The present paper covers the actional mechanism of trifluoroacetic acid for the separation of biopolymers investigated by using the parameters of stoichiometric displacement model for retention(SDM-R) in reversed-phas...The present paper covers the actional mechanism of trifluoroacetic acid for the separation of biopolymers investigated by using the parameters of stoichiometric displacement model for retention(SDM-R) in reversed-phase liquid chromatography. It was found that the trifluoroacetic acid(TFA) may participate in, or stimulate the association among displacing agent molecules in mobile phase, and decrease the affinity of both the associate molecules of the displacing agent and the TFA-protein ion-pairing. The former dominates over the separation selectivity of biopolymers as the concentration of TFA is lower than a given value, and the two contrary functions partly offset to each other and the latter dominates as its concentration is greater than the given value.展开更多
The paper aims at investigating the encoding of self-propelled motion events in Homeric Greek in the light of the typology of motion events,taking into account the case of to go.The verbal class of the self-propelled ...The paper aims at investigating the encoding of self-propelled motion events in Homeric Greek in the light of the typology of motion events,taking into account the case of to go.The verbal class of the self-propelled motion refers to those verbs expressing the idea of a simple translational motion,such as to go,to move,without any information about the manner of motion(see,by contrast,the class of the manner-of-motion verbs,such as to run,to swim)or about the path of motion(see,by contrast,the class of the path verbs,such as to enter,to exit).According to Talmy(2000),world languages can be distinguished depending on whether they prototypically express the semantic component of Path in or outside the motion verb.Languages belonging to the S(atellite)-Framed type tend to convey Path outside the motion verb,in a satellite element,such as a particle,an adposition(adpositional phrase),a preverb,an adverb(ial),a nominal case marker.The prototypical encoding pattern of the S-Framed languages,such as Homeric Greek,involves a motion verb conveying Manner and a satellite conveying Path,i.e.,[manner-of-motion verb+Path-satellite].Nonetheless,another pattern is used by this type of languages,albeit less prototypical,which involves a motion verb conveying only Motion and a satellite conveying Path,i.e.,[self-propelled motion verb+Path-satellite].Verb-inherent actionality,namely telicity,turns out to be a strong feature within the ancient Indo-European languages,such as Homeric Greek,playing a role not only in the development of aspectual/tense morphology,but also in the encoding of motion events,at least with reference to manner-of-motion verbs.The present paper aims at verifying the role of inherent telicity within self-propelled motion verbs,through the analysis of Homeric verbs for go.The study takes into account the Homeric suppletive paradigm for go,focusing on ερχομαι“go;come”and ηλθον(aorist)“go;come”(also with reference to the unclear actional opposition between ερχομαι and ειμι“go;come”).From the textual analysis of all the occurrences of both ερχομαι and ηλθον,as well as their co-occurring Path-encoding elements in the Iliad and the Odyssey,data show to what extent verbal inherent telicity plays an important role in motion event encoding also within the class of self-propelled motion verbs.展开更多
In this paper,we consider the fractional critical Schrödinger equation(FCSE)(-Δ)^(s)u-|u|2^(*)s-2 u=0,where u∈˙H^(s)(R^(N)),N≥4,0<s<1 and 2^(*)s=2 N/N-2 s is the critical Sobolev exponent of order s.By ...In this paper,we consider the fractional critical Schrödinger equation(FCSE)(-Δ)^(s)u-|u|2^(*)s-2 u=0,where u∈˙H^(s)(R^(N)),N≥4,0<s<1 and 2^(*)s=2 N/N-2 s is the critical Sobolev exponent of order s.By virtue of the variational method and the concentration compactness principle with the equivariant group action,we obtain some new type of nonradial,sign-changing solutions of(FCSE)in the energy space˙H^(s)(R^(N)).The key component is that we take the equivariant group action to construct several subspace of˙H^(s)(R^(N))with trivial intersection,then combine the concentration compactness argument in the Sobolev space with fractional order to show the compactness property of Palais-Smale sequences in each subspace and obtain the multiple solutions of(FCSE)in˙H^(s)(R^(N)).展开更多
为了规避网络广告延时效应带来的不确定性风险,企业往往会采用效果付费(cost per action, CPA)方式进行网络推广。本文在CPA模式下研究考虑延时效应的供应链网络广告决策与协调问题。首先,建立含有时间延迟的品牌信誉动态模型和效果依...为了规避网络广告延时效应带来的不确定性风险,企业往往会采用效果付费(cost per action, CPA)方式进行网络推广。本文在CPA模式下研究考虑延时效应的供应链网络广告决策与协调问题。首先,建立含有时间延迟的品牌信誉动态模型和效果依赖的网络广告投入成本模型,并构建CPA模式下供应链网络广告微分博弈模型,再利用最优控制理论求解得到分散式决策与集中式决策下供应链系统的最优网络广告策略、定价策略、品牌信誉以及利润。其次,对决策结果进行综合比较分析,明确供应链系统的最佳决策机制,参照最佳决策供应链系统,设计一种动态批发价格契约,使供应链实现完美协调。最后,通过数值算例验证研究结果的有效性,对网络广告投入、品牌信誉、利润以及协调参数进行灵敏度分析。研究发现,与传统广告研究结论不同,CPA模式下制造商的最优网络广告投入高度依赖于时间,且遵循“逐降-早停”原则;CPA模式下短暂的网络广告延时效应和良好的销售效果可以增加双方合作的积极性,进而企业倾向于整体获利最大的集中式决策机制。本文研究成果为供应链企业网络推广实践提供了重要的理论指导。展开更多
Despite ongoing advancements in cancer treatment,the emergence of primary and acquired resistance poses a significant challenge for both traditional chemotherapy and immune checkpoint blockade therapies.The demand for...Despite ongoing advancements in cancer treatment,the emergence of primary and acquired resistance poses a significant challenge for both traditional chemotherapy and immune checkpoint blockade therapies.The demand for targeted therapeutics for multidrug-resistant cancer is more important than ever.Peptides,as emerging alternatives to current anticancer drugs,offer exquisite versatility in facilitating the design of novel oncology drugs,with the core superiorities of good biocompatibility and a low tendency to induce drug resistance.This review comprehensively introduces the pharmacological mechanisms of peptide-based drugs and strategies for overcoming multidrug resistance(MDR)in cancers,including inducing cell membrane lysis,targeting organelles,activating anticancer immune responses,enhancing drug uptake,targeting ATP-binding cassette(ABC)transporters,and targeting B-cell lymphoma-2(BCL-2)family proteins.Additionally,the current clinical applications of representative peptides in combating MDR cancers and their potential directions for medicinal chemistry research have been thoroughly discussed.This review offers essential insights into the novel treatment approaches for MDR cancers and highlights the trends and perspectives in this field.展开更多
Combined with elastic network model(ENM),the perturbation response scanning(PRS)has emerged as a robust technique for pinpointing allosteric interactions within proteins.Here,we proposed the PRS analysis of drug-targe...Combined with elastic network model(ENM),the perturbation response scanning(PRS)has emerged as a robust technique for pinpointing allosteric interactions within proteins.Here,we proposed the PRS analysis of drug-target networks(DTNs),which could provide a promising avenue in network medicine.We demonstrated the utility of the method by introducing a deep learning and network perturbation-based framework,for drug repurposing of multiple sclerosis(MS).First,the MS comorbidity network was constructed by performing a random walk with restart algorithm based on shared genes between MS and other diseases as seed nodes.Then,based on topological analysis and functional annotation,the neurotransmission module was identified as the“therapeutic module”of MS.Further,perturbation scores of drugs on the module were calculated by constructing the DTN and introducing the PRS analysis,giving a list of repurposable drugs for MS.Mechanism of action analysis both at pathway and structural levels screened dihydroergocristine as a candidate drug of MS by targeting a serotonin receptor of se-rotonin 2B receptor(HTR2B).Finally,we established a cuprizone-induced chronic mouse model to evaluate the alteration of HTR2B in mouse brain regions and observed that HTR2B was significantly reduced in the cuprizone-induced mouse cortex.These findings proved that the network perturbation modeling is a promising avenue for drug repurposing of MS.As a useful systematic method,our approach can also be used to discover the new molecular mechanism and provide effective candidate drugs for other complex diseases.展开更多
The study by Yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of ...The study by Yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC targets.Key genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC patients.Molecular docking con-firmed strong binding affinity of curcumin to these genes.In vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.展开更多
In this paper,we study the Bowen entropy of stable sets in positive entropy G-system of amenable group actions.The lower bound of the Bowen entropy of these sets are estimated.
In the last few years,scholars have continued to refine the understanding of conservatism through cultural psychology.The application of Symbolic Action Theory,particularly Ernst Boesch’s framework,remains central to...In the last few years,scholars have continued to refine the understanding of conservatism through cultural psychology.The application of Symbolic Action Theory,particularly Ernst Boesch’s framework,remains central to discussions,illustrating how conservatism is not merely a political stance but a dynamic system of behaviors that reinforces societal values through symbolic actions(Kölbl,2020).Additionally,recent studies have highlighted the interaction between cultural conservatism and collective identity,with particular focus on how conservatism can manifest in diverse cultural settings(Yilmaz&Alper,2019).Research also underscores the relevance of symbolic politics in shaping both individual attitudes and broader political actions,contributing to the understanding of how symbolic meanings sustain social conservatism in different cultural contexts(Chin&Levey,2022).展开更多
On the morning of May 31st,the parallel forum"Ecological Actions to Carry Forward the Shared Values of Mankind,"as part of the 4th Dialogue on Exchanges and Mutual Learning among Civilisations,was held in Du...On the morning of May 31st,the parallel forum"Ecological Actions to Carry Forward the Shared Values of Mankind,"as part of the 4th Dialogue on Exchanges and Mutual Learning among Civilisations,was held in Dunhuang.More than 50 experts and scholars from different countries,including China,Kenya and Japan,engaged in indepth discussions on the theme.展开更多
ln order to improve the level of investment promotion and redouble effortsto enhance services,on February l9th,the 2025 Action Plan for StabilizingForeign lnvestment was released,proposing 20 measures in four aspects....ln order to improve the level of investment promotion and redouble effortsto enhance services,on February l9th,the 2025 Action Plan for StabilizingForeign lnvestment was released,proposing 20 measures in four aspects.Cur-rently,with increasing uncertainties in the external environment,China facesmultple difficulties and challenges in attracting foreign investment.展开更多
A Green Lifestyle The Double Take column looks at a single topic from an African and Chinese perspective.This month,we explore how personal actions are related to sustainable development.
[Objectives]To investigate the antibacterial mechanism of Common Cnidium Fruit using network pharmacology.[Methods]Active components and targets of Common Cnidium Fruit were screened and obtained using the TCMSP datab...[Objectives]To investigate the antibacterial mechanism of Common Cnidium Fruit using network pharmacology.[Methods]Active components and targets of Common Cnidium Fruit were screened and obtained using the TCMSP database and HIT2.0 database.The collected targets were intersected with antibacterial/bacteriostatic targets obtained from the GeneCards database and OMIM database to identify the antibacterial/bacteriostatic targets of Common Cnidium Fruit.The active component-target network diagram of Common Cnidium Fruit was constructed using Cytoscape software and topological analysis was performed.GO enrichment analysis was performed on the target genes using the DAVID database.[Results]Screening yielded 25 active components of Common Cnidium Fruit,corresponding to 77 targets.Analysis identified 25 core antibacterial/bacteriostatic targets for Common Cnidium Fruit.Network analysis indicated that Common Cnidium Fruit may exert antibacterial/bacteriostatic effects through active components such asβ-sitosterol,stigmasterol,and xanthoxylin,while activating the body's immune regulatory functions by acting on targets including CASP3,PTGS2,BCL2,JUN,and ESR1.[Conclusions]Common Cnidium Fruit may exert antibacterial/bacteriostatic effects through multiple pathways via a mechanism involving multiple components,multiple targets,and multiple pathways.展开更多
Taking Zhejiang Province as an example,this paper explores the mechanisms and implementation pathways through which the low-altitude economy drives the transformation and upgrading of the tourism industry.It finds tha...Taking Zhejiang Province as an example,this paper explores the mechanisms and implementation pathways through which the low-altitude economy drives the transformation and upgrading of the tourism industry.It finds that the low-altitude economy can effectively promote the development of high-end and diversified tourism in Zhejiang by innovating tourism formats,optimizing resource allocation,and enhancing tourist experiences.Besides,it analyzes the current development status of the low-altitude economy in Zhejiang and its potential for integration with tourism,revealing specific enabling pathways for tourism transformation,including low-altitude sightseeing,aviation tourism,and low-altitude sports.Finally,it proposes policy recommendations such as strengthening policy support,enhancing infrastructure development,and cultivating market entities.The findings aim to provide theoretical references and practical guidance for the high-quality development of tourism in Zhejiang Province.展开更多
[Objectives]To explore the pharmacodynamic effect of the Castanopsis sclerophylla(Lindl)Schottk fruit on diarrhea model mice.[Methods]The anti-diarrheal efficacy of the C.sclerophylla fruit was evaluated using a casto...[Objectives]To explore the pharmacodynamic effect of the Castanopsis sclerophylla(Lindl)Schottk fruit on diarrhea model mice.[Methods]The anti-diarrheal efficacy of the C.sclerophylla fruit was evaluated using a castor oil-induced acute diarrhea model in mice and the small intestinal charcoal propulsion test,with assessment of onset time of diarrhea,frequency of loose stools,and small intestinal propulsion rate.[Results]Compared with the model group,the C.sclerophylla frui-treated group demonstrated significantly delayed onset of diarrhea,reduced frequency of loose stools,and decreased small intestinal charcoal propulsion rate in a dose-dependent manner,with the high-dose group achieving efficacy comparable to the loperamide-treated group.[Conclusions]The C.sclerophylla fruit has certain anti-diarrhea effect,and its anti-diarrhea mechanism may be related to the inhibition of small intestinal peristalsis.展开更多
The task of student action recognition in the classroom is to precisely capture and analyze the actions of students in classroom videos,providing a foundation for realizing intelligent and accurate teaching.However,th...The task of student action recognition in the classroom is to precisely capture and analyze the actions of students in classroom videos,providing a foundation for realizing intelligent and accurate teaching.However,the complex nature of the classroom environment has added challenges and difficulties in the process of student action recognition.In this research article,with regard to the circumstances where students are prone to be occluded and classroom computing resources are restricted in real classroom scenarios,a lightweight multi-modal fusion action recognition approach is put forward.This proposed method is capable of enhancing the accuracy of student action recognition while concurrently diminishing the number of parameters of the model and the Computation Amount,thereby achieving a more efficient and accurate recognition performance.In the feature extraction stage,this method fuses the keypoint heatmap with the RGB(Red-Green-Blue color model)image.In order to fully utilize the unique information of different modalities for feature complementarity,a Feature Fusion Module(FFE)is introduced.The FFE encodes and fuses the unique features of the two modalities during the feature extraction process.This fusion strategy not only achieves fusion and complementarity between modalities,but also improves the overall model performance.Furthermore,to reduce the computational load and parameter scale of the model,we use keypoint information to crop RGB images.At the same time,the first three networks of the lightweight feature extraction network X3D are used to extract dual-branch features.These methods significantly reduce the computational load and parameter scale.The number of parameters of the model is 1.40 million,and the computation amount is 5.04 billion floating-point operations per second(GFLOPs),achieving an efficient lightweight design.In the Student Classroom Action Dataset(SCAD),the accuracy of the model is 88.36%.In NTU 60(Nanyang Technological University Red-Green-Blue-Depth RGB+Ddataset with 60 categories),the accuracies on X-Sub(The people in the training set are different from those in the test set)and X-View(The perspectives of the training set and the test set are different)are 95.76%and 98.82%,respectively.On the NTU 120 dataset(Nanyang Technological University Red-Green-Blue-Depth dataset with 120 categories),RGB+Dthe accuracies on X-Sub and X-Set(the perspectives of the training set and the test set are different)are 91.97%and 93.45%,respectively.The model has achieved a balance in terms of accuracy,computation amount,and the number of parameters.展开更多
Charlie,a father from Sunderland,was enjoying a meal with friends when sudden panic erupted at a nearby table.A woman began to choke,her face turning red as her breaths became shallow.Her friend wildly pounded her bac...Charlie,a father from Sunderland,was enjoying a meal with friends when sudden panic erupted at a nearby table.A woman began to choke,her face turning red as her breaths became shallow.Her friend wildly pounded her back,and others yelled for help.Without hesitation,Charlie sprang into action.展开更多
Twenty short-statured maize inbred lines were collected from CIMMYT India and Mexico through the Plant Breeding Division, Bangladesh Agricultural Research Institute (BARI), Gazipur. The experiment was conducted from N...Twenty short-statured maize inbred lines were collected from CIMMYT India and Mexico through the Plant Breeding Division, Bangladesh Agricultural Research Institute (BARI), Gazipur. The experiment was conducted from November 2020 to April 2021 in three different agroecological regions such as BARI, Gazipur, RARS Barisal and RARS Rangpur. Seven inbred lines were selected on the basis of genetic diversity and per se performance and they were crossed separately in a 7 × 7 half diallel fashion, producing 21F1 hybrids in 2019 which were evaluated at three locations. However, variances due to GCA were much higher in magnitude than SCA for all the characters indicating preponderance of additive gene effects on the inheritance of these characters. Two parents viz., P3 (CML33) and P4 (CML41) were good general combiners and two crosses viz., P4 × P5 (CML41 × CML31) and P5 × P7 (CML31 × CML124) expressed significant positive SCA effects coupled with significant positive heterosis for grain yield and for most of the yield contributing characters over the two commercial check varieties BHM 9 and NK40. Four crosses: P1 × P5 (CML116 × CML31), P1 × P6 (CML116 × CML32), P2 × P6 (CML72 × CML32) and P3 × P4 (CML33 × CML41), exhibited significant and negative SCA effects for both plant and ear height which were desirable for short stature. Genotypes x location interaction was also significant for maximum characters, suggesting that genotypes interacted significantly in different environments.展开更多
The emergence of embodied cognition theory has altered our traditional understanding of children’s language learning,emphasizing the close connection between the body,environment,and movement.This paper discusses the...The emergence of embodied cognition theory has altered our traditional understanding of children’s language learning,emphasizing the close connection between the body,environment,and movement.This paper discusses the opportunities,challenges,and future directions of research on children’s language learning from the perspective of embodied cognition.It concludes that multisensory engagement can greatly improve children’s comprehension and memorization of language knowledge and that language acquisition is intimately tied to bodily perception,movement,and emotional experience.In addition,children’s language acquisition can also be effectively aided by embodied cognition techniques as multimedia aids,gesture and enactment,and imagery.Based on previous evidence,we propose an integrated language learning framework and a new relevance-integration taxonomy for children’s language learning from the perspectives of embodied cognition and cognitive load theories.In order to support the long-term growth of children’s language education,future research should focus more on the requirement of embodied language learning in the preschool-primary transition and optimize the teaching objectives and contents.展开更多
基金Supported by the National Natrual Science Foundation of China
文摘The present paper covers the actional mechanism of trifluoroacetic acid for the separation of biopolymers investigated by using the parameters of stoichiometric displacement model for retention(SDM-R) in reversed-phase liquid chromatography. It was found that the trifluoroacetic acid(TFA) may participate in, or stimulate the association among displacing agent molecules in mobile phase, and decrease the affinity of both the associate molecules of the displacing agent and the TFA-protein ion-pairing. The former dominates over the separation selectivity of biopolymers as the concentration of TFA is lower than a given value, and the two contrary functions partly offset to each other and the latter dominates as its concentration is greater than the given value.
文摘The paper aims at investigating the encoding of self-propelled motion events in Homeric Greek in the light of the typology of motion events,taking into account the case of to go.The verbal class of the self-propelled motion refers to those verbs expressing the idea of a simple translational motion,such as to go,to move,without any information about the manner of motion(see,by contrast,the class of the manner-of-motion verbs,such as to run,to swim)or about the path of motion(see,by contrast,the class of the path verbs,such as to enter,to exit).According to Talmy(2000),world languages can be distinguished depending on whether they prototypically express the semantic component of Path in or outside the motion verb.Languages belonging to the S(atellite)-Framed type tend to convey Path outside the motion verb,in a satellite element,such as a particle,an adposition(adpositional phrase),a preverb,an adverb(ial),a nominal case marker.The prototypical encoding pattern of the S-Framed languages,such as Homeric Greek,involves a motion verb conveying Manner and a satellite conveying Path,i.e.,[manner-of-motion verb+Path-satellite].Nonetheless,another pattern is used by this type of languages,albeit less prototypical,which involves a motion verb conveying only Motion and a satellite conveying Path,i.e.,[self-propelled motion verb+Path-satellite].Verb-inherent actionality,namely telicity,turns out to be a strong feature within the ancient Indo-European languages,such as Homeric Greek,playing a role not only in the development of aspectual/tense morphology,but also in the encoding of motion events,at least with reference to manner-of-motion verbs.The present paper aims at verifying the role of inherent telicity within self-propelled motion verbs,through the analysis of Homeric verbs for go.The study takes into account the Homeric suppletive paradigm for go,focusing on ερχομαι“go;come”and ηλθον(aorist)“go;come”(also with reference to the unclear actional opposition between ερχομαι and ειμι“go;come”).From the textual analysis of all the occurrences of both ερχομαι and ηλθον,as well as their co-occurring Path-encoding elements in the Iliad and the Odyssey,data show to what extent verbal inherent telicity plays an important role in motion event encoding also within the class of self-propelled motion verbs.
基金supported by National Key Research and Development Program of China(No.2020YFA0712900)NSFC(No.112371240 and No.12431008)supported by NSFC(No.12001284)。
文摘In this paper,we consider the fractional critical Schrödinger equation(FCSE)(-Δ)^(s)u-|u|2^(*)s-2 u=0,where u∈˙H^(s)(R^(N)),N≥4,0<s<1 and 2^(*)s=2 N/N-2 s is the critical Sobolev exponent of order s.By virtue of the variational method and the concentration compactness principle with the equivariant group action,we obtain some new type of nonradial,sign-changing solutions of(FCSE)in the energy space˙H^(s)(R^(N)).The key component is that we take the equivariant group action to construct several subspace of˙H^(s)(R^(N))with trivial intersection,then combine the concentration compactness argument in the Sobolev space with fractional order to show the compactness property of Palais-Smale sequences in each subspace and obtain the multiple solutions of(FCSE)in˙H^(s)(R^(N)).
文摘为了规避网络广告延时效应带来的不确定性风险,企业往往会采用效果付费(cost per action, CPA)方式进行网络推广。本文在CPA模式下研究考虑延时效应的供应链网络广告决策与协调问题。首先,建立含有时间延迟的品牌信誉动态模型和效果依赖的网络广告投入成本模型,并构建CPA模式下供应链网络广告微分博弈模型,再利用最优控制理论求解得到分散式决策与集中式决策下供应链系统的最优网络广告策略、定价策略、品牌信誉以及利润。其次,对决策结果进行综合比较分析,明确供应链系统的最佳决策机制,参照最佳决策供应链系统,设计一种动态批发价格契约,使供应链实现完美协调。最后,通过数值算例验证研究结果的有效性,对网络广告投入、品牌信誉、利润以及协调参数进行灵敏度分析。研究发现,与传统广告研究结论不同,CPA模式下制造商的最优网络广告投入高度依赖于时间,且遵循“逐降-早停”原则;CPA模式下短暂的网络广告延时效应和良好的销售效果可以增加双方合作的积极性,进而企业倾向于整体获利最大的集中式决策机制。本文研究成果为供应链企业网络推广实践提供了重要的理论指导。
基金supported by the Science and Technology Innovation Program of Hunan Province(No.2022RC1168)National Natural Science Foundation of China(Nos.82322073,82173846,82304533)+12 种基金CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2023-I2M-3-009)Key project at central government level:The ability establishment of sustainable use for valuable Chinese medicine resources(No.2060302)China Postdoctoral Science Foundation(No.2021M702215)Oriental Scholars of Shanghai Universities(No.TP2022081)Jiangxi Province Thousand Talents Program(No.jxsq2023102168)Young Talent Lifting Project of China Association of Chinese Medicine(No.CACM-(2021-QNRC2-A08))Shanghai Rising-Star Program(No.22QA1409100)Shanghai Sailing Program(No.22YF1445000)2021 Shanghai Science and Technology Innovation Action Plan(No.21S11902800)Three-year Action Plan for Shanghai TCM Development and Inheritance Program(Nos.ZY(2021-2023)-0208,ZY(2021-2023)-0401)High level Key Discipline of National Administration of Traditional Chinese Medicine(No.71)Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202004)Innovation team of high-level local universities in Shanghai:Strategic Innovation Team of TCM Chemical Biology。
文摘Despite ongoing advancements in cancer treatment,the emergence of primary and acquired resistance poses a significant challenge for both traditional chemotherapy and immune checkpoint blockade therapies.The demand for targeted therapeutics for multidrug-resistant cancer is more important than ever.Peptides,as emerging alternatives to current anticancer drugs,offer exquisite versatility in facilitating the design of novel oncology drugs,with the core superiorities of good biocompatibility and a low tendency to induce drug resistance.This review comprehensively introduces the pharmacological mechanisms of peptide-based drugs and strategies for overcoming multidrug resistance(MDR)in cancers,including inducing cell membrane lysis,targeting organelles,activating anticancer immune responses,enhancing drug uptake,targeting ATP-binding cassette(ABC)transporters,and targeting B-cell lymphoma-2(BCL-2)family proteins.Additionally,the current clinical applications of representative peptides in combating MDR cancers and their potential directions for medicinal chemistry research have been thoroughly discussed.This review offers essential insights into the novel treatment approaches for MDR cancers and highlights the trends and perspectives in this field.
基金supported by the National Natural Science Foundation of China(Grant Nos.:32271292,31872723,32200778,and 22377089)the Jiangsu Students Innovation and Entrepre-neurship Training Program,China(Program No.:202210285081Z)+6 种基金the Project of MOE Key Laboratory of Geriatric Diseases and Immunology,China(Project No.:JYN202404)Proj-ect Funded by the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions,Natural Science Foundation of Jiangsu Province,China(Project No.:BK20220494)Suzhou Medical and Health Technology Innovation Project,China(Grant No.:SKY2022107)the Clinical Research Center of Neuro-logical Disease in The Second Affiliated Hospital of Soochow University,China(Grant No.:ND2022A04)State Key Laboratory of Drug Research(Grant No.:SKLDR-2023-KF-05)Jiangsu Shuang-chuang Program for Doctor,Young Science Talents Promotion Project of Jiangsu Science and Technology Association(Program No.:TJ-2023-019)Young Science Talents Promotion Project of Suzhou Science and Technology Association,Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases,and startup funding(Grant Nos.:NH21500221,NH21500122,and NH21500123)to Qifei Cong.
文摘Combined with elastic network model(ENM),the perturbation response scanning(PRS)has emerged as a robust technique for pinpointing allosteric interactions within proteins.Here,we proposed the PRS analysis of drug-target networks(DTNs),which could provide a promising avenue in network medicine.We demonstrated the utility of the method by introducing a deep learning and network perturbation-based framework,for drug repurposing of multiple sclerosis(MS).First,the MS comorbidity network was constructed by performing a random walk with restart algorithm based on shared genes between MS and other diseases as seed nodes.Then,based on topological analysis and functional annotation,the neurotransmission module was identified as the“therapeutic module”of MS.Further,perturbation scores of drugs on the module were calculated by constructing the DTN and introducing the PRS analysis,giving a list of repurposable drugs for MS.Mechanism of action analysis both at pathway and structural levels screened dihydroergocristine as a candidate drug of MS by targeting a serotonin receptor of se-rotonin 2B receptor(HTR2B).Finally,we established a cuprizone-induced chronic mouse model to evaluate the alteration of HTR2B in mouse brain regions and observed that HTR2B was significantly reduced in the cuprizone-induced mouse cortex.These findings proved that the network perturbation modeling is a promising avenue for drug repurposing of MS.As a useful systematic method,our approach can also be used to discover the new molecular mechanism and provide effective candidate drugs for other complex diseases.
基金Supported by The College Students’Innovation and Entrepreneurship Competition,No.2024cxcy504 and No.202410459164.
文摘The study by Yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC targets.Key genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC patients.Molecular docking con-firmed strong binding affinity of curcumin to these genes.In vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.
基金Supported by NSFC(No.11861010),also supported by NSFC(No.12171175),also supported by NSFC(No.12261006)NSF of Guangxi Province(No.2018GXNSFFA281008)Project of Guangxi First Class Disciplines of Statistics(No.GJKY-2022-01)。
文摘In this paper,we study the Bowen entropy of stable sets in positive entropy G-system of amenable group actions.The lower bound of the Bowen entropy of these sets are estimated.
基金supported by the Philosophy and Social Science Research Fund of Zhejiang Province(Grant No.24ZJQN095YB)the Educational and Teaching Reform Project of HDU-ITMO Joint Institute(Grant No.SGJ2023JG007).
文摘In the last few years,scholars have continued to refine the understanding of conservatism through cultural psychology.The application of Symbolic Action Theory,particularly Ernst Boesch’s framework,remains central to discussions,illustrating how conservatism is not merely a political stance but a dynamic system of behaviors that reinforces societal values through symbolic actions(Kölbl,2020).Additionally,recent studies have highlighted the interaction between cultural conservatism and collective identity,with particular focus on how conservatism can manifest in diverse cultural settings(Yilmaz&Alper,2019).Research also underscores the relevance of symbolic politics in shaping both individual attitudes and broader political actions,contributing to the understanding of how symbolic meanings sustain social conservatism in different cultural contexts(Chin&Levey,2022).
文摘On the morning of May 31st,the parallel forum"Ecological Actions to Carry Forward the Shared Values of Mankind,"as part of the 4th Dialogue on Exchanges and Mutual Learning among Civilisations,was held in Dunhuang.More than 50 experts and scholars from different countries,including China,Kenya and Japan,engaged in indepth discussions on the theme.
文摘ln order to improve the level of investment promotion and redouble effortsto enhance services,on February l9th,the 2025 Action Plan for StabilizingForeign lnvestment was released,proposing 20 measures in four aspects.Cur-rently,with increasing uncertainties in the external environment,China facesmultple difficulties and challenges in attracting foreign investment.
文摘A Green Lifestyle The Double Take column looks at a single topic from an African and Chinese perspective.This month,we explore how personal actions are related to sustainable development.
基金Supported by Scientific Research Platform Project of Putuo District,Shanghai(2024QX04).
文摘[Objectives]To investigate the antibacterial mechanism of Common Cnidium Fruit using network pharmacology.[Methods]Active components and targets of Common Cnidium Fruit were screened and obtained using the TCMSP database and HIT2.0 database.The collected targets were intersected with antibacterial/bacteriostatic targets obtained from the GeneCards database and OMIM database to identify the antibacterial/bacteriostatic targets of Common Cnidium Fruit.The active component-target network diagram of Common Cnidium Fruit was constructed using Cytoscape software and topological analysis was performed.GO enrichment analysis was performed on the target genes using the DAVID database.[Results]Screening yielded 25 active components of Common Cnidium Fruit,corresponding to 77 targets.Analysis identified 25 core antibacterial/bacteriostatic targets for Common Cnidium Fruit.Network analysis indicated that Common Cnidium Fruit may exert antibacterial/bacteriostatic effects through active components such asβ-sitosterol,stigmasterol,and xanthoxylin,while activating the body's immune regulatory functions by acting on targets including CASP3,PTGS2,BCL2,JUN,and ESR1.[Conclusions]Common Cnidium Fruit may exert antibacterial/bacteriostatic effects through multiple pathways via a mechanism involving multiple components,multiple targets,and multiple pathways.
文摘Taking Zhejiang Province as an example,this paper explores the mechanisms and implementation pathways through which the low-altitude economy drives the transformation and upgrading of the tourism industry.It finds that the low-altitude economy can effectively promote the development of high-end and diversified tourism in Zhejiang by innovating tourism formats,optimizing resource allocation,and enhancing tourist experiences.Besides,it analyzes the current development status of the low-altitude economy in Zhejiang and its potential for integration with tourism,revealing specific enabling pathways for tourism transformation,including low-altitude sightseeing,aviation tourism,and low-altitude sports.Finally,it proposes policy recommendations such as strengthening policy support,enhancing infrastructure development,and cultivating market entities.The findings aim to provide theoretical references and practical guidance for the high-quality development of tourism in Zhejiang Province.
基金Supported by Zhongshan City Medical Research Project(2023A020437).
文摘[Objectives]To explore the pharmacodynamic effect of the Castanopsis sclerophylla(Lindl)Schottk fruit on diarrhea model mice.[Methods]The anti-diarrheal efficacy of the C.sclerophylla fruit was evaluated using a castor oil-induced acute diarrhea model in mice and the small intestinal charcoal propulsion test,with assessment of onset time of diarrhea,frequency of loose stools,and small intestinal propulsion rate.[Results]Compared with the model group,the C.sclerophylla frui-treated group demonstrated significantly delayed onset of diarrhea,reduced frequency of loose stools,and decreased small intestinal charcoal propulsion rate in a dose-dependent manner,with the high-dose group achieving efficacy comparable to the loperamide-treated group.[Conclusions]The C.sclerophylla fruit has certain anti-diarrhea effect,and its anti-diarrhea mechanism may be related to the inhibition of small intestinal peristalsis.
基金supported by the National Natural Science Foundation of China under Grant 62107034the Major Science and Technology Project of Yunnan Province(202402AD080002)Yunnan International Joint R&D Center of China-Laos-Thailand Educational Digitalization(202203AP140006).
文摘The task of student action recognition in the classroom is to precisely capture and analyze the actions of students in classroom videos,providing a foundation for realizing intelligent and accurate teaching.However,the complex nature of the classroom environment has added challenges and difficulties in the process of student action recognition.In this research article,with regard to the circumstances where students are prone to be occluded and classroom computing resources are restricted in real classroom scenarios,a lightweight multi-modal fusion action recognition approach is put forward.This proposed method is capable of enhancing the accuracy of student action recognition while concurrently diminishing the number of parameters of the model and the Computation Amount,thereby achieving a more efficient and accurate recognition performance.In the feature extraction stage,this method fuses the keypoint heatmap with the RGB(Red-Green-Blue color model)image.In order to fully utilize the unique information of different modalities for feature complementarity,a Feature Fusion Module(FFE)is introduced.The FFE encodes and fuses the unique features of the two modalities during the feature extraction process.This fusion strategy not only achieves fusion and complementarity between modalities,but also improves the overall model performance.Furthermore,to reduce the computational load and parameter scale of the model,we use keypoint information to crop RGB images.At the same time,the first three networks of the lightweight feature extraction network X3D are used to extract dual-branch features.These methods significantly reduce the computational load and parameter scale.The number of parameters of the model is 1.40 million,and the computation amount is 5.04 billion floating-point operations per second(GFLOPs),achieving an efficient lightweight design.In the Student Classroom Action Dataset(SCAD),the accuracy of the model is 88.36%.In NTU 60(Nanyang Technological University Red-Green-Blue-Depth RGB+Ddataset with 60 categories),the accuracies on X-Sub(The people in the training set are different from those in the test set)and X-View(The perspectives of the training set and the test set are different)are 95.76%and 98.82%,respectively.On the NTU 120 dataset(Nanyang Technological University Red-Green-Blue-Depth dataset with 120 categories),RGB+Dthe accuracies on X-Sub and X-Set(the perspectives of the training set and the test set are different)are 91.97%and 93.45%,respectively.The model has achieved a balance in terms of accuracy,computation amount,and the number of parameters.
文摘Charlie,a father from Sunderland,was enjoying a meal with friends when sudden panic erupted at a nearby table.A woman began to choke,her face turning red as her breaths became shallow.Her friend wildly pounded her back,and others yelled for help.Without hesitation,Charlie sprang into action.
文摘Twenty short-statured maize inbred lines were collected from CIMMYT India and Mexico through the Plant Breeding Division, Bangladesh Agricultural Research Institute (BARI), Gazipur. The experiment was conducted from November 2020 to April 2021 in three different agroecological regions such as BARI, Gazipur, RARS Barisal and RARS Rangpur. Seven inbred lines were selected on the basis of genetic diversity and per se performance and they were crossed separately in a 7 × 7 half diallel fashion, producing 21F1 hybrids in 2019 which were evaluated at three locations. However, variances due to GCA were much higher in magnitude than SCA for all the characters indicating preponderance of additive gene effects on the inheritance of these characters. Two parents viz., P3 (CML33) and P4 (CML41) were good general combiners and two crosses viz., P4 × P5 (CML41 × CML31) and P5 × P7 (CML31 × CML124) expressed significant positive SCA effects coupled with significant positive heterosis for grain yield and for most of the yield contributing characters over the two commercial check varieties BHM 9 and NK40. Four crosses: P1 × P5 (CML116 × CML31), P1 × P6 (CML116 × CML32), P2 × P6 (CML72 × CML32) and P3 × P4 (CML33 × CML41), exhibited significant and negative SCA effects for both plant and ear height which were desirable for short stature. Genotypes x location interaction was also significant for maximum characters, suggesting that genotypes interacted significantly in different environments.
基金supported by the Humanities and Social Science Fund of the Ministry of Education of China(23YJA190012)Guangdong Provincial College Student Innovation and Entrepreneurship Training Program(S202410577105)+1 种基金Huizhou Philosophy and Social Sciences Discipline Co-Construction Project(HZ2023GJ128)Characteristic Innovation Project of Colleges and Universities in Guangdong Province(2021WTSCX090).
文摘The emergence of embodied cognition theory has altered our traditional understanding of children’s language learning,emphasizing the close connection between the body,environment,and movement.This paper discusses the opportunities,challenges,and future directions of research on children’s language learning from the perspective of embodied cognition.It concludes that multisensory engagement can greatly improve children’s comprehension and memorization of language knowledge and that language acquisition is intimately tied to bodily perception,movement,and emotional experience.In addition,children’s language acquisition can also be effectively aided by embodied cognition techniques as multimedia aids,gesture and enactment,and imagery.Based on previous evidence,we propose an integrated language learning framework and a new relevance-integration taxonomy for children’s language learning from the perspectives of embodied cognition and cognitive load theories.In order to support the long-term growth of children’s language education,future research should focus more on the requirement of embodied language learning in the preschool-primary transition and optimize the teaching objectives and contents.
