Tumor drug resistance has been reported to be associated with drug efflux in tumor cells.Recently,a noninvasive and safe mechanism,sonodynamic therapy(SDT),has been proposed to be an oxidative stress strategy to poten...Tumor drug resistance has been reported to be associated with drug efflux in tumor cells.Recently,a noninvasive and safe mechanism,sonodynamic therapy(SDT),has been proposed to be an oxidative stress strategy to potentially overcome drug efflux,but with efficacy limitation.Herein,we propose a systematic strategy for optimizing SDT,especially revealing the key role of acoustics parameters acting in SDT efficiency.A doxorubicin(DOX)-loaded sonosensitive micelle(DPM)mediated“sono-force”combination(chemotherapy and sonodynamic)therapy strategy,named DPCSTs,which was designed for amplifying SDT to augment oxidative stress to overcome drug efflux and induce robust long-term inhibition of tumor development by optimized acoustic parameters.The sub-10 nm size DPM enhanced tumor targeting and renal clearance.Meanwhile,another important component,doxorubicin,significantly suppressed residual tumors(78.6%)due to“sono-force”augmented oxidative stress reversing drug efflux,finally leading to long-term tumor development limitation in vivo.It is the first time to propose a systematic strategy for optimizing SDT regimens to overcome resistance,which can synergize with chemotherapy to exert long-term tumor development inhibition.We believe that this work will advance SDT-related research to a new level,and improve our understanding of overcoming resistance of targeted cancer therapy.展开更多
Objective： To examine whether vocal characteristics estimated by acoustic parameters were associated with phlegm, yin deficiency, or cold-heat patterns. Methods： A total of 75 college students （males：females = 53...Objective： To examine whether vocal characteristics estimated by acoustic parameters were associated with phlegm, yin deficiency, or cold-heat patterns. Methods： A total of 75 college students （males：females = 53：22） aged 19-24 years were enrolled in this study. Each subject was asked to complete the phlegm pattern questionnaire （PPQ）, yin deficiency questionnaire （YDQ） and cold-heat questionnaire （CHQ）. For the acoustic analysis, each subject was asked to produce a sustained vowel sound （/a/） for 3 s to be used to calculate acoustic parameters. Then, habitual fundamental frequency （F0）, jitter, shimmer, F0 tremor, mean F0, standard deviation of F0, maximum F0, minimum F0, normalized noise energy, harmonic-to-noise ratio, signal-to-noise ratio, amplitude tremor, and power ratio were calculated using the Dr. Speech software. Finally, four hierarchical regression models with pattern questionnaire scores as dependent variables were formed to examine which factors among acoustic parameters, sex, and age were predictive of those pattern scores. Results： PPQ, YDQ, heat, and cold pattern scores all formed significant regression model equations and the adjusted R2 values were 0.281, 0.164, 0.156, and 0.170, respectively. There were aging effects in the PPQ and YDQ models （standardized β =0.199, 0.271, respectively）. Vocal tremor-related Fo tremor and vocal ringing-related power ratio parameters were associated with PPQ and YDQ scores. Gender was directly predictive of PPQ and indirectly moderated the relationship between power ratio and YDQ score. Vocal pitch- related habitual F0 and mean F0 were associated with heat and cold scores. These results indicate that the vocal qualities of phlegm- and yin deficiency-susceptible subjects tend to be ringing and less tremorous, and those of heat- and cold-susceptible subjects tend to be high-pitched. Conclusion： Our study results suggest that vocal characteristics estimated by acoustic parameters are partially predictive of phlegm, yin deficiency, heat, and cold patterns. In terms of phlegm and yin deficiency patterns, there were direct or moderating effects of sex and age.展开更多
Based on Jacobson's free length theory and the dependence of ultrasonic velocity on the free length in organic liquids, the equation of nonlinearity acoustic parameter B/A was given, and the calculated nonlinearit...Based on Jacobson's free length theory and the dependence of ultrasonic velocity on the free length in organic liquids, the equation of nonlinearity acoustic parameter B/A was given, and the calculated nonlinearity acoustic parameter B/A in some organic liquids are in good agreement with the measured results.展开更多
This research scrutinizes acoustic discrepancies in pronouncing 100 basic core words in Mandarin Chinese and Arabic between 100 Saudi Arabian speakers,compared with 30 native Mandarin speakers.Analyzed acoustic parame...This research scrutinizes acoustic discrepancies in pronouncing 100 basic core words in Mandarin Chinese and Arabic between 100 Saudi Arabian speakers,compared with 30 native Mandarin speakers.Analyzed acoustic parameters included F0 contour,jitter,shimmer,HarmonicstoNoise Ratio(HNR),Cepstral Peak Prominence(CPP),H1-H2,H1-A1,H1-A2,and H1-A3.Results from a linear mixed effects model revealed significant variations in parameters when Saudi speakers alternated between Mandarin Chinese and Arabic,except for H1-H2 and H1-A1.A better vocal control ability and higher pitch were observed in their Mandarin Chinese production,suggesting a potentially elevated level of linguistic tension during their second language production.Distinct proficiency levels in Mandarin Chinese yielded significant differences only in HNR and H1-H2,with no statistically significant distinctions observed in other parameters.Comparing the Mandarin Chinese pronunciation of Saudi Arabian speakers with that of native Mandarin speakers,statistically significant differences emerged in four parameters:jitter,HNR,H1-A1,and H1-A3.These four parameters prove effective in distinguishing Mandarin Chinese interlanguage from native Mandarin pronunciation.Furthermore,a comparison between Saudi speakers'Arabic and Chinese speakers'Mandarin exhibited significant differences in jitter,shimmer,HNR,and CPP.The findings underscore the pivotal role of certain acoustic parameters,such as jitter and HNR,in evaluating speech quality and proficiency in L2 learners.展开更多
In this paper,a semi-analytical method was proposed to evaluate the acoustic nonlinearity parameter for single crystals of Cu,Ag and Au.The acoustic nonlinearity parameter can be derived analytically by general expres...In this paper,a semi-analytical method was proposed to evaluate the acoustic nonlinearity parameter for single crystals of Cu,Ag and Au.The acoustic nonlinearity parameter can be derived analytically by general expressions in terms of the interatomic potentials with the distances between each pair of atoms in these transition metals.To evaluate the acoustic nonlinearity parameter,one needs to conduct one step molecular static simulation and obtain the equilibrium positions of all the atoms.Further,based on this method,numerical experiments with molecular dynamic code LAMMPS were given to compute the acoustic nonlinearity parameter of Cu,Ag and Au.To illustrate the validity of these expressions,comparison was made between calculation results and data in the literature.Reasonable agreement is observed.Because of the analytical nature of this method,it provides a fundamental understanding of the nonlinear elastic behavior of these transition metals.展开更多
Exploring new acoustic parameters is essential to develop a noninvasive imaging technique for the surgery of silicone oil tamponades. In this study, the acoustic nonlinearity parameters B/A of varied silicone oil samp...Exploring new acoustic parameters is essential to develop a noninvasive imaging technique for the surgery of silicone oil tamponades. In this study, the acoustic nonlinearity parameters B/A of varied silicone oil samples （e.g., linear or hyper-branched） are experimentally measured by using a modified thermodynamic method. The results show that： （i） when the concentration of the silicone oil with a molecular weight of 5 × 10^4 increases from 0.5 g/100 ml to 8 g/100 ml, the corresponding B/A value increases by about 18%, but the acoustic velocity only increases by about 0.1%; （ii） when the molecular weight of the hyper-branched silicone oil is enhanced from 2 × 10^5 to 1 × 10^6, the B/A value increases by about 22%, while the acoustic velocity is only raised by about 0.2%. This study suggests that the B/A parameter of the silicone oil is more sensitive to the change in its molecular structure than that of the acoustic velocity. Thus, the B/A parameter might be utilized as an effective index for the development and optimization of the noninvasive imaging of the surgery of silicone oil tamponades.展开更多
This study presents a general approach to derive the acoustic nonlinearity parameters induced by various types of dislocation configurations including dislocation strings （monopoles）, dislocation dipoles, dislocatio...This study presents a general approach to derive the acoustic nonlinearity parameters induced by various types of dislocation configurations including dislocation strings （monopoles）, dislocation dipoles, dislocation pileups and extended dislocations. It is found that expressions of the acoustic nonlinearity parameter induced by such a variety of dislocation con- figurations share a common mathematical form. They are all scaled with （Lch/b）n, where Lch is a characteristic length of the dislocation configuration, b is the magnitude of the Burgers vector, and n is either 3 or 4. Semiquantitative analysis is presented to compare the magnitudes of the acoustic nonlinearity parameters among different types of dislocation configurations.展开更多
Advertisement calls are essential for communication among anuran amphibians,with their production influenced by a range of environmental factors and morphological traits.To understand the primary sources of variation ...Advertisement calls are essential for communication among anuran amphibians,with their production influenced by a range of environmental factors and morphological traits.To understand the primary sources of variation of advertisement calls in male Leptobrachium liui,we recorded their advertisement calls during the breeding season and analyzed two primary acoustic parameters: call duration(CD) and dominant frequency(DF),along with their within-individual coefficients of variation.Additionally,we collected nest-related environmental parameters and morphological traits to investigate how these factors influence the variation in advertisement calls.Our analyses revealed that both nest-related environmental parameters(particularly water temperature) and individual morphological traits(especially head morphology) significantly influenced advertisement call characteristics in male L.liui.Water temperature showed a negative relationship with CD,while head morphology was positively associated with both CD and DF.These findings enhance our understanding of the factors shaping acoustic communication in L.liui during the breeding season and highlight the importance of both environmental and morphological factors in anuran vocalization.展开更多
The geological tectonic zone is closely related to outburst.Taking the outburst coal bodies in tectonic zones as the research object,combined with DIC and AE monitoring technologies and discrete element simulation,the...The geological tectonic zone is closely related to outburst.Taking the outburst coal bodies in tectonic zones as the research object,combined with DIC and AE monitoring technologies and discrete element simulation,the mechanical response,crack evolution and energy characteristics of coal bodies under different loading rates(impact disturbances)were studied.The results show that both the uniaxial compressive strength and elastic modulus are positively correlated with the loading rate,with a maximum increase in compressive strength of 25.15%.The uniaxial compressive strength is more sensitive to impact disturbances.The failure modes of coal bodies can be divided into the“slip-crack synchronization(S&C)type”and the“crack-first-then-slip(C&S)type”.The slip in tectonic zones is more severe at high loading rates.At low loading rates,shear cracks dominate(60.01%),while the proportion of tensile cracks increases significantly(70.52%)at high loading rates.Additionally,the rate of axial crack growth decreases as the loading rate increases.The peak values of total energy and dissipated energy increase significantly with the loading rate,and the peak energy of the C&S type is greater than that of the S&C type.Energy is preferentially released through the slip of tectonic zones and the propagation of radial cracks.展开更多
Advertisement calls play an important role in influencing female mate choice and are regarded as one of the key characters responsible for reproductive isolation and speciation events in frogs and toads. The black-spi...Advertisement calls play an important role in influencing female mate choice and are regarded as one of the key characters responsible for reproductive isolation and speciation events in frogs and toads. The black-spined toad, Bufo melanostictus, is one of the most common amphibians in Southeast Asia and is frequently observed in human habitations throughout its distributional range. The advertisement calls of the toad have not been well described. Here, we report the advertisement calls of this species from Lishui, Zhejiang, China during its breeding season. The advertisement calls of B. melanostictus are composed of single notes with a single harmonic frequency emitted sporadically. The call parameters recorded in this study were highly variable across recording times and with different body sizes. Dominant frequency was negatively correlated with body size. Comparing the calls of the B. melanostictus population from Lishui with the populations from five other localities(Bangkok, Thailand; Coorg, India; Burma, Myanmar; Bali, Indonesia; Halimun-Salak National Park, Indonesia), we found that call structure was similar among five different populations with no harmonics, while the Halimun-Salak National Park population contained two clear harmonics. Dominant frequency was similar between Bali(1.56 kHz) and Coorg(1.6 kHz) populations, while it was highly variable among other populations. Besides call duration, call interval and pulse/call rate may also be significantly different among the comparing populations. Pooling the available data, we observed some similarities and differences in call parameters among the six populations.展开更多
The purpose of the present contribution is to explore the technique to use Acoustic Doppler Current Pro- filers （ADCPs） for suspended sediment flux measurements, which may be applied to coastal embayment environment...The purpose of the present contribution is to explore the technique to use Acoustic Doppler Current Pro- filers （ADCPs） for suspended sediment flux measurements, which may be applied to coastal embayment environments such as estuaries and tidal inlets for sediment exchange and budget studies. Based on tidal cycle measurements from the entrance of ]iaozhou Bay, Shandong Peninsula, eastern China, statistical rela- tionships between the suspended sediment concentration （SSC） and ADCP echo intensity output are estab- lished. Echo intensity data obtained during an ADCP survey along two cross-sections during a spring tidal phase were transformed into SSC data. The ADCP current velocity and SSC data were then used to calculate the flux of fine-grained sediment. The results show that net sediment transport at the entrance is directed towards the open sea, with an order of magnitude of 103 t per spring tidal cycle; hence, although Jiaozhou Bay is a low SSC environment, the tidally induced suspended sediment transport can be intense.展开更多
AIM： To study the relation between acoustic parameters and histological structure of biological tissue and to provide the basis for high-resolution image of biological tissues and quantitative ultrasonic diagnosis of...AIM： To study the relation between acoustic parameters and histological structure of biological tissue and to provide the basis for high-resolution image of biological tissues and quantitative ultrasonic diagnosis of liver disease. METHODS： Ultrasonic imaging and tissue characterization of four normal porcine liver and five cirrhotic liver tissue samples were performed using a high frequency imaging system. RESULTS： The acoustic parameters of cirrhotic liver tissue were larger than those of normal liver tissue. The sound velocity was 1577 m/s in normal liver tissue and 1631 m/s in cirrhotic liver tissue. At 35 MHz, the attenuation coefficient was 3.0 dB/mm in normal liver tissue and 4.1 dB/mm in cirrhotic liver tissue. The backscatter coefficient was 0.00431 dB/Srmm in cirrhotic liver tissue and 0.00303 dB/Srmm in normal liver tissue. The backscatter coefficient increased with the frequency. The high frequency images coincided with their histological features. CONCLUSION： The acoustic parameters, especially the sound backscatter coefficient, are sensitive to the changes of liver tissues and can be used to differentiate between the normal and pathological liver tissues. High frequency image system is a useful device for highresolution image and tissue characterization.展开更多
Based on Schaaff＇s collision factor theory （CFT） in liquids, the equations for nonlinear ultrasonic parameters in both organic liquid and binary organic liquid mixtures are deduced. The nonlinear ultrasonic paramet...Based on Schaaff＇s collision factor theory （CFT） in liquids, the equations for nonlinear ultrasonic parameters in both organic liquid and binary organic liquid mixtures are deduced. The nonlinear ultrasonic parameters, including pressure coefficient, temperature coefficients of ultrasonic velocity, and nonlinear acoustic parameter B/A in both organic liquid and binary organic liquid mixtures, are evaluated for comparison with the measured results and data from other sources. The equations show that the coefficient of ultrasonic velocity and nonlinear acoustic parameter B/A are closely related to molecular interactions. These nonlinear ultrasonic parameters reflect some information of internal structure and outside status of the medium or mixtures. From the exponent of repulsive forces of the molecules, several thermodynamic parameters, pressure and temperature of the medium, the nonlinear ultrasonic parameters and ultrasonic nature of the medium can be evaluated. When evaluating and studying nonlinear acoustic parameter B/A of binary organic liquid mixtures, there is no need to know the nonlinear acoustic parameter B/A of the components. Obviously, the equation reveals the connection between the nonlinear ultrasonic nature and internal structure and outside status of the mixtures more directly and distinctly than traditional mixture law for B/A, e.g. Apfel＇s and Sehgal＇s laws for liquid binary mixtures.展开更多
The study is based on an observation of the pronunciation of a group of undergraduate students of English as a Second Language （ESL） whose mother tongue is Arabic and who have no formal training in the spoken variet...The study is based on an observation of the pronunciation of a group of undergraduate students of English as a Second Language （ESL） whose mother tongue is Arabic and who have no formal training in the spoken variety of English other than that received in the classroom. The study of acquisition of pronunciation of consonant clusters at morphological, particularly at the morphophonological levels indicates that the learners are sensitive to the syllabic structure viz., cccv type and cccvcc type, at the word-initial, medial and final positions. Samples of words with different consonant clusters were tested with a homogeneous group of students. Words of identical morphological categories were used as the data to test the students＇ level of perception. These were analyzed using Speech Analyzer Version 2.5. The data includes consonant clusters like plosive-fricative, plosive-plosive, fricative-fricative and plosive-fricative-trill/liquid combinations. The results varied according to the perceptual and articulatory abilities of the learners. It was observed that the plosive perception and acquisition of three-consonant clusters of plosive-plosive word initially, plosive-plosive combinations word finally and plosive-fricative type, posed more difficulty for the learners. The tendency to drop one of the consonants of the cluster was more pronounced with syllables ending in plural morphemes and those ending in -mp, -pt, -kt, -nt, -bt, etc. Difficulty was also noticed with the initial plosive＋/r/, plosive＋/1/combinations, especially in word initial positions. Across the syllable boundaries, these clusters are almost inaudible with some speakers. The difficulty in the articulation of these consonant clusters can be accounted for the mother tongue influence, as in the case of many other features. The results of the analysis have a pedagogical implication in the use of such words with consonant clusters, to teach reading skills to the students of undergraduate level in the present setting and promote self-learning through the use of speech tools.展开更多
Density,ultrasonic velocity and viscosity of imidazolinone derivatives are studied in dimethyl formamide(DMF) at 308.15 K.From the experimental data,various acoustical parameters,such as specific impedance Z,isentropi...Density,ultrasonic velocity and viscosity of imidazolinone derivatives are studied in dimethyl formamide(DMF) at 308.15 K.From the experimental data,various acoustical parameters,such as specific impedance Z,isentropic compressibilityκs,Rao's molar sound function Rm,van der Waals constant b,relaxation strength r,intermolecular free length Lf,internal pressureπ,solvation number Sn,relative association RA,etc.are evaluated,which helps in understanding the molecular interactions occurring in these solutions.展开更多
Strength and deformability characteristics of rock with pre-existing fissures are governed by cracking behavior. To further research the effects of pre-existing fissures on the mechanical properties and crack coalesce...Strength and deformability characteristics of rock with pre-existing fissures are governed by cracking behavior. To further research the effects of pre-existing fissures on the mechanical properties and crack coalescence process, a series of uniaxial compression tests were carried out for rock-like material with two unparallel fissures.In the present study, cement, quartz sand, and water were used to fabricate a kind of brittle rock-like material cylindrical model specimen. The mechanical properties of rock-like material specimen used in this research were all in good agreement with the brittle rock materials. Two unparallel fissures（a horizontal fissure and an inclined fissure） were created by inserting steel during molding the model specimen.Then all the pre-fissured rock-like specimens were tested under uniaxial compression by a rock mechanics servocontrolled testing system. The peak strength and Young＇s modulus of pre-fissured specimen all first decreased and then increased when the fissure angle increased from 0？to 75？.In order to investigate the crack initiation, propagation and coalescence process, photographic monitoring was adopted to capture images during the entire deformation process.Moreover, acoustic emission（AE） monitoring technique was also used to obtain the AE evolution characteristic of prefissured specimen. The relationship between axial stress, AE events, and the crack coalescence process was set up： when a new crack was initiated or a crack coalescence occurred, thecorresponding axial stress dropped in the axial stress–time curve and a big AE event could be observed simultaneously.Finally, the mechanism of crack propagation under microscopic observation was discussed. These experimental results are expected to increase the understanding of the strength failure behavior and the cracking mechanism of rock containing unparallel fissures.展开更多
Professor Beranek talked about the sound qualities of concert hall. The 58 famous concert halls in the world were graded according to the subjective comparison from the professional musicians and music lovers. Six mea...Professor Beranek talked about the sound qualities of concert hall. The 58 famous concert halls in the world were graded according to the subjective comparison from the professional musicians and music lovers. Six measurable objective parameters were proposed. The ranking according to these parameters were presented.展开更多
The integral expression for acoustic field due to a point source in shallow waterwhile sediment is either a liquid or a solid is derived. The synthetic full waveforms are simulatedusing real axis integration and FFF m...The integral expression for acoustic field due to a point source in shallow waterwhile sediment is either a liquid or a solid is derived. The synthetic full waveforms are simulatedusing real axis integration and FFF method. The effects of the seabed sediment parametersand center frequency of the source on the low frequency acoustic wave propagation in shallowwater are investigated. The conclusion is that the wave groups received in far field are thoseof the mode waves of the source center frequency. The possibility for inversely deducing thecompressional and shear sound speeds of sediment using the least square optimum through themeasured group velocities of a selected mode at different frequencies is discussed.展开更多
Regard for the fuzziness and the randomness in some acoustic fields,a method for the numerical analysis of the 2D acoustic field with Fuzzy-Random parameters was proposed based on the equivalent conversion of informat...Regard for the fuzziness and the randomness in some acoustic fields,a method for the numerical analysis of the 2D acoustic field with Fuzzy-Random parameters was proposed based on the equivalent conversion of information entropy.In the proposed method,a fuzzyrandom acoustic field was treated as a pure fuzzy acoustic field or a pure random acoustic field by transforming all the variables into fuzzy variables or random variables.Perturbation finite element methods for analyzing the two-dimensional acoustic fuzzy and random field are deduced.The sound pressure response of a 2D acoustic tube and the 2D acoustic cavity of a car with fuzzy-random parameters were analyzed by the proposed method and the Monte Carlo method,the results show that the proposed method can be well applied to the numerical analysis of the 2D acoustic field with fuzzy-random parameters,and has good prospect of engineering application.展开更多
In this paper, the influence of molecular structure of proteins on the acoustic non-linearity parameter B/A has been studied. By using biochemical technique, three proteins such as bovine serum albumin, bovine hemoglo...In this paper, the influence of molecular structure of proteins on the acoustic non-linearity parameter B/A has been studied. By using biochemical technique, three proteins such as bovine serum albumin, bovine hemoglobin and pepsin were employed and their quarternary,tertiary and secondary protein structures were perturbed by the denaturing agent sodium do-decyl sulfate (SDS) solution, while their primary structures of protein were not changed. This means that only the structural features were altered and the chemical composition maintained unchanged. B/A has been measured by using improved thermodynamic method. The experi-mental results show that when the concentration of SDS solution increases, the alterations of the protein structure increase, and the contribution of protein to the B/A value decreases. Re-sults indicate that the B/A values can display the destruction of molecular structure of protein.Some explanation of these phenomena has also been made in this paper.展开更多
基金supported by grants from the Key Project of International Cooperation of National Natural Science Foundation(W2411072)the National Key Research and Development Program of China(No.2023YFC3402600)Key R&D Special Project of Henan Province(No.231111311900).
文摘Tumor drug resistance has been reported to be associated with drug efflux in tumor cells.Recently,a noninvasive and safe mechanism,sonodynamic therapy(SDT),has been proposed to be an oxidative stress strategy to potentially overcome drug efflux,but with efficacy limitation.Herein,we propose a systematic strategy for optimizing SDT,especially revealing the key role of acoustics parameters acting in SDT efficiency.A doxorubicin(DOX)-loaded sonosensitive micelle(DPM)mediated“sono-force”combination(chemotherapy and sonodynamic)therapy strategy,named DPCSTs,which was designed for amplifying SDT to augment oxidative stress to overcome drug efflux and induce robust long-term inhibition of tumor development by optimized acoustic parameters.The sub-10 nm size DPM enhanced tumor targeting and renal clearance.Meanwhile,another important component,doxorubicin,significantly suppressed residual tumors(78.6%)due to“sono-force”augmented oxidative stress reversing drug efflux,finally leading to long-term tumor development limitation in vivo.It is the first time to propose a systematic strategy for optimizing SDT regimens to overcome resistance,which can synergize with chemotherapy to exert long-term tumor development inhibition.We believe that this work will advance SDT-related research to a new level,and improve our understanding of overcoming resistance of targeted cancer therapy.
文摘Objective： To examine whether vocal characteristics estimated by acoustic parameters were associated with phlegm, yin deficiency, or cold-heat patterns. Methods： A total of 75 college students （males：females = 53：22） aged 19-24 years were enrolled in this study. Each subject was asked to complete the phlegm pattern questionnaire （PPQ）, yin deficiency questionnaire （YDQ） and cold-heat questionnaire （CHQ）. For the acoustic analysis, each subject was asked to produce a sustained vowel sound （/a/） for 3 s to be used to calculate acoustic parameters. Then, habitual fundamental frequency （F0）, jitter, shimmer, F0 tremor, mean F0, standard deviation of F0, maximum F0, minimum F0, normalized noise energy, harmonic-to-noise ratio, signal-to-noise ratio, amplitude tremor, and power ratio were calculated using the Dr. Speech software. Finally, four hierarchical regression models with pattern questionnaire scores as dependent variables were formed to examine which factors among acoustic parameters, sex, and age were predictive of those pattern scores. Results： PPQ, YDQ, heat, and cold pattern scores all formed significant regression model equations and the adjusted R2 values were 0.281, 0.164, 0.156, and 0.170, respectively. There were aging effects in the PPQ and YDQ models （standardized β =0.199, 0.271, respectively）. Vocal tremor-related Fo tremor and vocal ringing-related power ratio parameters were associated with PPQ and YDQ scores. Gender was directly predictive of PPQ and indirectly moderated the relationship between power ratio and YDQ score. Vocal pitch- related habitual F0 and mean F0 were associated with heat and cold scores. These results indicate that the vocal qualities of phlegm- and yin deficiency-susceptible subjects tend to be ringing and less tremorous, and those of heat- and cold-susceptible subjects tend to be high-pitched. Conclusion： Our study results suggest that vocal characteristics estimated by acoustic parameters are partially predictive of phlegm, yin deficiency, heat, and cold patterns. In terms of phlegm and yin deficiency patterns, there were direct or moderating effects of sex and age.
文摘Based on Jacobson's free length theory and the dependence of ultrasonic velocity on the free length in organic liquids, the equation of nonlinearity acoustic parameter B/A was given, and the calculated nonlinearity acoustic parameter B/A in some organic liquids are in good agreement with the measured results.
基金supported by the National-Social Science Foundation of China “Acous-tic Database and Computational Research onCore Words of Languages in China” ( No.19ZDA300)
文摘This research scrutinizes acoustic discrepancies in pronouncing 100 basic core words in Mandarin Chinese and Arabic between 100 Saudi Arabian speakers,compared with 30 native Mandarin speakers.Analyzed acoustic parameters included F0 contour,jitter,shimmer,HarmonicstoNoise Ratio(HNR),Cepstral Peak Prominence(CPP),H1-H2,H1-A1,H1-A2,and H1-A3.Results from a linear mixed effects model revealed significant variations in parameters when Saudi speakers alternated between Mandarin Chinese and Arabic,except for H1-H2 and H1-A1.A better vocal control ability and higher pitch were observed in their Mandarin Chinese production,suggesting a potentially elevated level of linguistic tension during their second language production.Distinct proficiency levels in Mandarin Chinese yielded significant differences only in HNR and H1-H2,with no statistically significant distinctions observed in other parameters.Comparing the Mandarin Chinese pronunciation of Saudi Arabian speakers with that of native Mandarin speakers,statistically significant differences emerged in four parameters:jitter,HNR,H1-A1,and H1-A3.These four parameters prove effective in distinguishing Mandarin Chinese interlanguage from native Mandarin pronunciation.Furthermore,a comparison between Saudi speakers'Arabic and Chinese speakers'Mandarin exhibited significant differences in jitter,shimmer,HNR,and CPP.The findings underscore the pivotal role of certain acoustic parameters,such as jitter and HNR,in evaluating speech quality and proficiency in L2 learners.
基金financially supported by the National Sci-Tech Support Plan(No.2015BAF06B01)。
文摘In this paper,a semi-analytical method was proposed to evaluate the acoustic nonlinearity parameter for single crystals of Cu,Ag and Au.The acoustic nonlinearity parameter can be derived analytically by general expressions in terms of the interatomic potentials with the distances between each pair of atoms in these transition metals.To evaluate the acoustic nonlinearity parameter,one needs to conduct one step molecular static simulation and obtain the equilibrium positions of all the atoms.Further,based on this method,numerical experiments with molecular dynamic code LAMMPS were given to compute the acoustic nonlinearity parameter of Cu,Ag and Au.To illustrate the validity of these expressions,comparison was made between calculation results and data in the literature.Reasonable agreement is observed.Because of the analytical nature of this method,it provides a fundamental understanding of the nonlinear elastic behavior of these transition metals.
基金Project supported by the National Basic Research Program of China(Grant No.2011CB707900)the National Natural Science Foundation of China(Grant Nos.81127901,11174141,61072027,and 11374155)the Natural Science Foundation of Jiangsu Province,China(Grant No.BE2011110)
文摘Exploring new acoustic parameters is essential to develop a noninvasive imaging technique for the surgery of silicone oil tamponades. In this study, the acoustic nonlinearity parameters B/A of varied silicone oil samples （e.g., linear or hyper-branched） are experimentally measured by using a modified thermodynamic method. The results show that： （i） when the concentration of the silicone oil with a molecular weight of 5 × 10^4 increases from 0.5 g/100 ml to 8 g/100 ml, the corresponding B/A value increases by about 18%, but the acoustic velocity only increases by about 0.1%; （ii） when the molecular weight of the hyper-branched silicone oil is enhanced from 2 × 10^5 to 1 × 10^6, the B/A value increases by about 22%, while the acoustic velocity is only raised by about 0.2%. This study suggests that the B/A parameter of the silicone oil is more sensitive to the change in its molecular structure than that of the acoustic velocity. Thus, the B/A parameter might be utilized as an effective index for the development and optimization of the noninvasive imaging of the surgery of silicone oil tamponades.
文摘This study presents a general approach to derive the acoustic nonlinearity parameters induced by various types of dislocation configurations including dislocation strings （monopoles）, dislocation dipoles, dislocation pileups and extended dislocations. It is found that expressions of the acoustic nonlinearity parameter induced by such a variety of dislocation con- figurations share a common mathematical form. They are all scaled with （Lch/b）n, where Lch is a characteristic length of the dislocation configuration, b is the magnitude of the Burgers vector, and n is either 3 or 4. Semiquantitative analysis is presented to compare the magnitudes of the acoustic nonlinearity parameters among different types of dislocation configurations.
基金supported by the County-School Cooperation Project in Suichang County (2024-HZ12)Ecological Discipline Construction Fund of Lishui University。
文摘Advertisement calls are essential for communication among anuran amphibians,with their production influenced by a range of environmental factors and morphological traits.To understand the primary sources of variation of advertisement calls in male Leptobrachium liui,we recorded their advertisement calls during the breeding season and analyzed two primary acoustic parameters: call duration(CD) and dominant frequency(DF),along with their within-individual coefficients of variation.Additionally,we collected nest-related environmental parameters and morphological traits to investigate how these factors influence the variation in advertisement calls.Our analyses revealed that both nest-related environmental parameters(particularly water temperature) and individual morphological traits(especially head morphology) significantly influenced advertisement call characteristics in male L.liui.Water temperature showed a negative relationship with CD,while head morphology was positively associated with both CD and DF.These findings enhance our understanding of the factors shaping acoustic communication in L.liui during the breeding season and highlight the importance of both environmental and morphological factors in anuran vocalization.
基金supported by the National Natural Science Foundation of China(Nos.52374122 and 51874165)the Liaoning Revitalization Talents Program(No.XLYC1902106).
文摘The geological tectonic zone is closely related to outburst.Taking the outburst coal bodies in tectonic zones as the research object,combined with DIC and AE monitoring technologies and discrete element simulation,the mechanical response,crack evolution and energy characteristics of coal bodies under different loading rates(impact disturbances)were studied.The results show that both the uniaxial compressive strength and elastic modulus are positively correlated with the loading rate,with a maximum increase in compressive strength of 25.15%.The uniaxial compressive strength is more sensitive to impact disturbances.The failure modes of coal bodies can be divided into the“slip-crack synchronization(S&C)type”and the“crack-first-then-slip(C&S)type”.The slip in tectonic zones is more severe at high loading rates.At low loading rates,shear cracks dominate(60.01%),while the proportion of tensile cracks increases significantly(70.52%)at high loading rates.Additionally,the rate of axial crack growth decreases as the loading rate increases.The peak values of total energy and dissipated energy increase significantly with the loading rate,and the peak energy of the C&S type is greater than that of the S&C type.Energy is preferentially released through the slip of tectonic zones and the propagation of radial cracks.
基金supported by the grants from the National Natural Science Foundation of China(30770310,30970435)the Natural Science Foundation of Zhejiang,China(Y307453)
文摘Advertisement calls play an important role in influencing female mate choice and are regarded as one of the key characters responsible for reproductive isolation and speciation events in frogs and toads. The black-spined toad, Bufo melanostictus, is one of the most common amphibians in Southeast Asia and is frequently observed in human habitations throughout its distributional range. The advertisement calls of the toad have not been well described. Here, we report the advertisement calls of this species from Lishui, Zhejiang, China during its breeding season. The advertisement calls of B. melanostictus are composed of single notes with a single harmonic frequency emitted sporadically. The call parameters recorded in this study were highly variable across recording times and with different body sizes. Dominant frequency was negatively correlated with body size. Comparing the calls of the B. melanostictus population from Lishui with the populations from five other localities(Bangkok, Thailand; Coorg, India; Burma, Myanmar; Bali, Indonesia; Halimun-Salak National Park, Indonesia), we found that call structure was similar among five different populations with no harmonics, while the Halimun-Salak National Park population contained two clear harmonics. Dominant frequency was similar between Bali(1.56 kHz) and Coorg(1.6 kHz) populations, while it was highly variable among other populations. Besides call duration, call interval and pulse/call rate may also be significantly different among the comparing populations. Pooling the available data, we observed some similarities and differences in call parameters among the six populations.
基金A project of the Mega-Science Program supported by the Ministry of Science and Technology of China:"Land-ocean boundary processes and their impacts on the formation of the Yangtze deposition system" under contract No.2013CB956500a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘The purpose of the present contribution is to explore the technique to use Acoustic Doppler Current Pro- filers （ADCPs） for suspended sediment flux measurements, which may be applied to coastal embayment environments such as estuaries and tidal inlets for sediment exchange and budget studies. Based on tidal cycle measurements from the entrance of ]iaozhou Bay, Shandong Peninsula, eastern China, statistical rela- tionships between the suspended sediment concentration （SSC） and ADCP echo intensity output are estab- lished. Echo intensity data obtained during an ADCP survey along two cross-sections during a spring tidal phase were transformed into SSC data. The ADCP current velocity and SSC data were then used to calculate the flux of fine-grained sediment. The results show that net sediment transport at the entrance is directed towards the open sea, with an order of magnitude of 103 t per spring tidal cycle; hence, although Jiaozhou Bay is a low SSC environment, the tidally induced suspended sediment transport can be intense.
基金Supported by the National Natural Science Foundation of China, No. 10204014
文摘AIM： To study the relation between acoustic parameters and histological structure of biological tissue and to provide the basis for high-resolution image of biological tissues and quantitative ultrasonic diagnosis of liver disease. METHODS： Ultrasonic imaging and tissue characterization of four normal porcine liver and five cirrhotic liver tissue samples were performed using a high frequency imaging system. RESULTS： The acoustic parameters of cirrhotic liver tissue were larger than those of normal liver tissue. The sound velocity was 1577 m/s in normal liver tissue and 1631 m/s in cirrhotic liver tissue. At 35 MHz, the attenuation coefficient was 3.0 dB/mm in normal liver tissue and 4.1 dB/mm in cirrhotic liver tissue. The backscatter coefficient was 0.00431 dB/Srmm in cirrhotic liver tissue and 0.00303 dB/Srmm in normal liver tissue. The backscatter coefficient increased with the frequency. The high frequency images coincided with their histological features. CONCLUSION： The acoustic parameters, especially the sound backscatter coefficient, are sensitive to the changes of liver tissues and can be used to differentiate between the normal and pathological liver tissues. High frequency image system is a useful device for highresolution image and tissue characterization.
文摘Based on Schaaff＇s collision factor theory （CFT） in liquids, the equations for nonlinear ultrasonic parameters in both organic liquid and binary organic liquid mixtures are deduced. The nonlinear ultrasonic parameters, including pressure coefficient, temperature coefficients of ultrasonic velocity, and nonlinear acoustic parameter B/A in both organic liquid and binary organic liquid mixtures, are evaluated for comparison with the measured results and data from other sources. The equations show that the coefficient of ultrasonic velocity and nonlinear acoustic parameter B/A are closely related to molecular interactions. These nonlinear ultrasonic parameters reflect some information of internal structure and outside status of the medium or mixtures. From the exponent of repulsive forces of the molecules, several thermodynamic parameters, pressure and temperature of the medium, the nonlinear ultrasonic parameters and ultrasonic nature of the medium can be evaluated. When evaluating and studying nonlinear acoustic parameter B/A of binary organic liquid mixtures, there is no need to know the nonlinear acoustic parameter B/A of the components. Obviously, the equation reveals the connection between the nonlinear ultrasonic nature and internal structure and outside status of the mixtures more directly and distinctly than traditional mixture law for B/A, e.g. Apfel＇s and Sehgal＇s laws for liquid binary mixtures.
文摘The study is based on an observation of the pronunciation of a group of undergraduate students of English as a Second Language （ESL） whose mother tongue is Arabic and who have no formal training in the spoken variety of English other than that received in the classroom. The study of acquisition of pronunciation of consonant clusters at morphological, particularly at the morphophonological levels indicates that the learners are sensitive to the syllabic structure viz., cccv type and cccvcc type, at the word-initial, medial and final positions. Samples of words with different consonant clusters were tested with a homogeneous group of students. Words of identical morphological categories were used as the data to test the students＇ level of perception. These were analyzed using Speech Analyzer Version 2.5. The data includes consonant clusters like plosive-fricative, plosive-plosive, fricative-fricative and plosive-fricative-trill/liquid combinations. The results varied according to the perceptual and articulatory abilities of the learners. It was observed that the plosive perception and acquisition of three-consonant clusters of plosive-plosive word initially, plosive-plosive combinations word finally and plosive-fricative type, posed more difficulty for the learners. The tendency to drop one of the consonants of the cluster was more pronounced with syllables ending in plural morphemes and those ending in -mp, -pt, -kt, -nt, -bt, etc. Difficulty was also noticed with the initial plosive＋/r/, plosive＋/1/combinations, especially in word initial positions. Across the syllable boundaries, these clusters are almost inaudible with some speakers. The difficulty in the articulation of these consonant clusters can be accounted for the mother tongue influence, as in the case of many other features. The results of the analysis have a pedagogical implication in the use of such words with consonant clusters, to teach reading skills to the students of undergraduate level in the present setting and promote self-learning through the use of speech tools.
文摘Density,ultrasonic velocity and viscosity of imidazolinone derivatives are studied in dimethyl formamide(DMF) at 308.15 K.From the experimental data,various acoustical parameters,such as specific impedance Z,isentropic compressibilityκs,Rao's molar sound function Rm,van der Waals constant b,relaxation strength r,intermolecular free length Lf,internal pressureπ,solvation number Sn,relative association RA,etc.are evaluated,which helps in understanding the molecular interactions occurring in these solutions.
基金supported by the National Natural Science Foundation of China (Grant 51179189)the National Basic Research 973 Program of China (Grant 2013CB036003)+2 种基金the Program for New Century Excellent Talents in University (Grant NCET-120961)Outstanding Innovation Team Project in China University of Mining and Technology (Grant 2014QN002)the Fundamental Research Funds for the Central Universities (Grants 2014YC10 and 2014XT03)
文摘Strength and deformability characteristics of rock with pre-existing fissures are governed by cracking behavior. To further research the effects of pre-existing fissures on the mechanical properties and crack coalescence process, a series of uniaxial compression tests were carried out for rock-like material with two unparallel fissures.In the present study, cement, quartz sand, and water were used to fabricate a kind of brittle rock-like material cylindrical model specimen. The mechanical properties of rock-like material specimen used in this research were all in good agreement with the brittle rock materials. Two unparallel fissures（a horizontal fissure and an inclined fissure） were created by inserting steel during molding the model specimen.Then all the pre-fissured rock-like specimens were tested under uniaxial compression by a rock mechanics servocontrolled testing system. The peak strength and Young＇s modulus of pre-fissured specimen all first decreased and then increased when the fissure angle increased from 0？to 75？.In order to investigate the crack initiation, propagation and coalescence process, photographic monitoring was adopted to capture images during the entire deformation process.Moreover, acoustic emission（AE） monitoring technique was also used to obtain the AE evolution characteristic of prefissured specimen. The relationship between axial stress, AE events, and the crack coalescence process was set up： when a new crack was initiated or a crack coalescence occurred, thecorresponding axial stress dropped in the axial stress–time curve and a big AE event could be observed simultaneously.Finally, the mechanism of crack propagation under microscopic observation was discussed. These experimental results are expected to increase the understanding of the strength failure behavior and the cracking mechanism of rock containing unparallel fissures.
文摘Professor Beranek talked about the sound qualities of concert hall. The 58 famous concert halls in the world were graded according to the subjective comparison from the professional musicians and music lovers. Six measurable objective parameters were proposed. The ranking according to these parameters were presented.
文摘The integral expression for acoustic field due to a point source in shallow waterwhile sediment is either a liquid or a solid is derived. The synthetic full waveforms are simulatedusing real axis integration and FFF method. The effects of the seabed sediment parametersand center frequency of the source on the low frequency acoustic wave propagation in shallowwater are investigated. The conclusion is that the wave groups received in far field are thoseof the mode waves of the source center frequency. The possibility for inversely deducing thecompressional and shear sound speeds of sediment using the least square optimum through themeasured group velocities of a selected mode at different frequencies is discussed.
基金supported by the Independent Subject of State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body in Hunan University(60870002)
文摘Regard for the fuzziness and the randomness in some acoustic fields,a method for the numerical analysis of the 2D acoustic field with Fuzzy-Random parameters was proposed based on the equivalent conversion of information entropy.In the proposed method,a fuzzyrandom acoustic field was treated as a pure fuzzy acoustic field or a pure random acoustic field by transforming all the variables into fuzzy variables or random variables.Perturbation finite element methods for analyzing the two-dimensional acoustic fuzzy and random field are deduced.The sound pressure response of a 2D acoustic tube and the 2D acoustic cavity of a car with fuzzy-random parameters were analyzed by the proposed method and the Monte Carlo method,the results show that the proposed method can be well applied to the numerical analysis of the 2D acoustic field with fuzzy-random parameters,and has good prospect of engineering application.
文摘In this paper, the influence of molecular structure of proteins on the acoustic non-linearity parameter B/A has been studied. By using biochemical technique, three proteins such as bovine serum albumin, bovine hemoglobin and pepsin were employed and their quarternary,tertiary and secondary protein structures were perturbed by the denaturing agent sodium do-decyl sulfate (SDS) solution, while their primary structures of protein were not changed. This means that only the structural features were altered and the chemical composition maintained unchanged. B/A has been measured by using improved thermodynamic method. The experi-mental results show that when the concentration of SDS solution increases, the alterations of the protein structure increase, and the contribution of protein to the B/A value decreases. Re-sults indicate that the B/A values can display the destruction of molecular structure of protein.Some explanation of these phenomena has also been made in this paper.
