Antibody-mediated rejection(AMR)remains a leading cause of kidney allograft failure,posing significant clinical and economic challenges.Donor-specific antibodies against human leukocyte antigens or non-human leukocyte...Antibody-mediated rejection(AMR)remains a leading cause of kidney allograft failure,posing significant clinical and economic challenges.Donor-specific antibodies against human leukocyte antigens or non-human leukocyte antigens are critical risk factors for AMR and graft loss.The diagnostic criteria and classification of AMR have evolved considerably over the past three decades,driven largely by the Banff classification.The latest Banff 2022 classification introduced two additional subcategories of“microvascular inflammation,donor-specific antibody-negative,C4d-negative”and“probable AMR”.Traditionally,graft monitoring has relied on non-specific markers such as serum creatinine and proteinuria,and the invasive biopsies.Noninvasive tools using blood and urine biomarkers,including cellular assays and molecular profiling,are increasingly being investigated.Technologies such as the Molecular Microscope Diagnostic System show promise,with studies reporting 80%sensitivity and 90%specificity in detecting AMR.Treatment of AMR remains inconsistent.Recent advances,including CD38 antibodies,have demonstrated up to 60%efficacy in reversing AMR,while complement inhibition shows potential in severe early cases.Ongoing clinical trials evaluating high-dose intravenous immunoglobulin,efgartigimod,fostamatinib,and other novel therapies aim to expand treatment options.These developments highlight the need for well-designed clinical trials to validate biomarkers and therapies and to improve long-term outcomes for kidney transplant recipients.展开更多
Post-kidney transplant rejection is a critical factor influencing transplant success rates and the survival of transplanted organs.With the rapid advancement of artificial intelligence technologies,machine learning(ML...Post-kidney transplant rejection is a critical factor influencing transplant success rates and the survival of transplanted organs.With the rapid advancement of artificial intelligence technologies,machine learning(ML)has emerged as a powerful data analysis tool,widely applied in the prediction,diagnosis,and mechanistic study of kidney transplant rejection.This mini-review systematically summarizes the recent applications of ML techniques in post-kidney transplant rejection,covering areas such as the construction of predictive models,identification of biomarkers,analysis of pathological images,assessment of immune cell infiltration,and formulation of personalized treatment strategies.By integrating multi-omics data and clinical information,ML has significantly enhanced the accuracy of early rejection diagnosis and the capability for prognostic evaluation,driving the development of precision medicine in the field of kidney transplantation.Furthermore,this article discusses the challenges faced in existing research and potential future directions,providing a theoretical basis and technical references for related studies.展开更多
The evaluation of the immunosuppression state in liver transplanted patients is crucial for a correct posttransplant management and a major step towards the personalisation of the immunosuppressive therapy. However, c...The evaluation of the immunosuppression state in liver transplanted patients is crucial for a correct posttransplant management and a major step towards the personalisation of the immunosuppressive therapy. However, current immunological monitoring after liver transplantation relies mainly on clinical judgment and on immunosuppressive drug levels, without a proper assessment of the real suppression of theimmunological system. Various markers have been studied in an attempt to identify a specific indicator of graft rejection and graft acceptance after liver transplantation. Considering acute rejection, the most studied markers are pro-inflammatory and immunoregulatory cytokines and other proteins related to inflammation. However there is considerable overlap with other conditions, and only few of them have been validated. Standard liver tests cannot be used as markers of graft rejection due to their low sensitivity and specificity and the weak correlation with the severity of histopathological findings. Several studies have been performed to identify biomarkers of tolerance in liver transplanted patients. Most of them are based on the analysis of peripheral blood samples and on the use of transcriptional profiling techniques. Amongst these, NK cell-related molecules seem to be the most valid marker of graft acceptance, whereas the role CD4+CD25+Foxp3+ T cells has still to be properly defined.展开更多
Metropolis-Hastings algorithms are slowed down by the computation of complex target distributions. To solve this problem, one can use the delayed acceptance Metropolis-Hastings algorithm (MHDA) of Christen and Fox (20...Metropolis-Hastings algorithms are slowed down by the computation of complex target distributions. To solve this problem, one can use the delayed acceptance Metropolis-Hastings algorithm (MHDA) of Christen and Fox (2005). However, the acceptance rate of a proposed value will always be less than in the standard Metropolis-Hastings. We can fix this problem by using the Metropolis-Hastings algorithm with delayed rejection (MHDR) proposed by Tierney and Mira (1999). In this paper, we combine the ideas of MHDA and MHDR to propose a new MH algorithm, named the Metropolis-Hastings algorithm with delayed acceptance and rejection (MHDAR). The new algorithm reduces the computational cost by division of the prior or likelihood functions and increase the acceptance probability by delay rejection of the second stage. We illustrate those accelerating features by a realistic example.展开更多
The output feedback active disturbance rejection control of a valve-controlled cylinder electro-hydraulic servo system is investigated in this paper.First,a comprehensive nonlinear mathematical model that encompasses ...The output feedback active disturbance rejection control of a valve-controlled cylinder electro-hydraulic servo system is investigated in this paper.First,a comprehensive nonlinear mathematical model that encompasses both matched and mismatched disturbances is formulated.Due to the fact that only position information can be measured,a linear Extended State Observer(ESO)is introduced to estimate unknown states and matched disturbances,while a dedicated disturbance observer is constructed to estimate mismatched disturbances.Different from the traditional observer results,the design of the disturbance observer used in this study is carried out under the constraint of output feedback.Furthermore,an output feedback nonlinear controller is proposed leveraging the aforementioned observers to achieve accurate trajectory tracking.To mitigate the inherent differential explosion problem of the traditional backstepping framework,a finite-time stable command filter is incorporated.Simultaneously,considering transient filtering errors,a set of error compensation signals are designed to counter their negative impact effectively.Theoretical analysis affirms that the proposed control strategy ensures the boundedness of all signals within the closed-loop system.Additionally,under the specific condition of only time-invariant disturbances in the system,the conclusion of asymptotic stability is established.Finally,the algorithm’s efficacy is validated through comparative experiments.展开更多
Permanent magnet synchronous motor based electro-mechanical actuation servo drives have widespread applications in the aviation field,such as unmanned aerial vehicle electric servos,electric cabin doors,and mechanical...Permanent magnet synchronous motor based electro-mechanical actuation servo drives have widespread applications in the aviation field,such as unmanned aerial vehicle electric servos,electric cabin doors,and mechanical arms.The performance of the servo drive,which encompasses the response to the torque,efficiency,control bandwidth and the steady-state positioning accuracy,significantly influences the performance of the aviation actuation.Consequently,enhancing the control bandwidth and refining the positioning accuracy of aviation electro-mechanical actuation servo drives have emerged as a focal point of research.This paper investigates the multi-source disturbances present in aviation electro-mechanical actuation servo systems and summarizes recent research on high-performance servo control methods based on active disturbance rejection control(ADRC).We present a comprehensive overview of the research status pertaining to servo control architecture,strategies for suppressing disturbances in the current loop,and ADRC-based strategies for the position loop.We delineate the research challenges and difficulties encountered by aviation electro-mechanical actuation servo drive control technology.展开更多
1 I Like Me follows a cheerful and confident little pig who celebrates everything about herself.From her curly tail to her big feet,she loves every part of herself.In the book,I remember that the pig enthusiastically ...1 I Like Me follows a cheerful and confident little pig who celebrates everything about herself.From her curly tail to her big feet,she loves every part of herself.In the book,I remember that the pig enthusiastically declares that no matter what she does,even if she's making mistakes,being silly or being a clumsy rookie(笨拙的新手)of trying something new,she will always like herself.展开更多
The study of Mecanum mobile robots typically assumes motion on planar surfaces,while the challenges posed by inclined terrains remain largely unexplored,leaving a significant gap in control applications for such scena...The study of Mecanum mobile robots typically assumes motion on planar surfaces,while the challenges posed by inclined terrains remain largely unexplored,leaving a significant gap in control applications for such scenarios.In this context,two critical issues emerge:the gravitational pull caused by adding a potential energy term in the robot dynamics,which drives the vehicle downhill,and several positioning errors due to vibrations and slippage of the Mecanum wheel.To address these challenges,this work presents an Active Disturbance Rejection Control(ADRC)-based framework designed to enable accurate tracking on inclined surfaces,despite the compounded effects of gravitational forces and slippage.Unlike conventional controllers,the proposed method requires minimal model knowledge while actively compensates for unknown dynamics and external disturbances in real time.A complete theoretical formulation is provided,supported by numerical simulations and comprehensive experimental validation.Results demonstrate that the ADRC structure significantly outperforms not only the traditional proportional-integral-derivative(PID)control but also a robust variant of PID combined with a Quasi-Sliding Mode control(PID-QSMC)strategy,achieving superior tracking.Notably,this study offers an important experimental validation of ADRC for Mecanum-wheeled robots operating on inclined surfaces.It contributes a practical and scalable solution to extend their operational capabilities beyond flat environments.展开更多
Antibody-mediated rejection(AMR)represents a major challenge in kidney transplantation,significantly contributing to tissue injury and graft failure.AMR is primarily driven by donor-specific alloantibodies(DSAs),which...Antibody-mediated rejection(AMR)represents a major challenge in kidney transplantation,significantly contributing to tissue injury and graft failure.AMR is primarily driven by donor-specific alloantibodies(DSAs),which recognize and bind to specific target antigens present within the transplanted kidney tissue.Upon binding,these DSAs commonly initiate activation of the complement system within the graft.The activation of the complement cascade sets off a powerful inflammatory response characterized by the recruitment and activation of immune cells,endothelial damage,and subsequent tissue injury.This inflammation underlies many clinical and histological manifestations of AMR,making complement activation a critical player in the disease process.Advancements in our understanding of how complement pathways contribute to kidney graft injury have opened new avenues for therapeutic intervention.Recent research has facilitated the development and application of novel therapies specifically designed to inhibit complement activation.Such targeted complement-inhibitory strategies have shown promise in improving graft outcomes by inhibiting complement-mediated damage and extending graft survival.This review comprehensively discusses the critical role of complement activation in inducing kidney graft injury with a focus on its role in AMR.By elucidating the detailed mechanisms and contributions of complement pathways,the review seeks to enhance the understanding necessary for developing targeted therapeutic interventions to prevent or treat AMR effectively.展开更多
Organ transplantation has long been recognized as an effective treatment for endstage organ failure,metabolic diseases,and malignant tumors.However,graft rejection caused by major histocompatibility complex mismatch r...Organ transplantation has long been recognized as an effective treatment for endstage organ failure,metabolic diseases,and malignant tumors.However,graft rejection caused by major histocompatibility complex mismatch remains a significant challenge.While modern immunosuppressants have made significant strides in reducing the incidence and risk of rejection,they have not been able to eliminate it completely.The intricate mechanisms underlying transplant rejection have been the subject of intense investigation by transplant immunologists.Among these factors,autophagy has emerged as a key player.Autophagy is an evolutionarily conserved mechanism in eukaryotic cells that mediates autophagocytosis and cellular protection.This process is regulated by autophagy-related genes and their encoded protein families,which maintain the material and energetic balance within cells.Additionally,autophagy has been reported to play crucial roles in the development,maturation,differentiation,and responses of immune cells.In the complex immune environment following transplantation,the role and mechanisms of autophagy are gradually being revealed.In this review,we aim to explore the current understanding of the role of autophagy in solid organ rejection after transplantation.Furthermore,we delve into the therapeutic advancements achieved by targeting autophagy involved in the rejection process.展开更多
BACKGROUND The Luminex platform,where beads are coated with single human leukocyte antigens(HLA),detects HLA antibodies with higher sensitivity and specificity compared to complement-dependent cytotoxicity(CDC)assay a...BACKGROUND The Luminex platform,where beads are coated with single human leukocyte antigens(HLA),detects HLA antibodies with higher sensitivity and specificity compared to complement-dependent cytotoxicity(CDC)assay and flow crossmatch(FCXM).The clinical significance of donor-specific antibodies(DSAs)detected by this method is still under investigation.AIM To report the impact of low-level pretransplant DSAs detected by the Luminex platform on the rates of acute rejection(AR),allograft function,and long-term graft survival.METHODS This retrospective study was conducted at the Immunology Department of Sindh Institute of Urology and Transplantation,Karachi,Pakistan between January 2013 and December 2022.During this period 2714 patients were transplanted.Out of these patients 78(2.9%)patients had low-level DSAs detected by the Luminex flow beads method and were negative by CDC and FCXM with their donors.All recipients received ABO-compatible live-related kidney transplants.All patients had a minimum follow-up of 1 year.Graft rejection rates,graft function,and patient and graft survival were analyzed.The estimated glomerular filtration rate was calculated by the full CKD-EPI formula.RESULTS The mean age of all recipients was 29.57±10.11 years and 34.53±9.09 years for the donors.In 48(61.5%)patients,the cause of end-stage kidney disease was unknown.DSA against HLA class I was detected in 36(46.1%)patients,class II in 35(44.8%)patients,and both class I and II in 7(8.9%)patients.AR episodes were encountered in 8(10.3%)cases.Seven(87.5%)had T cell mediated rejection(type IA)and one acute antibody-mediated rejection.Antibody status was re-evaluated at the time of biopsy-proven ARs.Five(62.5%)patients lost their DSAs,while three(37.5%)had persistent DSAs.The mean estimated glomerular filtration rate at 1 year was 80.56±27.48 mL/min/1.73 m2 and at the last follow-up 73.41±28.80 mL/min/1.73 m2.The 1-year and 10-year patient and graft survival rates were 99%and 79%and 95%and 75%,respectively.During the follow-up period,10(12.8%)patients died,8 patients had a functioning graft,and 2 patients had failed grafts.Eight patients died due to cardiopulmonary arrest,and two died due to sepsis with failed grafts.CONCLUSION Patients with pretransplant low-level DSAs on Luminex without CDC and FCXM reactivity had good allograft outcomes at 1 year and 10 years as long as they are induced with biological agents and given potent maintenance immunosuppressants.展开更多
The output regulation approach has effectively addressed the speed tracking and disturbance rejection problem of permanent magnet synchronous motor(PMSM).Although accurate speed tracking under time-varying load torque...The output regulation approach has effectively addressed the speed tracking and disturbance rejection problem of permanent magnet synchronous motor(PMSM).Although accurate speed tracking under time-varying load torque disturbance has been achieved,the number of disturbance frequencies should be known.In this paper,an adaptive observer-based error feedback control method is proposed,which can solve the speed tracking control problem of PMSM subject to completely unknown multi-frequency sinusoidal load torque disturbance,requiring only the upper bound of the number of disturbance frequencies.The design steps of this method can be divided into the following three steps.In step one,a filtered transformation is applied to convert the observer canonical form of the error system and the transformed exosystem into an adaptive observer form.In step two,an adaptive observer is designed to estimate the unknown parameters of the exosystem and states of the adaptive observer form.In step three,an adaptive observer-based error feedback controller is designed to solve this control problem.The effectiveness of the proposed method is demonstrated by experimental results.展开更多
The integration of Learning Management Systems(LMSs)into educational settings is becoming increasingly common,especially in the digital field.Understanding the factors influencing the acceptance and effective use of L...The integration of Learning Management Systems(LMSs)into educational settings is becoming increasingly common,especially in the digital field.Understanding the factors influencing the acceptance and effective use of LMS is essential to ensure successful implementation.The Technology Acceptance Model(TAM)has been widely used to check user acceptance of various technologies,including LMS.This study conducted a systematic literature review(SLR)to analyze existing research on the application of TAM in the context of LMS.A comprehensive search of the academic database was conducted to identify relevant studies published in 2010-2025.The review synthesizes findings related to the core constructs of TAM—Perceived Usability,Perceived Ease of Use,Behavioral Intent,and Actual Use—as well as extended factors such as system quality,self-efficacy,and social influence.The results reveal circumstantial evidence supporting the predictive power of TAM in LMS adoption,while also highlighting emerging trends and gaps in the literature.This review contributes to a deeper understanding of user acceptance in a digital learning environment and provides recommendations for future research and practical LMS implementation strategies.展开更多
The Master Intelligent interview is based on the Stimulus-Organism-Response(SOR)theory,this study integrates key constructs from the Technology Acceptance Model(TAM)and the Theory of Planned Behavior(TPB),namely attit...The Master Intelligent interview is based on the Stimulus-Organism-Response(SOR)theory,this study integrates key constructs from the Technology Acceptance Model(TAM)and the Theory of Planned Behavior(TPB),namely attitude and behavioral intention,to develop a dual-path model of how AI empowerment influences college graduates’acceptance of intelligent interview technology.Taking AI empowerment as the independent variable,perceived risk and attitude as mediating variables,and behavioral intention as the outcome variable,the study employs questionnaire surveys and structural equation modeling(SEM)for empirical analysis.The results show that AI empowerment exerts a significant positive impact on attitude,perceived risk,and behavioral intention.Both perceived risk and attitude play significant mediating roles between AI empowerment and behavioral intention.Interestingly,perceived risk does not suppress behavioral intention;instead,it positively promotes it through a“rational trade-off”mechanism.Moreover,perceived risk and attitude form a significant chain-mediated pathway,revealing a continuous psychological transmission mechanism of“rational cognition-emotional adjustment-behavioral decision-making”.This study enriches the theoretical framework of AI technology acceptance,extends the application of the SOR model to the context of intelligent recruitment,and provides valuable implications for optimizing university career guidance and enterprise recruitment systems.展开更多
BACKGROUND Malabsorptive bariatric surgery,including Roux-en-Y gastric bypass and duodenal switch,are known to be more metabolically effective than restrictive surgery.However,the permanent alteration of gastrointesti...BACKGROUND Malabsorptive bariatric surgery,including Roux-en-Y gastric bypass and duodenal switch,are known to be more metabolically effective than restrictive surgery.However,the permanent alteration of gastrointestinal anatomy from these operations has been shown to alter the kinetics of drug absorption and may make subsequent surgeries more technically challenging.AIM To evaluate perioperative liver transplant outcomes and rates of acute cellular rejection in recipients with prior malabsorptive bariatric surgery.METHODS Patients who underwent liver transplantation at a single institution between 2005-2024 with a history of malabsorptive bariatric surgery were identified.Matched controls were selected based on age,sex,listing model for end-stage liver disease(MELD),and primary liver diagnosis.RESULTS A total of 12 liver transplant patients with prior malabsorptive surgery and 25 controls were included.The mean age in the malabsorptive group was 50.5 years at the time of transplant and 92%were female.The mean MELD at the time of transplant was 27.6 and mean body mass index was 28.There were no significant differences in length of stay,post operative complications,or 1 year survival between the controls and malabsorptive patients.However,the malabsorptive group was significantly more likely to experience biopsy-proven and clinically treated acute cellular rejection than the controls(24%vs 66.7%,P=0.012),more frequent rejection episodes(0.28±0.53 vs 1.0±0.91,P=0.006),and earlier time to first rejection episode(P=0.002).CONCLUSION Previous malabsorptive bariatric surgery in liver transplant recipients did not increase the risk of perioperative complications or mortality but significantly increased the rate and frequency of acute cellular rejection.展开更多
Objectives:College students face increasing mental health challenges.Although Acceptance and CommitmentTherapy(ACT)is effective,the efficacy of Internet-based ACT(iACT)needs further exploration.Methods:This study exam...Objectives:College students face increasing mental health challenges.Although Acceptance and CommitmentTherapy(ACT)is effective,the efficacy of Internet-based ACT(iACT)needs further exploration.Methods:This study examines the efficacy of iACT on college students’mental health through a randomized controlled trial.We recruited 90 college students(19.16±1.02 years old)and randomly divided them into the iACT group,face-to-face ACT group,and control group.The effects of the interventions were evaluated using the comprehensive assessment of ACT processes(CompACT)and the Depression Anxiety Stress Scales(DASS-21).Results:Two-factor repeated measures ANOVA revealed a significant time main effect of iACT.Face-to-face ACT and iACT effectively improved college students’psychological flexibility[F(2,83)=18.78,p<0.001,η^(2)=0.18]and alleviated their negative emotions[F(2,82)=41.17,p<0.001,η^(2)=0.36].Face-to-face ACT exhibited sustained effects on improving participants’psychological flexibility and alleviating their negative emotions(p<0.001),while iACT showed no sustained effect on improving participants’psychological flexibility(p>0.05).Conclusion:While iACT and face-to-face ACT are effective shortterm interventions,face-to-face ACT demonstrates superior sustainability.Integrating guided sessions into iACT may enhance long-term outcomes.These findings advocate for blended interventions to address college students’mental health needs,particularly in resource-limited settings.展开更多
BACKGROUND The pathophysiology behind gastroesophageal reflux disease and its association with poor outcomes after lung transplantation is incompletely understood.The physiologic impact of lung transplantation on pulm...BACKGROUND The pathophysiology behind gastroesophageal reflux disease and its association with poor outcomes after lung transplantation is incompletely understood.The physiologic impact of lung transplantation on pulmonary function,intrathoracic pressures,and vagal innervation may affect esophageal motility,bolus clearance and reflux risk.However,the effect of changes in esophageal function after lung transplantation on the risk of poor post-transplant outcomes remains unclear.AIM To evaluate the association between change in esophageal motility pre-/post-lung transplantation and rejection outcome.METHODS This was a retrospective cohort study of lung transplant recipients who underwent both pre-and post-transplant esophageal testing including high resolution manometry(HRM)at a tertiary center.Acute cellular rejection(ACR)was defined histologically per International Society for Heart and Lung Transplantation criteria.Univariate analyses were performed using student’s t-test,χ2 test,and Spearman’s correlation where appropriate.Multivariable time-to-event analysis using Cox proportional hazards model was applied.Subjects not meeting ACR outcome were censored at death or date of last clinic visit.RESULTS 55 subjects(65%men,mean age:61,median follow-up:840 days)were included,with 17 (31%) experiencing ACR. Increase in failed swallows correlated with lower baseline total lung capacity(TLC) (R = -0.32, P = 0.05) and decreased post-transplant esophageal bolus clearance (R = -0.45, P = 0.004). Onmultivariable analysis, post-transplant hypomotility independently predicted increased ACR (HR: 3.62, 95%CI:1.11-11.8;P = 0.03). Kaplan-Meier analysis demonstrated increased ACR for subjects with increased vs unchangedfailed swallows post-transplant (P = 0.048). On Cox regression, a 20% elevated risk of ACR was found for every10% increase in failed swallows, after controlling for confounders including reflux severityCONCLUSIONEsophageal hypomotility, specifically an increase in failed swallows on HRM, from pre- to post-lungtransplantation was independently associated with ACR. Additionally, lower baseline TLC correlated with increasein failed swallows, suggesting restrictive lung disease may be associated with post-transplant esophagealhypomotility. Lung transplantation may affect esophageal function and contribute to rejection outcomes. Routineesophageal function testing may help identify patients at higher risk for poor lung transplantation outcomes.展开更多
With the growing adoption of artificial intelligence algorithms and neural networks,online learning and adaptive methods for updating the bandwidth have become increasingly prevalent.However,the conditions required to...With the growing adoption of artificial intelligence algorithms and neural networks,online learning and adaptive methods for updating the bandwidth have become increasingly prevalent.However,the conditions required to ensure closed-loop stability when employing a time-varying bandwidth,as well as the supporting mathematical foundations,remain insufficiently studied.This paper investigates the stability condition for active disturbance rejection control(ADRC)with a time-varying bandwidth extended state observer(ESO).A new stability condition is derived,which means that the upper bound of rate of change for ESO bandwidth should be restricted.Moreover,under the proposed condition,the closed-loop stability of ADRC with a time-varying bandwidth observer is rigorously proved for nonlinear uncertainties.In simulations,the necessity of the proposed condition is illustrated,demonstrating that the rate of change of ESO bandwidth is crucial for closed-loop stability.展开更多
The introduction of the digital renminbi(eCNY)by the People’s Bank of China serves as a means for the central bank to effectively comprehend macroeconomic dynamics and enhance payment infrastructure within the domest...The introduction of the digital renminbi(eCNY)by the People’s Bank of China serves as a means for the central bank to effectively comprehend macroeconomic dynamics and enhance payment infrastructure within the domestic market.Among the pioneering digital currencies,the eCNY is at the forefront of technological research and development,pilot implementation,and the establishment of a robust system.Thus,employing the unified theory of acceptance and use of technology,this study aims to explore the factors shaping the adoption of the eCNY and to determine the mediating effects of intention toward the eCNY and the moderating role of age and gender among various relationships.A cross-sectional survey methodology was deployed to collect data from pilot communities situated within the Yangtze River Delta,Pearl River Delta,and Beijing–Tianjin–Hebei regions.The empirical analysis comprised 809 valid online questionnaires,and the examination was conducted through structural equation modeling employing the partial least squares technique,ultimately subjecting the conceptual model to a comprehensive assessment.The results for intention to use the eCNY indicate that performance expectancy,effort expectancy,social influence,and perceived government policy have significant effects.Facilitating conditions and intentions toward the eCNY positively influenced its actual use.According to the findings of this study,age and sex did not moderate the effect of each hypothesis on the intention to use in the research model.This study breaks new ground by investigating the adoption of the eCNY,a novel form of currency,highlighting its multifaceted nature and providing empirical evidence for a comprehensive model encompassing psychological,social,and contextual factors.This study employs social surveys to identify obstacles in the process of promoting the widespread adoption of the eCNY and offers suggestions to the central bank and government to increase user enthusiasm and decrease user perceptions of risk,thereby promoting its widespread adoption.展开更多
According to a BBC report,2016 marked the year when virtual reality(VR)transitioned from concept to reality1.VR has emerged in various fields and is highly effective in many ways.The implementation of VR technology in...According to a BBC report,2016 marked the year when virtual reality(VR)transitioned from concept to reality1.VR has emerged in various fields and is highly effective in many ways.The implementation of VR technology in teaching and learning has gradually become popular.Through the 3D realistic learning environment,learners are immersed in the virtual environment.Language education needs to create an immersive English learning environment and atmosphere.Therefore,in order to understand the substantial benefits of integrating VR into English language acquisition,this research will adopt the VR teaching materials to Freshman English Courses.For students who will participate in the use of VR technology to learn English,the pre-test,post-test,and surveys will be analyzed.Through the analysis of questionnaire data,explore whether the VR model is effective in enhancing learning interest and motivation,and evaluate the effectiveness of enhancing language ability learning.This research is based on the Technology Acceptance Model,using Pivot Report and SPSS software to analyze the results of the tests.Pearson correlation coefficient analysis will be also adopted to explore the three aspects of the usage of VR:(a)Does VR really work for enhancing learning motivation and interest?;(b)To explore the feasibility of VR in the educational field analyzed by the Technology Acceptance Model(TAM,Technology Acceptance Model);and(c)Learning effectiveness of the participants.The results of this research will provide references for language teachers who would like to implement innovative teaching,enrich teaching materials,and enhance learning effectiveness.展开更多
文摘Antibody-mediated rejection(AMR)remains a leading cause of kidney allograft failure,posing significant clinical and economic challenges.Donor-specific antibodies against human leukocyte antigens or non-human leukocyte antigens are critical risk factors for AMR and graft loss.The diagnostic criteria and classification of AMR have evolved considerably over the past three decades,driven largely by the Banff classification.The latest Banff 2022 classification introduced two additional subcategories of“microvascular inflammation,donor-specific antibody-negative,C4d-negative”and“probable AMR”.Traditionally,graft monitoring has relied on non-specific markers such as serum creatinine and proteinuria,and the invasive biopsies.Noninvasive tools using blood and urine biomarkers,including cellular assays and molecular profiling,are increasingly being investigated.Technologies such as the Molecular Microscope Diagnostic System show promise,with studies reporting 80%sensitivity and 90%specificity in detecting AMR.Treatment of AMR remains inconsistent.Recent advances,including CD38 antibodies,have demonstrated up to 60%efficacy in reversing AMR,while complement inhibition shows potential in severe early cases.Ongoing clinical trials evaluating high-dose intravenous immunoglobulin,efgartigimod,fostamatinib,and other novel therapies aim to expand treatment options.These developments highlight the need for well-designed clinical trials to validate biomarkers and therapies and to improve long-term outcomes for kidney transplant recipients.
文摘Post-kidney transplant rejection is a critical factor influencing transplant success rates and the survival of transplanted organs.With the rapid advancement of artificial intelligence technologies,machine learning(ML)has emerged as a powerful data analysis tool,widely applied in the prediction,diagnosis,and mechanistic study of kidney transplant rejection.This mini-review systematically summarizes the recent applications of ML techniques in post-kidney transplant rejection,covering areas such as the construction of predictive models,identification of biomarkers,analysis of pathological images,assessment of immune cell infiltration,and formulation of personalized treatment strategies.By integrating multi-omics data and clinical information,ML has significantly enhanced the accuracy of early rejection diagnosis and the capability for prognostic evaluation,driving the development of precision medicine in the field of kidney transplantation.Furthermore,this article discusses the challenges faced in existing research and potential future directions,providing a theoretical basis and technical references for related studies.
文摘The evaluation of the immunosuppression state in liver transplanted patients is crucial for a correct posttransplant management and a major step towards the personalisation of the immunosuppressive therapy. However, current immunological monitoring after liver transplantation relies mainly on clinical judgment and on immunosuppressive drug levels, without a proper assessment of the real suppression of theimmunological system. Various markers have been studied in an attempt to identify a specific indicator of graft rejection and graft acceptance after liver transplantation. Considering acute rejection, the most studied markers are pro-inflammatory and immunoregulatory cytokines and other proteins related to inflammation. However there is considerable overlap with other conditions, and only few of them have been validated. Standard liver tests cannot be used as markers of graft rejection due to their low sensitivity and specificity and the weak correlation with the severity of histopathological findings. Several studies have been performed to identify biomarkers of tolerance in liver transplanted patients. Most of them are based on the analysis of peripheral blood samples and on the use of transcriptional profiling techniques. Amongst these, NK cell-related molecules seem to be the most valid marker of graft acceptance, whereas the role CD4+CD25+Foxp3+ T cells has still to be properly defined.
文摘Metropolis-Hastings algorithms are slowed down by the computation of complex target distributions. To solve this problem, one can use the delayed acceptance Metropolis-Hastings algorithm (MHDA) of Christen and Fox (2005). However, the acceptance rate of a proposed value will always be less than in the standard Metropolis-Hastings. We can fix this problem by using the Metropolis-Hastings algorithm with delayed rejection (MHDR) proposed by Tierney and Mira (1999). In this paper, we combine the ideas of MHDA and MHDR to propose a new MH algorithm, named the Metropolis-Hastings algorithm with delayed acceptance and rejection (MHDAR). The new algorithm reduces the computational cost by division of the prior or likelihood functions and increase the acceptance probability by delay rejection of the second stage. We illustrate those accelerating features by a realistic example.
基金supported by the National Key R&D Program of China(No.2021YFB2011300)the Special Funds Project for the Transformation of Scientific and Technological Achievements of Jiangsu Province,China(No.BA2023039)+1 种基金the National Natural Science Foundation of China(No.52075262)the Fundamental Research Funds for the Central Universities,China(No.30922010706).
文摘The output feedback active disturbance rejection control of a valve-controlled cylinder electro-hydraulic servo system is investigated in this paper.First,a comprehensive nonlinear mathematical model that encompasses both matched and mismatched disturbances is formulated.Due to the fact that only position information can be measured,a linear Extended State Observer(ESO)is introduced to estimate unknown states and matched disturbances,while a dedicated disturbance observer is constructed to estimate mismatched disturbances.Different from the traditional observer results,the design of the disturbance observer used in this study is carried out under the constraint of output feedback.Furthermore,an output feedback nonlinear controller is proposed leveraging the aforementioned observers to achieve accurate trajectory tracking.To mitigate the inherent differential explosion problem of the traditional backstepping framework,a finite-time stable command filter is incorporated.Simultaneously,considering transient filtering errors,a set of error compensation signals are designed to counter their negative impact effectively.Theoretical analysis affirms that the proposed control strategy ensures the boundedness of all signals within the closed-loop system.Additionally,under the specific condition of only time-invariant disturbances in the system,the conclusion of asymptotic stability is established.Finally,the algorithm’s efficacy is validated through comparative experiments.
基金supported by the National Natural Science Foundation of China(Nos.52177059 and 52407064).
文摘Permanent magnet synchronous motor based electro-mechanical actuation servo drives have widespread applications in the aviation field,such as unmanned aerial vehicle electric servos,electric cabin doors,and mechanical arms.The performance of the servo drive,which encompasses the response to the torque,efficiency,control bandwidth and the steady-state positioning accuracy,significantly influences the performance of the aviation actuation.Consequently,enhancing the control bandwidth and refining the positioning accuracy of aviation electro-mechanical actuation servo drives have emerged as a focal point of research.This paper investigates the multi-source disturbances present in aviation electro-mechanical actuation servo systems and summarizes recent research on high-performance servo control methods based on active disturbance rejection control(ADRC).We present a comprehensive overview of the research status pertaining to servo control architecture,strategies for suppressing disturbances in the current loop,and ADRC-based strategies for the position loop.We delineate the research challenges and difficulties encountered by aviation electro-mechanical actuation servo drive control technology.
文摘1 I Like Me follows a cheerful and confident little pig who celebrates everything about herself.From her curly tail to her big feet,she loves every part of herself.In the book,I remember that the pig enthusiastically declares that no matter what she does,even if she's making mistakes,being silly or being a clumsy rookie(笨拙的新手)of trying something new,she will always like herself.
文摘The study of Mecanum mobile robots typically assumes motion on planar surfaces,while the challenges posed by inclined terrains remain largely unexplored,leaving a significant gap in control applications for such scenarios.In this context,two critical issues emerge:the gravitational pull caused by adding a potential energy term in the robot dynamics,which drives the vehicle downhill,and several positioning errors due to vibrations and slippage of the Mecanum wheel.To address these challenges,this work presents an Active Disturbance Rejection Control(ADRC)-based framework designed to enable accurate tracking on inclined surfaces,despite the compounded effects of gravitational forces and slippage.Unlike conventional controllers,the proposed method requires minimal model knowledge while actively compensates for unknown dynamics and external disturbances in real time.A complete theoretical formulation is provided,supported by numerical simulations and comprehensive experimental validation.Results demonstrate that the ADRC structure significantly outperforms not only the traditional proportional-integral-derivative(PID)control but also a robust variant of PID combined with a Quasi-Sliding Mode control(PID-QSMC)strategy,achieving superior tracking.Notably,this study offers an important experimental validation of ADRC for Mecanum-wheeled robots operating on inclined surfaces.It contributes a practical and scalable solution to extend their operational capabilities beyond flat environments.
文摘Antibody-mediated rejection(AMR)represents a major challenge in kidney transplantation,significantly contributing to tissue injury and graft failure.AMR is primarily driven by donor-specific alloantibodies(DSAs),which recognize and bind to specific target antigens present within the transplanted kidney tissue.Upon binding,these DSAs commonly initiate activation of the complement system within the graft.The activation of the complement cascade sets off a powerful inflammatory response characterized by the recruitment and activation of immune cells,endothelial damage,and subsequent tissue injury.This inflammation underlies many clinical and histological manifestations of AMR,making complement activation a critical player in the disease process.Advancements in our understanding of how complement pathways contribute to kidney graft injury have opened new avenues for therapeutic intervention.Recent research has facilitated the development and application of novel therapies specifically designed to inhibit complement activation.Such targeted complement-inhibitory strategies have shown promise in improving graft outcomes by inhibiting complement-mediated damage and extending graft survival.This review comprehensively discusses the critical role of complement activation in inducing kidney graft injury with a focus on its role in AMR.By elucidating the detailed mechanisms and contributions of complement pathways,the review seeks to enhance the understanding necessary for developing targeted therapeutic interventions to prevent or treat AMR effectively.
基金Supported by the National Natural Science Foundation of China,No.82100691China Postdoctoral Science Foundation,No.2021M693631.
文摘Organ transplantation has long been recognized as an effective treatment for endstage organ failure,metabolic diseases,and malignant tumors.However,graft rejection caused by major histocompatibility complex mismatch remains a significant challenge.While modern immunosuppressants have made significant strides in reducing the incidence and risk of rejection,they have not been able to eliminate it completely.The intricate mechanisms underlying transplant rejection have been the subject of intense investigation by transplant immunologists.Among these factors,autophagy has emerged as a key player.Autophagy is an evolutionarily conserved mechanism in eukaryotic cells that mediates autophagocytosis and cellular protection.This process is regulated by autophagy-related genes and their encoded protein families,which maintain the material and energetic balance within cells.Additionally,autophagy has been reported to play crucial roles in the development,maturation,differentiation,and responses of immune cells.In the complex immune environment following transplantation,the role and mechanisms of autophagy are gradually being revealed.In this review,we aim to explore the current understanding of the role of autophagy in solid organ rejection after transplantation.Furthermore,we delve into the therapeutic advancements achieved by targeting autophagy involved in the rejection process.
文摘BACKGROUND The Luminex platform,where beads are coated with single human leukocyte antigens(HLA),detects HLA antibodies with higher sensitivity and specificity compared to complement-dependent cytotoxicity(CDC)assay and flow crossmatch(FCXM).The clinical significance of donor-specific antibodies(DSAs)detected by this method is still under investigation.AIM To report the impact of low-level pretransplant DSAs detected by the Luminex platform on the rates of acute rejection(AR),allograft function,and long-term graft survival.METHODS This retrospective study was conducted at the Immunology Department of Sindh Institute of Urology and Transplantation,Karachi,Pakistan between January 2013 and December 2022.During this period 2714 patients were transplanted.Out of these patients 78(2.9%)patients had low-level DSAs detected by the Luminex flow beads method and were negative by CDC and FCXM with their donors.All recipients received ABO-compatible live-related kidney transplants.All patients had a minimum follow-up of 1 year.Graft rejection rates,graft function,and patient and graft survival were analyzed.The estimated glomerular filtration rate was calculated by the full CKD-EPI formula.RESULTS The mean age of all recipients was 29.57±10.11 years and 34.53±9.09 years for the donors.In 48(61.5%)patients,the cause of end-stage kidney disease was unknown.DSA against HLA class I was detected in 36(46.1%)patients,class II in 35(44.8%)patients,and both class I and II in 7(8.9%)patients.AR episodes were encountered in 8(10.3%)cases.Seven(87.5%)had T cell mediated rejection(type IA)and one acute antibody-mediated rejection.Antibody status was re-evaluated at the time of biopsy-proven ARs.Five(62.5%)patients lost their DSAs,while three(37.5%)had persistent DSAs.The mean estimated glomerular filtration rate at 1 year was 80.56±27.48 mL/min/1.73 m2 and at the last follow-up 73.41±28.80 mL/min/1.73 m2.The 1-year and 10-year patient and graft survival rates were 99%and 79%and 95%and 75%,respectively.During the follow-up period,10(12.8%)patients died,8 patients had a functioning graft,and 2 patients had failed grafts.Eight patients died due to cardiopulmonary arrest,and two died due to sepsis with failed grafts.CONCLUSION Patients with pretransplant low-level DSAs on Luminex without CDC and FCXM reactivity had good allograft outcomes at 1 year and 10 years as long as they are induced with biological agents and given potent maintenance immunosuppressants.
基金supported by the National Natural Science Foundation of China(Nos.62273127 and 62073217)the Dreams Foundation of Jianghuai Advance Technology Center(No.2023-ZM01J006)the Anhui Provincial Key Research and Development Project(No.2022a05020025).
文摘The output regulation approach has effectively addressed the speed tracking and disturbance rejection problem of permanent magnet synchronous motor(PMSM).Although accurate speed tracking under time-varying load torque disturbance has been achieved,the number of disturbance frequencies should be known.In this paper,an adaptive observer-based error feedback control method is proposed,which can solve the speed tracking control problem of PMSM subject to completely unknown multi-frequency sinusoidal load torque disturbance,requiring only the upper bound of the number of disturbance frequencies.The design steps of this method can be divided into the following three steps.In step one,a filtered transformation is applied to convert the observer canonical form of the error system and the transformed exosystem into an adaptive observer form.In step two,an adaptive observer is designed to estimate the unknown parameters of the exosystem and states of the adaptive observer form.In step three,an adaptive observer-based error feedback controller is designed to solve this control problem.The effectiveness of the proposed method is demonstrated by experimental results.
文摘The integration of Learning Management Systems(LMSs)into educational settings is becoming increasingly common,especially in the digital field.Understanding the factors influencing the acceptance and effective use of LMS is essential to ensure successful implementation.The Technology Acceptance Model(TAM)has been widely used to check user acceptance of various technologies,including LMS.This study conducted a systematic literature review(SLR)to analyze existing research on the application of TAM in the context of LMS.A comprehensive search of the academic database was conducted to identify relevant studies published in 2010-2025.The review synthesizes findings related to the core constructs of TAM—Perceived Usability,Perceived Ease of Use,Behavioral Intent,and Actual Use—as well as extended factors such as system quality,self-efficacy,and social influence.The results reveal circumstantial evidence supporting the predictive power of TAM in LMS adoption,while also highlighting emerging trends and gaps in the literature.This review contributes to a deeper understanding of user acceptance in a digital learning environment and provides recommendations for future research and practical LMS implementation strategies.
基金The 2025 Guizhou University of Finance and Economics University-level Project“Research on the‘Action-Learning’Strategy of Artificial Intelligence in Complex Tasks”(Project No.:2025BAZYSY287)。
文摘The Master Intelligent interview is based on the Stimulus-Organism-Response(SOR)theory,this study integrates key constructs from the Technology Acceptance Model(TAM)and the Theory of Planned Behavior(TPB),namely attitude and behavioral intention,to develop a dual-path model of how AI empowerment influences college graduates’acceptance of intelligent interview technology.Taking AI empowerment as the independent variable,perceived risk and attitude as mediating variables,and behavioral intention as the outcome variable,the study employs questionnaire surveys and structural equation modeling(SEM)for empirical analysis.The results show that AI empowerment exerts a significant positive impact on attitude,perceived risk,and behavioral intention.Both perceived risk and attitude play significant mediating roles between AI empowerment and behavioral intention.Interestingly,perceived risk does not suppress behavioral intention;instead,it positively promotes it through a“rational trade-off”mechanism.Moreover,perceived risk and attitude form a significant chain-mediated pathway,revealing a continuous psychological transmission mechanism of“rational cognition-emotional adjustment-behavioral decision-making”.This study enriches the theoretical framework of AI technology acceptance,extends the application of the SOR model to the context of intelligent recruitment,and provides valuable implications for optimizing university career guidance and enterprise recruitment systems.
文摘BACKGROUND Malabsorptive bariatric surgery,including Roux-en-Y gastric bypass and duodenal switch,are known to be more metabolically effective than restrictive surgery.However,the permanent alteration of gastrointestinal anatomy from these operations has been shown to alter the kinetics of drug absorption and may make subsequent surgeries more technically challenging.AIM To evaluate perioperative liver transplant outcomes and rates of acute cellular rejection in recipients with prior malabsorptive bariatric surgery.METHODS Patients who underwent liver transplantation at a single institution between 2005-2024 with a history of malabsorptive bariatric surgery were identified.Matched controls were selected based on age,sex,listing model for end-stage liver disease(MELD),and primary liver diagnosis.RESULTS A total of 12 liver transplant patients with prior malabsorptive surgery and 25 controls were included.The mean age in the malabsorptive group was 50.5 years at the time of transplant and 92%were female.The mean MELD at the time of transplant was 27.6 and mean body mass index was 28.There were no significant differences in length of stay,post operative complications,or 1 year survival between the controls and malabsorptive patients.However,the malabsorptive group was significantly more likely to experience biopsy-proven and clinically treated acute cellular rejection than the controls(24%vs 66.7%,P=0.012),more frequent rejection episodes(0.28±0.53 vs 1.0±0.91,P=0.006),and earlier time to first rejection episode(P=0.002).CONCLUSION Previous malabsorptive bariatric surgery in liver transplant recipients did not increase the risk of perioperative complications or mortality but significantly increased the rate and frequency of acute cellular rejection.
基金funded by the Education and Teaching Reform Research Major Project of Anhui Province(2022xqhz023)(2023sx170).
文摘Objectives:College students face increasing mental health challenges.Although Acceptance and CommitmentTherapy(ACT)is effective,the efficacy of Internet-based ACT(iACT)needs further exploration.Methods:This study examines the efficacy of iACT on college students’mental health through a randomized controlled trial.We recruited 90 college students(19.16±1.02 years old)and randomly divided them into the iACT group,face-to-face ACT group,and control group.The effects of the interventions were evaluated using the comprehensive assessment of ACT processes(CompACT)and the Depression Anxiety Stress Scales(DASS-21).Results:Two-factor repeated measures ANOVA revealed a significant time main effect of iACT.Face-to-face ACT and iACT effectively improved college students’psychological flexibility[F(2,83)=18.78,p<0.001,η^(2)=0.18]and alleviated their negative emotions[F(2,82)=41.17,p<0.001,η^(2)=0.36].Face-to-face ACT exhibited sustained effects on improving participants’psychological flexibility and alleviating their negative emotions(p<0.001),while iACT showed no sustained effect on improving participants’psychological flexibility(p>0.05).Conclusion:While iACT and face-to-face ACT are effective shortterm interventions,face-to-face ACT demonstrates superior sustainability.Integrating guided sessions into iACT may enhance long-term outcomes.These findings advocate for blended interventions to address college students’mental health needs,particularly in resource-limited settings.
文摘BACKGROUND The pathophysiology behind gastroesophageal reflux disease and its association with poor outcomes after lung transplantation is incompletely understood.The physiologic impact of lung transplantation on pulmonary function,intrathoracic pressures,and vagal innervation may affect esophageal motility,bolus clearance and reflux risk.However,the effect of changes in esophageal function after lung transplantation on the risk of poor post-transplant outcomes remains unclear.AIM To evaluate the association between change in esophageal motility pre-/post-lung transplantation and rejection outcome.METHODS This was a retrospective cohort study of lung transplant recipients who underwent both pre-and post-transplant esophageal testing including high resolution manometry(HRM)at a tertiary center.Acute cellular rejection(ACR)was defined histologically per International Society for Heart and Lung Transplantation criteria.Univariate analyses were performed using student’s t-test,χ2 test,and Spearman’s correlation where appropriate.Multivariable time-to-event analysis using Cox proportional hazards model was applied.Subjects not meeting ACR outcome were censored at death or date of last clinic visit.RESULTS 55 subjects(65%men,mean age:61,median follow-up:840 days)were included,with 17 (31%) experiencing ACR. Increase in failed swallows correlated with lower baseline total lung capacity(TLC) (R = -0.32, P = 0.05) and decreased post-transplant esophageal bolus clearance (R = -0.45, P = 0.004). Onmultivariable analysis, post-transplant hypomotility independently predicted increased ACR (HR: 3.62, 95%CI:1.11-11.8;P = 0.03). Kaplan-Meier analysis demonstrated increased ACR for subjects with increased vs unchangedfailed swallows post-transplant (P = 0.048). On Cox regression, a 20% elevated risk of ACR was found for every10% increase in failed swallows, after controlling for confounders including reflux severityCONCLUSIONEsophageal hypomotility, specifically an increase in failed swallows on HRM, from pre- to post-lungtransplantation was independently associated with ACR. Additionally, lower baseline TLC correlated with increasein failed swallows, suggesting restrictive lung disease may be associated with post-transplant esophagealhypomotility. Lung transplantation may affect esophageal function and contribute to rejection outcomes. Routineesophageal function testing may help identify patients at higher risk for poor lung transplantation outcomes.
基金supported partially by the National Natural Science Foundation(No.62473344)the T-Flight Laboratory in ShanXi Provincial(No.GSFC2024NBKY05)+1 种基金the Natural Science Basic Research Program of Shaanxi(No.2025JC-YBQN-035)the National Natural Science Foundation of China(Grant No.92471204).
文摘With the growing adoption of artificial intelligence algorithms and neural networks,online learning and adaptive methods for updating the bandwidth have become increasingly prevalent.However,the conditions required to ensure closed-loop stability when employing a time-varying bandwidth,as well as the supporting mathematical foundations,remain insufficiently studied.This paper investigates the stability condition for active disturbance rejection control(ADRC)with a time-varying bandwidth extended state observer(ESO).A new stability condition is derived,which means that the upper bound of rate of change for ESO bandwidth should be restricted.Moreover,under the proposed condition,the closed-loop stability of ADRC with a time-varying bandwidth observer is rigorously proved for nonlinear uncertainties.In simulations,the necessity of the proposed condition is illustrated,demonstrating that the rate of change of ESO bandwidth is crucial for closed-loop stability.
基金funded by Jiangsu Education Department(Ref.No.2022SJYB0750).
文摘The introduction of the digital renminbi(eCNY)by the People’s Bank of China serves as a means for the central bank to effectively comprehend macroeconomic dynamics and enhance payment infrastructure within the domestic market.Among the pioneering digital currencies,the eCNY is at the forefront of technological research and development,pilot implementation,and the establishment of a robust system.Thus,employing the unified theory of acceptance and use of technology,this study aims to explore the factors shaping the adoption of the eCNY and to determine the mediating effects of intention toward the eCNY and the moderating role of age and gender among various relationships.A cross-sectional survey methodology was deployed to collect data from pilot communities situated within the Yangtze River Delta,Pearl River Delta,and Beijing–Tianjin–Hebei regions.The empirical analysis comprised 809 valid online questionnaires,and the examination was conducted through structural equation modeling employing the partial least squares technique,ultimately subjecting the conceptual model to a comprehensive assessment.The results for intention to use the eCNY indicate that performance expectancy,effort expectancy,social influence,and perceived government policy have significant effects.Facilitating conditions and intentions toward the eCNY positively influenced its actual use.According to the findings of this study,age and sex did not moderate the effect of each hypothesis on the intention to use in the research model.This study breaks new ground by investigating the adoption of the eCNY,a novel form of currency,highlighting its multifaceted nature and providing empirical evidence for a comprehensive model encompassing psychological,social,and contextual factors.This study employs social surveys to identify obstacles in the process of promoting the widespread adoption of the eCNY and offers suggestions to the central bank and government to increase user enthusiasm and decrease user perceptions of risk,thereby promoting its widespread adoption.
文摘According to a BBC report,2016 marked the year when virtual reality(VR)transitioned from concept to reality1.VR has emerged in various fields and is highly effective in many ways.The implementation of VR technology in teaching and learning has gradually become popular.Through the 3D realistic learning environment,learners are immersed in the virtual environment.Language education needs to create an immersive English learning environment and atmosphere.Therefore,in order to understand the substantial benefits of integrating VR into English language acquisition,this research will adopt the VR teaching materials to Freshman English Courses.For students who will participate in the use of VR technology to learn English,the pre-test,post-test,and surveys will be analyzed.Through the analysis of questionnaire data,explore whether the VR model is effective in enhancing learning interest and motivation,and evaluate the effectiveness of enhancing language ability learning.This research is based on the Technology Acceptance Model,using Pivot Report and SPSS software to analyze the results of the tests.Pearson correlation coefficient analysis will be also adopted to explore the three aspects of the usage of VR:(a)Does VR really work for enhancing learning motivation and interest?;(b)To explore the feasibility of VR in the educational field analyzed by the Technology Acceptance Model(TAM,Technology Acceptance Model);and(c)Learning effectiveness of the participants.The results of this research will provide references for language teachers who would like to implement innovative teaching,enrich teaching materials,and enhance learning effectiveness.
