针对数字视频IP核间高速流数据传输,设计并实现了一种基于AXI4-Stream总线的数字视频接口IP核,对外部输入ITU601格式的数字视频信号,将其格式转化为符合AXI4-Stream总线协议的信号,并通过IP核的主端口输出到下一级IP核的从端口。采用Xil...针对数字视频IP核间高速流数据传输,设计并实现了一种基于AXI4-Stream总线的数字视频接口IP核,对外部输入ITU601格式的数字视频信号,将其格式转化为符合AXI4-Stream总线协议的信号,并通过IP核的主端口输出到下一级IP核的从端口。采用Xilinx ISE Design Suite 14.6软件综合设计实现,结合ISE自带ISim软件完成功能仿真,通过实际硬件电路验证了设计的正确性及可行性。展开更多
Esculetin,a natural dihydroxy coumarin derived from the Chinese herbal medicine Cortex Fraxini,has demonstrated significant pharmacological activities,including anticancer properties.Ferroptosis,an iron-dependent form...Esculetin,a natural dihydroxy coumarin derived from the Chinese herbal medicine Cortex Fraxini,has demonstrated significant pharmacological activities,including anticancer properties.Ferroptosis,an iron-dependent form of regulated cell death,has garnered considerable attention due to its lethal effect on tumor cells.However,the exact role of ferroptosis in esculetin-mediated anti-hepatocellular carcinoma(HCC)effects remains poorly understood.This study investigated the impact of esculetin on HCC cells both in vitro and in vivo.The findings indicate that esculetin effectively inhibited the growth of HCC cells.Importantly,esculetin promoted the accumulation of intracellular Fe^(2+),leading to an increase in ROS production through the Fenton reaction.This event subsequently induced lipid peroxidation(LPO)and triggered ferroptosis within the HCC cells.The occurrence of ferroptosis was confirmed by the elevation of malondialdehyde(MDA)levels,the depletion of glutathione peroxidase(GSH-Px)activity,and the disruption of mitochondrial morphology.Notably,the inhibitor of ferroptosis,ferrostatin-1(Fer-1),attenuated the anti-tumor effect of esculetin in HCC cells.Furthermore,the findings revealed that esculetin inhibited the Nrf2-xCT/GPx4 axis signaling in HCC cells.Overexpression of Nrf2 upregulated the expression of downstream SLC7A11 and GPX4,consequently alleviating esculetin-induced ferroptosis.In conclusion,this study suggests that esculetin exerts an anti-HCC effect by inhibiting the activity of the Nrf2-xCT/GPx4 axis,thereby triggering ferroptosis in HCC cells.These findings may contribute to the potential clinical use of esculetin as a candidate for HCC treatment.展开更多
为了满足航天设备与计算机之间实时高带宽的数据传输需求,设计了一种基于PCIe3.0总线接口的高速数据传输系统,实现了数据通过读数板卡采集,然后以短突发或连续模式与主机之间的数据传输。该设计采用SG-DMA(scatter-gather direct memory...为了满足航天设备与计算机之间实时高带宽的数据传输需求,设计了一种基于PCIe3.0总线接口的高速数据传输系统,实现了数据通过读数板卡采集,然后以短突发或连续模式与主机之间的数据传输。该设计采用SG-DMA(scatter-gather direct memory access)数据传输方式,相比于传统Block DMA,降低了CPU资源利用率的同时减少了DMA的中断时间,提高了系统的整体性能。通过Qt Creator平台开发的上位机程序,在上位机软件界面测得PCIe写带宽可达4698 MBps,读带宽可达4797 MBps,PCIe平均总线利用率高达58.86%,完全满足工程中对高带宽数据传输的需求。展开更多
文摘针对数字视频IP核间高速流数据传输,设计并实现了一种基于AXI4-Stream总线的数字视频接口IP核,对外部输入ITU601格式的数字视频信号,将其格式转化为符合AXI4-Stream总线协议的信号,并通过IP核的主端口输出到下一级IP核的从端口。采用Xilinx ISE Design Suite 14.6软件综合设计实现,结合ISE自带ISim软件完成功能仿真,通过实际硬件电路验证了设计的正确性及可行性。
基金supported by the Natural Science Foundations of Fujian Province(Nos.2021J05063 and 2023J01541)a startup grant for High-level Talents of Fujian Medical University(No.XRCZX2021014)。
文摘Esculetin,a natural dihydroxy coumarin derived from the Chinese herbal medicine Cortex Fraxini,has demonstrated significant pharmacological activities,including anticancer properties.Ferroptosis,an iron-dependent form of regulated cell death,has garnered considerable attention due to its lethal effect on tumor cells.However,the exact role of ferroptosis in esculetin-mediated anti-hepatocellular carcinoma(HCC)effects remains poorly understood.This study investigated the impact of esculetin on HCC cells both in vitro and in vivo.The findings indicate that esculetin effectively inhibited the growth of HCC cells.Importantly,esculetin promoted the accumulation of intracellular Fe^(2+),leading to an increase in ROS production through the Fenton reaction.This event subsequently induced lipid peroxidation(LPO)and triggered ferroptosis within the HCC cells.The occurrence of ferroptosis was confirmed by the elevation of malondialdehyde(MDA)levels,the depletion of glutathione peroxidase(GSH-Px)activity,and the disruption of mitochondrial morphology.Notably,the inhibitor of ferroptosis,ferrostatin-1(Fer-1),attenuated the anti-tumor effect of esculetin in HCC cells.Furthermore,the findings revealed that esculetin inhibited the Nrf2-xCT/GPx4 axis signaling in HCC cells.Overexpression of Nrf2 upregulated the expression of downstream SLC7A11 and GPX4,consequently alleviating esculetin-induced ferroptosis.In conclusion,this study suggests that esculetin exerts an anti-HCC effect by inhibiting the activity of the Nrf2-xCT/GPx4 axis,thereby triggering ferroptosis in HCC cells.These findings may contribute to the potential clinical use of esculetin as a candidate for HCC treatment.
