Objective:To explore the mechanism of Lianqiao-Heye(Fructus Forsythiae and Folium Nelumbinis,FF-FN)drug pair in treating acute pharyngitis(AP)by network pharmacology.Methods:The chemical components and potential thera...Objective:To explore the mechanism of Lianqiao-Heye(Fructus Forsythiae and Folium Nelumbinis,FF-FN)drug pair in treating acute pharyngitis(AP)by network pharmacology.Methods:The chemical components and potential therapeutic targets of FF-FN drug pair were obtained from TCMSP firstly,and databases GeneCards,DrugBank,OMIM and PharmGKB were utilized to get the genes related to AP and the intersection of the results was obtained.Then Cytoscape software was used to construct drug-component-target network diagram to screen out the key compounds.Protein interaction network(PPI)was established using String database,and the core targets were screened by CytoNCA topology analysis.R language software was used for GO biological function analysis and KEGG pathway analysis.Finally,the docking verification of key compounds and core target molecules was carried out by AutoDock software.Results:A total of 38 active compounds and 917 potential therapeutic targets were obtained from FF-FN drug pair,while a total of 1534 targets were screened out for AP,among which,the number of intersection targets was 117.7 core targets were screened out from PPI core network,with JUN,TP53,CXCL8 and RELA included.A total of 2487 biological processes were involved in GO enrichment analysis,and 157 related pathways were screened out by KEGG.Based on results of molecular docking verification,the key compounds such as quercetin,luteolin and wogonin in FF-FN drug pair were proved capable of binding to the core targets and a good affinity was shown.Conclusion:FF-FN pair can intervene AP through multiple targets and multiple pathways,including PI3KAkts signaling pathway,AGE-RAGE signaling pathway and IL-17 signaling pathway.The combination of quercetin,luteolin,wogonin,kaempferol andβ-sitosterol with JUN,RELA,MAPK1,TNF and MYC can possibly be one of the mechanisms regarding to the therapeutic effect.展开更多
Objective: to explore the clinical efficacy of Sheshao Qingyan Decoction in treating 30 cases of acute pharyngitis. Methods: from March 2020 to January 2022, 30 patients with acute pharyngitis due to wind-heat syndrom...Objective: to explore the clinical efficacy of Sheshao Qingyan Decoction in treating 30 cases of acute pharyngitis. Methods: from March 2020 to January 2022, 30 patients with acute pharyngitis due to wind-heat syndrome were treated with Sheshao Qingyan Decoction in our hospital, and the clinical effect was observed and analyzed. Results: the total effective rate was 96.66%, and the incidence of adverse reactions was 3.33%. Conclusion: for acute pharyngitis patients with wind-heat syndrome, the application of Sheshao Qingyan Decoction can not only effectively improve the symptoms of patients to a certain extent, but also reduce the incidence of adverse reactions after treatment, so it is worthy of further clinical application.展开更多
Objective: to explore the clinical application of open-throat sword spray in the treatment of children with acute pharyngitis and acute suppurative tonsillitis is significant or not. Methods: 50 children with acute ph...Objective: to explore the clinical application of open-throat sword spray in the treatment of children with acute pharyngitis and acute suppurative tonsillitis is significant or not. Methods: 50 children with acute pharyngitis and acute suppurative tonsillitis treated in pediatrics of our hospital from June 2020 to January 2021 were divided into groups according to the order of admission for diagnosis and treatment. The groups were named control group and experimental group, with 25 patients in each group. The control group was given routine nursing mode in 25 cases, and the remaining 25 cases were automatically incorporated into the experimental group and were treated with open-throat sword spray treatment. The treatment lasted for 15 days. After the end of the treatment, full-time nurses were responsible for recording the clinical efficacy, blood picture index and adverse reactions of the two groups in detail. Results: the clinical efficacy, blood index and the incidence of adverse reactions were compared between the two groups. The total effective rate, c-reactive protein, neutrophil level, white blood cell count and the incidence of adverse reactions were significantly different between the two groups. The total effective rate, c-reactive protein, neutrophil level and white blood cell count in experimental group were significantly better than those in control group, and the incidence of adverse reactions in experimental group was significantly lower than that in control group (P < 0.05). Conclusion: in the clinical treatment of children with acute pharyngitis and acute suppurative tonsillitis, taking open throat spray can achieve significant clinical curative effect, significantly better than conventional western medicine treatment, not only reduces the incidence of adverse reactions, but also improves the clinical symptoms of children, it is the ideal treatment plan for children with acute pharyngitis and acute suppurative tonsillitis.展开更多
Objective: Viral pharyngitis, commonly known as a sore throat, is a widespread condition affecting people of all ages globally. This study aimed to assess the effectiveness of a medical device containing the combined ...Objective: Viral pharyngitis, commonly known as a sore throat, is a widespread condition affecting people of all ages globally. This study aimed to assess the effectiveness of a medical device containing the combined drugs of natural essential oils (CDNEO) formulation in managing throat pain in patients with acute viral pharyngitis. With the growing resistance to traditional antibacterial treatments, essential oils have attracted interest for their potential analgesic, anti-inflammatory, and antibacterial properties. Results: The study involved 81 patients randomly divided into two groups: those taking a medical device containing combined drugs of natural essential oils (CDNEO) and those taking a placebo. A questionnaire was used to assess throat pain among the participants, with 45 receiving the CDNEO and 36 the placebo. The CDNEO group experienced a significant reduction in throat pain, with the average VAS score decreasing from 5.36 to 1.09, compared to the placebo group, which saw a decrease from 4.97 to 2.19. This difference, with p Conclusion: By using a double-blind research method, it was possible to evaluate the effectiveness of the oils more objectively, since there was also a control placebo group. The study shows that CDNEO significantly reduces throat pain and decreases the need for additional pain relief medication in patients with acute viral pharyngitis. The findings suggest that natural essential oils could serve as an alternative treatment for pharyngitis, particularly in efforts to minimize NSAID use and combat antibiotic resistance.展开更多
Objective: to analyze the effect of nursing intervention for inhalation of aerosolized acute chronic pharyngitis. Methods: 73 patients with acute and chronic pharyngitis were randomly divided into two groups, 36 cases...Objective: to analyze the effect of nursing intervention for inhalation of aerosolized acute chronic pharyngitis. Methods: 73 patients with acute and chronic pharyngitis were randomly divided into two groups, 36 cases in the control group and 37 cases in the study group. Results: the total efficiency of the study group was significantly higher than that of the control group (P<0.05). Conclusion: the reasonable nursing intervention can accelerate the recovery of patients with acute and chronic pharyngitis by atomizing inhalation, which is worth popularizing.展开更多
conjugate vaccine(PCV13)has reduced vaccine-type carriage rates,though regarding serotype replacement remain.Methods:This study conducted a 2-year prospective cohort study(February 2023–February 2025)in Suqian,Jiangs...conjugate vaccine(PCV13)has reduced vaccine-type carriage rates,though regarding serotype replacement remain.Methods:This study conducted a 2-year prospective cohort study(February 2023–February 2025)in Suqian,Jiangsu Province,enrolling 2-month-old infants and monitoring for acute respiratory infections(ARIs).Pharyngeal swabs collected during ARIs were analyzed using targeted next-generation sequencing(tNGS)to identify respiratory pathogens,and Streptococcus pneumoniae(S.pneumoniae)-positive samples were serotyped using multiplex PCR.Risk ratios(RRs)for S.pneumoniae detection were estimated using Poisson regression,with sensitivity analysis performed using inverse probability of treatment weighting(IPTW).Results:Among 579 children,1,527 swabs were collected,yielding an overall S.pneumoniae detection incidence of 35.2%.Vaccinated children receiving 3–4 PCV13 doses demonstrated significantly lower detection rates than unvaccinated children[23.1%vs.40.2%;adjusted RR=0.70;95%confidence interval(CI):0.50,0.98;P=0.036].IPTW analysis confirmed these findings.Non-vaccine serotypes predominated,particularly the 10A and 15A/15F strains.Conclusion:PCV13 vaccination was associated with reduced S.pneumoniae detection among children with ARIs,despite dominance of non-vaccine serotypes.Our findings emphasize the importance of ongoing surveillance for S.pneumoniae and highlight the need to expand the serotype coverage of pneumococcal vaccines.展开更多
文摘Objective:To explore the mechanism of Lianqiao-Heye(Fructus Forsythiae and Folium Nelumbinis,FF-FN)drug pair in treating acute pharyngitis(AP)by network pharmacology.Methods:The chemical components and potential therapeutic targets of FF-FN drug pair were obtained from TCMSP firstly,and databases GeneCards,DrugBank,OMIM and PharmGKB were utilized to get the genes related to AP and the intersection of the results was obtained.Then Cytoscape software was used to construct drug-component-target network diagram to screen out the key compounds.Protein interaction network(PPI)was established using String database,and the core targets were screened by CytoNCA topology analysis.R language software was used for GO biological function analysis and KEGG pathway analysis.Finally,the docking verification of key compounds and core target molecules was carried out by AutoDock software.Results:A total of 38 active compounds and 917 potential therapeutic targets were obtained from FF-FN drug pair,while a total of 1534 targets were screened out for AP,among which,the number of intersection targets was 117.7 core targets were screened out from PPI core network,with JUN,TP53,CXCL8 and RELA included.A total of 2487 biological processes were involved in GO enrichment analysis,and 157 related pathways were screened out by KEGG.Based on results of molecular docking verification,the key compounds such as quercetin,luteolin and wogonin in FF-FN drug pair were proved capable of binding to the core targets and a good affinity was shown.Conclusion:FF-FN pair can intervene AP through multiple targets and multiple pathways,including PI3KAkts signaling pathway,AGE-RAGE signaling pathway and IL-17 signaling pathway.The combination of quercetin,luteolin,wogonin,kaempferol andβ-sitosterol with JUN,RELA,MAPK1,TNF and MYC can possibly be one of the mechanisms regarding to the therapeutic effect.
文摘Objective: to explore the clinical efficacy of Sheshao Qingyan Decoction in treating 30 cases of acute pharyngitis. Methods: from March 2020 to January 2022, 30 patients with acute pharyngitis due to wind-heat syndrome were treated with Sheshao Qingyan Decoction in our hospital, and the clinical effect was observed and analyzed. Results: the total effective rate was 96.66%, and the incidence of adverse reactions was 3.33%. Conclusion: for acute pharyngitis patients with wind-heat syndrome, the application of Sheshao Qingyan Decoction can not only effectively improve the symptoms of patients to a certain extent, but also reduce the incidence of adverse reactions after treatment, so it is worthy of further clinical application.
文摘Objective: to explore the clinical application of open-throat sword spray in the treatment of children with acute pharyngitis and acute suppurative tonsillitis is significant or not. Methods: 50 children with acute pharyngitis and acute suppurative tonsillitis treated in pediatrics of our hospital from June 2020 to January 2021 were divided into groups according to the order of admission for diagnosis and treatment. The groups were named control group and experimental group, with 25 patients in each group. The control group was given routine nursing mode in 25 cases, and the remaining 25 cases were automatically incorporated into the experimental group and were treated with open-throat sword spray treatment. The treatment lasted for 15 days. After the end of the treatment, full-time nurses were responsible for recording the clinical efficacy, blood picture index and adverse reactions of the two groups in detail. Results: the clinical efficacy, blood index and the incidence of adverse reactions were compared between the two groups. The total effective rate, c-reactive protein, neutrophil level, white blood cell count and the incidence of adverse reactions were significantly different between the two groups. The total effective rate, c-reactive protein, neutrophil level and white blood cell count in experimental group were significantly better than those in control group, and the incidence of adverse reactions in experimental group was significantly lower than that in control group (P < 0.05). Conclusion: in the clinical treatment of children with acute pharyngitis and acute suppurative tonsillitis, taking open throat spray can achieve significant clinical curative effect, significantly better than conventional western medicine treatment, not only reduces the incidence of adverse reactions, but also improves the clinical symptoms of children, it is the ideal treatment plan for children with acute pharyngitis and acute suppurative tonsillitis.
文摘Objective: Viral pharyngitis, commonly known as a sore throat, is a widespread condition affecting people of all ages globally. This study aimed to assess the effectiveness of a medical device containing the combined drugs of natural essential oils (CDNEO) formulation in managing throat pain in patients with acute viral pharyngitis. With the growing resistance to traditional antibacterial treatments, essential oils have attracted interest for their potential analgesic, anti-inflammatory, and antibacterial properties. Results: The study involved 81 patients randomly divided into two groups: those taking a medical device containing combined drugs of natural essential oils (CDNEO) and those taking a placebo. A questionnaire was used to assess throat pain among the participants, with 45 receiving the CDNEO and 36 the placebo. The CDNEO group experienced a significant reduction in throat pain, with the average VAS score decreasing from 5.36 to 1.09, compared to the placebo group, which saw a decrease from 4.97 to 2.19. This difference, with p Conclusion: By using a double-blind research method, it was possible to evaluate the effectiveness of the oils more objectively, since there was also a control placebo group. The study shows that CDNEO significantly reduces throat pain and decreases the need for additional pain relief medication in patients with acute viral pharyngitis. The findings suggest that natural essential oils could serve as an alternative treatment for pharyngitis, particularly in efforts to minimize NSAID use and combat antibiotic resistance.
文摘Objective: to analyze the effect of nursing intervention for inhalation of aerosolized acute chronic pharyngitis. Methods: 73 patients with acute and chronic pharyngitis were randomly divided into two groups, 36 cases in the control group and 37 cases in the study group. Results: the total efficiency of the study group was significantly higher than that of the control group (P<0.05). Conclusion: the reasonable nursing intervention can accelerate the recovery of patients with acute and chronic pharyngitis by atomizing inhalation, which is worth popularizing.
基金Supported by Science Fund for Distinguished Young Scholars of Jiangsu Province(grant number:BK20220064).
文摘conjugate vaccine(PCV13)has reduced vaccine-type carriage rates,though regarding serotype replacement remain.Methods:This study conducted a 2-year prospective cohort study(February 2023–February 2025)in Suqian,Jiangsu Province,enrolling 2-month-old infants and monitoring for acute respiratory infections(ARIs).Pharyngeal swabs collected during ARIs were analyzed using targeted next-generation sequencing(tNGS)to identify respiratory pathogens,and Streptococcus pneumoniae(S.pneumoniae)-positive samples were serotyped using multiplex PCR.Risk ratios(RRs)for S.pneumoniae detection were estimated using Poisson regression,with sensitivity analysis performed using inverse probability of treatment weighting(IPTW).Results:Among 579 children,1,527 swabs were collected,yielding an overall S.pneumoniae detection incidence of 35.2%.Vaccinated children receiving 3–4 PCV13 doses demonstrated significantly lower detection rates than unvaccinated children[23.1%vs.40.2%;adjusted RR=0.70;95%confidence interval(CI):0.50,0.98;P=0.036].IPTW analysis confirmed these findings.Non-vaccine serotypes predominated,particularly the 10A and 15A/15F strains.Conclusion:PCV13 vaccination was associated with reduced S.pneumoniae detection among children with ARIs,despite dominance of non-vaccine serotypes.Our findings emphasize the importance of ongoing surveillance for S.pneumoniae and highlight the need to expand the serotype coverage of pneumococcal vaccines.
