[Objectives]This study was conducted to investigate the antibacterial effect of a self-designed acne-relieving Chinese herbal formula and prepare a kind of acne-removing soap according to the antibacterial effect.[Met...[Objectives]This study was conducted to investigate the antibacterial effect of a self-designed acne-relieving Chinese herbal formula and prepare a kind of acne-removing soap according to the antibacterial effect.[Methods]Chinese herbs Lonicera japonica,Taraxacum mongolicum,Scutellaria baicalensis,Angelica dahurica,Centella asiatica and Aloe vera,were decocted with water,and the antibacterial effects on Staphylococcus aureus,Staphylococcus albus,Candida albicans and Propionibacterium acnei were tested by inhibition zone experiments.The soap base was prepared by saponification of coconut oil,palm oil,hazelnut oil and sodium hydroxide,and then the herbal liquid was added into the soap.[Results]The liquid had bacteriostatic effect on S.aureus,S.albus and P.acnes,but no inhibitory effect on C.albicans.The best bacteriostatic effect on S.aureus and S.albus was achieved at 330 mg/ml,and the best bacteriostatic effect on P.acnes was at 160 mg/ml.[Conclusions]The Chinese herbal formula has antibacterial effect.The handmade soap made from the Chinese herbal formula has the characteristics of smooth surface,moderate hardness,fine texture,rich foam and fresh smell.展开更多
Acne vulgaris is one of the most common skin disorders affecting millions of patients worldwide,its long-lasting inflammation greatly reduces life quality and causes negative psychosocial impacts.Conventional treatmen...Acne vulgaris is one of the most common skin disorders affecting millions of patients worldwide,its long-lasting inflammation greatly reduces life quality and causes negative psychosocial impacts.Conventional treatments often along with side effects and issues of patient compliance,and ineffective in treating severe conditions.In recent years,microneedle(MN)has emerged as a versatile therapeutic technology,owing to its minimally invasive,effective,and reduced side effects.However,there are few review articles that systematically summarize the progress of microneedles for the treatment of acne.Here conclude the material,function,and application of microneedle technology in the treatment of acne,with a particular focus on two types of anti-acne microneedle:drug-loaded microneedle(DMN)and radio-frequency microneedle(RMN).DMN facilitates targeted drug delivery to the skin's deeper layers,while RMN utilizes radio-frequency currents to stimulate collagen regeneration,thus addressing acne scarring.Additionally,future directions for advanced acne-treating microneedle technology are envisioned,such as diversified drug loading,multi-functionality,production process optimization,and personalized treatment.These different directions are expected to further enhance the safety,efficacy,and patient satisfaction of microneedle acne treatments.展开更多
To verify the inhibitory ability of the combination on the biofilm production of Propionibacterium acnes and its ameliorative effect on facial acne problems.The ability of the combination to inhibit the biofilm format...To verify the inhibitory ability of the combination on the biofilm production of Propionibacterium acnes and its ameliorative effect on facial acne problems.The ability of the combination to inhibit the biofilm formation of Propionibacterium acnes was verified by suspension quantification and crystal violet staining,and then 60 effective volunteers were selected for the efficacy measurement of topical acne elimination combinations+bases for 4 consecutive weeks,which were measured by a professional instrument,and the volunteers’facial acne lesion areas and acne lesion colours were evaluated respectively.In vitro tests verified that the combination can inhibit the formation of P.acnes biofilm and will not completely kill P.acnes and will not disrupt the micro-ecological balance of the skin;3%and 5%acne combinations can reduce the biofilm of P.acnes by 61.3%and 61.6%respectively;after 4 weeks of continuous use,the area of acne lesions of the samples with 5%acne combinations decreased by 54.61%and the colour of acne lesions decreased by 54.61%compared with the area of acne lesions before the use of the combination.54.61%,acne lesion colour a^(*)decreased by 13.74%,and the subjects’self-assessment of the mildness and non-irritation of the samples in the test group had a 100%agreement rate.The acne combination can improve acne problems by inhibiting the biofilm formation of Propionibacterium acnes,and has a mild and effective acne elimination effect.展开更多
Acne is a common skin disorder of teenagers and continues into adulthood. Research has been limited regarding acne prevalence, perception and health care utilization in Saudi Arabia. The objective of this study was to...Acne is a common skin disorder of teenagers and continues into adulthood. Research has been limited regarding acne prevalence, perception and health care utilization in Saudi Arabia. The objective of this study was to assess acne prevalence in final year female medical students in Jeddah, Saudi Arabia using the global acne grading system (GAGS) compared with student’s self-report of their acne. This is a cross-sectional study conducted among 151 students during 2016, in which students were interviewed subjectively and examined objectively by a trained physician. This study showed that acne was reported subjectively by 83.4% of female students compared to 98% of students assessed objectively by the global acne grading system. 14.6% of students claimed having no acne while it was objectively present, which was statistically significant (Χ2 = 15.4, P 2 months in 39.1% of students. Acne was present in 41.1% of the students parents compared to 83.4% in their siblings. A total of 41.7% of student had trunk acne. 60.9% of students had scarring and 72.8% of them had pigmentation. Moderate to severe acne students had higher siblings acne history of 95.2% (Χ2 = 5.85, P 2 = 4.05, P 2 = 4.87, P < 0.05) which was statistically significant. Our study confirms that acne is very common in female medical students in Jeddah, Saudi Arabia with a prevalence rate of 98%. Knowledge regarding acne treatment was inadequate demonstrating the need for educational and awareness programs about early treatment that will prevent suffering from acne scarring or pigmentation.展开更多
Background:Acne vulgaris is a common skin disorder that impacts quality of life.Both acne and menstrual symptoms share a hormonal pathogenesis,often linked to hormonal imbalances in women.This suggests a relationship ...Background:Acne vulgaris is a common skin disorder that impacts quality of life.Both acne and menstrual symptoms share a hormonal pathogenesis,often linked to hormonal imbalances in women.This suggests a relationship between acne counts and the various phases of the menstrual cycle.Objective:In this study,we aimed to assess the relationship between acne counts and the menstrual cycle in healthy young Indian women suffering from mild to moderate acne.The objective was to further understand the role of the various phases of the menstrual cycle in acne flares.Methods:This study explores the data from two(2)previously conducted clinical trials.The studies originally aimed to evaluate the efficacy of topical creams in the reduction of acne lesion count on the face.The data from these studies were retrieved and compiled.The number of days between the last menstrual period(LMP)and the actual day of the visit was calculated and regrouped as follows:1–7 days(early to mid-follicular phase),8–15 days(mid-to late follicular phase),16–24 days(post-ovulation to early luteal phase)and>24 days(mid-to late luteal phase).Subsequently,the global acne count—recorded by the dermatologist as part of the study procedures—was cross-tabulated with these menstrual phases using measures of central tendency and dispersion,followed by inferential analyses to evaluate differences between groups.Results:On average,the female subjects visiting the centre during the end of their luteal phase or bleeding days had higher acne counts(p=0.032).This effect was statistically significant only at the baseline visit,which followed a 14-day washout period involving the use of a neutral cleanser and adoption of a general skincare routine.During the product use phase,the effect of the menstrual cycle diminished.Conclusion:The study demonstrates an association between acne flares and the menstrual cycle:acne counts are likely to be higher by an average of 5–6 units during the late luteal and early follicular phases.Such differences may impact the outcome of clinical trials if not carefully monitored and accounted for in study designs and data analysis.展开更多
Background:Acne affects individuals across all ages and ethnic groups.Truncal acne has received limited attention,and its mechanisms and characteristics remain poorly understood.Objective:This article aims to provide ...Background:Acne affects individuals across all ages and ethnic groups.Truncal acne has received limited attention,and its mechanisms and characteristics remain poorly understood.Objective:This article aims to provide a comprehensive analysis of truncal acne,identifying its characteristics and exploring assessment methods and management of truncal acne.Methods:The study examines the causes and contributing factors of truncal acne by analyzing the skin characteristics and acne phenotypes of the trunk area.It also evaluates the existing methods for assessing the severity of truncal acne.Results:Trunk sebum secretion and pH levels are lower than those of the face,while the degree of microbial imbalance is greater.Variability in androgen levels and gender differences also influence truncal acne.Additionally,contact with certain materials exacerbates acne outbreaks on the trunk.The study highlights the advantages,disadvantages,mechanisms of action,and specific targets of each product.Conclusion:This paper provides insights for future research and practical approaches to truncal acne management,assisting in selecting effective products for managing truncal acne.展开更多
Cutibacterium acnes were used to induce lipase production,and to establish ex-vivo skin model of inflammatory response and post-inflammatory hyperpigmentation,in purpose of exploring the mechanism of chamomilla recuti...Cutibacterium acnes were used to induce lipase production,and to establish ex-vivo skin model of inflammatory response and post-inflammatory hyperpigmentation,in purpose of exploring the mechanism of chamomilla recutita extract.Clinical study was designed to investigate the effects of chamomilla recutita extract on Chinese volunteers with sequelae of adult acne,by evaluating the severity of acne,post-acne erythema and pigmentation,skin basic physiological conditions.The results showed that chamomilla recutita extract inhibited lipase activity,cellular inflammatory response,and melanin production.In the clinical study,the acnes were relieved 173%,with a 78%lower post-acne erythema index and 202%less hyperpigmentation as compared to placebo,after applying samples containing 1%chamomilla recutita extract for 28 days.Meanwhile,chamomilla recutita extract showed instant oil control effect.The extract significantly reduced sebum secretion by 293%,increased skin moisture content by 102%,and strengthened the skin barrier by 193%after 28 days application,which provided favorable skin physiological basis for the prevention and improvement of acne vulgaris and sequelae.展开更多
BACKGROUND Synovitis,acne,pustulosis,hyperostosis,and osteitis(SAPHO)syndrome,a rare inflammatory disease,was described in 1987 by Chamot et al,who identified its common characteristics and transitional forms through ...BACKGROUND Synovitis,acne,pustulosis,hyperostosis,and osteitis(SAPHO)syndrome,a rare inflammatory disease,was described in 1987 by Chamot et al,who identified its common characteristics and transitional forms through case reports.The inci-dence rate is now 1 in 10000 among Caucasians and 0.00144 in 10000 among Japanese.Pneumothorax occurs when gas enters the pleural cavity,typically due to lung disease or chest trauma,and is characterized as either spontaneous or traumatic.Spontaneous pneumothorax is commonly linked to congenital lung tissue abnormalities or lung conditions,such as ruptured pulmonary bullae,emphysema,and bronchial asthma.Respiratory involvement in SAPHO syn-drome has historically been noted.CASE SUMMARY We present the case of a 44-year-old male patient who had previously been diagnosed with SAPHO syndrome.Following a two-year cessation of methotrexate therapy,he experienced recurrent anterior chest wall and joint pain accompanied by dyspnea.We conducted a comprehensive examination for the patient,which included physical examination,laboratory tests,and imaging studies.The clinical presentation and treatment outcomes suggest that his pneumothorax was related to an episode of SAPHO syndrome.We performed closed thoracic drainage surgery for the patient and treated his symptoms with etoricoxib(60 mg daily).Upon discharge,methotrexate was prescribed again.In subsequent follow-ups,there was no recurrence of joint and respiratory symptoms observed in the patient.CONCLUSION SAPHO syndrome has been proposed as a transitional stage between ankylosing spondylitis and psoriatic arthritis.One study reported a 0.29%incidence of spontaneous pneumothorax in patients with ankylosing spondylitis,higher than in the general population.Additionally,30%of patients with SAPHO syndrome test positive for HLA-B27,an antigen linked to ankylosing spondylitis.Symptomatically,some patients with SAPHO syndrome meet diagnostic criteria for ankylosing spondylitis,with sternoclavicular joint involvement and paravertebral ossific-ations resembling syndesmophytes in ankylosing spondylitis.These features suggest a possible linked between SAPHO syndrome and ankylosing spondylitis.展开更多
Objective To evaluate the efficacy of fire-needle therapy for acne to provide an objective basis for clinical decisions.Method Pub Med,Chinese Biomedical Medicine disc（CBM）,Chinese National knowledge infrastructure...Objective To evaluate the efficacy of fire-needle therapy for acne to provide an objective basis for clinical decisions.Method Pub Med,Chinese Biomedical Medicine disc（CBM）,Chinese National knowledge infrastructure（CNKI）,and Wanfang database were searched to include eligible randomized controlled trails.Bias risk was assessed and data were extracted.Meta-analysis was performed and as was subgroup analysis.Results Thirty-three RCTs involving 3362 patients were included.Most of them had a high risk or unclear risk of bias regarding allocation concealment,incomplete outcome data and selective reporting.Compared with control groups,meta-analysis revealed that fireneedle therapy had an overall higher total effectiveness rate（RR=1.19,95% CI：1.16–1.22,P0.000 01）.Subgroup analysis showed fire-needle therapy was associated with an increased total effective rate（RR=1.20,95%CI：1.14–1.28,P0.000 01）,when compared against drug therapy.Fire-Needle therapy was associated with an increased total effective rate（RR=1.18,95%CI：1.12–1.24,P0.000 01）,when fire-needle plus other TCM therapy was compared against other therapy.fire-needle therapy was associated with an increased total effective rate（RR=1.18,95%CI：1.13–1.24,P0.000 01）,when fire-needle plus Chinese herb therapy was compared against Chinese herb therapy alone.fireneedle therapy was associated with an increased total effective rate（RR=1.28,95%CI：1.18–1.39,P0.000 01）,when compared fire-needle plus Western drug therapy against western drug therapy alone.Adverse events were not reported in most articles.Conclusion Our study showed that fire-needle appears to be an effective therapy for treating acne,but the evidence is currently insufficient due to the poor quality of the studies.The safety of fire-needle therapy is also uncertain due to the small sample size and the lack of reporting in included articles.Larger sample,higher quality studies are needed.展开更多
Objective To observe clinical effect of fire needling and pricking bloodletting on acne vulgaris. Methods Sixty-seven patients of acne vulgaris were treated by fire needling at pimple, blackhead and pustule, and prick...Objective To observe clinical effect of fire needling and pricking bloodletting on acne vulgaris. Methods Sixty-seven patients of acne vulgaris were treated by fire needling at pimple, blackhead and pustule, and pricking bloodletting at ěrjiān （耳尖 EX 11） and Géshū （膈俞 BL 17） by three-edged needle, twice a week. Clinical effect was observed after 8 times of treatment. Results Among 67 cases, 42 cases were cured, 21 cases were markedly effective, and 4 cases were effective. The cured rate was 62.69%, and the cured and markedly effective rate was 94.03%. Conclusion The fire needling and pricking bloodletting has a significant effect in the treatment of acne vulgaris with high cured rate, worthy of clinical promotion展开更多
Acne vulgaris is a chronic dermatologic problem with multiple factors involved in its pathogenesis. Alternative solutions to acne treatment were instigated by antibiotic resistance despite of its extensive use. Purifi...Acne vulgaris is a chronic dermatologic problem with multiple factors involved in its pathogenesis. Alternative solutions to acne treatment were instigated by antibiotic resistance despite of its extensive use. Purified bee venom （PBV） has been proposed as a promising candidate for that purpose. The present study was designed to confirm the antibacterial effect of PBV and access the efficacy of cosmetics containing PBV in subjects with acne vulgaris. METHODS： The skin bacterium Propionibacterium acnes was incubated with PBV at various concentrations and bacterial growth was evaluated using the colony forming unit （CFU） assay. The mechanism of PBV employed in killing P. acnes was examined by scanning electron microscopy （SEM） and transmission electron microscopy （TEM）. In addition, a total of 12 subjects were randomized in a double-blind, controlled trial to receive either cosmetics containing PBV or cosmetics without PBV for two weeks. Evaluations included lesion counts and skin microorganism. RESULTS： PBV exhibited antimicrobial activity in a concentration-dependent manner, reducing the number of P. acnes CFU by approximately 6 logs at a concentration of 0.5 mg. When PBV concentration was higher than 1.0 mg, no P. acnes colonies were spotted on an agar. TEM and SEM of untreated P. acnes illustrated the normal pleomorphic structure, whereas the PBV- treated bacterium lost the integrity of surface architecture. Significant difference （P=0.027） in the grading levels based on numbers of lesion counts for inflammatory and noninflammatory was observed in favour of the PBV group compared with the control group. In terms of average decrement of skin microorganism, subjects receiving cosmetics containing PBV experienced a significant 57.5% decrease of adenosine triphosphate levels, whereas participants receiving cosmetics without PBV experienced a nonsignificant decrease of 4.7%. CONCLUSION： These results show that the in vitro actions of antimicrobial activity of PBV were translated in vivo. Cosmetics containing PBV provided a certain degree of efficacy in terms of lesion counts and skin microorganism concentration compared with cosmetics without PBV in subjects with acne vulgaris. PBV may be a good candidate compound for developing therapeutic drua for the treatment of acne vulaaris.展开更多
Background:Acne vulgaris,a common skin disease,affects up to 80% of the population.Moderate to severe acne requires treatment with a combination of topical and oral drugs such as antibiotics,hormones and retinoids.Ret...Background:Acne vulgaris,a common skin disease,affects up to 80% of the population.Moderate to severe acne requires treatment with a combination of topical and oral drugs such as antibiotics,hormones and retinoids.Retinoids have many contraindications and adverse effects requiring close monitoring.The study's objectives were to describe prescribing trends in acne medication over time in a military setting,and assess physician adherence to guidelines for acne treatment,including drug precautions,clinical monitoring,and treatment progression.Methods:We conducted a descriptive,serial cross-sectional study of acne drugs prescribed in the Israel Defense Forces(IDF) in the years 2002–2007,analyzing the classes of drugs prescribed and patient characteristics.In addition,the clinical quality of the medical encounter was assessed by examining physician adherence to IDF guidelines.Results:Between 2002 and 2007,64,281 patients were treated for acne.Treatment courses generally persisted for 1–2 months.Over 70% of female patients receiving oral retinoids were not concomitantly receiving oral contraceptives.Conclusions:This study provides a unique perspective of acne treatment in a military setting,overall displaying good adherence to general guidelines.The common prescription of oral retinoids to young females without concomitant contraception is alarming.展开更多
Until now, etiology of acne vulgaris is still uncertain. Although clinicians usually deny the association between Demodex infestation and acne vulgaris, it has been proved in some clinical practices. To confirm the as...Until now, etiology of acne vulgaris is still uncertain. Although clinicians usually deny the association between Demodex infestation and acne vulgaris, it has been proved in some clinical practices. To confirm the association between Demodex infestation and acne vulgaris, a meta-analysis was conducted. Predefined selection criteria were applied to search all published papers that analyzed the association between Demodex infestation and acne vulgaris (January 1950 to August 2011) in ISI Web of Knowledge, MEDLINE, and China National Knowledge Infrastructure (CNKI) databases. A meta-analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) based on fixed effects models or random effects models. We enrolled the 60 Chinese and 3 English papers in this meta-analysis, which covered Turkey and 25 different provinces/municipalities in China and 42 130 participants in-cluding students and residents, aged from 1 to 78 years. The pooled OR in random effects models is 2.80 (95% CI, 2.34-3.36). Stability is robust according to sensitivity analysis. The fail-safe number is 18 477, suggesting that at least 18 477 articles with negative conclusions would be needed to reverse the conclusion that acne vulgaris was related to Demodex infestation. So the effect of publication bias was insignificant and could be ignored. It was concluded that acne vulgaris is associated with Demodex infestation. This indicates that when regular treatments for acne vulgaris are ineffective, examination of Demodex mites and necessary acaricidal therapies should be considered.展开更多
OBJECTIVE: To culturally translate the cardiff acne disability index(CADI) into Korean, and to examine its relationship with clinical acne severity,pathological patterns, and general quality of life(Qo L).METHODS: The...OBJECTIVE: To culturally translate the cardiff acne disability index(CADI) into Korean, and to examine its relationship with clinical acne severity,pathological patterns, and general quality of life(Qo L).METHODS: The CADI was culturally and lin-guistically translated into Korean via translation,back-translation, and face validity test process. Two hundred and fifty-four Korean adolescents were asked to complete the Korean version of the CADI(K-CADI), the Phlegm Pattern, the Cold-Heat Pattern, and the Korean version of the General Health Questionnaires. A clinician estimated acne severity for the adolescents, using the Korean Acne Grading System. Finally, reliability and validity of the K-CADI was examined, and the relationships between acne severity, Phlegm, Cold, and Heat patterns, and Qo L level were examined via pathway analysis.RESULTS: The K-CADI had satisfactory internal consistency(α = 0.827). The examination of construct validity indicated that the K-CADI had one factor(explaining 59.6% of the total variance). Pathway analysis showed satisfactory model fit(normal fit index = 0.960 and comparative fit index = 0.983),and acne-related Qo L was determinant to Phlegm,Heat, and Cold patterns(0.13-0.27 of β), and Phlegm and Heat patterns lowered one's Qo L level(0.17-0.34 of β).CONCLUSION: The K-CADI is a valid and reliable instrument. Phlegm and Heat patterns should be managed when treating acne since they have a moderating effect on general Qo L aggravation.展开更多
Acne is a kind of common skin disease in modern young people. Damp-heat constitution is the pathological basis of acne. Influenced by external factors, damp-heat constitution can lead to acne in the three pattern type...Acne is a kind of common skin disease in modern young people. Damp-heat constitution is the pathological basis of acne. Influenced by external factors, damp-heat constitution can lead to acne in the three pattern types, including lung meridian wind-heat, spleen and stomach damp-heat and phlegm stasis congestion and stagnation. Therefore, according to the thought of traditional Chinese medicine, the only way to completely solve the problem of recurrent acne is to correct the damp-heat constitution. TCM external therapy has always been the common therapy for acne, but the specific application scheme of the therapy has not been systematically summarized. In this paper, the relationship between damp-heat constitution and acne, and the design of TCM external therapy for acne on the face oriented by damp-heat constitution will be systematically discussed on the basis of long-term clinical practice and theory summary.展开更多
Background: The microneedle fractional RF handpiece used in our study (Intensif Handpiece, EndyMed Medical, Caesarea, Israel) is a novel handpiece that uses a tip with 25 non-insulated, gold plated microneedle electro...Background: The microneedle fractional RF handpiece used in our study (Intensif Handpiece, EndyMed Medical, Caesarea, Israel) is a novel handpiece that uses a tip with 25 non-insulated, gold plated microneedle electrodes. The needles are inserted into the skin by a specially designed electronically controlled, smooth motion motor minimizing patient discomfort. RF emission delivered over the whole dermal portion of the needle allows effective coagulation resulting in minimal or no bleeding, together with bulk volumetric heating. Study Design/Materials and Methods: The study included 20 patients, treated for depressed acne scars using the IntensifTM?Microneedles handpiece (EndyMed PRO Platform System, EndyMed Medical, Caesarea, Israel). The degree of clinical improvement was assessed by the global aesthetic improvement scale (GAIS) and subjects satisfaction by post treatment questionnaires. Results: The number of treatments per patient varied between 1 and 6 (average 3.3 treatments per patient). Eleven patients (55%) reported none to minimal pain, six (30%) moderate discomfort and only three (15%) reported significant pain. Objective evaluation of the improvement by a board certified dermatologist showed improvement in 95% of patients. 25% showed excellent improvement, 50% experienced good improvement, and the 20% showed minimal improvement. One patient showed no improvement. Conclusions: The presented results show that the tested electronically controlled motorized insertion, non-insulated microneedle treatment technology provides a minimal discomfort, minimal downtime, effective and safe treatment for depressed acne scars.展开更多
Objective:Propionibacterium acnes(P.acnes)plays an important role in the development of acne,an inflammatory skin disease with a high-incidence.In this study,we used high-throughput RNA sequencing(RNA-seq)to reveal th...Objective:Propionibacterium acnes(P.acnes)plays an important role in the development of acne,an inflammatory skin disease with a high-incidence.In this study,we used high-throughput RNA sequencing(RNA-seq)to reveal the anti-inflammatory mechanism of baicalin on P.acnes-induced acne in rabbits.Methods:The Kligman method was used to induce acne in the ears of New Zealand rabbits.The effect of baicalin on the acne model was evaluated by the number of acne lesions and hematoxylin and eosin(H&E)staining of acne tissues.Enzyme-linked immunoabsorbent assay was used to measure the protein expression levels of tumor necrosis factor a(TNFA),interleukin-1 b(IL1B),IL6,and IL8 in the serum of rabbits.RNA-seq was performed to investigate the mechanism of anti-inflammatory activities of baicalin on acne.Immunohistochemical analysis and Western blot were used to validate the expression levels of related proteins in acne tissues.Results:Baicalin treatment significantly reduced the number of acne lesions and lesions of the ear as well as levels of serum inflammatory cytokines.RNA-seq data showed that baicalin treatment globally suppressed inflammation,especially the TNF signaling pathway and Staphylococcus aureus infection pathway,in the rabbit acne model.Conclusion: Baicalin effectively ameliorates P. acnes-induced acne in rabbits by suppressingthe inflammatory response in rabbits.展开更多
基金Supported by National Undergraduate Innovation and Entrepreneurship Training Program of Guangxi University of Chinese Medicine in 2022(202210600026).
文摘[Objectives]This study was conducted to investigate the antibacterial effect of a self-designed acne-relieving Chinese herbal formula and prepare a kind of acne-removing soap according to the antibacterial effect.[Methods]Chinese herbs Lonicera japonica,Taraxacum mongolicum,Scutellaria baicalensis,Angelica dahurica,Centella asiatica and Aloe vera,were decocted with water,and the antibacterial effects on Staphylococcus aureus,Staphylococcus albus,Candida albicans and Propionibacterium acnei were tested by inhibition zone experiments.The soap base was prepared by saponification of coconut oil,palm oil,hazelnut oil and sodium hydroxide,and then the herbal liquid was added into the soap.[Results]The liquid had bacteriostatic effect on S.aureus,S.albus and P.acnes,but no inhibitory effect on C.albicans.The best bacteriostatic effect on S.aureus and S.albus was achieved at 330 mg/ml,and the best bacteriostatic effect on P.acnes was at 160 mg/ml.[Conclusions]The Chinese herbal formula has antibacterial effect.The handmade soap made from the Chinese herbal formula has the characteristics of smooth surface,moderate hardness,fine texture,rich foam and fresh smell.
基金support from the College Students’Innovative Entrepreneurial Training Plan Program(Northwestern Polytechnical University),the National Natural Science Foundation of China(No.52473265)the Shaanxi Provincial Science Fund for Distinguished Young Scholars(No.2023-JC-JQ-32).
文摘Acne vulgaris is one of the most common skin disorders affecting millions of patients worldwide,its long-lasting inflammation greatly reduces life quality and causes negative psychosocial impacts.Conventional treatments often along with side effects and issues of patient compliance,and ineffective in treating severe conditions.In recent years,microneedle(MN)has emerged as a versatile therapeutic technology,owing to its minimally invasive,effective,and reduced side effects.However,there are few review articles that systematically summarize the progress of microneedles for the treatment of acne.Here conclude the material,function,and application of microneedle technology in the treatment of acne,with a particular focus on two types of anti-acne microneedle:drug-loaded microneedle(DMN)and radio-frequency microneedle(RMN).DMN facilitates targeted drug delivery to the skin's deeper layers,while RMN utilizes radio-frequency currents to stimulate collagen regeneration,thus addressing acne scarring.Additionally,future directions for advanced acne-treating microneedle technology are envisioned,such as diversified drug loading,multi-functionality,production process optimization,and personalized treatment.These different directions are expected to further enhance the safety,efficacy,and patient satisfaction of microneedle acne treatments.
文摘To verify the inhibitory ability of the combination on the biofilm production of Propionibacterium acnes and its ameliorative effect on facial acne problems.The ability of the combination to inhibit the biofilm formation of Propionibacterium acnes was verified by suspension quantification and crystal violet staining,and then 60 effective volunteers were selected for the efficacy measurement of topical acne elimination combinations+bases for 4 consecutive weeks,which were measured by a professional instrument,and the volunteers’facial acne lesion areas and acne lesion colours were evaluated respectively.In vitro tests verified that the combination can inhibit the formation of P.acnes biofilm and will not completely kill P.acnes and will not disrupt the micro-ecological balance of the skin;3%and 5%acne combinations can reduce the biofilm of P.acnes by 61.3%and 61.6%respectively;after 4 weeks of continuous use,the area of acne lesions of the samples with 5%acne combinations decreased by 54.61%and the colour of acne lesions decreased by 54.61%compared with the area of acne lesions before the use of the combination.54.61%,acne lesion colour a^(*)decreased by 13.74%,and the subjects’self-assessment of the mildness and non-irritation of the samples in the test group had a 100%agreement rate.The acne combination can improve acne problems by inhibiting the biofilm formation of Propionibacterium acnes,and has a mild and effective acne elimination effect.
文摘Acne is a common skin disorder of teenagers and continues into adulthood. Research has been limited regarding acne prevalence, perception and health care utilization in Saudi Arabia. The objective of this study was to assess acne prevalence in final year female medical students in Jeddah, Saudi Arabia using the global acne grading system (GAGS) compared with student’s self-report of their acne. This is a cross-sectional study conducted among 151 students during 2016, in which students were interviewed subjectively and examined objectively by a trained physician. This study showed that acne was reported subjectively by 83.4% of female students compared to 98% of students assessed objectively by the global acne grading system. 14.6% of students claimed having no acne while it was objectively present, which was statistically significant (Χ2 = 15.4, P 2 months in 39.1% of students. Acne was present in 41.1% of the students parents compared to 83.4% in their siblings. A total of 41.7% of student had trunk acne. 60.9% of students had scarring and 72.8% of them had pigmentation. Moderate to severe acne students had higher siblings acne history of 95.2% (Χ2 = 5.85, P 2 = 4.05, P 2 = 4.87, P < 0.05) which was statistically significant. Our study confirms that acne is very common in female medical students in Jeddah, Saudi Arabia with a prevalence rate of 98%. Knowledge regarding acne treatment was inadequate demonstrating the need for educational and awareness programs about early treatment that will prevent suffering from acne scarring or pigmentation.
文摘Background:Acne vulgaris is a common skin disorder that impacts quality of life.Both acne and menstrual symptoms share a hormonal pathogenesis,often linked to hormonal imbalances in women.This suggests a relationship between acne counts and the various phases of the menstrual cycle.Objective:In this study,we aimed to assess the relationship between acne counts and the menstrual cycle in healthy young Indian women suffering from mild to moderate acne.The objective was to further understand the role of the various phases of the menstrual cycle in acne flares.Methods:This study explores the data from two(2)previously conducted clinical trials.The studies originally aimed to evaluate the efficacy of topical creams in the reduction of acne lesion count on the face.The data from these studies were retrieved and compiled.The number of days between the last menstrual period(LMP)and the actual day of the visit was calculated and regrouped as follows:1–7 days(early to mid-follicular phase),8–15 days(mid-to late follicular phase),16–24 days(post-ovulation to early luteal phase)and>24 days(mid-to late luteal phase).Subsequently,the global acne count—recorded by the dermatologist as part of the study procedures—was cross-tabulated with these menstrual phases using measures of central tendency and dispersion,followed by inferential analyses to evaluate differences between groups.Results:On average,the female subjects visiting the centre during the end of their luteal phase or bleeding days had higher acne counts(p=0.032).This effect was statistically significant only at the baseline visit,which followed a 14-day washout period involving the use of a neutral cleanser and adoption of a general skincare routine.During the product use phase,the effect of the menstrual cycle diminished.Conclusion:The study demonstrates an association between acne flares and the menstrual cycle:acne counts are likely to be higher by an average of 5–6 units during the late luteal and early follicular phases.Such differences may impact the outcome of clinical trials if not carefully monitored and accounted for in study designs and data analysis.
文摘Background:Acne affects individuals across all ages and ethnic groups.Truncal acne has received limited attention,and its mechanisms and characteristics remain poorly understood.Objective:This article aims to provide a comprehensive analysis of truncal acne,identifying its characteristics and exploring assessment methods and management of truncal acne.Methods:The study examines the causes and contributing factors of truncal acne by analyzing the skin characteristics and acne phenotypes of the trunk area.It also evaluates the existing methods for assessing the severity of truncal acne.Results:Trunk sebum secretion and pH levels are lower than those of the face,while the degree of microbial imbalance is greater.Variability in androgen levels and gender differences also influence truncal acne.Additionally,contact with certain materials exacerbates acne outbreaks on the trunk.The study highlights the advantages,disadvantages,mechanisms of action,and specific targets of each product.Conclusion:This paper provides insights for future research and practical approaches to truncal acne management,assisting in selecting effective products for managing truncal acne.
文摘Cutibacterium acnes were used to induce lipase production,and to establish ex-vivo skin model of inflammatory response and post-inflammatory hyperpigmentation,in purpose of exploring the mechanism of chamomilla recutita extract.Clinical study was designed to investigate the effects of chamomilla recutita extract on Chinese volunteers with sequelae of adult acne,by evaluating the severity of acne,post-acne erythema and pigmentation,skin basic physiological conditions.The results showed that chamomilla recutita extract inhibited lipase activity,cellular inflammatory response,and melanin production.In the clinical study,the acnes were relieved 173%,with a 78%lower post-acne erythema index and 202%less hyperpigmentation as compared to placebo,after applying samples containing 1%chamomilla recutita extract for 28 days.Meanwhile,chamomilla recutita extract showed instant oil control effect.The extract significantly reduced sebum secretion by 293%,increased skin moisture content by 102%,and strengthened the skin barrier by 193%after 28 days application,which provided favorable skin physiological basis for the prevention and improvement of acne vulgaris and sequelae.
基金Supported by The National Natural Science Foundation of China,No.82074246.
文摘BACKGROUND Synovitis,acne,pustulosis,hyperostosis,and osteitis(SAPHO)syndrome,a rare inflammatory disease,was described in 1987 by Chamot et al,who identified its common characteristics and transitional forms through case reports.The inci-dence rate is now 1 in 10000 among Caucasians and 0.00144 in 10000 among Japanese.Pneumothorax occurs when gas enters the pleural cavity,typically due to lung disease or chest trauma,and is characterized as either spontaneous or traumatic.Spontaneous pneumothorax is commonly linked to congenital lung tissue abnormalities or lung conditions,such as ruptured pulmonary bullae,emphysema,and bronchial asthma.Respiratory involvement in SAPHO syn-drome has historically been noted.CASE SUMMARY We present the case of a 44-year-old male patient who had previously been diagnosed with SAPHO syndrome.Following a two-year cessation of methotrexate therapy,he experienced recurrent anterior chest wall and joint pain accompanied by dyspnea.We conducted a comprehensive examination for the patient,which included physical examination,laboratory tests,and imaging studies.The clinical presentation and treatment outcomes suggest that his pneumothorax was related to an episode of SAPHO syndrome.We performed closed thoracic drainage surgery for the patient and treated his symptoms with etoricoxib(60 mg daily).Upon discharge,methotrexate was prescribed again.In subsequent follow-ups,there was no recurrence of joint and respiratory symptoms observed in the patient.CONCLUSION SAPHO syndrome has been proposed as a transitional stage between ankylosing spondylitis and psoriatic arthritis.One study reported a 0.29%incidence of spontaneous pneumothorax in patients with ankylosing spondylitis,higher than in the general population.Additionally,30%of patients with SAPHO syndrome test positive for HLA-B27,an antigen linked to ankylosing spondylitis.Symptomatically,some patients with SAPHO syndrome meet diagnostic criteria for ankylosing spondylitis,with sternoclavicular joint involvement and paravertebral ossific-ations resembling syndesmophytes in ankylosing spondylitis.These features suggest a possible linked between SAPHO syndrome and ankylosing spondylitis.
基金Supported by National Basic Research Program of China(973 program):2012CB518504Guangdong Administration of TCM Research Foundation:20151233
文摘Objective To evaluate the efficacy of fire-needle therapy for acne to provide an objective basis for clinical decisions.Method Pub Med,Chinese Biomedical Medicine disc（CBM）,Chinese National knowledge infrastructure（CNKI）,and Wanfang database were searched to include eligible randomized controlled trails.Bias risk was assessed and data were extracted.Meta-analysis was performed and as was subgroup analysis.Results Thirty-three RCTs involving 3362 patients were included.Most of them had a high risk or unclear risk of bias regarding allocation concealment,incomplete outcome data and selective reporting.Compared with control groups,meta-analysis revealed that fireneedle therapy had an overall higher total effectiveness rate（RR=1.19,95% CI：1.16–1.22,P0.000 01）.Subgroup analysis showed fire-needle therapy was associated with an increased total effective rate（RR=1.20,95%CI：1.14–1.28,P0.000 01）,when compared against drug therapy.Fire-Needle therapy was associated with an increased total effective rate（RR=1.18,95%CI：1.12–1.24,P0.000 01）,when fire-needle plus other TCM therapy was compared against other therapy.fire-needle therapy was associated with an increased total effective rate（RR=1.18,95%CI：1.13–1.24,P0.000 01）,when fire-needle plus Chinese herb therapy was compared against Chinese herb therapy alone.fireneedle therapy was associated with an increased total effective rate（RR=1.28,95%CI：1.18–1.39,P0.000 01）,when compared fire-needle plus Western drug therapy against western drug therapy alone.Adverse events were not reported in most articles.Conclusion Our study showed that fire-needle appears to be an effective therapy for treating acne,but the evidence is currently insufficient due to the poor quality of the studies.The safety of fire-needle therapy is also uncertain due to the small sample size and the lack of reporting in included articles.Larger sample,higher quality studies are needed.
文摘Objective To observe clinical effect of fire needling and pricking bloodletting on acne vulgaris. Methods Sixty-seven patients of acne vulgaris were treated by fire needling at pimple, blackhead and pustule, and pricking bloodletting at ěrjiān （耳尖 EX 11） and Géshū （膈俞 BL 17） by three-edged needle, twice a week. Clinical effect was observed after 8 times of treatment. Results Among 67 cases, 42 cases were cured, 21 cases were markedly effective, and 4 cases were effective. The cured rate was 62.69%, and the cured and markedly effective rate was 94.03%. Conclusion The fire needling and pricking bloodletting has a significant effect in the treatment of acne vulgaris with high cured rate, worthy of clinical promotion
基金supported by a grant from BioGreen21 Program, Rural Development Administration (Code#:PJ009519), Republic of Korea
文摘Acne vulgaris is a chronic dermatologic problem with multiple factors involved in its pathogenesis. Alternative solutions to acne treatment were instigated by antibiotic resistance despite of its extensive use. Purified bee venom （PBV） has been proposed as a promising candidate for that purpose. The present study was designed to confirm the antibacterial effect of PBV and access the efficacy of cosmetics containing PBV in subjects with acne vulgaris. METHODS： The skin bacterium Propionibacterium acnes was incubated with PBV at various concentrations and bacterial growth was evaluated using the colony forming unit （CFU） assay. The mechanism of PBV employed in killing P. acnes was examined by scanning electron microscopy （SEM） and transmission electron microscopy （TEM）. In addition, a total of 12 subjects were randomized in a double-blind, controlled trial to receive either cosmetics containing PBV or cosmetics without PBV for two weeks. Evaluations included lesion counts and skin microorganism. RESULTS： PBV exhibited antimicrobial activity in a concentration-dependent manner, reducing the number of P. acnes CFU by approximately 6 logs at a concentration of 0.5 mg. When PBV concentration was higher than 1.0 mg, no P. acnes colonies were spotted on an agar. TEM and SEM of untreated P. acnes illustrated the normal pleomorphic structure, whereas the PBV- treated bacterium lost the integrity of surface architecture. Significant difference （P=0.027） in the grading levels based on numbers of lesion counts for inflammatory and noninflammatory was observed in favour of the PBV group compared with the control group. In terms of average decrement of skin microorganism, subjects receiving cosmetics containing PBV experienced a significant 57.5% decrease of adenosine triphosphate levels, whereas participants receiving cosmetics without PBV experienced a nonsignificant decrease of 4.7%. CONCLUSION： These results show that the in vitro actions of antimicrobial activity of PBV were translated in vivo. Cosmetics containing PBV provided a certain degree of efficacy in terms of lesion counts and skin microorganism concentration compared with cosmetics without PBV in subjects with acne vulgaris. PBV may be a good candidate compound for developing therapeutic drua for the treatment of acne vulaaris.
文摘Background:Acne vulgaris,a common skin disease,affects up to 80% of the population.Moderate to severe acne requires treatment with a combination of topical and oral drugs such as antibiotics,hormones and retinoids.Retinoids have many contraindications and adverse effects requiring close monitoring.The study's objectives were to describe prescribing trends in acne medication over time in a military setting,and assess physician adherence to guidelines for acne treatment,including drug precautions,clinical monitoring,and treatment progression.Methods:We conducted a descriptive,serial cross-sectional study of acne drugs prescribed in the Israel Defense Forces(IDF) in the years 2002–2007,analyzing the classes of drugs prescribed and patient characteristics.In addition,the clinical quality of the medical encounter was assessed by examining physician adherence to IDF guidelines.Results:Between 2002 and 2007,64,281 patients were treated for acne.Treatment courses generally persisted for 1–2 months.Over 70% of female patients receiving oral retinoids were not concomitantly receiving oral contraceptives.Conclusions:This study provides a unique perspective of acne treatment in a military setting,overall displaying good adherence to general guidelines.The common prescription of oral retinoids to young females without concomitant contraception is alarming.
基金supported by the National Natural Science Foundation of China (No. 30872199)the Natural Science Foundation of Shaanxi Province (No. 2006C247), China
文摘Until now, etiology of acne vulgaris is still uncertain. Although clinicians usually deny the association between Demodex infestation and acne vulgaris, it has been proved in some clinical practices. To confirm the association between Demodex infestation and acne vulgaris, a meta-analysis was conducted. Predefined selection criteria were applied to search all published papers that analyzed the association between Demodex infestation and acne vulgaris (January 1950 to August 2011) in ISI Web of Knowledge, MEDLINE, and China National Knowledge Infrastructure (CNKI) databases. A meta-analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) based on fixed effects models or random effects models. We enrolled the 60 Chinese and 3 English papers in this meta-analysis, which covered Turkey and 25 different provinces/municipalities in China and 42 130 participants in-cluding students and residents, aged from 1 to 78 years. The pooled OR in random effects models is 2.80 (95% CI, 2.34-3.36). Stability is robust according to sensitivity analysis. The fail-safe number is 18 477, suggesting that at least 18 477 articles with negative conclusions would be needed to reverse the conclusion that acne vulgaris was related to Demodex infestation. So the effect of publication bias was insignificant and could be ignored. It was concluded that acne vulgaris is associated with Demodex infestation. This indicates that when regular treatments for acne vulgaris are ineffective, examination of Demodex mites and necessary acaricidal therapies should be considered.
文摘OBJECTIVE: To culturally translate the cardiff acne disability index(CADI) into Korean, and to examine its relationship with clinical acne severity,pathological patterns, and general quality of life(Qo L).METHODS: The CADI was culturally and lin-guistically translated into Korean via translation,back-translation, and face validity test process. Two hundred and fifty-four Korean adolescents were asked to complete the Korean version of the CADI(K-CADI), the Phlegm Pattern, the Cold-Heat Pattern, and the Korean version of the General Health Questionnaires. A clinician estimated acne severity for the adolescents, using the Korean Acne Grading System. Finally, reliability and validity of the K-CADI was examined, and the relationships between acne severity, Phlegm, Cold, and Heat patterns, and Qo L level were examined via pathway analysis.RESULTS: The K-CADI had satisfactory internal consistency(α = 0.827). The examination of construct validity indicated that the K-CADI had one factor(explaining 59.6% of the total variance). Pathway analysis showed satisfactory model fit(normal fit index = 0.960 and comparative fit index = 0.983),and acne-related Qo L was determinant to Phlegm,Heat, and Cold patterns(0.13-0.27 of β), and Phlegm and Heat patterns lowered one's Qo L level(0.17-0.34 of β).CONCLUSION: The K-CADI is a valid and reliable instrument. Phlegm and Heat patterns should be managed when treating acne since they have a moderating effect on general Qo L aggravation.
文摘Acne is a kind of common skin disease in modern young people. Damp-heat constitution is the pathological basis of acne. Influenced by external factors, damp-heat constitution can lead to acne in the three pattern types, including lung meridian wind-heat, spleen and stomach damp-heat and phlegm stasis congestion and stagnation. Therefore, according to the thought of traditional Chinese medicine, the only way to completely solve the problem of recurrent acne is to correct the damp-heat constitution. TCM external therapy has always been the common therapy for acne, but the specific application scheme of the therapy has not been systematically summarized. In this paper, the relationship between damp-heat constitution and acne, and the design of TCM external therapy for acne on the face oriented by damp-heat constitution will be systematically discussed on the basis of long-term clinical practice and theory summary.
文摘Background: The microneedle fractional RF handpiece used in our study (Intensif Handpiece, EndyMed Medical, Caesarea, Israel) is a novel handpiece that uses a tip with 25 non-insulated, gold plated microneedle electrodes. The needles are inserted into the skin by a specially designed electronically controlled, smooth motion motor minimizing patient discomfort. RF emission delivered over the whole dermal portion of the needle allows effective coagulation resulting in minimal or no bleeding, together with bulk volumetric heating. Study Design/Materials and Methods: The study included 20 patients, treated for depressed acne scars using the IntensifTM?Microneedles handpiece (EndyMed PRO Platform System, EndyMed Medical, Caesarea, Israel). The degree of clinical improvement was assessed by the global aesthetic improvement scale (GAIS) and subjects satisfaction by post treatment questionnaires. Results: The number of treatments per patient varied between 1 and 6 (average 3.3 treatments per patient). Eleven patients (55%) reported none to minimal pain, six (30%) moderate discomfort and only three (15%) reported significant pain. Objective evaluation of the improvement by a board certified dermatologist showed improvement in 95% of patients. 25% showed excellent improvement, 50% experienced good improvement, and the 20% showed minimal improvement. One patient showed no improvement. Conclusions: The presented results show that the tested electronically controlled motorized insertion, non-insulated microneedle treatment technology provides a minimal discomfort, minimal downtime, effective and safe treatment for depressed acne scars.
基金This work was supported by the National Natural Science Foundation of China(81430099)International S&T Cooperation Program of China(2014DFA32950).
文摘Objective:Propionibacterium acnes(P.acnes)plays an important role in the development of acne,an inflammatory skin disease with a high-incidence.In this study,we used high-throughput RNA sequencing(RNA-seq)to reveal the anti-inflammatory mechanism of baicalin on P.acnes-induced acne in rabbits.Methods:The Kligman method was used to induce acne in the ears of New Zealand rabbits.The effect of baicalin on the acne model was evaluated by the number of acne lesions and hematoxylin and eosin(H&E)staining of acne tissues.Enzyme-linked immunoabsorbent assay was used to measure the protein expression levels of tumor necrosis factor a(TNFA),interleukin-1 b(IL1B),IL6,and IL8 in the serum of rabbits.RNA-seq was performed to investigate the mechanism of anti-inflammatory activities of baicalin on acne.Immunohistochemical analysis and Western blot were used to validate the expression levels of related proteins in acne tissues.Results:Baicalin treatment significantly reduced the number of acne lesions and lesions of the ear as well as levels of serum inflammatory cytokines.RNA-seq data showed that baicalin treatment globally suppressed inflammation,especially the TNF signaling pathway and Staphylococcus aureus infection pathway,in the rabbit acne model.Conclusion: Baicalin effectively ameliorates P. acnes-induced acne in rabbits by suppressingthe inflammatory response in rabbits.
