Bionic micro/nanomotor systems,which combine biomimetic design with the motion performance,have shown great potential in many fields.However,so far,it remains a challenge to design and fabricate biomimetic micro/nanom...Bionic micro/nanomotor systems,which combine biomimetic design with the motion performance,have shown great potential in many fields.However,so far,it remains a challenge to design and fabricate biomimetic micro/nanomotors with high flexibility to perform complex tasks in complicated and changeable environments.In this work,inspired by the suckerfishes(vip)-shark(host)motion behavior,we designed and prepared a kind of intelligent two-stage micro@nanomotor with weak acid-triggered release of nanomotor.When the suckerfishes,who clinged to the surface of large fish or the bottom of boat and marched with them,reached bait-rich waters,they detached from the host to engage in foraging behavior.Inspired by the suckerfishes-shark system and the coordinated bond interaction,a large amount of Janus Au-Pt nanomotors with hydrogen peroxide(H_(2)O_(2))-driven capacity,analogous to suckerfishes,were attached onto immovable yolk-shell structured polydopamine-mesoporous silica(PDA-MS)micromotor as the host to create two-stage PDA-MS@Au-Pt micro@nanomotor.PDA-MS@Au-Pt micro@nanomotor moved directionally by self-thermophoresis under the propulsion of near infrared ray(NIR)light with low power density.When the PDA-MS@Au-Pt entered into the weak acidic environment formed by a low concentration of H_(2)O_(2),most small Au-Pt nanomotors were detached from the surface of PDA-MS due to the weak acidic sensitivity of the coordinated bond,and then performed self-diffusiophoresis in the environment containing a low concentration of H_(2)O_(2) as a chemical fuel.This bionic intelligent system,which consists of a large-sized micromotor and lots of small-sized nanomotors,should provide a new insight for active two-stage cargo delivery.展开更多
A mixed drug self-delivery system(DSDS)with high drug content(>50%)was developed to regulate pHtriggered drug release,based on two doxorubicin(DOX)-DOX dimmers:D-DOX_(ADH) and D-DOX_(car) conjugated with acid-labil...A mixed drug self-delivery system(DSDS)with high drug content(>50%)was developed to regulate pHtriggered drug release,based on two doxorubicin(DOX)-DOX dimmers:D-DOX_(ADH) and D-DOX_(car) conjugated with acid-labile dynamic covalent bonds(hydrazone and carbamate,respectively)and stabilized with PEGylated D-DOX_(ADH)(D-DOX_(ADH)-PEG).Owing to the different stability of the dynamic covalent bonds in the two dimers and the noncovalent interaction between them,pH-triggered drug release could be easily regulated by adjusting the feeding ratios of the two DOX-DOX dimers in the mixed DSDS.Similar in vitro cellular toxicity was achieved with the mixed DSDS nanoparticles prepared with different feeding ratios.The mixed DSDS nanoparticles had a similar DOX content and diameter but different drug releasing rates.The MTT assays revealed that a high anti-tumor efficacy could be achieved with the slowrelease mixed DSDS nanoparticles.展开更多
Stroke is the leading cause of death and disability.Currently,there is no effective pharmacological treatment for this disease,which can be partially attributed to the inability to efficiently deliver therapeutics to ...Stroke is the leading cause of death and disability.Currently,there is no effective pharmacological treatment for this disease,which can be partially attributed to the inability to efficiently deliver therapeutics to the brain.Here we report the development of natural compound-derived nanoparticles(NPs),which function both as a potent therapeutic agent for stroke treatment and as an efficient carrier for drug delivery to the ischemic brain.First,we screened a collection of natural nanomaterials and identified betulinic acid(BA)as one of the most potent antioxidants for stroke treatment.Next,we engineered BA NPs for preferential drug release in acidic ischemic tissue through chemically converting BA to betulinic amine(BAM)and for targeted drug delivery through surface conjugation of AMD3100,a CXCR4 antagonist.The resulting AMD3100-conjugated BAM NPs,or A-BAM NPs,were then assessed as a therapeutic agent for stroke treatment and as a carrier for delivery of NA1,a neuroprotective peptide.We show that intravenous administration of A-BAM NPs effectively improved recovery from stroke and its efficacy was further enhanced when NA1 was encapsulated.Due to their multifunctionality and significant efficacy,we anticipate that A-BAM NPs have the potential to be translated both as a therapeutic agent and as a drug carrier to improve the treatment of stroke.展开更多
基金supported by Fundamental Research Funds for the Central Universities(No.FRF-BR-23-02B)China Postdoctoral Science Foundation(No.2023M731408)+2 种基金Jiangsu Funding Program for Excellent Postdoctoral Talent(No.2023ZB640)Jiangsu Province Capability Improvement Project through Science,technology and Education(Jiangsu Provincial Medical Key Discipline,ZDXK202222)Natural Science Foundation of Jiangsu Province(No.BK20230731).
文摘Bionic micro/nanomotor systems,which combine biomimetic design with the motion performance,have shown great potential in many fields.However,so far,it remains a challenge to design and fabricate biomimetic micro/nanomotors with high flexibility to perform complex tasks in complicated and changeable environments.In this work,inspired by the suckerfishes(vip)-shark(host)motion behavior,we designed and prepared a kind of intelligent two-stage micro@nanomotor with weak acid-triggered release of nanomotor.When the suckerfishes,who clinged to the surface of large fish or the bottom of boat and marched with them,reached bait-rich waters,they detached from the host to engage in foraging behavior.Inspired by the suckerfishes-shark system and the coordinated bond interaction,a large amount of Janus Au-Pt nanomotors with hydrogen peroxide(H_(2)O_(2))-driven capacity,analogous to suckerfishes,were attached onto immovable yolk-shell structured polydopamine-mesoporous silica(PDA-MS)micromotor as the host to create two-stage PDA-MS@Au-Pt micro@nanomotor.PDA-MS@Au-Pt micro@nanomotor moved directionally by self-thermophoresis under the propulsion of near infrared ray(NIR)light with low power density.When the PDA-MS@Au-Pt entered into the weak acidic environment formed by a low concentration of H_(2)O_(2),most small Au-Pt nanomotors were detached from the surface of PDA-MS due to the weak acidic sensitivity of the coordinated bond,and then performed self-diffusiophoresis in the environment containing a low concentration of H_(2)O_(2) as a chemical fuel.This bionic intelligent system,which consists of a large-sized micromotor and lots of small-sized nanomotors,should provide a new insight for active two-stage cargo delivery.
文摘A mixed drug self-delivery system(DSDS)with high drug content(>50%)was developed to regulate pHtriggered drug release,based on two doxorubicin(DOX)-DOX dimmers:D-DOX_(ADH) and D-DOX_(car) conjugated with acid-labile dynamic covalent bonds(hydrazone and carbamate,respectively)and stabilized with PEGylated D-DOX_(ADH)(D-DOX_(ADH)-PEG).Owing to the different stability of the dynamic covalent bonds in the two dimers and the noncovalent interaction between them,pH-triggered drug release could be easily regulated by adjusting the feeding ratios of the two DOX-DOX dimers in the mixed DSDS.Similar in vitro cellular toxicity was achieved with the mixed DSDS nanoparticles prepared with different feeding ratios.The mixed DSDS nanoparticles had a similar DOX content and diameter but different drug releasing rates.The MTT assays revealed that a high anti-tumor efficacy could be achieved with the slowrelease mixed DSDS nanoparticles.
基金supported by Grant NS110721(JZ,KNS),EB023366(FH),EB011968(FH),CA140102(FH)from the NIH,United States,and Grants 18TPA34170180 and 19CSLOI34770004(JZ)from the AHA,United States.
文摘Stroke is the leading cause of death and disability.Currently,there is no effective pharmacological treatment for this disease,which can be partially attributed to the inability to efficiently deliver therapeutics to the brain.Here we report the development of natural compound-derived nanoparticles(NPs),which function both as a potent therapeutic agent for stroke treatment and as an efficient carrier for drug delivery to the ischemic brain.First,we screened a collection of natural nanomaterials and identified betulinic acid(BA)as one of the most potent antioxidants for stroke treatment.Next,we engineered BA NPs for preferential drug release in acidic ischemic tissue through chemically converting BA to betulinic amine(BAM)and for targeted drug delivery through surface conjugation of AMD3100,a CXCR4 antagonist.The resulting AMD3100-conjugated BAM NPs,or A-BAM NPs,were then assessed as a therapeutic agent for stroke treatment and as a carrier for delivery of NA1,a neuroprotective peptide.We show that intravenous administration of A-BAM NPs effectively improved recovery from stroke and its efficacy was further enhanced when NA1 was encapsulated.Due to their multifunctionality and significant efficacy,we anticipate that A-BAM NPs have the potential to be translated both as a therapeutic agent and as a drug carrier to improve the treatment of stroke.
