Cobalt-based phosphides show excellent hydrogen evolution reaction(HER)performance,however,improving the intrinsic activity and stability of it in alkaline electrolyte still remains a challenge.Herein,CoRuOH/Co_(2)P/C...Cobalt-based phosphides show excellent hydrogen evolution reaction(HER)performance,however,improving the intrinsic activity and stability of it in alkaline electrolyte still remains a challenge.Herein,CoRuOH/Co_(2)P/CF with heterojunction structure was developed by means of molten salt and rapid hydrolysis(30 s).The OH-from rapid surface hydrolysis of Co_(2)P as a hydrogen adsorption site can facilitate the formation of thin CoRuOH layer as a water dissociation site,which may bring out better synergistic effect for alkaline HER.Moreover,the covering of CoRuOH can improve the stability of Co_(2)P for HER.When drives at 100 mA/cm^(2),it only requires overpotential of 81 mV in 1.0 mol/L KOH(25℃).Even at higher current density(1000 mA/cm^(2)),CoRuOH/Co_(2)P/CF can also operate stability for at least 100 h.When coupling with NiFe-LDH/IF in a two-electrode system,the voltage of NiFe-LDH/IF(+)||CoRuOH/Co_(2)P/CF(-)at 1000 mA/cm^(2)is merely 1.77 V with 100 h,demonstrating great potential for water splitting.The implementation of this work provides a new strategy and reference for the further improvement of transition metal phosphides as HER electrocatalysts.展开更多
While double perovskites of PrBaCo_(2)O_(6)(PBC)have been extensively developed as the cathodes for proton-conducting solid oxide fuel cells(H-SOFCs),the effects of Sr-or Ca-doping at the A site on the activity and st...While double perovskites of PrBaCo_(2)O_(6)(PBC)have been extensively developed as the cathodes for proton-conducting solid oxide fuel cells(H-SOFCs),the effects of Sr-or Ca-doping at the A site on the activity and stability of the oxygen reduction reaction are yet to be fully studied.Here,the effect of A-site doping on the oxygen reduction reaction activity and stability has been studied by evaluating the performance of both symmetrical and single cells.It is shown that Ca-doped PBC(PrBa_(0.8)Ca_(0.2)Co_(2)O_(6),PBCC)shows a slightly smaller polarization resistance(0.076Ωcm^(2))than that(0.085Ωcm^(2))of Sr-doped PBC(PrBa0.8Sr0.2Co2O6,PBSC)at 700◦C in wet air.Moreover,the degradation rate of PBCC is 0.0003Ωcm^(2)h^(−1)(0.3%h−1)in 100 h,about 1/10 of that of PBSC at 700◦C in wet air.In addition,it is also confirmed that single cells with PBCC cathode show higher peak power density(1.22Wcm^(−2)vs.1.08Wcm^(−2)at 650◦C)and better durability(degradation rate of 0.1%h^(−1)vs.0.13%h^(−1))than those with PBSC cathode.The distribution of relaxation time analyses suggests that the better stability of the PBCC electrode may come from the fast and stable surface oxygen exchange process in the medium frequency range of the electrochemical impedance spectrum.展开更多
The catalytic activity of polycobaltprotoporphyrin(PCoPP)was compared with adsorbed cobaltprotoporphyrin monolayer.The results have shown that PCoPP film shows higher catalytic activity and stability than monolayer on...The catalytic activity of polycobaltprotoporphyrin(PCoPP)was compared with adsorbed cobaltprotoporphyrin monolayer.The results have shown that PCoPP film shows higher catalytic activity and stability than monolayer on glass carbon electrode in both alkaline and acid solution. Catalytic activity of PCoPP goes through a maximum with increase of film thickness.A model was proposed to explain such dependence.The effect of film thickness and solution pH on the stability of PCoPP film was studied.展开更多
There has been a continuous need for high active, excellently durable and low-cost electrocatalysts for rechargeable zinc-air batteries. Among many low-cost metal based candidates, transition metal oxides with the CNT...There has been a continuous need for high active, excellently durable and low-cost electrocatalysts for rechargeable zinc-air batteries. Among many low-cost metal based candidates, transition metal oxides with the CNTs composite have gained increasing attention. In this paper, the 3-D hollow sphere MnO_2 nanotube-supported Co_3O_4 nanoparticles and its carbon nanotubes hybrid material(Co_3 O_4/MnO_2-CNTs) have been synthesized via a simple co-precipitation method combined with post-heat treatment. The morphology and composition of the catalysts are thoroughly analyzed through SEM, TEM, TEM-mapping, XRD, EDX and XPS. In comparison with the commercial 20% Pt/C, Co_3O_4/MnO_2,bare MnO_2 nanotubes and CNTs, the hybrid Co_3O_4/MnO_2-CNTs-350 exhibits perfect bi-functional catalytic activity toward oxygen reduction reaction and oxygen evolution reaction under alkaline condition(0.1 M KOH). Therefore, high cell performances are achieved which result in an appropriate open circuit voltage(～1.47 V),a high discharge peak power density(340 mW cm^(-2)) and a large specific capacity(775 mAh g^(-1) at 10 mA cm^(-2)) for the primary Zn-air battery, a small charge-discharge voltage gap and a high cycle-life(504 cycles at 10 mA cm^(-2) with 10 min per cycle) for the rechargeable Zn-air battery. In particular, the simple synthesis method is suitable for a large-scale production of this bifunctional material due to a green, cost effective and readily available process.展开更多
The tumor suppressor p53 is a multifunctional, highly regulated, and promoter-specific transcriptional factor that is uniquely sensitive to DNA damage and cellular stress signaling. The mechanisms by which p53 directs...The tumor suppressor p53 is a multifunctional, highly regulated, and promoter-specific transcriptional factor that is uniquely sensitive to DNA damage and cellular stress signaling. The mechanisms by which p53 directs a damaged cell down either a cell growth arrest or an apoptotic pathway remain poorly understood. Evidence suggests that the in vivo functions of p53 seem to balance the cell-fate choice with the type and severity of damage that occurs. The concept of antirepression, or inhibition of factors that normally keep p53 at bay, may help explain the physiological mechanisms for p53 activation. These factors also provide novel chemotherapeutic targets for the reactivation of p53 in tumors harboring a wild-type copy of the gene.展开更多
The development of low-cost and efficient electrocatalysts for oxygen evolution reaction(OER)in acid electro-lytes is critical to the widespread implementation of proton electrolyte membrane water electrolyzers(PEMWE)...The development of low-cost and efficient electrocatalysts for oxygen evolution reaction(OER)in acid electro-lytes is critical to the widespread implementation of proton electrolyte membrane water electrolyzers(PEMWE)towards carbon neutralization.Noble metal Ir-and Ru-based materials are state-of-the-art catalysts but still suffer from prohibitive price and scarcity.In this context,a variety of noble metal-free catalysts have been developed to decrease the cost of PEMWE.In this review,we first summarize the activity expression mechanism and stability issues for non-precious metal catalysts,highlighting the origins of performance degradation and the possible mitigation strategies.Then,we systematically review several recently developed noble metal-free catalysts,focusing on the design rationale and the structure-performance relation.Finally,the development prospects of non-noble metal catalysts are prospected,with the potential challenges for practical applications presented.展开更多
InP shows a very high efficiency for solar light to electricity conversion in solar cell and may present an expectation property in photocatalytic hydrogen evolution.However,it suffers serious corrosion in water dispe...InP shows a very high efficiency for solar light to electricity conversion in solar cell and may present an expectation property in photocatalytic hydrogen evolution.However,it suffers serious corrosion in water dispersion.In this paper,it is demonstrated that the stability and activity of the InP-based catalyst are effectively enhanced by applying an anti-corrosion SnO layer and In(OH)_(3)transition layer,which reduces the crystal mismatch between SnO and InP and increases charge transfer.The obtained Pt/SnO/In(OH)_(3)/InP exhibits a hydrogen production rate of 144.42μmol/g in_(3)h under visible light illumination in multi-cycle tests without remarkable decay,12_(3)times higher than that of naked In(OH)_(3)/InP without any electron donor under visible irradiation.展开更多
The p53 tumor suppressor is a sequence-specific transcription factor that undergoes an abundance of post-translational modifications for its regulation and activation.Acetylation of p53 is an important reversible enzy...The p53 tumor suppressor is a sequence-specific transcription factor that undergoes an abundance of post-translational modifications for its regulation and activation.Acetylation of p53 is an important reversible enzymatic process that occurs in response to DNA damage and genotoxic stress and is indispensible for p53 transcriptional activity.p53 was the first non-histone protein shown to be acetylated by histone acetyl transferases,and a number of more recent in vivo models have underscored the importance of this type of modification for p53 activity.Here,we review the current knowledge and recent findings of p53 acetylation and deacetylation and discuss the implications of these processes for the p53 pathway.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.52174283 and 52274308)。
文摘Cobalt-based phosphides show excellent hydrogen evolution reaction(HER)performance,however,improving the intrinsic activity and stability of it in alkaline electrolyte still remains a challenge.Herein,CoRuOH/Co_(2)P/CF with heterojunction structure was developed by means of molten salt and rapid hydrolysis(30 s).The OH-from rapid surface hydrolysis of Co_(2)P as a hydrogen adsorption site can facilitate the formation of thin CoRuOH layer as a water dissociation site,which may bring out better synergistic effect for alkaline HER.Moreover,the covering of CoRuOH can improve the stability of Co_(2)P for HER.When drives at 100 mA/cm^(2),it only requires overpotential of 81 mV in 1.0 mol/L KOH(25℃).Even at higher current density(1000 mA/cm^(2)),CoRuOH/Co_(2)P/CF can also operate stability for at least 100 h.When coupling with NiFe-LDH/IF in a two-electrode system,the voltage of NiFe-LDH/IF(+)||CoRuOH/Co_(2)P/CF(-)at 1000 mA/cm^(2)is merely 1.77 V with 100 h,demonstrating great potential for water splitting.The implementation of this work provides a new strategy and reference for the further improvement of transition metal phosphides as HER electrocatalysts.
基金Natural Science Foundation of Guangdong Province,Grant/Award Number:2021A1515010395Fundamental Research Funds for the Central Universities,Grant/Award Number:2022ZYGXZR002+2 种基金National Natural Science Foundation of China,Grant/Award Numbers:22179039,22005105Pearl River Talent Recruitment Program,Grant/Award Number:2019QN01C693Guangdong Innovative and Entrepreneurial Research Team Program,Grant/Award Number:2021ZT09L392。
文摘While double perovskites of PrBaCo_(2)O_(6)(PBC)have been extensively developed as the cathodes for proton-conducting solid oxide fuel cells(H-SOFCs),the effects of Sr-or Ca-doping at the A site on the activity and stability of the oxygen reduction reaction are yet to be fully studied.Here,the effect of A-site doping on the oxygen reduction reaction activity and stability has been studied by evaluating the performance of both symmetrical and single cells.It is shown that Ca-doped PBC(PrBa_(0.8)Ca_(0.2)Co_(2)O_(6),PBCC)shows a slightly smaller polarization resistance(0.076Ωcm^(2))than that(0.085Ωcm^(2))of Sr-doped PBC(PrBa0.8Sr0.2Co2O6,PBSC)at 700◦C in wet air.Moreover,the degradation rate of PBCC is 0.0003Ωcm^(2)h^(−1)(0.3%h−1)in 100 h,about 1/10 of that of PBSC at 700◦C in wet air.In addition,it is also confirmed that single cells with PBCC cathode show higher peak power density(1.22Wcm^(−2)vs.1.08Wcm^(−2)at 650◦C)and better durability(degradation rate of 0.1%h^(−1)vs.0.13%h^(−1))than those with PBSC cathode.The distribution of relaxation time analyses suggests that the better stability of the PBCC electrode may come from the fast and stable surface oxygen exchange process in the medium frequency range of the electrochemical impedance spectrum.
文摘The catalytic activity of polycobaltprotoporphyrin(PCoPP)was compared with adsorbed cobaltprotoporphyrin monolayer.The results have shown that PCoPP film shows higher catalytic activity and stability than monolayer on glass carbon electrode in both alkaline and acid solution. Catalytic activity of PCoPP goes through a maximum with increase of film thickness.A model was proposed to explain such dependence.The effect of film thickness and solution pH on the stability of PCoPP film was studied.
基金financial support from the National Natural Science Foundation of China (U1510120, 91645110)the Project of Introducing Overseas Intelligence High Education of China (2017-2018)+1 种基金the Graduate Thesis Innovation Foundation of Donghua University (EG2016034)the College of Environmental Science and Engineering, State Environmental Protection Engineering Center for Pollution Treatment and Control in Textile Industry, Donghua University
文摘There has been a continuous need for high active, excellently durable and low-cost electrocatalysts for rechargeable zinc-air batteries. Among many low-cost metal based candidates, transition metal oxides with the CNTs composite have gained increasing attention. In this paper, the 3-D hollow sphere MnO_2 nanotube-supported Co_3O_4 nanoparticles and its carbon nanotubes hybrid material(Co_3 O_4/MnO_2-CNTs) have been synthesized via a simple co-precipitation method combined with post-heat treatment. The morphology and composition of the catalysts are thoroughly analyzed through SEM, TEM, TEM-mapping, XRD, EDX and XPS. In comparison with the commercial 20% Pt/C, Co_3O_4/MnO_2,bare MnO_2 nanotubes and CNTs, the hybrid Co_3O_4/MnO_2-CNTs-350 exhibits perfect bi-functional catalytic activity toward oxygen reduction reaction and oxygen evolution reaction under alkaline condition(0.1 M KOH). Therefore, high cell performances are achieved which result in an appropriate open circuit voltage(～1.47 V),a high discharge peak power density(340 mW cm^(-2)) and a large specific capacity(775 mAh g^(-1) at 10 mA cm^(-2)) for the primary Zn-air battery, a small charge-discharge voltage gap and a high cycle-life(504 cycles at 10 mA cm^(-2) with 10 min per cycle) for the rechargeable Zn-air battery. In particular, the simple synthesis method is suitable for a large-scale production of this bifunctional material due to a green, cost effective and readily available process.
文摘The tumor suppressor p53 is a multifunctional, highly regulated, and promoter-specific transcriptional factor that is uniquely sensitive to DNA damage and cellular stress signaling. The mechanisms by which p53 directs a damaged cell down either a cell growth arrest or an apoptotic pathway remain poorly understood. Evidence suggests that the in vivo functions of p53 seem to balance the cell-fate choice with the type and severity of damage that occurs. The concept of antirepression, or inhibition of factors that normally keep p53 at bay, may help explain the physiological mechanisms for p53 activation. These factors also provide novel chemotherapeutic targets for the reactivation of p53 in tumors harboring a wild-type copy of the gene.
基金the National Key R&D Program of China(No.2021YFB4000200)the National Natural Science Foundation of China(No.22232004)+1 种基金the Instrument Developing Project of the Chinese Academy of Sciences,the Jilin Province Development and Reform Commission Program(2023C032-6)the Jilin Province Science and Technology Development Program(No.20210301008GX,YDZJ202202CXJD011,20210502002ZP)for financial support.
文摘The development of low-cost and efficient electrocatalysts for oxygen evolution reaction(OER)in acid electro-lytes is critical to the widespread implementation of proton electrolyte membrane water electrolyzers(PEMWE)towards carbon neutralization.Noble metal Ir-and Ru-based materials are state-of-the-art catalysts but still suffer from prohibitive price and scarcity.In this context,a variety of noble metal-free catalysts have been developed to decrease the cost of PEMWE.In this review,we first summarize the activity expression mechanism and stability issues for non-precious metal catalysts,highlighting the origins of performance degradation and the possible mitigation strategies.Then,we systematically review several recently developed noble metal-free catalysts,focusing on the design rationale and the structure-performance relation.Finally,the development prospects of non-noble metal catalysts are prospected,with the potential challenges for practical applications presented.
文摘InP shows a very high efficiency for solar light to electricity conversion in solar cell and may present an expectation property in photocatalytic hydrogen evolution.However,it suffers serious corrosion in water dispersion.In this paper,it is demonstrated that the stability and activity of the InP-based catalyst are effectively enhanced by applying an anti-corrosion SnO layer and In(OH)_(3)transition layer,which reduces the crystal mismatch between SnO and InP and increases charge transfer.The obtained Pt/SnO/In(OH)_(3)/InP exhibits a hydrogen production rate of 144.42μmol/g in_(3)h under visible light illumination in multi-cycle tests without remarkable decay,12_(3)times higher than that of naked In(OH)_(3)/InP without any electron donor under visible irradiation.
文摘The p53 tumor suppressor is a sequence-specific transcription factor that undergoes an abundance of post-translational modifications for its regulation and activation.Acetylation of p53 is an important reversible enzymatic process that occurs in response to DNA damage and genotoxic stress and is indispensible for p53 transcriptional activity.p53 was the first non-histone protein shown to be acetylated by histone acetyl transferases,and a number of more recent in vivo models have underscored the importance of this type of modification for p53 activity.Here,we review the current knowledge and recent findings of p53 acetylation and deacetylation and discuss the implications of these processes for the p53 pathway.
