A new series of benzothiazole Schiff bases 3–29 was synthesized and screened for antitumor activity against cervical cancer（Hela） and kidney fibroblast cancer（COS-7） cell lines. Results indicated that compounds 3...A new series of benzothiazole Schiff bases 3–29 was synthesized and screened for antitumor activity against cervical cancer（Hela） and kidney fibroblast cancer（COS-7） cell lines. Results indicated that compounds 3, 14, 19, 27 and 28 have promising activity against Hela cell line with IC50 values of 2.41,3.06, 6.46, 2.22 and 6.25 mmol/L, respectively, in comparison to doxorubicin as a reference antitumor agent（IC50 2.05 mmol/L）. In addition, compound 3 displayed excellent activity against COS-7 cell line with IC50 value of 4.31 mmol/L in comparison to doxorubicin（IC50 3.04 mmol/L）. In the present work,structure based pharmacophore mapping, molecular docking, protein-ligand interaction, fingerprints and binding energy calculations were employed in a virtual screening strategy to identify the interaction between the compounds and the active site of the putative target, EGFR tyrosine kinase. Molecular properties, toxicity, drug-likeness, and drug score profiles of compounds 3, 14, 19, 27, 28 and 29 were also assessed.展开更多
Stop frequency models, as one of the elements of activity based models, represent an important part of travel behavior. Unobserved heterogeneity across the travelers should be taken into consideration to prevent biase...Stop frequency models, as one of the elements of activity based models, represent an important part of travel behavior. Unobserved heterogeneity across the travelers should be taken into consideration to prevent biasedness and inconsistency in the estimated parameters in the stop frequency models. Additionally, previous studies on the stop frequency have mostly been done in larger metropolitan areas and less attention has been paid to the areas with less population. This study addresses these gaps by using 2012 travel data from a medium sized U.S. urban area using the work tour for the case study. Stop in the work tour were classified into three groups of outbound leg, work based subtour, and inbound leg of the commutes. Latent Class Poisson Regression Models were used to analyze the data. The results indicate the presence of heterogeneity across the commuters. Using latent class models significantly improves the predictive power of the models compared to regular one class Poisson regression models. In contrast to one class Poisson models, gender becomes insignificant in predicting the number of tours when unobserved heterogeneity is accounted for. The commuters are associated with increased stops on their work based subtour when the employment density of service-related occupations increases in their work zone, but employment density of retail employment does not significantly contribute to the stop making likelihood of the commuters. Additionally, an increase in the number of work tours was associated with fewer stops on the inbound leg of the commute. The results of this study suggest the consideration of unobserved heterogeneity in the stop frequency models and help transportation agencies and policy makers make better inferences from such models.展开更多
This work proposes an alternative strategy to the use of a speed sensor in <span style="white-space:normal;font-size:10pt;font-family:;" "="">the implementation of active and reactive po...This work proposes an alternative strategy to the use of a speed sensor in <span style="white-space:normal;font-size:10pt;font-family:;" "="">the implementation of active and reactive power based model reference adaptive system (PQ-MRAS) estimator in order to calculate the rotor and stator resistances of an induction motor (IM) and the use of these parameters for the detection of inter-turn short circuits (ITSC) faults in the stator of this motor. The rotor and stator resistance estimation part of the IM is performed by the PQ-MRAS method in which the rotor angular velocity is reconstructed from the interconnected high gain observer (IHGO). The ITSC fault detection part is done by the derivation of stator resistance estimated by the PQ-</span><span style="white-space:normal;font-size:10pt;font-family:;" "="">MRAS estimator. In addition to the speed sensorless detection of ITSC faults of the IM, an approach to determine the number of shorted turns based on the difference between the phase current of the healthy and faulty machine is proposed. Simulation results obtained from the MATLAB/Simulink platform have shown that the PQ-MRAS estimator using an interconnected high-</span><span style="white-space:normal;font-size:10pt;font-family:;" "="">gain observer gives very similar results to those using the speed sensor. The </span><span style="white-space:normal;font-size:10pt;font-family:;" "="">estimation errors in the cases of speed variation and load torque are al</span><span style="white-space:normal;font-size:10pt;font-family:;" "="">mos</span><span style="white-space:normal;font-size:10pt;font-family:;" "="">t identical. Variations in stator and rotor resistances influence the per</span><span style="white-space:normal;font-size:10pt;font-family:;" "="">formance of the observer and lead to poor estimation of the rotor resistance. The results of ITSC fault detection using IHGO are very similar to the results in the literature using the same diagnostic approach with a speed sensor.</span>展开更多
文摘A new series of benzothiazole Schiff bases 3–29 was synthesized and screened for antitumor activity against cervical cancer（Hela） and kidney fibroblast cancer（COS-7） cell lines. Results indicated that compounds 3, 14, 19, 27 and 28 have promising activity against Hela cell line with IC50 values of 2.41,3.06, 6.46, 2.22 and 6.25 mmol/L, respectively, in comparison to doxorubicin as a reference antitumor agent（IC50 2.05 mmol/L）. In addition, compound 3 displayed excellent activity against COS-7 cell line with IC50 value of 4.31 mmol/L in comparison to doxorubicin（IC50 3.04 mmol/L）. In the present work,structure based pharmacophore mapping, molecular docking, protein-ligand interaction, fingerprints and binding energy calculations were employed in a virtual screening strategy to identify the interaction between the compounds and the active site of the putative target, EGFR tyrosine kinase. Molecular properties, toxicity, drug-likeness, and drug score profiles of compounds 3, 14, 19, 27, 28 and 29 were also assessed.
文摘Stop frequency models, as one of the elements of activity based models, represent an important part of travel behavior. Unobserved heterogeneity across the travelers should be taken into consideration to prevent biasedness and inconsistency in the estimated parameters in the stop frequency models. Additionally, previous studies on the stop frequency have mostly been done in larger metropolitan areas and less attention has been paid to the areas with less population. This study addresses these gaps by using 2012 travel data from a medium sized U.S. urban area using the work tour for the case study. Stop in the work tour were classified into three groups of outbound leg, work based subtour, and inbound leg of the commutes. Latent Class Poisson Regression Models were used to analyze the data. The results indicate the presence of heterogeneity across the commuters. Using latent class models significantly improves the predictive power of the models compared to regular one class Poisson regression models. In contrast to one class Poisson models, gender becomes insignificant in predicting the number of tours when unobserved heterogeneity is accounted for. The commuters are associated with increased stops on their work based subtour when the employment density of service-related occupations increases in their work zone, but employment density of retail employment does not significantly contribute to the stop making likelihood of the commuters. Additionally, an increase in the number of work tours was associated with fewer stops on the inbound leg of the commute. The results of this study suggest the consideration of unobserved heterogeneity in the stop frequency models and help transportation agencies and policy makers make better inferences from such models.
文摘This work proposes an alternative strategy to the use of a speed sensor in <span style="white-space:normal;font-size:10pt;font-family:;" "="">the implementation of active and reactive power based model reference adaptive system (PQ-MRAS) estimator in order to calculate the rotor and stator resistances of an induction motor (IM) and the use of these parameters for the detection of inter-turn short circuits (ITSC) faults in the stator of this motor. The rotor and stator resistance estimation part of the IM is performed by the PQ-MRAS method in which the rotor angular velocity is reconstructed from the interconnected high gain observer (IHGO). The ITSC fault detection part is done by the derivation of stator resistance estimated by the PQ-</span><span style="white-space:normal;font-size:10pt;font-family:;" "="">MRAS estimator. In addition to the speed sensorless detection of ITSC faults of the IM, an approach to determine the number of shorted turns based on the difference between the phase current of the healthy and faulty machine is proposed. Simulation results obtained from the MATLAB/Simulink platform have shown that the PQ-MRAS estimator using an interconnected high-</span><span style="white-space:normal;font-size:10pt;font-family:;" "="">gain observer gives very similar results to those using the speed sensor. The </span><span style="white-space:normal;font-size:10pt;font-family:;" "="">estimation errors in the cases of speed variation and load torque are al</span><span style="white-space:normal;font-size:10pt;font-family:;" "="">mos</span><span style="white-space:normal;font-size:10pt;font-family:;" "="">t identical. Variations in stator and rotor resistances influence the per</span><span style="white-space:normal;font-size:10pt;font-family:;" "="">formance of the observer and lead to poor estimation of the rotor resistance. The results of ITSC fault detection using IHGO are very similar to the results in the literature using the same diagnostic approach with a speed sensor.</span>
