Ferritin has good thermal stability,resistance to certain acids and bases,and targeting,and has broad application prospects in the synthesis of gold nanostars(AuNS).In this study,we screened monodisperse AuNS with uni...Ferritin has good thermal stability,resistance to certain acids and bases,and targeting,and has broad application prospects in the synthesis of gold nanostars(AuNS).In this study,we screened monodisperse AuNS with uniform particle size and morphology through a one-step synthesis method and coupled the synthesized AuNS with oyster ferritin(GF1).The results showed that the surface plasmon resonance(SPR)peaks of the coupled GF1@AuNS changed signifi cantly,and the changes in infrared spectra and potential confirmed the success of the synthesis,while the microscopic morphology showed an increase in particle size and surface peak coverage.Furthermore,GF1@AuNS does not induce cell death in the 100µmol/L range,is highly stable in physiological environments,and exhibits good X-ray attenuation in micro-computed tomography.Due to the unique functional activity of ferritin and AuNS,GF1@AuNS has potential applications in food detection and drug development in the future.展开更多
Gold nanoparticle is an important photothermal conversion material in photothermal imaging and photothermal therapy research.There are diverse gold nanoparticles,including gold nanospheres,gold nanorods,gold nanocages...Gold nanoparticle is an important photothermal conversion material in photothermal imaging and photothermal therapy research.There are diverse gold nanoparticles,including gold nanospheres,gold nanorods,gold nanocages,gold nanoshells and gold nanostars.Among them,gold nanostar(AuNS)possesses more excellent prospective imaging contrast agent for cancer diagnosis than other shapes of gold nanoparticles because of its larger photon interception area and cross section as well as scattering characteristics.The properties of AuNS are susceptible to synthetic methods and conditions.In this study,we presented surfactant-free methods to synthesize AuNS,discussed the relationship of AuNS characterization with the synthetic conditions and tested its photothermal effect.The results indicated that length and number of branches in AuNSs were the main factor for absorption wavelength in photothermal conversion,and the Au NSs could be more precisely controlled by changing the synthesis conditions.展开更多
Employing first-principles methods, based on the density function theory, and using the LANL2DZ basis sets, the ground-state geometric, the stable and the electronic properties of Aun-2Y2 clusters are investigated in ...Employing first-principles methods, based on the density function theory, and using the LANL2DZ basis sets, the ground-state geometric, the stable and the electronic properties of Aun-2Y2 clusters are investigated in this paper. Meanwhile, the differences in property among pure gold clusters, pure yttrium clusters, gold clusters doped with one yttrium atom, and gold clusters doped with two yttrium atoms are studied. We find that when gold clusters are doped by two yttrium atoms, the odd-even oscillatory behaviours of Aun-1Y and Aun disappear. The properties of Aun-2Y2 clusters are close to those of pure yttrium clusters.展开更多
基金supported by the National Natural Science Foundation of China(31730069 and 31771926).
文摘Ferritin has good thermal stability,resistance to certain acids and bases,and targeting,and has broad application prospects in the synthesis of gold nanostars(AuNS).In this study,we screened monodisperse AuNS with uniform particle size and morphology through a one-step synthesis method and coupled the synthesized AuNS with oyster ferritin(GF1).The results showed that the surface plasmon resonance(SPR)peaks of the coupled GF1@AuNS changed signifi cantly,and the changes in infrared spectra and potential confirmed the success of the synthesis,while the microscopic morphology showed an increase in particle size and surface peak coverage.Furthermore,GF1@AuNS does not induce cell death in the 100µmol/L range,is highly stable in physiological environments,and exhibits good X-ray attenuation in micro-computed tomography.Due to the unique functional activity of ferritin and AuNS,GF1@AuNS has potential applications in food detection and drug development in the future.
基金National Nature Science Foundation of China(Grant No.81673365,81803459)
文摘Gold nanoparticle is an important photothermal conversion material in photothermal imaging and photothermal therapy research.There are diverse gold nanoparticles,including gold nanospheres,gold nanorods,gold nanocages,gold nanoshells and gold nanostars.Among them,gold nanostar(AuNS)possesses more excellent prospective imaging contrast agent for cancer diagnosis than other shapes of gold nanoparticles because of its larger photon interception area and cross section as well as scattering characteristics.The properties of AuNS are susceptible to synthetic methods and conditions.In this study,we presented surfactant-free methods to synthesize AuNS,discussed the relationship of AuNS characterization with the synthetic conditions and tested its photothermal effect.The results indicated that length and number of branches in AuNSs were the main factor for absorption wavelength in photothermal conversion,and the Au NSs could be more precisely controlled by changing the synthesis conditions.
基金Project supported by the National Natural Science Foundation of China (Grant No. 10276028)the Education Committee of Chongqing,China (Grant No. KJ051105)
文摘Employing first-principles methods, based on the density function theory, and using the LANL2DZ basis sets, the ground-state geometric, the stable and the electronic properties of Aun-2Y2 clusters are investigated in this paper. Meanwhile, the differences in property among pure gold clusters, pure yttrium clusters, gold clusters doped with one yttrium atom, and gold clusters doped with two yttrium atoms are studied. We find that when gold clusters are doped by two yttrium atoms, the odd-even oscillatory behaviours of Aun-1Y and Aun disappear. The properties of Aun-2Y2 clusters are close to those of pure yttrium clusters.
