Broiler ascites syndrome(AS)is one of the main diseases threatening the health of broilers.It is well documented that myocardial hypertrophy and failure is one of the key mechanisms of broiler ascites syndrome.Therefo...Broiler ascites syndrome(AS)is one of the main diseases threatening the health of broilers.It is well documented that myocardial hypertrophy and failure is one of the key mechanisms of broiler ascites syndrome.Therefore,prevention of cardiac hypertrophy and failure would be one goal to reduce broiler ascites syndrome incidence.Myocardial hyper-trophy and failure are closely related to endoplasmic reticulum stress(ERS)in cardiac myocytes,and the endoplasmic reticulum stress signaling system(ATF6-DR5)is one of the important pathways of myocardial apoptosis.Excessive hyper-trophy will affect the heart muscle's normal contraction and diastole function,and the heart will turn from compen-sated to decompensate thus causing myocardial injury.Myocardial apoptosis is a core component of the pathological changes of this myocardial injury.Nano-selenium is a kind of red elemental selenium nanoparticle.Due to its excellent physical,chemical and biological properties,it has attracted extensive academic attention in recent years.It has been proven to have excellent antioxidant,antibacterial,antitumor,antihypertrophic,and antiapoptotic abilties.Herein,nano-selenium(1μmol/L)can inhibit hydrogen peroxide(H_(2)O_(2))-induced oxidative stress in broiler primary cardiomyocytes,and at the same time reduce cardiomyocyte apoptosis.In vivo,nano-selenium can reduce broiler myocardial injury-related enzyme indicators(AST,CK and LDH),and alleviate myocardial injury.It can also activate the antioxidant enzyme system(SOD,GSH-Px and CAT)and reduce MDA,and make the recovery ofT-AOC ability in the organization.Meanwhile,nano-selenium can down-regulate the genes and proteins expression of ATF-6,GRP-78,CHOP and caspase 12 in the ERS-related signaling pathway,and inhibit that of downstream-related caspase 3,Bax and caspase 9,and increase that of the downstream anti-apoptotic Bcl-2,thereby maintaining the homeostasis of the endoplasmic reticulum and alleviating cardiomyocyte apoptosis.It can be seen that nano-selenium can protect the damaged myocardium in the broiler ascites caused by high-salt drinking by regulating the ATF6-DR5 signaling pathway.This study was performed in chickens and cardiomyocyte cells and attempted to demonstrate that selenium nanoparticles can protect the damaged myocar-dium in broiler ascites.This paper provides a new idea for preventing and treating broiler ascites syndrome.展开更多
Diabetic nephropathy(DN)is a well-known microvascular complication in patients with diabetes mellitus,which is characterized by the accumulation of extracellular matrix in the glomerular and tubulointerstitial compart...Diabetic nephropathy(DN)is a well-known microvascular complication in patients with diabetes mellitus,which is characterized by the accumulation of extracellular matrix in the glomerular and tubulointerstitial compartments,along with the hyalinization of intrarenal vasculature.DN has recently emerged as a leading cause of chronic and end-stage renal disease.While the pathobiology of other diabetic microvascular complications,such as retinopathy,is largely understood and has reasonable therapeutic options,the mechanisms and management strategies for DN remain incompletely elucidated.In this editorial,we comment on the article by Liu et al,focusing on the mechanisms underlying the detrimental impact ofβ-arrestin-2 on the kidneys in the context of DN.The authors suggest that inhibitingβ-arrestin-2 could alleviate renal damage through suppressing apoptosis of glomerular endothelial cells(GENCs),highlightingβ-arrestin-2 as a promising therapeutic target for DN.The study proposed thatβ-arrestin-2 triggers endoplasmic reticulum(ER)stress via the ATF6 signaling pathway,thereby promoting GENC apoptosis and exacerbating DN progression.Given the novel and crucial role ofβ-arrestin-2 in ER stress-related DN,it is imperative to further exploreβ-arrestin-2,its roles in ER stress and the potential therapeutic implications in DN.展开更多
基金Central Fundamental Research Fund for Universities(No.2662020DKPY013)Thirteenth Five-Year Plan Key R&D Program(No.2016YFD0501208)Innovation and Entrepreneurship Training Program for College Students in Hubei Province(S202110504039).
文摘Broiler ascites syndrome(AS)is one of the main diseases threatening the health of broilers.It is well documented that myocardial hypertrophy and failure is one of the key mechanisms of broiler ascites syndrome.Therefore,prevention of cardiac hypertrophy and failure would be one goal to reduce broiler ascites syndrome incidence.Myocardial hyper-trophy and failure are closely related to endoplasmic reticulum stress(ERS)in cardiac myocytes,and the endoplasmic reticulum stress signaling system(ATF6-DR5)is one of the important pathways of myocardial apoptosis.Excessive hyper-trophy will affect the heart muscle's normal contraction and diastole function,and the heart will turn from compen-sated to decompensate thus causing myocardial injury.Myocardial apoptosis is a core component of the pathological changes of this myocardial injury.Nano-selenium is a kind of red elemental selenium nanoparticle.Due to its excellent physical,chemical and biological properties,it has attracted extensive academic attention in recent years.It has been proven to have excellent antioxidant,antibacterial,antitumor,antihypertrophic,and antiapoptotic abilties.Herein,nano-selenium(1μmol/L)can inhibit hydrogen peroxide(H_(2)O_(2))-induced oxidative stress in broiler primary cardiomyocytes,and at the same time reduce cardiomyocyte apoptosis.In vivo,nano-selenium can reduce broiler myocardial injury-related enzyme indicators(AST,CK and LDH),and alleviate myocardial injury.It can also activate the antioxidant enzyme system(SOD,GSH-Px and CAT)and reduce MDA,and make the recovery ofT-AOC ability in the organization.Meanwhile,nano-selenium can down-regulate the genes and proteins expression of ATF-6,GRP-78,CHOP and caspase 12 in the ERS-related signaling pathway,and inhibit that of downstream-related caspase 3,Bax and caspase 9,and increase that of the downstream anti-apoptotic Bcl-2,thereby maintaining the homeostasis of the endoplasmic reticulum and alleviating cardiomyocyte apoptosis.It can be seen that nano-selenium can protect the damaged myocardium in the broiler ascites caused by high-salt drinking by regulating the ATF6-DR5 signaling pathway.This study was performed in chickens and cardiomyocyte cells and attempted to demonstrate that selenium nanoparticles can protect the damaged myocar-dium in broiler ascites.This paper provides a new idea for preventing and treating broiler ascites syndrome.
基金Supported by National Natural Science Foundation of China,No.82303047,No.82372507,No.82172196 and No.32401046Natural Science Foundation of Hunan Province,No.2022JJ40801。
文摘Diabetic nephropathy(DN)is a well-known microvascular complication in patients with diabetes mellitus,which is characterized by the accumulation of extracellular matrix in the glomerular and tubulointerstitial compartments,along with the hyalinization of intrarenal vasculature.DN has recently emerged as a leading cause of chronic and end-stage renal disease.While the pathobiology of other diabetic microvascular complications,such as retinopathy,is largely understood and has reasonable therapeutic options,the mechanisms and management strategies for DN remain incompletely elucidated.In this editorial,we comment on the article by Liu et al,focusing on the mechanisms underlying the detrimental impact ofβ-arrestin-2 on the kidneys in the context of DN.The authors suggest that inhibitingβ-arrestin-2 could alleviate renal damage through suppressing apoptosis of glomerular endothelial cells(GENCs),highlightingβ-arrestin-2 as a promising therapeutic target for DN.The study proposed thatβ-arrestin-2 triggers endoplasmic reticulum(ER)stress via the ATF6 signaling pathway,thereby promoting GENC apoptosis and exacerbating DN progression.Given the novel and crucial role ofβ-arrestin-2 in ER stress-related DN,it is imperative to further exploreβ-arrestin-2,its roles in ER stress and the potential therapeutic implications in DN.
