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Reliability and validity of the preparatory grief scale for use with hemodialysis patients
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作者 Yue-Juan Li Xue Li +1 位作者 Mei-Juan Li Yu-Lin Gao 《World Journal of Psychiatry》 2025年第9期201-209,共9页
BACKGROUND During the gradual decline of physical and social functioning associated with end-stage renal disease,patients might experience a premonition of impending death,resulting in a series of pre-mourning grief r... BACKGROUND During the gradual decline of physical and social functioning associated with end-stage renal disease,patients might experience a premonition of impending death,resulting in a series of pre-mourning grief responses called preparatory grief.The preparatory grief in advanced cancer patients(PGAC)scale is the most widely used preparatory grief scale for patients on hemodialysis in China.AIM To verify the reliability and validity of the PGAC scale in patients on hemodialysis.METHODS In total,327 patients undergoing regular hemodialysis in the blood purification center of three grade-A tertiary hospitals in Guangdong and Guizhou provinces were selected by convenience sampling.The assessment was administered using the general information questionnaire and the Chinese version of PGAC.SPSS 25.0 and Amos 24.0 were used for item analysis,confirmatory factor analysis(CFA),convergent validity,and internal consistency reliability estimation.RESULTS In the modified Chinese version of PGAC,7 dimensions covering 27 total items were retained.CFA revealed a good fit of the factor model(chi-square degree of freedom=2.056,standardized root mean square residual=0.0479,root mean square error of approximation=0.0570,GFI=0.872,AGFI=0.841,IFI=0.931,CFI=0.930,TLI=0.919).The factor loadings of the items ranged 0.503-0.884.The composite reliability ranged 0.664-0.914,and the average variance extracted ranged 0.366-0.747.Cronbach’sαof the scale was 0.945,and Cronbach’sαfor various dimensions ranged 0.662-0.914.CONCLUSION The modified PGAC has good reliability and validity,and it can effectively measure preparatory grief in patients on hemodialysis. 展开更多
关键词 Preparatory grief HEMODIALYSIS SCALE RELIABILITY validity
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Reliability,validity and measurement invariance of the difficulties in emotion regulation Scale-8 in Chinese adolescents
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作者 Yali Zhang Hao Jiang +1 位作者 Yuewen Bian Fuhai Zhang 《Journal of Psychology in Africa》 2025年第2期271-275,共5页
This study aimed to determine the reliability,validity and measurement invariance of scores from the Difficulties in Emotion Regulation Scale-8 in Chinese context.A total of 1114 Chinese adolescents were participants ... This study aimed to determine the reliability,validity and measurement invariance of scores from the Difficulties in Emotion Regulation Scale-8 in Chinese context.A total of 1114 Chinese adolescents were participants in three phases:N=424 for the initial DERS-8 measure completion;N=586 the DERS-8,General Anxiety Disorder Scale,Depression Scale and Emotion Regulation Scale completion,with an interval of one month.Then an additional 104 adolescents also completed DERS-8,General Anxiety Disorder Scale,Depression Scale and Emotion Regulation Scale.Both exploratory and confirmatory factor analyses confirmed the one-factor model of the scale,and the fitness indicators wereχ^(2)/df=4.05,RMSEA=0.07,CFI=0.98,and TLI=0.97.Each item of the DERS-8 had good discrimination.The internal consistency reliability coefficient,split-half reliability coefficient and test-retest reliability coefficient of the scale scores were 0.90,0.87 and 0.66,respectively.The findings suggest the Chinese version of the DERS-8 is a reliable measure of difficulty of emotion regulation in Chinese adolescents. 展开更多
关键词 difficulties in emotion regulation RELIABILITY validity adolescents
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Translation,validity,and reliability of the Thai de Morton Mobility Index in patients following hip surgery
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作者 Chanokporn Jitpanya Surachai Maninet Chanipa Yoryuenyong 《International Journal of Nursing Sciences》 2025年第4期386-392,I0005,共8页
Objective:This study aimed to translate the de Morton Mobility Index(DEMMI)into Thai and assess its measurement properties.Methods:The de Morton Mobility Index(DEMMI)was translated into Thai using a cross-cultural tra... Objective:This study aimed to translate the de Morton Mobility Index(DEMMI)into Thai and assess its measurement properties.Methods:The de Morton Mobility Index(DEMMI)was translated into Thai using a cross-cultural translation method.A cross-sectional study was conducted in four public hospitals in Thailand between January and March 2023.A total of 260 patients were recruited from outpatient clinics.Convergent and known-group validity were evaluated through hypothesis testing.Construct validity was examined using confirmatory factor analysis.Reliability was assessed using Cronbach’s a coefficient.We also employed the Rasch analysis to validate validity and person reliability.Results:Content validity was high(S-CVI=0.96,I-CVI range:0.80e1.00).Strong convergent validity was observed,with a significant correlation(r=0.761,P<0.001)between the Thai DEMMI and the Parker Mobility Scale(PMS).Known-group validity was evident,demonstrating differences in scores across various patient groups.A confirmatory factor analysis supported the hypothesized factor structure of the Thai DEMMI with good fit indices:χ^(2)(df=4)=5.101,P=0.2771;χ^(2)/df=1.275,RMSEA=0.033;CFI=0.998;TLI=0.995;SRMR=0.016.The Thai DEMMI exhibited high internal consistency(Cronbach’s a=0.88).Rasch analysis revealed good person reliability(0.91)and acceptable information-weighted fit means square statistic(0.73-1.06).However,most items showed good fit based on the outlier-sensitive fit means square statistics(Outfit MNSQ),one exhibited a high Outfit MNSQ value of 29.94,suggesting a potential misfit.Conclusion:This study demonstrated the acceptable validity and reliability of the Thai DEMMI.Further evaluation of its responsiveness to change is still recommended. 展开更多
关键词 Hip fractures PATIENTS Recovery of function RELIABILITY validity
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WPPSI-III in Sudan:Validity,reliability,and confirmatory factor analysis in khartoum kindergarten and primary schools
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作者 Rwaa Omer Ali Ahmed Salaheldin Farah Attallah Bakhiet +2 位作者 Ayman Mohamed Taha Abdelaziz Ahmed FadlAlMawla AbdulRadi Ismael Salamah Albursan 《Journal of Psychology in Africa》 2025年第4期431-439,共9页
The study aims to determine the validity and reliability of the Wechsler Preschool and Primary Scale of Intelligence–Third Edition(WPPSI-III)scores in a sample of kindergarten and lower primary pupils from Khartoum S... The study aims to determine the validity and reliability of the Wechsler Preschool and Primary Scale of Intelligence–Third Edition(WPPSI-III)scores in a sample of kindergarten and lower primary pupils from Khartoum State,Sudan.It also aims to examine whether test’s factor structure in this sample replicated that of the original WPPSI-III.The study sample consisted of 384 kindergarten and primary school children in Khartoum State(females=50%mean age=4.14,SD=1.37),selected using stratified random sampling across its seven localities:Khartoum,Jebel Awliya,Khartoum Bahri,East Nile,Omdurman,Ombada,Karari.For concurrent validation,the children additionally completed the Goodenough Draw-a-Man Test,and the Colored Progressive Matrices.WPPSI-III scores demonstrated high internal consistency across the subtest items.Confirmatory factor analysis indicators for total,verbal,and performance intelligence were all excellent.The scale also showed weak to strong score stability ranging from 0.25(weak)to 0.88(strong)based on the Spearman-Brown equation,0.25 to 0.75 based on the Guttman split-half method.The Cronbach’s alpha coefficient scores ranged from 0.54 to 0.93.The WPPSI-III and Goodenough Draw-a-Man Test scores concurrent validity scores were poor(0.05)to modest(0.31),and while those with the Colored Progressive Matrices test were poor(r=0.04–0.18).Thesefindings provide evidence to suggest that the WPPSI-III is appropriate for research use with kindergarten and lower primary school students in Khartoum State,Sudan. 展开更多
关键词 intelligence tests VALIDATION RELIABILITY primary schools kindergartens confirmatory factor analysis cognitive abilities WPPSI-III SUDAN
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The Application Effect of “Expiration Manager” Mini Program in the Validity Management of Articles in Ward
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作者 Xiaofei Mi Huilin Ouyang +1 位作者 Guohui Zhou Fang Chen 《Journal of Clinical and Nursing Research》 2025年第3期26-32,共7页
The purpose of this study is to investigate the effectiveness of the“expiration manager”mini program in managing the validity of ward items.The program was used to manage frequently and infrequently used consumables... The purpose of this study is to investigate the effectiveness of the“expiration manager”mini program in managing the validity of ward items.The program was used to manage frequently and infrequently used consumables by setting up an automatic reminder function.The item failure rate and the time required for nurses to conduct counts over 6 months before and after implementation were compared,as well as evaluated system availability using the System Usability scale(SUS).Results showed that after implementing the mini program,both the item failure rate and non-recognition rate significantly decreased(P<0.05),while the inspection pass rate significantly increased(P<0.05),and the monthly inventory time was reduced(P<0.05).The SUS evaluation yielded a total score of 74.38±11.73,with learnability at 80.21±20.27 and availability at 72.92±11.18,all indicating good user acceptance.In conclusion,the“expiration manager”mini program can effectively improve the efficiency of item expiration management,reduce the risk of expiration,and save inspection time,thereby demonstrating high user acceptance and promising potential for wider adoption. 展开更多
关键词 “Expiration manager”mini program Medical articles validity period management Information application
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Validity,Reliability,and Measurement Invariance of the Thai Smartphone Application-Based Addiction Scale and Bergen Social Media Addiction Scale 被引量:1
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作者 Kamolthip Ruckwongpatr Chirawat Paratthakonkun +8 位作者 Usanut Sangtongdee Iqbal Pramukti Ira Nurmala Kanokwan Angkasith Weena Thanachaisakul Jatuphum Ketchatturat Mark DGriffiths Yi-Kai Kao Chung-Ying Lin 《International Journal of Mental Health Promotion》 2024年第4期293-302,共10页
Background:In recent years,there has been increased research interest in both smartphone addiction and social media addiction as well as the development of psychometric instruments to assess these constructs.However,t... Background:In recent years,there has been increased research interest in both smartphone addiction and social media addiction as well as the development of psychometric instruments to assess these constructs.However,there is a lack of psychometric evaluation for instruments assessing smartphone addiction and social media addiction in Thailand.The present study evaluated the psychometric properties and gender measurement invariance of the Thai version of the Smartphone Application-Based Addiction Scale(SABAS)and Bergen Social Media Addiction Scale(BSMAS).Method:A total of 801 Thai university students participated in an online survey from January 2022 to July 2022 which included demographic information,SABAS,BSMAS,and the Internet Gaming Disorder Scale-Short Form(IGDS9-SF).Results:Confirmatory Factor Analyses(CFAs)found that both the SABAS and BSMAS had a one-factor structure.Findings demonstrated adequate psychometric properties of both instruments and also supported measurement invariance across genders.Moreover,scores on the SABAS and BSMAS were correlated with scores on the IGDS9-SF.Conclusion:The results indicated that the SABAS and BSMAS are useful psychometric instruments for assessing the risk of smartphone addiction and social media addiction among Thai young adults. 展开更多
关键词 Factor analysis smartphone addiction social media addiction smartphone application-based addiction scale bergen social media addiction scale psychometric validation
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Surface and Content Validity of the Mentoring Function Scale for Novice Nurses
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作者 Aimi Furukawa Yasuko Hosoda 《Open Journal of Nursing》 2024年第8期401-411,共11页
This study aimed to examine the surface and content validity of the Mentoring Function Scale for Novice Nurses, used to assess the mentoring of entry-level nurses, and to refine the scale items. In Study 1, six nurse ... This study aimed to examine the surface and content validity of the Mentoring Function Scale for Novice Nurses, used to assess the mentoring of entry-level nurses, and to refine the scale items. In Study 1, six nurse education researchers, selected using convenience sampling, with five or more years of nursing experience and experience teaching novice nurses, were invited to an expert meeting in July 2015. A group interview was conducted that lasted approximately 120 minutes. Study 2 examined the content validity index. Between September and November 2015, we distributed a self-administered questionnaire survey to 11 participants selected by convenience sampling. The participants included five nurse education researchers with a minimum of five years of nursing experience and experience teaching novice nurses, as well as six clinical nurses with a master’s degree or higher. Finally, 81 questionnaire items were retained from the initial 125 items. The 81-item Mentoring Function Scale for Novice Nurses had higher content validity than the original scale. To further increase the scale’s applicability, future studies should assess its reliability, construct validity, and criterion-related validity. 展开更多
关键词 Novice Nurses Mentoring Function Surface and Content validity Item-Level Content validity Index
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Scoring and Consequential Validity Evidence of Computer-and Paper-Based Writing Tests in Times of Change
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作者 María GUAPACHA-CHAMORRO Orlando CHAVES-VARÓN 《Chinese Journal of Applied Linguistics》 2024年第3期450-480,525,共32页
Little is known about how the assessment modality,i.e.,computer-based(CB)and paper-based(PB)tests,affects language teachers’scorings,perceptions,and preferences and,therefore,the validity and fairness of classroom wr... Little is known about how the assessment modality,i.e.,computer-based(CB)and paper-based(PB)tests,affects language teachers’scorings,perceptions,and preferences and,therefore,the validity and fairness of classroom writing assessments.The present mixed-methods study used Shaw and Weir’s(2007)sociocognitive writing test validation framework to examine the scoring and consequential validity evidence of CB and PB writing tests in EFL classroom assessment in higher education.Original handwritten and word-processed texts of 38 EFL university students were transcribed to their opposite format and assessed by three language lecturers(N=456 texts,152 per teacher)to examine the scoring validity of CB and PB tests.The teachers’perceptions of text quality and preferences for assessment modality accounted for the consequential validity evidence of both tests.Findings revealed that the assessment modality impacted teachers’scorings,perceptions,and preferences.The teachers awarded higher scores to original and transcribed handwritten texts,particularly text organization and language use.The teachers’perceptions of text quality differed from their ratings,and physical,psychological,and experiential characteristics influenced their preferences for assessment modality.The results have implications for the validity and fairness of CB and PB writing tests and teachers’assessment practices. 展开更多
关键词 scoring validity consequential validity CB and PB writing tests classroom assessment
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Construction and Validity of Chinese Translation of the Universal Mental Health Literacy Scale for Adolescents
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作者 Qi Wang Qi Wang +4 位作者 Yuxuan Ji Kexu Chen Kaiyun Li Fanlu Jia Ting Peng 《International Journal of Mental Health Promotion》 2024年第8期671-677,共7页
Background:In this study,the Universal Mental Health Literacy Scale for Adolescents(UMHL-A)was revised and tested for its reliability and validity in Chinese middle school students,thus establishing a useful tool for ... Background:In this study,the Universal Mental Health Literacy Scale for Adolescents(UMHL-A)was revised and tested for its reliability and validity in Chinese middle school students,thus establishing a useful tool for assessing the mental health of individuals in this occupation.Methods:Our sample comprised 1208 junior high school students(58.85%male),aged between 11 and 15 years old.The Chinese version of the scale includes a mental health attitude subscale and mental health knowledge subscale,including attitudes towards seeking help,attitudes related to stigma,general mental health knowledge,and knowledge about specific mental illnesses,encapsulated in a total of 17 items.A series of psychometric analyses such as exploratory factor analysis(EFA),confirmatory factor analysis(CFA),and internal consistency reliability estimation were carried out in this study.Results:The results of the CFA indicated that the two-factor model had an acceptable model fit(Attitude(UMHL-A Likert):χ^(2)/df=4.107;RMSEA=0.072;SRMR=0.045;TLI=0.932;CFI=0.954;Knowledge(UMHL-A T/F):χ^(2)/df=3.647;RMSEA=0.066;SRMR=0.044;TLI=0.923;CFI=0.945).The Cronbach’s alpha coefficient of subscales of the Chinese version UMHL-A were 0.80 and 0.78,respectively.Conclusion:In general,the Chinese version of the Universal Mental Health Literacy Scale for adolescents has good reliability and validity and can be used as a tool to measure the mental health literacy of Chinese adolescents. 展开更多
关键词 Mental health literacy CHINESE adolescents validity
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Validity and Reliability of a Mental Health Recovery Checklist for Young Adults
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作者 Brianna Cerrito Jamie Xiao +2 位作者 Amie DiTomasso Amanda Fialk Jocelyn Bolin 《International Journal of Mental Health Promotion》 2024年第4期317-323,共7页
The purpose of the present study is to evaluate the internal consistency and construct validity of a self-report checklist measuring clinical mental health recovery across six key domains:family and relationships,occu... The purpose of the present study is to evaluate the internal consistency and construct validity of a self-report checklist measuring clinical mental health recovery across six key domains:family and relationships,occupation and school,physical health,mental health,spirituality,and social support systems.The Mental Health Recovery Checklist(MHRC)was developed at The Dorm,an intensive outpatient mental health treatment program for young adults in New York,NY,and Washington DC that services individuals between the ages of 18 and 35 years old.The present study is cross-sectional,as data were pulled from clients’records who were discharged between January 2018 and May 2023.Pearson Correlations and Cronbach’s alpha were used to determine scale reliability.To establish validity,an Exploratory Factor Analysis(EFA)was conducted to assess a single-factor model using Principal Axis Factoring.Cronbach’s alpha was high(α=0.88),indicating good reliability.In the EFA,all items loaded strongly on a single factor.The unidimensional structure revealed in the EFA highlights the interconnected nature of various life domains as they pertain to mental health recovery in young adults.Future research is warranted to explore whether there are additional dimensions of mental health recovery that have not been assessed in the present scale. 展开更多
关键词 Mental health recovery young adult validation study mental health checklist
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数字试验测试验证标准体系 被引量:3
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作者 陶飞 马昕 +31 位作者 张辰源 易航 刘蔚然 魏宇鹏 邹孝付 王子同 任羿 陶岚 葛军 丁露 卓兰 韩丽 弓志强 谭永华 郄永军 周文 李建双 杨春霞 许鸿杰 蔺文杰 刘广 孙波 李海旭 阎德劲 李少伟 罗谦 王敬贤 罗英 尚政国 刘志新 易贤 张文丰 《计算机集成制造系统》 北大核心 2025年第1期1-19,共19页
数字试验测试验证(Digital Experiment,Testing,and Validation,D-ETV)是利用“数力”和“智力”更好地了解产品或系统基本属性和性能特征的方法,是实现高质高效研制运维的重要支撑手段。然而,在物理试验测试验证(Physical Experiment,T... 数字试验测试验证(Digital Experiment,Testing,and Validation,D-ETV)是利用“数力”和“智力”更好地了解产品或系统基本属性和性能特征的方法,是实现高质高效研制运维的重要支撑手段。然而,在物理试验测试验证(Physical Experiment,Testing,and Validation,P-ETV)向D-ETV演化的过程中,因缺乏基础共性标准参考,导致不同人员对D-ETV的理解与认识存在差异;因缺乏关键技术标准参考,导致D-ETV实现难;因缺乏通用支撑、安全、行业应用等标准参考,导致D-ETV实施难。针对上述问题,首先从D-ETV有何用、如何用、何处用3个角度对D-ETV标准需求进行分析。在作者团队前期提出的D-ETV通用流程“D”模型及关键技术基础上,进一步建立并完善“析-定-建-测-评-融”D-ETV理论体系。面向航空航天、工程机械、船舶、电子信息、汽车等领域的国家重大需求,与相关研究院所和企业共同尝试探索建立一套D-ETV标准体系,包括基础共性、关键技术、通用支撑、安全和行业应用5类标准。期望相关工作为D-ETV理论研究、标准研制、行业应用提供参考,助力我国试验测试验证向数字化、智能化、服务化方向发展,进而为我国装备高质量发展提供支撑。 展开更多
关键词 数字试验测试验证 标准体系 数字试验 数字测试 数字验证 数字鉴定
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基于机器学习的玉米自交系杂种优势类群研究 被引量:3
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作者 曹士亮 张建国 +7 位作者 于滔 杨耿斌 李文跃 马雪娜 孙艳杰 韩微波 唐贵 单大鹏 《中国农业科学》 北大核心 2025年第2期203-213,I0001,I0002,共13页
【目的】优化玉米杂种优势类群划分与判别分析方法,为玉米育种提供指导和参考。【方法】采用固相芯片对60份糯玉米自交系进行基因分型,通过质量控制获得不同密度的SNP标记,采用群体结构分析和遗传距离聚类的方法对60份糯玉米进行类群划... 【目的】优化玉米杂种优势类群划分与判别分析方法,为玉米育种提供指导和参考。【方法】采用固相芯片对60份糯玉米自交系进行基因分型,通过质量控制获得不同密度的SNP标记,采用群体结构分析和遗传距离聚类的方法对60份糯玉米进行类群划分,比较不同密度分子标记和分群方法的差异。在此基础上,分别采用随机森林和支持向量机对类群划分结果进行抽样和交叉验证,比较玉米自交系类群判别的预测精度。【结果】通过不同的质量控制标准分别获得11431和4022个分子标记,基于2种分子标记密度,分别将60份材料分成5个类群和4个类群,其中,以11431个SNP标记为基础,通过群体结构分析和遗传距离聚类结果发现,类群内样本一致性为63.33%,以4022个SNP标记进行分群,发现2种类群划分方法的群内样本一致性为90.00%;比较玉米自交系类群判别的预测精度结果为:基于4022个标记,随机森林和支持向量机预测精度的平均值(91.43%)高于11431个标记的预测精度的平均值(86.25%),其中,预测精度最高的是采用4022个标记的随机森林预测,预测精度为94.17%。【结论】聚类分析法最终将60份玉米糯自交系分为4个类群,运用随机森林和支持向量机对类群划分结果进行抽样和交叉验证,发现随机森林法比支持向量机法能获得更高的预测精度。 展开更多
关键词 玉米 机器学习 交叉验证 类群划分 判别分析
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血液透析病人照顾者负担问卷的汉化及信效度检验 被引量:2
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作者 张静 徐丹 +3 位作者 王文峰 周一鸣 程惠玲 张青 《护理研究》 北大核心 2025年第4期611-616,共6页
目的:将血液透析病人照顾者负担问卷(CBQ-HP)进行汉化并进行信效度检验。方法:遵循Beaton翻译模型对问卷进行翻译、专家咨询、预调查和原作者审查,形成中文版CBQ-HP。采用方便抽样法调查480名血液透析病人家庭照顾者,以检验中文版CBQ-H... 目的:将血液透析病人照顾者负担问卷(CBQ-HP)进行汉化并进行信效度检验。方法:遵循Beaton翻译模型对问卷进行翻译、专家咨询、预调查和原作者审查,形成中文版CBQ-HP。采用方便抽样法调查480名血液透析病人家庭照顾者,以检验中文版CBQ-HP的信效度。结果:中文版CBQ-HP条目水平的内容效度指数为0.833~1.000,量表水平的内容效度指数为0.905。探索性因子分析提取4个公因子,累计方差贡献率为69.192%。验证性因子分析的模型适配度良好。总量表Cronbach's α系数为0.931,4个维度的Cronbach's α系数为0.832~0.914,重测信度为0.771。中文版CBQ-HP总分与Zarit照顾者负担量表总分的相关系数为0.736(P<0.001)。结论:中文版CBQ-HP具有较好的信度和效度,可用于我国血液透析病人家庭照顾者负担的测量。 展开更多
关键词 血液透析 家庭照顾者 照顾者负担 量表 信度 效度
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探讨开心散改善阿尔茨海默病的作用机制 被引量:5
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作者 何晓明 王晓彤 +8 位作者 闵冬雨 王欣欣 程美佳 刘勇明 鞠业涛 杨雅丽 袁常斌 于畅洋 张力 《中国实验方剂学杂志》 北大核心 2025年第1期20-29,共10页
目的:基于网络药理学、分子对接及动物实验验证,探讨开心散治疗阿尔茨海默病(AD)的作用机制。方法:①采用中药系统药理数据分析平台(TCMSP)和中医药百科全书(ETCM)数据库获取开心散的活性成分及靶点;利用GeneCards、在线人类孟德尔遗传... 目的:基于网络药理学、分子对接及动物实验验证,探讨开心散治疗阿尔茨海默病(AD)的作用机制。方法:①采用中药系统药理数据分析平台(TCMSP)和中医药百科全书(ETCM)数据库获取开心散的活性成分及靶点;利用GeneCards、在线人类孟德尔遗传数据库(OMIM)、TTD、PharmGKB和DrugBank数据库获取AD的相关靶点;对开心散的活性成分作用靶点与AD相关靶点取交集(共同靶点);STRING数据库对共同靶点进行网络互作分析,构筑蛋白质-蛋白质相互作用(PPI)网络;应用Cytoscape内的CytoNCA插件筛选出核心靶点;Metascape平台执行基因本体(GO)功能富集分析及京都基因与基因组百科全书(KEGG)通路富集分析;借助Cytoscape 3.8.2建立“药物-活性成分-靶点”互作网络;AutoDock Vina进行分子对接;②利用东莨菪碱(SCOP)造模,腹腔注射,每日1次。将32只雄性C57/BL6小鼠随机分为空白(CON)组(0.9%氯化钠,n=8)、模型(SCOP)组(3 mg·kg^(-1)·d^(-1),n=8)、盐酸多奈哌齐组(SCOP 3 mg·kg^(-1)·d^(-1)+盐酸多奈哌齐3 mg·kg^(-1)·d^(-1),n=8)、开心散组(SCOP 3 mg·kg^(-1)·d^(-1)+开心散6.5 g·kg^(-1)·d^(-1),n=8)。各组小鼠0.9%氯化钠、开心散或盐酸多奈哌齐灌胃给药,2次/d,连续14 d。采用Morris水迷宫实验观察小鼠学习记忆能力;苏木素-伊红(HE)染色法观察小鼠海马CA1区病理变化;酶联免疫吸附测定法(ELISA)测定小鼠血清乙酰胆碱(ACh)与乙酰胆碱酯酶(AChE)含量;蛋白免疫印迹法(Western blot)检测小鼠海马中信号转导和转录激活因子3(STAT3)、核转录因子(NF)-κB p65蛋白表达水平。结果:①共得到开心散73种活性成分,筛选出开心散对治疗AD的潜在作用靶点(共同靶点)578个;关键活性成分:山柰酚、吉九里香碱等;潜在核心靶点:STAT3、NF-κB p65等;GO功能富集分析得到3124条生物功能、254条细胞构件、461条分子功能;KEGG通路富集分析获得248条通路,主要涉及癌症相关通路、TRP通路、环磷酸腺苷(cAMP)通路、NF-κB通路等;分子对接显示,关键活性成分与目标靶点结合力较稳定。②Morris水迷宫实验表示开心散可以改善SCOP诱导的小鼠学习记忆能力;HE染色及ELISA检测结果表明开心散对小鼠中枢神经损伤有改善;Western blot检测表明开心散对SCOP模型小鼠海马组织中NF-κB p65磷酸化与STAT3磷酸化水平有下调作用。结论:开心散可以改善SCOP模型小鼠的认知障碍功能,并且可能通过调节NF-κB p65、STAT3等靶点来参与NF-κB信号通路等,减少海马神经元损伤从而发挥治疗AD的作用。 展开更多
关键词 开心散 阿尔茨海默病 网络药理学 分子对接 东莨菪碱 作用机制 实验验证
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生育动机量表的编制和信效度检验 被引量:1
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作者 刘天俐 董一萱 +5 位作者 杨婷 叶兆辉 杨帆 张雨琪 黄博文 朱廷劭 《人口与发展》 北大核心 2025年第2期94-104,共11页
编制适用于当代中国育龄人群的生育动机量表,以推动生育动机研究的发展。综合运用文献调研、专家咨询和认知访谈等方法编制量表题项,采用分层抽样的方法,线上调查2000名18~40岁的育龄男女,使用因子分析、相关分析和计算克伦巴赫阿尔法... 编制适用于当代中国育龄人群的生育动机量表,以推动生育动机研究的发展。综合运用文献调研、专家咨询和认知访谈等方法编制量表题项,采用分层抽样的方法,线上调查2000名18~40岁的育龄男女,使用因子分析、相关分析和计算克伦巴赫阿尔法等方法检验量表的信效度。新编制的生育动机量表分为积极生育动机和消极生育动机两个亚量表。积极生育动机量表18题,涵盖追求渴望和习俗规范两个维度,克伦巴赫阿尔法值为0.94,得分与生育意愿显著正相关。消极生育动机量表13题,涵盖情感社会和躯体物质两个维度,克伦巴赫阿尔法值为0.91,得分与生育意愿显著负相关。新编制的生育动机量表适用于测量我国育龄人群的生育动机水平。 展开更多
关键词 生育动机 量表 信度 效度
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Reliability and Validity of Warwick-Edinburgh Mental Well-Being Scale among Chinese Civil Servants
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作者 Shulan Lei Shujuan Wang +4 位作者 Zhuohong Zhu Min Lu Xinying Li Yiming Shen Jing Chen 《International Journal of Mental Health Promotion》 2024年第1期61-67,共7页
The purpose of this study was to explore the reliability and validity of the Warwick-Edinburgh Mental Well-being Scale(WEMWBS)among Chinese civil servants,thus establishing a useful tool for assessing the mental healt... The purpose of this study was to explore the reliability and validity of the Warwick-Edinburgh Mental Well-being Scale(WEMWBS)among Chinese civil servants,thus establishing a useful tool for assessing the mental health of individuals in this occupation.The WEMWBS,Satisfaction with Life Scale(SWLS),and Depression Anxiety and Stress Scale-21(DASS-21)were administered to a sample of 2,624 civil servants(42.860±9.690 years)in a city located within Shandong Province,China.Thefindings revealed significant differences between groups with high and low scores on each item of the WEMWBS(t=48.127–78.308,all p<0.01).The item-total correlation of WEMWBS ranged from 0.752 to 0.911(all p<0.01).Scree plot and parallel analysis results suggested a one-factor solution with factor loadings ranging from 0.762–0.918,accounting for 73.16%of the total variance.Confirmatory factor analysis supported a single-factor model of the Chinese version of the WEMWBS(CFI=0.997,TLI=0.996,RMSEA=0.0330).The Chinese version of the WEMWBS was positively correlated with the SWLS(r=0.710,both p<0.01)and negatively correlated with depression,anxiety,stress,and total DASS-21 score(r=-0.512,-0.437,-0.488,-0.497,all p<0.01).The Cronbach’s alpha coefficient and Guttman split-half coefficient of the Chinese version of the WEMWBS were 0.970 and 0.953,respectively.In conclusion,the 14-item Chinese version of the WEMWBS demonstrated strong reliability and validity,establishing its utility as a precise tool for measuring and assessing the mental health status of civil servants in China. 展开更多
关键词 RELIABILITY validity Warwick-Edinburgh Mental Well-Being Scale Chinese civil servants
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基于临床-影像特征预测ⅠA期浸润性肺腺癌高级别组织学亚型模型的外部验证 被引量:1
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作者 容宇 韩念樵 +6 位作者 郝雁冰 胡建丽 牛亚进 张兰 董跃华 张难 刘俊峰 《中国胸心血管外科临床杂志》 北大核心 2025年第8期1096-1104,共9页
目的对基于临床-CT影像特征的预测模型进行外部验证,用于术前识别早期肺腺癌中微乳头型及实性型等高级别组织学亚型(high-grade pattern,HGP),以指导临床治疗决策。方法本研究使用已开发的预测模型,在河北医科大学第四医院临床ⅠA期肺... 目的对基于临床-CT影像特征的预测模型进行外部验证,用于术前识别早期肺腺癌中微乳头型及实性型等高级别组织学亚型(high-grade pattern,HGP),以指导临床治疗决策。方法本研究使用已开发的预测模型,在河北医科大学第四医院临床ⅠA期肺腺癌患者中进行外部验证。纳入肿瘤大小、密度和分叶特征等因素,分析模型的识别能力、校准性能以及临床影响。结果纳入患者650例,其中男293例、女357例,年龄30~82岁。经验证发现,该模型在区分HGP方面显示出良好的性能(曲线下面积>0.7)。在对原始模型进行校准后,模型校准性能得到改善。决策曲线分析显示阈值概率>0.6时,模型预测的HGP患者人群接近实际情况。结论这项研究证实了基于临床-影像特征的预测模型在临床上识别ⅠA期肺腺癌HGP方面的有效性。模型的成功应用可能对于确定手术方案和改善患者预后具有重要意义。尽管存在一些局限性,但这些发现为未来研究提供了新方向。 展开更多
关键词 临床预测模型 肺腺癌 高级别组织学亚型 外部验证
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基于无人机高光谱的冬小麦LAI估算及LAI遥感产品检验 被引量:1
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作者 李军玲 李梦夏 +3 位作者 熊坤 田宏伟 张渝晨 余卫东 《生态学杂志》 北大核心 2025年第4期1306-1313,共8页
冬小麦叶面积指数(LAI)的动态变化,可用于其长势监测和估产。针对目前地面观测数据和卫星数据的尺度不匹配易引起的尺度效应,以及常用的多光谱数据相对高光谱数据的弱敏感性,为有效利用高光谱信息,优选出最佳波段进而构建LAI估算模型以... 冬小麦叶面积指数(LAI)的动态变化,可用于其长势监测和估产。针对目前地面观测数据和卫星数据的尺度不匹配易引起的尺度效应,以及常用的多光谱数据相对高光谱数据的弱敏感性,为有效利用高光谱信息,优选出最佳波段进而构建LAI估算模型以提高LAI估测精度,本文引入无人机高光谱数据作为地面观测和卫星数据的桥梁进行相关研究。实验获取了冬小麦返青期地面实测LAI数据、无人机高光谱数据、高分一号卫星(GF-1)数据。在此基础上,首先对高光谱数据进行不同形式的特征变量变换和计算。通过建立感兴趣区,计算得到和地面观测尺度一致的无人机影像像元。最后进行同尺度下多个植被指数及光谱变换形式和LAI的相关性分析,筛选LAI敏感波段或指数,开展基于无人机和GF-1卫星的不同尺度下冬小麦LAI反演。结果表明:冬小麦LAI敏感波段或指数为635、655、693、704、714、721、724、763、806、813、900和936 nm一阶导,714、717、763、767、784、806、813、900、903和936 nm二阶导以及敏感光谱指数SDy、DVI、MSAVI2、NLI和SAVI,并利用多元逐步回归、偏最小二乘法、岭回归等构建无人机高光谱影像LAI反演模型,通过精度比较认为岭回归建模最优;基于升尺度方法建立了GF-1冬小麦LAI估算模型,并将模拟结果作为相对真值对LAI遥感反演产品进行了真实性检验,FY3_1KM_LAI产品和GF_1KM_LAI产品相关系数达到0.787,说明FY3_LAI产品和相对真值有很强的相关性,可以用于日常业务服务和科研中。本文通过尺度扩展分析不同数据来源下反演模型精度,探讨不同遥感信息源在估算冬小麦LAI方面的能力,对作物管理提供科学指导,也为精准农业研究提供理论依据。 展开更多
关键词 叶面积指数 高分一号卫星 无人机高光谱数据 真实性检验 岭回归
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中国英语口译学习者语境构建能力验证分析 被引量:1
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作者 谌莉文 赵芳贤 谢波 《外语教学》 北大核心 2025年第1期86-93,共8页
语境构建已成为当下口译语境研究的共识,但对口译学习者语境构建能力的构念效度仍缺乏评估。本文对国内4所高校312名英语口译学习者开展交传测试和问卷调查,运用AMOS建模工具,验证分析语境构建能力的要素构成和运作机理及其对口译信息... 语境构建已成为当下口译语境研究的共识,但对口译学习者语境构建能力的构念效度仍缺乏评估。本文对国内4所高校312名英语口译学习者开展交传测试和问卷调查,运用AMOS建模工具,验证分析语境构建能力的要素构成和运作机理及其对口译信息忠实度的影响。结果显示,中国英语口译学习者语境构建能力与情景融入、文化沟通、语篇推理、心理调控4个潜在变量的在线运作有关,前者对后四者的作用力呈递增趋势;同时,语境构建能力与口译信息忠实度直接正相关,4个潜在变量通过语境构建能力间接作用于口译信息忠实度。分析表明,掌握语境资源并不能自动提升传译效果,教学培训中不仅要培养学生的语境资源获取能力,更应着力培养学生语境资源运用能力,重点强化其心理调控能力训练。 展开更多
关键词 口译学习者 语境构建能力 构念效度 验证分析
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基于Toulmin模型的英语听力认知诊断测评后效研究 被引量:1
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作者 董艳云 马晓梅 《西安外国语大学学报》 北大核心 2025年第1期59-65,共7页
本文根据Toulmin论证模型,提出“英语听力认知诊断测评的使用对学生有益”的主张及理由,旨在对该测评使用后效进行论证,为“以评促学”提供实证依据。通过准实验混合研究发现:实验组的听力后测成绩、成绩上升概率、属性掌握水平的跨越概... 本文根据Toulmin论证模型,提出“英语听力认知诊断测评的使用对学生有益”的主张及理由,旨在对该测评使用后效进行论证,为“以评促学”提供实证依据。通过准实验混合研究发现:实验组的听力后测成绩、成绩上升概率、属性掌握水平的跨越概率(除A5“理解主旨大意”外)皆显著高于对照组。基于学习投入理论,本文进一步分析了不同群组对诊断反馈的投入表现,结果表明:中水平组反馈投入最充分,听力成绩提高显著,成为最受益群体;高水平组情感投入不足,但认知投入充分,成为次受益群体;而低水平组情感投入积极,但行为及认知投入不足,成绩提升与对照组相比无显著差异。本研究结果为“以评促学”提供了可靠有效的证据。 展开更多
关键词 Toulmin模型 英语听力 认知诊断反馈 后效 学习投入
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