BACKGROUND Chronic myelomonocytic leukemia(CMML),a rare clonal hematopoietic stem cell disorder characterized by myelodysplastic syndrome and myeloproliferative neoplasms,has a generally poor prognosis,and easily prog...BACKGROUND Chronic myelomonocytic leukemia(CMML),a rare clonal hematopoietic stem cell disorder characterized by myelodysplastic syndrome and myeloproliferative neoplasms,has a generally poor prognosis,and easily progresses to acute myeloid leukemia.The simultaneous incidence of hematologic malignancies and solid tumors is extremely low,and CMML coinciding with lung malignancies is even rarer.Here,we report a case of CMML,with ASXL1 and EZH2 gene mutations,combined with non-small cell lung cancer(lung squamous cell carcinoma).CASE SUMMARY A 63-year-old male,suffering from toothache accompanied by coughing,sputum,and bloody sputum for three months,was given a blood test after experiencing continuous bleeding resulting from a tooth extraction at a local hospital.Based on morphological results,the patient was diagnosed with CMML and bronchoscopy was performed in situ to confirm the diagnosis of squamous cell carcinoma in the lower lobe of the lung.After receiving azacitidine,programmed cell death protein 1,and platinum-based chemotherapy drugs,the patient developed severe myelosuppression and eventually fatal leukocyte stasis and dyspnea.CONCLUSION During the treatment and observation of CMML and be vigilant of the growth of multiple primary malignant tumors.展开更多
附加性梳样结构(additional sex combs like,ASXL)1是ASXL家族(包括ASXL1、ASXL2、ASXL3)成员,参与表观遗传调控,在维持基因表达稳态中发挥重要作用。ASXL1基因突变广泛存在于多种髓系肿瘤中,其突变与预后不良相关,在正常造血系统中的...附加性梳样结构(additional sex combs like,ASXL)1是ASXL家族(包括ASXL1、ASXL2、ASXL3)成员,参与表观遗传调控,在维持基因表达稳态中发挥重要作用。ASXL1基因突变广泛存在于多种髓系肿瘤中,其突变与预后不良相关,在正常造血系统中的确切作用以及突变的ASXL1对造血系统恶性肿瘤发展的作用尚未完全阐明。展开更多
文摘BACKGROUND Chronic myelomonocytic leukemia(CMML),a rare clonal hematopoietic stem cell disorder characterized by myelodysplastic syndrome and myeloproliferative neoplasms,has a generally poor prognosis,and easily progresses to acute myeloid leukemia.The simultaneous incidence of hematologic malignancies and solid tumors is extremely low,and CMML coinciding with lung malignancies is even rarer.Here,we report a case of CMML,with ASXL1 and EZH2 gene mutations,combined with non-small cell lung cancer(lung squamous cell carcinoma).CASE SUMMARY A 63-year-old male,suffering from toothache accompanied by coughing,sputum,and bloody sputum for three months,was given a blood test after experiencing continuous bleeding resulting from a tooth extraction at a local hospital.Based on morphological results,the patient was diagnosed with CMML and bronchoscopy was performed in situ to confirm the diagnosis of squamous cell carcinoma in the lower lobe of the lung.After receiving azacitidine,programmed cell death protein 1,and platinum-based chemotherapy drugs,the patient developed severe myelosuppression and eventually fatal leukocyte stasis and dyspnea.CONCLUSION During the treatment and observation of CMML and be vigilant of the growth of multiple primary malignant tumors.
文摘附加性梳样结构(additional sex combs like,ASXL)1是ASXL家族(包括ASXL1、ASXL2、ASXL3)成员,参与表观遗传调控,在维持基因表达稳态中发挥重要作用。ASXL1基因突变广泛存在于多种髓系肿瘤中,其突变与预后不良相关,在正常造血系统中的确切作用以及突变的ASXL1对造血系统恶性肿瘤发展的作用尚未完全阐明。
