Heart failure(HF)represents a multifaceted clinical syndrome featured by cardiac structural or functional abnormalities secondary to diverse etiologies.Neurohormonal activation,including sympathetic nervous system(SNS...Heart failure(HF)represents a multifaceted clinical syndrome featured by cardiac structural or functional abnormalities secondary to diverse etiologies.Neurohormonal activation,including sympathetic nervous system(SNS)and the renin-angiotensin-aldosterone system(RAAS),is one of the most important mechanisms underlying the pathogenesis of HF.Since the 1990s,a growing number of experimental and clinical studies have shown that immunoinflammation makes an important contribution to the pathogenesis of HF.Recently,the immunoinflammation mechanisms of HF have been highlighted by clinical studies showing that interleukin(IL)-1β antagonists can prevent HF in patients with coronary heart disease(CHD)and acute ST-segment elevation myocardial infarction(STEMI).展开更多
基金The Noncommunicable Chronic Diseases—National Science and Technology Major Project(Nos.2025ZD0548400 and 2023ZD0504600)the National Key Research and Development Program(No.2022YFC2503501)+1 种基金Hubei Technology Innovation Project(No.2024BCB046)Key Research and Development Program of Wuhan(No.2024020702030092).
文摘Heart failure(HF)represents a multifaceted clinical syndrome featured by cardiac structural or functional abnormalities secondary to diverse etiologies.Neurohormonal activation,including sympathetic nervous system(SNS)and the renin-angiotensin-aldosterone system(RAAS),is one of the most important mechanisms underlying the pathogenesis of HF.Since the 1990s,a growing number of experimental and clinical studies have shown that immunoinflammation makes an important contribution to the pathogenesis of HF.Recently,the immunoinflammation mechanisms of HF have been highlighted by clinical studies showing that interleukin(IL)-1β antagonists can prevent HF in patients with coronary heart disease(CHD)and acute ST-segment elevation myocardial infarction(STEMI).
