Introduction: Acne vulgaris and acne scarring are prevalent conditions that can have a negative effect on a patient’s quality of life. Fractional radiofrequency technologies have been shown to be clinically safe and ...Introduction: Acne vulgaris and acne scarring are prevalent conditions that can have a negative effect on a patient’s quality of life. Fractional radiofrequency technologies have been shown to be clinically safe and effective in managing acne scars through dermal remodeling without causing direct damage to the epidermis. In a recently published study, we presented our clinical and histological results in the treatment of patients with active acne and acne related scarring using a Fractional RF (FRF) device. In the current article we demonstrate long term follow-up results, up to two years post last fractional treatment. Methods: Four out of the eight patients who completed a four treatment regimen were invited for long term follow-up visit to document treatment results. In some cases, touch-up treatments were conducted to optimize clinical results. Results: Patients demonstrated significant improvement of acne lesions, acne scarring, pores and skin texture. Long term photos demonstrated that clinical improvement progressed with time. Conclusion: The current study further supports the previous findings that FRF is a safe and effective treatment modality for active acne and acne related scars. Treatment protocol can be customized according to patient needs and clinical results last for long term.展开更多
Background: Post-acne scarring remains a current challenge to prevent and treat despite advancement in acne treatment. There are two types of scars, atrophic and hypertrophic scars, depending on whether there is a net...Background: Post-acne scarring remains a current challenge to prevent and treat despite advancement in acne treatment. There are two types of scars, atrophic and hypertrophic scars, depending on whether there is a net loss or gain of collagen. Objective: The main objectives of this study were to compare the efficacy of using microneedling combined with either plasma gel or amniotic fluid gel in treatment of atrophic post acne scars with clinical and histological evaluation. Methods: This study included Twenty-three cases with atrophic post acne scars. The treated area on the face was divided equally into two halves. Before the procedure, we applied thick layer of local anesthetic cream for approximately 45 to 60 minutes. Microneedling using dermapen combined with irradiated amniotic gel topically was applied to left side of the face and platelet rich plasma gel was applied to the right side. Patients received four sessions with 3 weeks interval between sessions. Clinical examination with histopathological analysis was carried out one month after the last session. Results: There was a significant increase in the improvement percentage of acne scars on right side (dermarpen and platelet rich plasma gel) than left side of face (dermapen and irradiated amniotic gel). Histologically, improvement of character of collagen and elastic fibers was noticed, especially on right side. Meanwhile, a significant increase in epidermal thickness on both sides of face was detected. Conclusion: Dermapen combined with either plasma gel or amniotic gel are promising effective therapeutic modalities for atrophic acne scars. However, combination of platelet rich plasma gel with dermapen has a higher therapeutic efficacy than that of amniotic gel with dermapen.展开更多
Objective: to investigate the effect of non-peeling dot array laser combined with photon skin rejuvenation in the treatment of acne scar. Methods: 22 patients with acne scar in our hospital from January 2019 to Decemb...Objective: to investigate the effect of non-peeling dot array laser combined with photon skin rejuvenation in the treatment of acne scar. Methods: 22 patients with acne scar in our hospital from January 2019 to December 2019 were randomly divided into two groups by number table method. The control group was treated with non-peeling dot array laser, and the experimental group was treated with non-peeling dot array laser combined with photon skin freshening. Acne scar symptom score and treatment effect were compared between the two groups before and after treatment. Results: after treatment, the scores of acne scar symptom in experimental group were lower than those in control group (P < 0.05). The therapeutic effect of the experimental group was higher than that of the control group (P < 0.05). Conclusion: the treatment of acne scar patients with non-peeling lattice laser combined with photon skin freshening has definite effect, can improve the symptoms, improve the treatment effect, so it is worth popularizing and applying.展开更多
Xiu-Feng Liu,Man-Chang Yu.In the article“Impact of 30.0%Supramolecular Salicylic Acid Combined With Ultra-Pulse Carbon Dioxide Fractional Laser Therapy on Facial Atrophic Acne Scars:A Retrospective Case-Control Study...Xiu-Feng Liu,Man-Chang Yu.In the article“Impact of 30.0%Supramolecular Salicylic Acid Combined With Ultra-Pulse Carbon Dioxide Fractional Laser Therapy on Facial Atrophic Acne Scars:A Retrospective Case-Control Study”by Liu et al.1,the study was incorrectly described as a“retrospective case-control study”in the title,while the study was designed to compare outcomes between groups receiving different interventions,meeting the definition of a cohort study,not a case-control study.展开更多
Objective:Current treatments for atrophic acne scars such as microneedling radiofrequency(MNRF)and fractional carbon dioxide(FCO_(2))laser have shown individual efficacy,but their combined effectiveness remains lackin...Objective:Current treatments for atrophic acne scars such as microneedling radiofrequency(MNRF)and fractional carbon dioxide(FCO_(2))laser have shown individual efficacy,but their combined effectiveness remains lacking.This study aimed to determine the effectiveness and safety of a sequential combination therapy with MNRF followed by FCO_(2) laser compared with each therapy administered alone for the treatment of atrophic acne scars.Methods:An open randomized trial was conducted on 45 patients with atrophic acne scars at Al-Salam Teaching Hospital,Mosul,Iraq,from January 2022 to July 2023.The patients were randomized into 3 groups,with 15 patients in each group:FCO_(2) group(6 sessions of FCO_(2) laser treatment),MNRF group(6 sessions of MNRF treatment),and combined group(3 sessions of MNRF treatment followed by 3 sessions of FCO_(2) laser treatment).The Goodman and Baron Global Quantitative Acne Scar Grading System(GBGQASGS)was used to assess the treatment effectiveness.Adverse effects of treatment were monitored.The pre-treatment and post-treatment GBGQASGS scores and the percentage reductions in the GBGQASGS scores in the 3 groups were assessed by analysis of variance.The effect size of each treatment regimen was assessed using the Cohen d effect size.Results:The 45 patients enrolled comprised 20(44.4%)men and 25(55.6%)women,with a mean age of 25.10±2.80 years and a GBGQASGS score of 28.93±6.19.All 3 types of treatment significantly reduced the GBGQASGS scores after 6 sessions(all P<0.05)as following:FCO_(2) group,from 28.66±5.71 to 11.66±2.71(59.3%reduction;Cohen d=3.80);MNRF group,from 27.26±6.93 to 11.66±3.09(57.2%reduction;Cohen d=2.90);Combined group,from 30.87±5.73 to 9.01±2.03(70.8%reduction;Cohen d=5.08).There was no difference in the GBGQASGS score of post-treatment among 3 groups(P=0.300),however,the combined group exhibited a significant reduction in the GBGQASGS score from pre-treatment to post-treatment(P<0.001).Post-inflammatory hyperpigmentation was reported in FCO_(2) and MNRF groups,tram-track scarring was found in FCO_(2) group,while no serious adverse effects were reported in the combined group.Conclusion:Sequential combination therapy with MNRF followed by FCO_(2) laser was as effective as each monotherapy for the treatment of atrophic acne scars with fewer adverse effects.The results may provide evidence for treatment choice.展开更多
Objective:Acne scarring is more common in patients with moderate to severe acne,and various monotherapies are useful to treat acne scars,however,studies evaluating the effect of combined treatments are still insuffici...Objective:Acne scarring is more common in patients with moderate to severe acne,and various monotherapies are useful to treat acne scars,however,studies evaluating the effect of combined treatments are still insufficient.This study was aimed to assess the impact of 30.0%supramolecular salicylic acid(SSA)combined with ultra-pulse carbon dioxide(CO_(2))fractional laser therapy on facial atrophic acne scars.Methods:This retrospective study included data from patients with atrophic acne scars treated from June 2020 to June 2022 in Mylike Cosmetology Hospital of Yunnan.The patients were divided into the combination group(SSA combined with ultra-pulse CO_(2)fractional laser therapy)and the laser group(ultra-pulse CO_(2)fractional laser therapy alone)depending on the treatments received.Four treatment sessions were conducted for each group.Follow-up visits were performed every 2 months after each treatment and included assessments of theÉchelle d’Évaluation clinique des cicatrices d’acnéscore,effective rate,and visual analog scale score.Continuous data were analyzed using Student t test.Dichotomous or unordered categorical data were compared using the Chi-square(χ2)test,and ordered categorical data were compared using the Mann-Whitney U test.Results:The combination and laser groups comprised 72 and 61 patients,respectively,and there were no significant differences in sex,age,or baselineÉchelle d’Évaluation clinique des cicatrices d’acnéscore between the 2 groups.The effective rate(95.8%vs.67.2%,P<0.001)was higher and the pain scores(during and after the intervention)were lower in the combination group than in the laser group(all P<0.001).The severity of erythema,edema,and crusting was milder in the combination group(P<0.001).The proportion of highly satisfied patients was higher(73.6%vs.31.2%,P<0.001)and the Dermatology Life Quality Index showed greater improvement(0.15±0.40 vs.1.39±1.53,P<0.001)in the combination group than that in the laser group.Conclusion:The combination of ultra-pulse CO_(2)fractional laser therapy and 30.0%SSA had improved efficacy in treating facial atrophic acne scars without increasing pain or inducing serious adverse reactions.展开更多
Tamanu oil, derived from the nuts of Calophyllum inophyllum, has gained increasing attention for its potential in acne management due to its purported anti-inflammatory and wound-healing properties. This analysis eval...Tamanu oil, derived from the nuts of Calophyllum inophyllum, has gained increasing attention for its potential in acne management due to its purported anti-inflammatory and wound-healing properties. This analysis evaluates the efficacy of tamanu oil in acne treatment with a specific focus on its impact on inflammation and scar reduction. The novelty of this research lies in its comprehensive analysis of tamanu oil’s dual mechanism of action: reducing acne-related inflammation and promoting the healing of acne scars. Clinical trials and laboratory analyses were conducted to assess the oil’s effectiveness in diminishing erythema, swelling, and post-acne scarring compared to conventional treatments. Preliminary findings demonstrate that tamanu oil significantly reduces inflammation and accelerates wound healing, potentially offering a promising adjunct or alternative to standard acne therapies. Future research should aim to optimize formulation and application protocols, long-term effects, and comparative therapeutic efficacy with other anti-inflammatory agents. Tamanu oil offers a novel and effective approach to acne management, with potential advantages that go beyond inflammation reduction to include enhanced scar reduction, making it a subject that warrants further investigation.展开更多
Introduction:Papular scarring of the nose and chin due to acne is an under-reported,under-recognized,and under-treated condition.Ablative carbon dioxide laser therapy(10,600 nm,continuous mode,energy of 15W)under loca...Introduction:Papular scarring of the nose and chin due to acne is an under-reported,under-recognized,and under-treated condition.Ablative carbon dioxide laser therapy(10,600 nm,continuous mode,energy of 15W)under local anesthesia is one of the choice.Here,we report series of patients with papular acne scars successfully treated with ablative carbon dioxide laser.Cases presentation:Five patients with papular scars of the nose and chin due to acne were treated at an outpatient dermatology clinic.All had type V skin according to the Fitzpatrick skin classification.Ablative carbon dioxide laser therapy(10,600 nm,continuous mode,energy of 15W)was performed under topical anesthesia.The patients were re-examined at 2-to 3-week intervals,and laser treatment was repeated as needed.Discussion:All of the five patients showed encouraging results.Good cosmetic results were achieved in all patients.The drawbacks of treatment were mild to moderate pain during the procedure and the need for posttreatment skin care.Conclusion:Ablative carbon dioxide laser therapy can potentially be used as a safe and effective treatment for papular scars of the nose and chin due to acne.展开更多
文摘Introduction: Acne vulgaris and acne scarring are prevalent conditions that can have a negative effect on a patient’s quality of life. Fractional radiofrequency technologies have been shown to be clinically safe and effective in managing acne scars through dermal remodeling without causing direct damage to the epidermis. In a recently published study, we presented our clinical and histological results in the treatment of patients with active acne and acne related scarring using a Fractional RF (FRF) device. In the current article we demonstrate long term follow-up results, up to two years post last fractional treatment. Methods: Four out of the eight patients who completed a four treatment regimen were invited for long term follow-up visit to document treatment results. In some cases, touch-up treatments were conducted to optimize clinical results. Results: Patients demonstrated significant improvement of acne lesions, acne scarring, pores and skin texture. Long term photos demonstrated that clinical improvement progressed with time. Conclusion: The current study further supports the previous findings that FRF is a safe and effective treatment modality for active acne and acne related scars. Treatment protocol can be customized according to patient needs and clinical results last for long term.
文摘Background: Post-acne scarring remains a current challenge to prevent and treat despite advancement in acne treatment. There are two types of scars, atrophic and hypertrophic scars, depending on whether there is a net loss or gain of collagen. Objective: The main objectives of this study were to compare the efficacy of using microneedling combined with either plasma gel or amniotic fluid gel in treatment of atrophic post acne scars with clinical and histological evaluation. Methods: This study included Twenty-three cases with atrophic post acne scars. The treated area on the face was divided equally into two halves. Before the procedure, we applied thick layer of local anesthetic cream for approximately 45 to 60 minutes. Microneedling using dermapen combined with irradiated amniotic gel topically was applied to left side of the face and platelet rich plasma gel was applied to the right side. Patients received four sessions with 3 weeks interval between sessions. Clinical examination with histopathological analysis was carried out one month after the last session. Results: There was a significant increase in the improvement percentage of acne scars on right side (dermarpen and platelet rich plasma gel) than left side of face (dermapen and irradiated amniotic gel). Histologically, improvement of character of collagen and elastic fibers was noticed, especially on right side. Meanwhile, a significant increase in epidermal thickness on both sides of face was detected. Conclusion: Dermapen combined with either plasma gel or amniotic gel are promising effective therapeutic modalities for atrophic acne scars. However, combination of platelet rich plasma gel with dermapen has a higher therapeutic efficacy than that of amniotic gel with dermapen.
文摘Objective: to investigate the effect of non-peeling dot array laser combined with photon skin rejuvenation in the treatment of acne scar. Methods: 22 patients with acne scar in our hospital from January 2019 to December 2019 were randomly divided into two groups by number table method. The control group was treated with non-peeling dot array laser, and the experimental group was treated with non-peeling dot array laser combined with photon skin freshening. Acne scar symptom score and treatment effect were compared between the two groups before and after treatment. Results: after treatment, the scores of acne scar symptom in experimental group were lower than those in control group (P < 0.05). The therapeutic effect of the experimental group was higher than that of the control group (P < 0.05). Conclusion: the treatment of acne scar patients with non-peeling lattice laser combined with photon skin freshening has definite effect, can improve the symptoms, improve the treatment effect, so it is worth popularizing and applying.
文摘Xiu-Feng Liu,Man-Chang Yu.In the article“Impact of 30.0%Supramolecular Salicylic Acid Combined With Ultra-Pulse Carbon Dioxide Fractional Laser Therapy on Facial Atrophic Acne Scars:A Retrospective Case-Control Study”by Liu et al.1,the study was incorrectly described as a“retrospective case-control study”in the title,while the study was designed to compare outcomes between groups receiving different interventions,meeting the definition of a cohort study,not a case-control study.
文摘Objective:Current treatments for atrophic acne scars such as microneedling radiofrequency(MNRF)and fractional carbon dioxide(FCO_(2))laser have shown individual efficacy,but their combined effectiveness remains lacking.This study aimed to determine the effectiveness and safety of a sequential combination therapy with MNRF followed by FCO_(2) laser compared with each therapy administered alone for the treatment of atrophic acne scars.Methods:An open randomized trial was conducted on 45 patients with atrophic acne scars at Al-Salam Teaching Hospital,Mosul,Iraq,from January 2022 to July 2023.The patients were randomized into 3 groups,with 15 patients in each group:FCO_(2) group(6 sessions of FCO_(2) laser treatment),MNRF group(6 sessions of MNRF treatment),and combined group(3 sessions of MNRF treatment followed by 3 sessions of FCO_(2) laser treatment).The Goodman and Baron Global Quantitative Acne Scar Grading System(GBGQASGS)was used to assess the treatment effectiveness.Adverse effects of treatment were monitored.The pre-treatment and post-treatment GBGQASGS scores and the percentage reductions in the GBGQASGS scores in the 3 groups were assessed by analysis of variance.The effect size of each treatment regimen was assessed using the Cohen d effect size.Results:The 45 patients enrolled comprised 20(44.4%)men and 25(55.6%)women,with a mean age of 25.10±2.80 years and a GBGQASGS score of 28.93±6.19.All 3 types of treatment significantly reduced the GBGQASGS scores after 6 sessions(all P<0.05)as following:FCO_(2) group,from 28.66±5.71 to 11.66±2.71(59.3%reduction;Cohen d=3.80);MNRF group,from 27.26±6.93 to 11.66±3.09(57.2%reduction;Cohen d=2.90);Combined group,from 30.87±5.73 to 9.01±2.03(70.8%reduction;Cohen d=5.08).There was no difference in the GBGQASGS score of post-treatment among 3 groups(P=0.300),however,the combined group exhibited a significant reduction in the GBGQASGS score from pre-treatment to post-treatment(P<0.001).Post-inflammatory hyperpigmentation was reported in FCO_(2) and MNRF groups,tram-track scarring was found in FCO_(2) group,while no serious adverse effects were reported in the combined group.Conclusion:Sequential combination therapy with MNRF followed by FCO_(2) laser was as effective as each monotherapy for the treatment of atrophic acne scars with fewer adverse effects.The results may provide evidence for treatment choice.
文摘Objective:Acne scarring is more common in patients with moderate to severe acne,and various monotherapies are useful to treat acne scars,however,studies evaluating the effect of combined treatments are still insufficient.This study was aimed to assess the impact of 30.0%supramolecular salicylic acid(SSA)combined with ultra-pulse carbon dioxide(CO_(2))fractional laser therapy on facial atrophic acne scars.Methods:This retrospective study included data from patients with atrophic acne scars treated from June 2020 to June 2022 in Mylike Cosmetology Hospital of Yunnan.The patients were divided into the combination group(SSA combined with ultra-pulse CO_(2)fractional laser therapy)and the laser group(ultra-pulse CO_(2)fractional laser therapy alone)depending on the treatments received.Four treatment sessions were conducted for each group.Follow-up visits were performed every 2 months after each treatment and included assessments of theÉchelle d’Évaluation clinique des cicatrices d’acnéscore,effective rate,and visual analog scale score.Continuous data were analyzed using Student t test.Dichotomous or unordered categorical data were compared using the Chi-square(χ2)test,and ordered categorical data were compared using the Mann-Whitney U test.Results:The combination and laser groups comprised 72 and 61 patients,respectively,and there were no significant differences in sex,age,or baselineÉchelle d’Évaluation clinique des cicatrices d’acnéscore between the 2 groups.The effective rate(95.8%vs.67.2%,P<0.001)was higher and the pain scores(during and after the intervention)were lower in the combination group than in the laser group(all P<0.001).The severity of erythema,edema,and crusting was milder in the combination group(P<0.001).The proportion of highly satisfied patients was higher(73.6%vs.31.2%,P<0.001)and the Dermatology Life Quality Index showed greater improvement(0.15±0.40 vs.1.39±1.53,P<0.001)in the combination group than that in the laser group.Conclusion:The combination of ultra-pulse CO_(2)fractional laser therapy and 30.0%SSA had improved efficacy in treating facial atrophic acne scars without increasing pain or inducing serious adverse reactions.
文摘Tamanu oil, derived from the nuts of Calophyllum inophyllum, has gained increasing attention for its potential in acne management due to its purported anti-inflammatory and wound-healing properties. This analysis evaluates the efficacy of tamanu oil in acne treatment with a specific focus on its impact on inflammation and scar reduction. The novelty of this research lies in its comprehensive analysis of tamanu oil’s dual mechanism of action: reducing acne-related inflammation and promoting the healing of acne scars. Clinical trials and laboratory analyses were conducted to assess the oil’s effectiveness in diminishing erythema, swelling, and post-acne scarring compared to conventional treatments. Preliminary findings demonstrate that tamanu oil significantly reduces inflammation and accelerates wound healing, potentially offering a promising adjunct or alternative to standard acne therapies. Future research should aim to optimize formulation and application protocols, long-term effects, and comparative therapeutic efficacy with other anti-inflammatory agents. Tamanu oil offers a novel and effective approach to acne management, with potential advantages that go beyond inflammation reduction to include enhanced scar reduction, making it a subject that warrants further investigation.
文摘Introduction:Papular scarring of the nose and chin due to acne is an under-reported,under-recognized,and under-treated condition.Ablative carbon dioxide laser therapy(10,600 nm,continuous mode,energy of 15W)under local anesthesia is one of the choice.Here,we report series of patients with papular acne scars successfully treated with ablative carbon dioxide laser.Cases presentation:Five patients with papular scars of the nose and chin due to acne were treated at an outpatient dermatology clinic.All had type V skin according to the Fitzpatrick skin classification.Ablative carbon dioxide laser therapy(10,600 nm,continuous mode,energy of 15W)was performed under topical anesthesia.The patients were re-examined at 2-to 3-week intervals,and laser treatment was repeated as needed.Discussion:All of the five patients showed encouraging results.Good cosmetic results were achieved in all patients.The drawbacks of treatment were mild to moderate pain during the procedure and the need for posttreatment skin care.Conclusion:Ablative carbon dioxide laser therapy can potentially be used as a safe and effective treatment for papular scars of the nose and chin due to acne.
