silicon cavity,and the silicon-based filter is integrated with the high-resistance silicon substrate.The interconnect line,cavity and filter of the silicon-based adapter board are designed with AutoCAD,and HFSS is adopted for 3D electromagnetic field simulation.According to the measured results,the radio frequency(RF)of the mixing multi-function chip is 40-44 GHz and its intermediate frequency(IF)can cover the Ku band with a chip size of 10 mm×11 mm×1 mm.The multiplier multi-function chip operates at 16-20 GHz.The fundamental suppression is greater than 50 dB and the second harmonic suppression is better than 40 dB with a chip size of 8 mm×8 mm×1 mm.The cascaded fully assembled mixing component achieves a spur of better than-50 dBc and a gain of better than 15 dB.展开更多
ACE(Adaptive Communication Environment)是用于开发高性能网络化应用与下一代中间件的面向对象框架。除了许多专用于开发网络通信软件的设计模式(比如 Reactor、Proactor、Half-Sync/Half-Async,等等),ACE还对GoF的Design Patten一书...ACE(Adaptive Communication Environment)是用于开发高性能网络化应用与下一代中间件的面向对象框架。除了许多专用于开发网络通信软件的设计模式(比如 Reactor、Proactor、Half-Sync/Half-Async,等等),ACE还对GoF的Design Patten一书中的许多设计模式作了大量应用。展开更多
This paper describes a versatile and computationally efficient method for coupling several finite element analysis(FEA)programs together so that the unique modeling and analysis capabilities of each code can be utiliz...This paper describes a versatile and computationally efficient method for coupling several finite element analysis(FEA)programs together so that the unique modeling and analysis capabilities of each code can be utilized simultaneously to simulate the static or dynamic response of a complete numerical system.An arbitrary number of finite element analysis software packages can be coupled by adding two special types of elements,namely generic and adapter elements,to each of the finite element applications using their programming interface.These elements are inserted at the interfaces between the different sub-domains of the complete system modeled by each finite element analysis software package.Exchange of data between the coupled FEA codes is accomplished in a modular and synchronized manner using OpenFresco(Opensource Framework for Experimental Setup and Control).OpenFresco is an objectoriented,environment independent software framework initially developed for hybrid simulation in which certain aspects of a complete structure are simulated numerically and other aspects are simultaneously tested physically.An important practical advantage of this coupled analysis approach is that all of the connected FEA codes run concurrently and continuously,decreasing analysis time consumption by an order of magnitude or more compared to more traditional approaches that shut down and restart the coupled analysis codes at each integration time step.The implementation and accuracy of this approach to FE software coupling are demonstrated using dynamic analyses of three simple structural models from the field of earthquake engineering.展开更多
To analyze main factors affecting the separation reliability between a missile and adapters for the launching process, a six DOF underwater dynamic model for the missile and adapters is utilized to simulate the separa...To analyze main factors affecting the separation reliability between a missile and adapters for the launching process, a six DOF underwater dynamic model for the missile and adapters is utilized to simulate the separation process, considering elastic forces of separating springs, hydrodynamic forces, gravity and buoyancy. Moreover, a criterion based on the maximum separating distance is put forward to determine whether adapters separate with the missile reliably. The results show that the magnitude and position of elastic force, the wedge angle and mass of the adapter significantly affect the separating process. The local sensitivity analysis for the reference status of design parameters demonstrates that the wedge angle of adapters has the maximum influence about 70. 4% on the separating distance.展开更多
In order to improve the system reliability and performance and to reduce the system cost, volume and weight, we have designed, fabricated and tested the multibus adapter system of a trimodular redundant fault tolerant...In order to improve the system reliability and performance and to reduce the system cost, volume and weight, we have designed, fabricated and tested the multibus adapter system of a trimodular redundant fault tolerant computer system on a single chip of 5000 gate CMOS gate array. The design, fabrication and test of this single chip system will be discussed..展开更多
High power lasers (> +21dBm) have gradually become the common solution for signal transmitting systems including regional cable television, Fiber To The Home (FTTH), and gigabit passive optical networks (G- PONs) d...High power lasers (> +21dBm) have gradually become the common solution for signal transmitting systems including regional cable television, Fiber To The Home (FTTH), and gigabit passive optical networks (G- PONs) due to their ability to generate signals that can be transmitted over long distances. However, if protective design is not implemented in the facility at the client side, users may be exposed to health hazards such as eye damage from these high-power lasers. High-power optical adapters with laser shutter use metal masks to prevent eye exposure to direct laser beams. They have progressively replaced conventional optical adapters and entered the market mainstream. Our study uses the Elastic-Plastic theory together with parametric design to investigate the effect of geometry on the initial spring-back angle of a laser shutter. Once the force stabilizes, the angles of the initial spring back are found to be the same as the simulated results for several attempts. In our study, it is observed that factors including the thickness of the metal masking plate, the initial design angle, the stiffness of the material and the boundary conditions have significant influence on the spring back angle. These can be used as references in design control.展开更多
This paper introduces the choices of the technology solutions pertinent to the industrial standard of Chinese communications industry, YD/T 1591 Technical Requirements and Test Method of Charger and lnterface for Mobi...This paper introduces the choices of the technology solutions pertinent to the industrial standard of Chinese communications industry, YD/T 1591 Technical Requirements and Test Method of Charger and lnterface for Mobile Telecommunication Terminal Equipment, as well as its development and revision process. It also elaborates the technology contents for Recommendation of Improving the Standard ITU-TL.1000.展开更多
We present an approach to classify medical text at a sentence level automatically.Given the inherent complexity of medical text classification,we employ adapters based on pre-trained language models to extract informa...We present an approach to classify medical text at a sentence level automatically.Given the inherent complexity of medical text classification,we employ adapters based on pre-trained language models to extract information from medical text,facilitating more accurate classification while minimizing the number of trainable parameters.Extensive experiments conducted on various datasets demonstrate the effectiveness of our approach.展开更多
Adoptive immune cell-based therapies have shown promise in cancer treatment,yet their efficacy against solid tumors is often limited by the immunosuppressive tumor microenvironment(TME).To overcome these barriers,we d...Adoptive immune cell-based therapies have shown promise in cancer treatment,yet their efficacy against solid tumors is often limited by the immunosuppressive tumor microenvironment(TME).To overcome these barriers,we design an innovative immune cell cocktail as a combinatorial biomaterial platform,which harnessing the complementary functions of neutrophils and natural killer(NK)cells derived from human pluripotent stem cells(hPSCs).Using CRISPR/Cas9,we introduce an anti-fluorescein isothiocyanate(FITC)chimeric antigen receptor(CAR)construct into the AAVS1 safe harbor locus of hPSCs,allowing for the differentiation of CAR-modified neutrophils and NK cells.These CAR neutrophils exhibit robust anti-tumor activity,forming immune synapses with tumor cells tagged via a bispecific adapter(FITC-folate),even in hypoxic TMEs,while CAR NK cells demonstrate antigen-specific cytotoxicity.Together,the cocktail biomaterial composed of CAR neutrophils and CAR NK cells creates a synergistic anti-tumor effect:having neutrophils enhance TME modulation,and NK cells provide targeted cytotoxicity.This biomaterial offers a scalable and off-the-shelf solution for producing CAR neutrophils and CAR NK cells,potentially reducing needs for high-dose exogenous cytokines and minimizing immune-related toxicities.Our findings suggest that hPSC-derived CAR neutrophils and CAR NK cells may form an effective immuno-cocktail biomaterial,offering a feasible strategy for advancing solid tumor immunotherapy through cellular synergy and TME adaptation.展开更多
Insulin resistance and dysregulated lipid meta- bolism are major causes of type 2 diabetes. Insulin and inflam- matory signal pathways play key roles in insulin resistance and fat accumulation. Specifically, adapter p...Insulin resistance and dysregulated lipid meta- bolism are major causes of type 2 diabetes. Insulin and inflam- matory signal pathways play key roles in insulin resistance and fat accumulation. Specifically, adapter proteins transduce sig- nals from insulin or cytokine receptors to the downstream pathways and may contribute to insulin resistance and disor- dered lipid metabolism in obesity and type 2 diabetes. Here, the recent advances in understanding the roles of adapter proteins in insulin resistance and lipid homeostasis are discussed.展开更多
Insulin resistance and dysregulated lipid metabolism are major causes of type 2 diabetes. Insulin and inflammatory signal pathways play key roles in insulin resistance and fat accumulation. Specifically, adapter prote...Insulin resistance and dysregulated lipid metabolism are major causes of type 2 diabetes. Insulin and inflammatory signal pathways play key roles in insulin resistance and fat accumulation. Specifically, adapter proteins transduce signals from insulin or cytokine receptors to the downstream pathways and may contribute to insulin resistance and disordered lipid metabolism in obesity and type 2 diabetes. Here, the recent advances in understanding the roles of adapter proteins in insulin resistance and lipid homeostasis are discussed.展开更多
In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the op...In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the optimality conditions of the problem,we introduce appropriate affine matrix and construct an affine scaling ARC subproblem with linearized constraints.Composite step methods and reduced Hessian methods are applied to tackle the linearized constraints.As a result,a standard unconstrained ARC subproblem is deduced and its solution can supply sufficient decrease.The fraction to the boundary rule maintains the strict feasibility(for nonnegative constraints on variables)of every iteration point.Reflection techniques are employed to prevent the iterations from approaching zero too early.Under mild assumptions,global convergence of the algorithm is analysed.Preliminary numerical results are reported.展开更多
文摘An ultra-wideband mixing component cascaded by a mixing multi-function chip and a frequency multiplier multi-function chip was demonstrated and implemented using 3D heterogeneous integration based on the silicon adapter board technology.Four layers of high-resistance silicon substrate stack packaging are implemented based on the wafer-level gold-gold bonding process.Each layer adopts though silicon via(TSV)technology to realize signal interconnection.A core monolithic integrated microwave chip(MMIC)is embedded in the silicon cavity,and the silicon-based filter is integrated with the high-resistance silicon substrate.The interconnect line,cavity and filter of the silicon-based adapter board are designed with AutoCAD,and HFSS is adopted for 3D electromagnetic field simulation.According to the measured results,the radio frequency(RF)of the mixing multi-function chip is 40-44 GHz and its intermediate frequency(IF)can cover the Ku band with a chip size of 10 mm×11 mm×1 mm.The multiplier multi-function chip operates at 16-20 GHz.The fundamental suppression is greater than 50 dB and the second harmonic suppression is better than 40 dB with a chip size of 8 mm×8 mm×1 mm.The cascaded fully assembled mixing component achieves a spur of better than-50 dBc and a gain of better than 15 dB.
文摘ACE(Adaptive Communication Environment)是用于开发高性能网络化应用与下一代中间件的面向对象框架。除了许多专用于开发网络通信软件的设计模式(比如 Reactor、Proactor、Half-Sync/Half-Async,等等),ACE还对GoF的Design Patten一书中的许多设计模式作了大量应用。
基金Funding for this work was provided in part by the National Science Foundation through a subaward from the NEES Consortium,Inc.under Cooperative Agreement CMS0402490.The authors appreciate the assistance of Dr.Frank McKenna of the University of California,Berkeley,Dr.John Hallquist of Livermore Software Technology Corporation,and Prof.Yoshikazu Takahashi of Kyoto University.The findings and conclusions are those of the authors alone,and may not reflect those of the sponsors.
文摘This paper describes a versatile and computationally efficient method for coupling several finite element analysis(FEA)programs together so that the unique modeling and analysis capabilities of each code can be utilized simultaneously to simulate the static or dynamic response of a complete numerical system.An arbitrary number of finite element analysis software packages can be coupled by adding two special types of elements,namely generic and adapter elements,to each of the finite element applications using their programming interface.These elements are inserted at the interfaces between the different sub-domains of the complete system modeled by each finite element analysis software package.Exchange of data between the coupled FEA codes is accomplished in a modular and synchronized manner using OpenFresco(Opensource Framework for Experimental Setup and Control).OpenFresco is an objectoriented,environment independent software framework initially developed for hybrid simulation in which certain aspects of a complete structure are simulated numerically and other aspects are simultaneously tested physically.An important practical advantage of this coupled analysis approach is that all of the connected FEA codes run concurrently and continuously,decreasing analysis time consumption by an order of magnitude or more compared to more traditional approaches that shut down and restart the coupled analysis codes at each integration time step.The implementation and accuracy of this approach to FE software coupling are demonstrated using dynamic analyses of three simple structural models from the field of earthquake engineering.
文摘To analyze main factors affecting the separation reliability between a missile and adapters for the launching process, a six DOF underwater dynamic model for the missile and adapters is utilized to simulate the separation process, considering elastic forces of separating springs, hydrodynamic forces, gravity and buoyancy. Moreover, a criterion based on the maximum separating distance is put forward to determine whether adapters separate with the missile reliably. The results show that the magnitude and position of elastic force, the wedge angle and mass of the adapter significantly affect the separating process. The local sensitivity analysis for the reference status of design parameters demonstrates that the wedge angle of adapters has the maximum influence about 70. 4% on the separating distance.
文摘In order to improve the system reliability and performance and to reduce the system cost, volume and weight, we have designed, fabricated and tested the multibus adapter system of a trimodular redundant fault tolerant computer system on a single chip of 5000 gate CMOS gate array. The design, fabrication and test of this single chip system will be discussed..
文摘High power lasers (> +21dBm) have gradually become the common solution for signal transmitting systems including regional cable television, Fiber To The Home (FTTH), and gigabit passive optical networks (G- PONs) due to their ability to generate signals that can be transmitted over long distances. However, if protective design is not implemented in the facility at the client side, users may be exposed to health hazards such as eye damage from these high-power lasers. High-power optical adapters with laser shutter use metal masks to prevent eye exposure to direct laser beams. They have progressively replaced conventional optical adapters and entered the market mainstream. Our study uses the Elastic-Plastic theory together with parametric design to investigate the effect of geometry on the initial spring-back angle of a laser shutter. Once the force stabilizes, the angles of the initial spring back are found to be the same as the simulated results for several attempts. In our study, it is observed that factors including the thickness of the metal masking plate, the initial design angle, the stiffness of the material and the boundary conditions have significant influence on the spring back angle. These can be used as references in design control.
文摘This paper introduces the choices of the technology solutions pertinent to the industrial standard of Chinese communications industry, YD/T 1591 Technical Requirements and Test Method of Charger and lnterface for Mobile Telecommunication Terminal Equipment, as well as its development and revision process. It also elaborates the technology contents for Recommendation of Improving the Standard ITU-TL.1000.
文摘We present an approach to classify medical text at a sentence level automatically.Given the inherent complexity of medical text classification,we employ adapters based on pre-trained language models to extract information from medical text,facilitating more accurate classification while minimizing the number of trainable parameters.Extensive experiments conducted on various datasets demonstrate the effectiveness of our approach.
基金supported by start-up package funding from The Hong Kong Polytechnic University(Y.C.)and the Shenzhen Science and Technology Program(No.JCYJ20241202130520027).
文摘Adoptive immune cell-based therapies have shown promise in cancer treatment,yet their efficacy against solid tumors is often limited by the immunosuppressive tumor microenvironment(TME).To overcome these barriers,we design an innovative immune cell cocktail as a combinatorial biomaterial platform,which harnessing the complementary functions of neutrophils and natural killer(NK)cells derived from human pluripotent stem cells(hPSCs).Using CRISPR/Cas9,we introduce an anti-fluorescein isothiocyanate(FITC)chimeric antigen receptor(CAR)construct into the AAVS1 safe harbor locus of hPSCs,allowing for the differentiation of CAR-modified neutrophils and NK cells.These CAR neutrophils exhibit robust anti-tumor activity,forming immune synapses with tumor cells tagged via a bispecific adapter(FITC-folate),even in hypoxic TMEs,while CAR NK cells demonstrate antigen-specific cytotoxicity.Together,the cocktail biomaterial composed of CAR neutrophils and CAR NK cells creates a synergistic anti-tumor effect:having neutrophils enhance TME modulation,and NK cells provide targeted cytotoxicity.This biomaterial offers a scalable and off-the-shelf solution for producing CAR neutrophils and CAR NK cells,potentially reducing needs for high-dose exogenous cytokines and minimizing immune-related toxicities.Our findings suggest that hPSC-derived CAR neutrophils and CAR NK cells may form an effective immuno-cocktail biomaterial,offering a feasible strategy for advancing solid tumor immunotherapy through cellular synergy and TME adaptation.
基金Acknowledgements This work was supported by the Changbai Mountain Scholars Program of Jilin Province 2013046 （to Z. C.）, the Jilin Talent Development Foundation 111860000 （to Z. C.）, the National Natural Science Foundation of China Grant 31500957 （to Z. C.）, and the startup funds from Northeast Normal University 120401204 （to Z. C.）. I thank Dr. Mark J. Canet （University of Michigan） for editing this manuscript. I also thank lab members （Xinzhi Li, Wangshu Qin, Linna Jia, Sha Li, Xiaomeng Ren, Xue Dong, and Jiana Liu） at Northeast Normal University for helpful discussion. I apologize to colleagues whose relevant work could not be cited here due to space limitation.
文摘Insulin resistance and dysregulated lipid meta- bolism are major causes of type 2 diabetes. Insulin and inflam- matory signal pathways play key roles in insulin resistance and fat accumulation. Specifically, adapter proteins transduce sig- nals from insulin or cytokine receptors to the downstream pathways and may contribute to insulin resistance and disor- dered lipid metabolism in obesity and type 2 diabetes. Here, the recent advances in understanding the roles of adapter proteins in insulin resistance and lipid homeostasis are discussed.
基金supported by the Changbai Mountain Scholars Program of Jilin Province 2013046(to Z.C.)the Jilin Talent Development Foundation 111860000(to Z.C.)+1 种基金the National Natural Science Foundation of China Grant 31500957(to Z.C.)the startup funds from Northeast Normal University120401204(to Z.C.)
文摘Insulin resistance and dysregulated lipid metabolism are major causes of type 2 diabetes. Insulin and inflammatory signal pathways play key roles in insulin resistance and fat accumulation. Specifically, adapter proteins transduce signals from insulin or cytokine receptors to the downstream pathways and may contribute to insulin resistance and disordered lipid metabolism in obesity and type 2 diabetes. Here, the recent advances in understanding the roles of adapter proteins in insulin resistance and lipid homeostasis are discussed.
基金Supported by the National Natural Science Foundation of China(12071133)Natural Science Foundation of Henan Province(252300421993)Key Scientific Research Project of Higher Education Institutions in Henan Province(25B110005)。
文摘In this paper,an adaptive cubic regularisation algorithm based on affine scaling methods(ARCBASM)is proposed for solving nonlinear equality constrained programming with nonnegative constraints on variables.From the optimality conditions of the problem,we introduce appropriate affine matrix and construct an affine scaling ARC subproblem with linearized constraints.Composite step methods and reduced Hessian methods are applied to tackle the linearized constraints.As a result,a standard unconstrained ARC subproblem is deduced and its solution can supply sufficient decrease.The fraction to the boundary rule maintains the strict feasibility(for nonnegative constraints on variables)of every iteration point.Reflection techniques are employed to prevent the iterations from approaching zero too early.Under mild assumptions,global convergence of the algorithm is analysed.Preliminary numerical results are reported.
