The discovery that somatic mammalian cells can be epigeneti- cally reprogrammed to induced pluripotent stem cells （iPSCs） through the exogenous expression of the Oct4, Sox2, Klf4 and c-Myc （OSKM） has demonstrated ...The discovery that somatic mammalian cells can be epigeneti- cally reprogrammed to induced pluripotent stem cells （iPSCs） through the exogenous expression of the Oct4, Sox2, Klf4 and c-Myc （OSKM） has demonstrated a new way for cell-replace- ment therapy in regenerative medicine （Li et al., 2013; Nishimura and Takahashi, 2013; Takahashi and Yamanaka, 2013）. This novel technology has opened new therapeutic opportunities to gener- ate stem cells in any tissue for cell replacement therapy in a num- ber of disorders （Yamanaka, 2012; Li et al., 2013; Nishimura and Takahashi, 2013; Takahashi and Yamanaka, 2013）. Just last week, two papers published in Nature, describing a surprisingly sim- ple method to turn mature cells into embryonic-like stem ceils by culturing cells in a low pH medium （Obokata et al., 2014a, 2014b）. This method by Obokata and colleagues is truly the sim- plest, cheapest, and fastest method ever achieved for reprogram- min~ somatic cells into multiootent stem cells.展开更多
开发了酸性无氰镀镉新工艺NCC-617。镀液组成为：氯化镉35-40 g/L,配位剂120-160 g/L,氯化钾140-180 g/L,光亮剂1.5-2.5 m L/L,辅助剂25-35 m L/L,p H 6.0-7.0。工艺条件为：挂镀──温度15-35℃,阴极电流密度0.5-1.5 A/dm^2;滚镀温度15...开发了酸性无氰镀镉新工艺NCC-617。镀液组成为：氯化镉35-40 g/L,配位剂120-160 g/L,氯化钾140-180 g/L,光亮剂1.5-2.5 m L/L,辅助剂25-35 m L/L,p H 6.0-7.0。工艺条件为：挂镀──温度15-35℃,阴极电流密度0.5-1.5 A/dm^2;滚镀温度15-30℃,槽电压4-7 V,滚筒转速3-5 r/min。在电流密度1 A/dm2下,镉的沉积速率为0.33μm/min。NCC-617镀液的电流效率为73%,均镀能力为41%-52%,深镀能力为9.2。镀镉层经低铬彩色钝化后中性盐雾试验2 000 h仍无白锈生成,其耐蚀性实现了重大突破。镀层的氢脆性和结合力合格。总之,NCC-617镀镉工艺具有镀液稳定,镀层性能优良,电镀废水容易处理的优点,具有较好的应用前景。展开更多
文摘The discovery that somatic mammalian cells can be epigeneti- cally reprogrammed to induced pluripotent stem cells （iPSCs） through the exogenous expression of the Oct4, Sox2, Klf4 and c-Myc （OSKM） has demonstrated a new way for cell-replace- ment therapy in regenerative medicine （Li et al., 2013; Nishimura and Takahashi, 2013; Takahashi and Yamanaka, 2013）. This novel technology has opened new therapeutic opportunities to gener- ate stem cells in any tissue for cell replacement therapy in a num- ber of disorders （Yamanaka, 2012; Li et al., 2013; Nishimura and Takahashi, 2013; Takahashi and Yamanaka, 2013）. Just last week, two papers published in Nature, describing a surprisingly sim- ple method to turn mature cells into embryonic-like stem ceils by culturing cells in a low pH medium （Obokata et al., 2014a, 2014b）. This method by Obokata and colleagues is truly the sim- plest, cheapest, and fastest method ever achieved for reprogram- min~ somatic cells into multiootent stem cells.
