[Objective] We aimed to investigate the preventive and therapeutical effect of compound of traditional Chinese drugs （Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root） on acute alc...[Objective] We aimed to investigate the preventive and therapeutical effect of compound of traditional Chinese drugs （Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root） on acute alcohol intoxication in mice. [Method] Acute alcohol intoxication was induced by administering alcohol to mice. Three different doses （low, middle and high） of compound of traditional Chinese drugs were administered to mice before and after administering alcohol respectively to investigate the preventive and therapeutical effect of drugs on acute alcohol intox-ication through doing statistical analysis about drunk mice and their sleeping time. The concentration of malondialdehyde （MDA）, reduced glutathione （GSH） and triglyc-erides （TG） in liver was also determined to investigate the protective effect of drugs on liver. [Result] The efficacy of compound of traditional Chinese drugs on acute al-cohol intoxication was dose-dependent. High-dose administration decreased the number of drunk mice significantly compared with control group; middle- and high-dose administration reduced the sleeping time of drunk mice and the concentration of MDA and TG in liver tissue; three doses al increased the concentration of GSH. [Conclusion] The compound of Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root had preventive and therapeutical effect on hangover, and it also had certain preventive and therapeutical effect on liver damage caused by alcohol.展开更多
Alcohol abuse constitutes a significant health hazard,leading to various organ damage,notably the liver and brain.Shanxi aged vinegar(SAV)is one of the famous fermented and functional foods containing a variety of bio...Alcohol abuse constitutes a significant health hazard,leading to various organ damage,notably the liver and brain.Shanxi aged vinegar(SAV)is one of the famous fermented and functional foods containing a variety of bioactive ingredients with beneficial effects on the human body.This study aimed to explore the potential protective effect of SAV in alleviating acute alcohol intoxication(AAI)in mice.It was found that SAV at 2.5 mL/kg BW effectively ameliorated the decline in behavioral abilities following alcohol consumption,characterized by a shortened sobering period.SAV reduces alcohol-induced liver damage by inhibiting hepatic function enzymes and oxidative stress levels.Additionally,SAV mitigated the overactivation of microglia and the downregulation of neurotransmitter levels including acetylcholinesterase(AchE),5-hydroxytryptamine(5-HT)and dopamine(DA),thereby reducing ethanol-induced brain damage.Meanwhile,SAV significantly decreased concentrations of alcohol and acetaldehyde in the blood and increased alcohol dehydrogenase(ADH)and acetaldehyde dehydrogenase(ALDH)activities in the liver,indicating enhancement of ethanol metabolism.Moreover,we found that some gut microbiota including Verrucomicrobiota,Akkermansia,and Enterococcus were downregulated after SAV treatment in mice with AAI.These bacteria showed a negative correlation with anti-oxidative markers(glutathione(GSH)and catalase(CAT))and enzymes related to ethanol metabolism pathways(ADH and ALDH),and a positive correlation with hepatic function markers(alanine aminotransferase(ALT),aspartate aminotransferase(AST),and malondialdehyde(MDA)),alcohol metabolites(alcohol and acetaldehyde)and neurotransmitters(AchE,5-HT,and DA).However,Bacteroidota,norank_f_Muribaculaceae,and Alistipes exhibited the opposite direction.These findings suggest that SAV possesses protective effects against hepatic and neuro-toxicity,and could be a potential functional food for AAI prevention.展开更多
Background: Acute intoxications result from intentionally or accidentally taking a relatively significant amount of a chemical substance which triggers disturbances in the level of psychophysiological functions, the c...Background: Acute intoxications result from intentionally or accidentally taking a relatively significant amount of a chemical substance which triggers disturbances in the level of psychophysiological functions, the complications of which may lead to mental disorders, physical causalities, and death. Any acute intoxication mostly requires emergency care. Objective: To highlight the prevalence, history, clinical features, emergency treatment, and prediction of acute intoxication cases referred to the emergency services at the Provincial General Reference Hospital in Bukavu, DR-Congo. Methods: A retrospective cross-sectional study was conducted from January 2021 to October 2022 based on an analysis of patients’ medical files. Triage was performed among all-type of patient files recorded in the computerized hospital database Ebale-Sante to sort cases of intoxication. Results: During the observational period, 3966 emergency admissions were counted, of which 321 (8.09%) patients were identified as having acute intoxication. Among these, 100 files that containing sufficient information fit the quality criteria for this study’s analysis. The victims were infants, adolescents and adults aged 1 - 45 years, and 52% were female and 48% were male. Most cases were accidental and, occurred at home, and the victims were driven to the hospital within 2 - 24 hours. The substances consumed included household products, drugs, and herbs. Resuscitation care, antidotes and supportive symptomatic medications ensured that 85% were healed and 10% experienced sequelae;however, 5% died. Conclusion: Acute intoxication occurs in infants mostly accidentally though the ingestion of household products and medicines. Furthermore, suicide cases may occur in traumatized adolescents and discordant couples. People should be informed about how to store hazardous products (e.g.: drugs, household products and pesticides), which should not be available to children, to avoid unintentional poisoning. Special training in clinical toxicology is required to reduce treatment failure.展开更多
基金Supported by National Natural Science Foundation of China(31100987)Project of Shandong University of Technology(4040-306018)Young Teacher Development Plan of Shandong University of Technology~~
文摘[Objective] We aimed to investigate the preventive and therapeutical effect of compound of traditional Chinese drugs （Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root） on acute alcohol intoxication in mice. [Method] Acute alcohol intoxication was induced by administering alcohol to mice. Three different doses （low, middle and high） of compound of traditional Chinese drugs were administered to mice before and after administering alcohol respectively to investigate the preventive and therapeutical effect of drugs on acute alcohol intox-ication through doing statistical analysis about drunk mice and their sleeping time. The concentration of malondialdehyde （MDA）, reduced glutathione （GSH） and triglyc-erides （TG） in liver was also determined to investigate the protective effect of drugs on liver. [Result] The efficacy of compound of traditional Chinese drugs on acute al-cohol intoxication was dose-dependent. High-dose administration decreased the number of drunk mice significantly compared with control group; middle- and high-dose administration reduced the sleeping time of drunk mice and the concentration of MDA and TG in liver tissue; three doses al increased the concentration of GSH. [Conclusion] The compound of Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root had preventive and therapeutical effect on hangover, and it also had certain preventive and therapeutical effect on liver damage caused by alcohol.
基金financially supported by the Natural Science Foundation of Tianjin(24JCYBJC01220)the Open Project Program of State Key Laboratory of Food Nutrition and Safety,Tianjin University of Science&Technology(SKLFNS-NF-202318)the foundation of Shanxi Provincial Key Laboratory for Vinegar Fermentation Science and Engineering,China(20220401931002).
文摘Alcohol abuse constitutes a significant health hazard,leading to various organ damage,notably the liver and brain.Shanxi aged vinegar(SAV)is one of the famous fermented and functional foods containing a variety of bioactive ingredients with beneficial effects on the human body.This study aimed to explore the potential protective effect of SAV in alleviating acute alcohol intoxication(AAI)in mice.It was found that SAV at 2.5 mL/kg BW effectively ameliorated the decline in behavioral abilities following alcohol consumption,characterized by a shortened sobering period.SAV reduces alcohol-induced liver damage by inhibiting hepatic function enzymes and oxidative stress levels.Additionally,SAV mitigated the overactivation of microglia and the downregulation of neurotransmitter levels including acetylcholinesterase(AchE),5-hydroxytryptamine(5-HT)and dopamine(DA),thereby reducing ethanol-induced brain damage.Meanwhile,SAV significantly decreased concentrations of alcohol and acetaldehyde in the blood and increased alcohol dehydrogenase(ADH)and acetaldehyde dehydrogenase(ALDH)activities in the liver,indicating enhancement of ethanol metabolism.Moreover,we found that some gut microbiota including Verrucomicrobiota,Akkermansia,and Enterococcus were downregulated after SAV treatment in mice with AAI.These bacteria showed a negative correlation with anti-oxidative markers(glutathione(GSH)and catalase(CAT))and enzymes related to ethanol metabolism pathways(ADH and ALDH),and a positive correlation with hepatic function markers(alanine aminotransferase(ALT),aspartate aminotransferase(AST),and malondialdehyde(MDA)),alcohol metabolites(alcohol and acetaldehyde)and neurotransmitters(AchE,5-HT,and DA).However,Bacteroidota,norank_f_Muribaculaceae,and Alistipes exhibited the opposite direction.These findings suggest that SAV possesses protective effects against hepatic and neuro-toxicity,and could be a potential functional food for AAI prevention.
文摘Background: Acute intoxications result from intentionally or accidentally taking a relatively significant amount of a chemical substance which triggers disturbances in the level of psychophysiological functions, the complications of which may lead to mental disorders, physical causalities, and death. Any acute intoxication mostly requires emergency care. Objective: To highlight the prevalence, history, clinical features, emergency treatment, and prediction of acute intoxication cases referred to the emergency services at the Provincial General Reference Hospital in Bukavu, DR-Congo. Methods: A retrospective cross-sectional study was conducted from January 2021 to October 2022 based on an analysis of patients’ medical files. Triage was performed among all-type of patient files recorded in the computerized hospital database Ebale-Sante to sort cases of intoxication. Results: During the observational period, 3966 emergency admissions were counted, of which 321 (8.09%) patients were identified as having acute intoxication. Among these, 100 files that containing sufficient information fit the quality criteria for this study’s analysis. The victims were infants, adolescents and adults aged 1 - 45 years, and 52% were female and 48% were male. Most cases were accidental and, occurred at home, and the victims were driven to the hospital within 2 - 24 hours. The substances consumed included household products, drugs, and herbs. Resuscitation care, antidotes and supportive symptomatic medications ensured that 85% were healed and 10% experienced sequelae;however, 5% died. Conclusion: Acute intoxication occurs in infants mostly accidentally though the ingestion of household products and medicines. Furthermore, suicide cases may occur in traumatized adolescents and discordant couples. People should be informed about how to store hazardous products (e.g.: drugs, household products and pesticides), which should not be available to children, to avoid unintentional poisoning. Special training in clinical toxicology is required to reduce treatment failure.
