From an evolutionary point of view, reproduction timing is an important adaptation which enables the transfer of genetic properties, thus enabling species continuation. Rodents inhabiting arid environments need reliab...From an evolutionary point of view, reproduction timing is an important adaptation which enables the transfer of genetic properties, thus enabling species continuation. Rodents inhabiting arid environments need reliable cues for triggering their reproduction. Results of previous studies showed that increased dietary salinity plays an important role as an ultimate regulator for desert adapted rodents＇ reproductive system. The authors aimed discovering pathways by which high salinity can affect the reproductive system and metabolic status of desert adapted common spiny mice, Acomys cahirinus. Mice were challenged with osmotic stress, water source salinity increased gradually from 0.9% - 5% NaCI under short days （SD） and long days （LD）. The authors assessed leptin and free fatty acid （FFA） levels using ELISA while, SYBR green technology was used for relative receptor expression （RQ） of target genes. Results revealed that serum levels of the hormone leptin were significantly （P 〈 0.05） reduced in salinity treated （ST） mice. Levels of FFA were significantly （P 〈 0.05） increased in LD- and SD-ST-males. In ST-SD females a significant increase （P 〈 0.05） in expression levels of leptin （Ob-Rt） mRNA receptor gene, in ovaries was noted. Aldosteron （Nr3c2） and vasopressin （AVP） mRNA receptor expression genes levels were significantly （P 〈 0.05） increased in both LD- and SD- ST- males.展开更多
The common spiny mouse(Acomys cahirinus)inhibits the foraging activity of the golden spiny mouse(A.russatus).These two sympatric species of spiny mice,which are considered habitat competitors,occur in extreme arid env...The common spiny mouse(Acomys cahirinus)inhibits the foraging activity of the golden spiny mouse(A.russatus).These two sympatric species of spiny mice,which are considered habitat competitors,occur in extreme arid environments.To test this theory of competition,the influence of urinary odors of both conspecific and heterospecific mice on the foraging behavior of A.russatus was studied under controlled laboratory conditions.Twenty adult males,born in captivity and unfamiliar to the odors of the donor mice,were tested in 3 experimental conditions choosing between 2 seed patches that were scented with urine of either heterospecifics(A.cahirinus),conspecifics(A.russatus)or controls(odors of the tested individual).Of the 20 males,12 were also tested with urine of unfamiliar gerbils,bushy-tailed jird,considered as competitors in the field.Both conspecific and heterospecific urine samples from Acomys significantly reduced foraging behavior of A.russatus when compared to the control odor.The inhibitory effect of the Acomys urine does not result from the novelty of chemical stimuli of the urine because no effect was shown with unfamiliar gerbil urine.The findings are in accordance with the general theory that A.cahirinus dominates the foraging activity of A.russatus.We hypothesize that chemical cues in the urine of Acomys spp.might induce a negative effect on the foraging behavior of A.russatus.展开更多
Dear Editor,BCUDCCo African spiny mouse,Acomys dimidiatus,is a mammalian model for regeneration studies because of its ability to functionally regenerate several tissues.As limited regenerative abilities in mammals ar...Dear Editor,BCUDCCo African spiny mouse,Acomys dimidiatus,is a mammalian model for regeneration studies because of its ability to functionally regenerate several tissues.As limited regenerative abilities in mammals are viewed as an antitumor strategy,it is intriguing how Acomys balances regeneration and tumor suppression.In this study,we investigated if Acomys is susceptible to carcinogenesis.We report that,like in mice,two oncogenic hits-activation of oncogenic RasG12v and inactivation of p53 or pRb-are sufficient to malignantly transform skin fibroblasts from Acomys.However,in viuo,Acomys showed resistance to DMBA/TPA-induced skin carcinogenesis.展开更多
文摘From an evolutionary point of view, reproduction timing is an important adaptation which enables the transfer of genetic properties, thus enabling species continuation. Rodents inhabiting arid environments need reliable cues for triggering their reproduction. Results of previous studies showed that increased dietary salinity plays an important role as an ultimate regulator for desert adapted rodents＇ reproductive system. The authors aimed discovering pathways by which high salinity can affect the reproductive system and metabolic status of desert adapted common spiny mice, Acomys cahirinus. Mice were challenged with osmotic stress, water source salinity increased gradually from 0.9% - 5% NaCI under short days （SD） and long days （LD）. The authors assessed leptin and free fatty acid （FFA） levels using ELISA while, SYBR green technology was used for relative receptor expression （RQ） of target genes. Results revealed that serum levels of the hormone leptin were significantly （P 〈 0.05） reduced in salinity treated （ST） mice. Levels of FFA were significantly （P 〈 0.05） increased in LD- and SD-ST-males. In ST-SD females a significant increase （P 〈 0.05） in expression levels of leptin （Ob-Rt） mRNA receptor gene, in ovaries was noted. Aldosteron （Nr3c2） and vasopressin （AVP） mRNA receptor expression genes levels were significantly （P 〈 0.05） increased in both LD- and SD- ST- males.
基金supported by the French‘Centre National de la Recherche Scientifique’(CNRS International Relationships Grants to Claude Baudoin in 1996 and 1998).
文摘The common spiny mouse(Acomys cahirinus)inhibits the foraging activity of the golden spiny mouse(A.russatus).These two sympatric species of spiny mice,which are considered habitat competitors,occur in extreme arid environments.To test this theory of competition,the influence of urinary odors of both conspecific and heterospecific mice on the foraging behavior of A.russatus was studied under controlled laboratory conditions.Twenty adult males,born in captivity and unfamiliar to the odors of the donor mice,were tested in 3 experimental conditions choosing between 2 seed patches that were scented with urine of either heterospecifics(A.cahirinus),conspecifics(A.russatus)or controls(odors of the tested individual).Of the 20 males,12 were also tested with urine of unfamiliar gerbils,bushy-tailed jird,considered as competitors in the field.Both conspecific and heterospecific urine samples from Acomys significantly reduced foraging behavior of A.russatus when compared to the control odor.The inhibitory effect of the Acomys urine does not result from the novelty of chemical stimuli of the urine because no effect was shown with unfamiliar gerbil urine.The findings are in accordance with the general theory that A.cahirinus dominates the foraging activity of A.russatus.We hypothesize that chemical cues in the urine of Acomys spp.might induce a negative effect on the foraging behavior of A.russatus.
基金supported by grants from the US National Institute on Aging to V.G.and A.S.All institutional guidelines for the care and use of laboratory animals were followedAll animal experiments were approved and performed in accordance with guidelines set forth by the University of Rochester Committee on Animal Resources with protocol number 2017-033(mouse)and 2017-027(Acomys dimidiatus,African spiny mice)All authors have read and approved the manuscript for publication,The data,analytic methods,and study materials will be made available to other researchers for purposes of reproducing the results or replicating the procedure.The RNA-seq raw data and count tables have been deposited in GEO(GSE287010).
文摘Dear Editor,BCUDCCo African spiny mouse,Acomys dimidiatus,is a mammalian model for regeneration studies because of its ability to functionally regenerate several tissues.As limited regenerative abilities in mammals are viewed as an antitumor strategy,it is intriguing how Acomys balances regeneration and tumor suppression.In this study,we investigated if Acomys is susceptible to carcinogenesis.We report that,like in mice,two oncogenic hits-activation of oncogenic RasG12v and inactivation of p53 or pRb-are sufficient to malignantly transform skin fibroblasts from Acomys.However,in viuo,Acomys showed resistance to DMBA/TPA-induced skin carcinogenesis.
