Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon(RAP).Despite its therapeutic effects,the surgical risk and unclear mechanism hamper th...Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon(RAP).Despite its therapeutic effects,the surgical risk and unclear mechanism hamper the clinical application.Numerous evidences support macrophages as the key immune cells during bone remodeling.Our study discovered that the monocyte-derived macrophages primarily exhibited a pro-inflammatory phenotype that dominated bone remodeling in corticotomy by CX3CR1CreERT2;R26GFP lineage tracing system.Fluorescence staining,flow cytometry analysis,and western blot determined the significantly enhanced expression of binding immunoglobulin protein(BiP)and emphasized the activation of sensor activating transcription factor 6(ATF6)in macrophages.Then,we verified that macrophage specific ATF6 deletion(ATF6f/f;CX3CR1CreERT2 mice)decreased the proportion of pro-inflammatory macrophages and therefore blocked the acceleration effect of corticotomy.In contrast,macrophage ATF6 overexpression exaggerated the acceleration of orthodontic tooth movement.In vitro experiments also proved that higher proportion of pro-inflammatory macrophages was positively correlated with higher expression of ATF6.At the mechanism level,RNA-seq and CUT&Tag analysis demonstrated that ATF6 modulated the macrophage-orchestrated inflammation through interacting with Tnfαpromotor and augmenting its transcription.Additionally,molecular docking simulation and dual-luciferase reporter system indicated the possible binding sites outside of the traditional endoplasmic reticulum-stress response element(ERSE).Taken together,ATF6 may aggravate orthodontic bone remodeling by promoting Tnfαtranscription in macrophages,suggesting that ATF6 may represent a promising therapeutic target for non-invasive accelerated orthodontics.展开更多
The Opinions on Acceleration of Implementation of Free Trade Zone Strategy,which was issued by the State Council in the end of 2015,clearly proposed the establishment of high standard global FTA(free trade zone)networ...The Opinions on Acceleration of Implementation of Free Trade Zone Strategy,which was issued by the State Council in the end of 2015,clearly proposed the establishment of high standard global FTA(free trade zone)network that is based on surrounding countries regions and covers the'Belt and Road'region.As of now,China has signed 14 FTA agreements with 22 countries and regions,including ASEAN(Association of Southeast展开更多
The results from a recent s tudy show that in the past five years,the transfer of rural labourers from agri-cultural work to non-agricultural sectors has accelerated and some 50 million rural labourers have made the s...The results from a recent s tudy show that in the past five years,the transfer of rural labourers from agri-cultural work to non-agricultural sectors has accelerated and some 50 million rural labourers have made the switch.This figure was produced by the State Statistical Bureau(SSB)based on data from Chind s 1%popu-1ation sample survey and annual popu-lation statistics.展开更多
Scientific progress has greatly improved the technical level of China’s highway and waterway transport in the past ten years. In order to modernize communications and transport and raise competitive power of enterpri...Scientific progress has greatly improved the technical level of China’s highway and waterway transport in the past ten years. In order to modernize communications and transport and raise competitive power of enterprises as early as possible, the Ministry of Communications has decided to add more scientific investment, planning to double the annual expense on scientific investment during the Ninth Five-year Plan period compared to the Eighth Five-year展开更多
Background Cellular repressor of ElA-stimulated genes(CREG) is homeostatic modulated gene,which regulate a number of cellular processes,including cell differentiation, motility and survival.Previous studies have demon...Background Cellular repressor of ElA-stimulated genes(CREG) is homeostatic modulated gene,which regulate a number of cellular processes,including cell differentiation, motility and survival.Previous studies have demonstrated that CREG was expressed in all three germ layers,suggesting that it might act as a vital regulator during embryonic developing.The aim of the present study was to investigate the role of CREG in an embryonic stem cell(ESC) differentiation model that recapitulates the developmental steps of vasculogenesis.Methods The ES cells were stably transfected either pCXN2-FLAG-CREG-IRES-EGFP plasmid or pDS1- shRNA-CREG plasmid to produce the CREG+/ES cells and CREG-siRNA/ES cells,respectively.Vasculogenesis was detected by whole mount immunostainings for CD31.Dil labeled acLDL staining assay was used to detect branching pseudopods in cultures in Matrigel.Real-time PCR and Western blot analysis were employed to determine expressions of VEGF and Flk-1.Results CREG +/ES-derived embryoid bodies(EBs) were found to form spontaneously a primitive vascular network after 6 days of differentiation.In contrast, wildtype EBs exhibit theirs vasculogenesis until 13 days of differentiation by whole mount immunostainings for CD31. CREG +/EBs developed more rapidly branching pseudopods at 9 days compared with that of wildtype EBs by Dil labeled acLDL staining assay.In contrast,CREG-siRNA/ES exhibits an undifferentiated morphogenesis associated with an increase in apoptotic cells in spite of being derived from LIF and feeder layers.Administration of CREG-siRNA/ES cells with recombinant CREG protein rescued the phenomena that CREG boosted vasculogenesis in a dose-dependent fasion. Mechanically,Real-time PCR and Western blot analysis revealed the expressions both VEGF and Flk-1 significantly in- creased in CREG+/EBs.Moreover,after treatment of CREG+ /EBs with neurtralizing antibody against VEGF,the rapid vasculogenesis was significantly repressed.Conclusions Our data strongely demonstrate that CREG play a pivotal role in accelerating vasculogenesis in development of ES cells. VEGF,as its important downstream effector,mediated this bio-function.展开更多
Scientific progress has greatly improved the technical level of China’shighway and waterway transport in the past decade.In order tomodernize communications and transport and raise competitivepower of enterprises as ...Scientific progress has greatly improved the technical level of China’shighway and waterway transport in the past decade.In order tomodernize communications and transport and raise competitivepower of enterprises as early as possible,the Ministry of Communicationshas decided to add more scientific investment,planning to double theannual expense on scientific investment during the Ninth Five-yearPlan period compared to the Eighth Five-year Plan period.Theministry will also conduct cooperative research,development,designand production with foreign scientific institutions and internationalorganizations.展开更多
A cosmological model with both acceleration and deceleration is proposed, rewriting and reinterpreting Einstein＇s Field Equations, with a variable cosmological parameter A denoting energy due to space-time, which may...A cosmological model with both acceleration and deceleration is proposed, rewriting and reinterpreting Einstein＇s Field Equations, with a variable cosmological parameter A denoting energy due to space-time, which may be considered as ＂vacuum energy＂ at the ＂beginning＂ of the universe. The cosmological constant is replaced by a variable cosmological parameter, which is a measure of the energy of space-time that could be converted to energy of matter and radiation and vice versa.展开更多
The rapid expansion of lake area in the Tibetan Plateau(TP)has attracted a considerable amount of concern in recent decades.Limited evidence has suggested that climate warming and the cryosphere change are the most pr...The rapid expansion of lake area in the Tibetan Plateau(TP)has attracted a considerable amount of concern in recent decades.Limited evidence has suggested that climate warming and the cryosphere change are the most prominent contributors to lake expansion.The widespread changes in lake area result from a combination of increased precipitation,melting glaciers,permafrost degradation,and changes in other components of terrestrial water.However,debate remains as to whether melting glaciers or increased precipitation have a greater impact on lake expansion.Varied topography and limited datasets hinder the ability to perform extensive research,and there is currently no definitive conclusion on the issue.展开更多
China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have alwa...China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.展开更多
From May to July, an American-style Texas barbecue will be jointly held by Unilever and Huajiayiyuan Restaurant at SOHO Shangdu, located at the center of Beijing’s Central Business District.
With the support by the National Natural Science Foundation of China and the'Strategic Priority Research Program'of the Chinese Academy of Sciences,a collaborative study by the research groups led by Professor...With the support by the National Natural Science Foundation of China and the'Strategic Priority Research Program'of the Chinese Academy of Sciences,a collaborative study by the research groups led by Professors Tian Zhixi(田志喜),Wang Guodong(王国栋),and Zhu Baoge(朱保葛)from the展开更多
Zhongjin Lingnan’s main business is mining,smelting and sales of non-ferrous metals such as lead,zinc,copper and silver.In its nonpublic offering scheme released earlier,a total of about 658 million yuan,including 46...Zhongjin Lingnan’s main business is mining,smelting and sales of non-ferrous metals such as lead,zinc,copper and silver.In its nonpublic offering scheme released earlier,a total of about 658 million yuan,including 460million yuan of raised funds will be invested in a new materials project.The construction projects include a high-performance展开更多
Chengtun Mining recently released its financial report,recording a rapid growth in both operating income and net profit.In 2016,the company achieved operating income of RMB 12.710 billion,up by 90.78%year-on-year,
Recent information about Jinwang Bismuth Industrial reveals that the company has developed the world’s first oxygen-rich sideblown redox duplex furnace technology,solving the long-standing problems of environmental p...Recent information about Jinwang Bismuth Industrial reveals that the company has developed the world’s first oxygen-rich sideblown redox duplex furnace technology,solving the long-standing problems of environmental protection and resource recycling in bismuth smelting.It’s learned that the company recovers up to100,000 tons of bismuth-containing lead-展开更多
On June 27,China(Qinghai)Lithium Industry and Power Battery International Summit Forum2018 was officially held in Xining,Qinghai.Wang Liming,vice-governor of Qinghai,noted at the forum that Qinghai boasts advantaged s...On June 27,China(Qinghai)Lithium Industry and Power Battery International Summit Forum2018 was officially held in Xining,Qinghai.Wang Liming,vice-governor of Qinghai,noted at the forum that Qinghai boasts advantaged salt lake resources,the proved lithium resources reserve here accounts for over 1/3 of the global resources reserve and over展开更多
基金supported by the National Natural Science Foundation of China(82071143,82371000,82270361)Key Research and Development Program of Jiangsu Province(BE2022795)+2 种基金the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_1801)the Jiangsu Province Capability Improvement Project through the Science,Technology and Education-Jiangsu Provincial Research Hospital Cultivation Unit(YJXYYJSDW4)Jiangsu Provincial Medical Innovation Center(CXZX202227).
文摘Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon(RAP).Despite its therapeutic effects,the surgical risk and unclear mechanism hamper the clinical application.Numerous evidences support macrophages as the key immune cells during bone remodeling.Our study discovered that the monocyte-derived macrophages primarily exhibited a pro-inflammatory phenotype that dominated bone remodeling in corticotomy by CX3CR1CreERT2;R26GFP lineage tracing system.Fluorescence staining,flow cytometry analysis,and western blot determined the significantly enhanced expression of binding immunoglobulin protein(BiP)and emphasized the activation of sensor activating transcription factor 6(ATF6)in macrophages.Then,we verified that macrophage specific ATF6 deletion(ATF6f/f;CX3CR1CreERT2 mice)decreased the proportion of pro-inflammatory macrophages and therefore blocked the acceleration effect of corticotomy.In contrast,macrophage ATF6 overexpression exaggerated the acceleration of orthodontic tooth movement.In vitro experiments also proved that higher proportion of pro-inflammatory macrophages was positively correlated with higher expression of ATF6.At the mechanism level,RNA-seq and CUT&Tag analysis demonstrated that ATF6 modulated the macrophage-orchestrated inflammation through interacting with Tnfαpromotor and augmenting its transcription.Additionally,molecular docking simulation and dual-luciferase reporter system indicated the possible binding sites outside of the traditional endoplasmic reticulum-stress response element(ERSE).Taken together,ATF6 may aggravate orthodontic bone remodeling by promoting Tnfαtranscription in macrophages,suggesting that ATF6 may represent a promising therapeutic target for non-invasive accelerated orthodontics.
文摘The Opinions on Acceleration of Implementation of Free Trade Zone Strategy,which was issued by the State Council in the end of 2015,clearly proposed the establishment of high standard global FTA(free trade zone)network that is based on surrounding countries regions and covers the'Belt and Road'region.As of now,China has signed 14 FTA agreements with 22 countries and regions,including ASEAN(Association of Southeast
文摘The results from a recent s tudy show that in the past five years,the transfer of rural labourers from agri-cultural work to non-agricultural sectors has accelerated and some 50 million rural labourers have made the switch.This figure was produced by the State Statistical Bureau(SSB)based on data from Chind s 1%popu-1ation sample survey and annual popu-lation statistics.
文摘Scientific progress has greatly improved the technical level of China’s highway and waterway transport in the past ten years. In order to modernize communications and transport and raise competitive power of enterprises as early as possible, the Ministry of Communications has decided to add more scientific investment, planning to double the annual expense on scientific investment during the Ninth Five-year Plan period compared to the Eighth Five-year
文摘Background Cellular repressor of ElA-stimulated genes(CREG) is homeostatic modulated gene,which regulate a number of cellular processes,including cell differentiation, motility and survival.Previous studies have demonstrated that CREG was expressed in all three germ layers,suggesting that it might act as a vital regulator during embryonic developing.The aim of the present study was to investigate the role of CREG in an embryonic stem cell(ESC) differentiation model that recapitulates the developmental steps of vasculogenesis.Methods The ES cells were stably transfected either pCXN2-FLAG-CREG-IRES-EGFP plasmid or pDS1- shRNA-CREG plasmid to produce the CREG+/ES cells and CREG-siRNA/ES cells,respectively.Vasculogenesis was detected by whole mount immunostainings for CD31.Dil labeled acLDL staining assay was used to detect branching pseudopods in cultures in Matrigel.Real-time PCR and Western blot analysis were employed to determine expressions of VEGF and Flk-1.Results CREG +/ES-derived embryoid bodies(EBs) were found to form spontaneously a primitive vascular network after 6 days of differentiation.In contrast, wildtype EBs exhibit theirs vasculogenesis until 13 days of differentiation by whole mount immunostainings for CD31. CREG +/EBs developed more rapidly branching pseudopods at 9 days compared with that of wildtype EBs by Dil labeled acLDL staining assay.In contrast,CREG-siRNA/ES exhibits an undifferentiated morphogenesis associated with an increase in apoptotic cells in spite of being derived from LIF and feeder layers.Administration of CREG-siRNA/ES cells with recombinant CREG protein rescued the phenomena that CREG boosted vasculogenesis in a dose-dependent fasion. Mechanically,Real-time PCR and Western blot analysis revealed the expressions both VEGF and Flk-1 significantly in- creased in CREG+/EBs.Moreover,after treatment of CREG+ /EBs with neurtralizing antibody against VEGF,the rapid vasculogenesis was significantly repressed.Conclusions Our data strongely demonstrate that CREG play a pivotal role in accelerating vasculogenesis in development of ES cells. VEGF,as its important downstream effector,mediated this bio-function.
文摘Scientific progress has greatly improved the technical level of China’shighway and waterway transport in the past decade.In order tomodernize communications and transport and raise competitivepower of enterprises as early as possible,the Ministry of Communicationshas decided to add more scientific investment,planning to double theannual expense on scientific investment during the Ninth Five-yearPlan period compared to the Eighth Five-year Plan period.Theministry will also conduct cooperative research,development,designand production with foreign scientific institutions and internationalorganizations.
文摘A cosmological model with both acceleration and deceleration is proposed, rewriting and reinterpreting Einstein＇s Field Equations, with a variable cosmological parameter A denoting energy due to space-time, which may be considered as ＂vacuum energy＂ at the ＂beginning＂ of the universe. The cosmological constant is replaced by a variable cosmological parameter, which is a measure of the energy of space-time that could be converted to energy of matter and radiation and vice versa.
基金supported by the National Natural Science Foundation of China(41421004,41825010)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA19070201)+1 种基金the Open Program of Joint Laboratory of Climate and Environment Change,Chengdu University of Information Technology(JLCEC201801)the CAS-PKU(Chinese Academy of Science-Peking University)Joint Research Program
文摘The rapid expansion of lake area in the Tibetan Plateau(TP)has attracted a considerable amount of concern in recent decades.Limited evidence has suggested that climate warming and the cryosphere change are the most prominent contributors to lake expansion.The widespread changes in lake area result from a combination of increased precipitation,melting glaciers,permafrost degradation,and changes in other components of terrestrial water.However,debate remains as to whether melting glaciers or increased precipitation have a greater impact on lake expansion.Varied topography and limited datasets hinder the ability to perform extensive research,and there is currently no definitive conclusion on the issue.
文摘China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.
文摘From May to July, an American-style Texas barbecue will be jointly held by Unilever and Huajiayiyuan Restaurant at SOHO Shangdu, located at the center of Beijing’s Central Business District.
文摘With the support by the National Natural Science Foundation of China and the'Strategic Priority Research Program'of the Chinese Academy of Sciences,a collaborative study by the research groups led by Professors Tian Zhixi(田志喜),Wang Guodong(王国栋),and Zhu Baoge(朱保葛)from the
文摘Zhongjin Lingnan’s main business is mining,smelting and sales of non-ferrous metals such as lead,zinc,copper and silver.In its nonpublic offering scheme released earlier,a total of about 658 million yuan,including 460million yuan of raised funds will be invested in a new materials project.The construction projects include a high-performance
文摘Chengtun Mining recently released its financial report,recording a rapid growth in both operating income and net profit.In 2016,the company achieved operating income of RMB 12.710 billion,up by 90.78%year-on-year,
文摘Recent information about Jinwang Bismuth Industrial reveals that the company has developed the world’s first oxygen-rich sideblown redox duplex furnace technology,solving the long-standing problems of environmental protection and resource recycling in bismuth smelting.It’s learned that the company recovers up to100,000 tons of bismuth-containing lead-
文摘On June 27,China(Qinghai)Lithium Industry and Power Battery International Summit Forum2018 was officially held in Xining,Qinghai.Wang Liming,vice-governor of Qinghai,noted at the forum that Qinghai boasts advantaged salt lake resources,the proved lithium resources reserve here accounts for over 1/3 of the global resources reserve and over
