Using an elementary method, we give a new proof of the all-associativity of octonions. As some applications, the known Taylor theorem is improved, and a new definition and new properties of octonionic determinant are ...Using an elementary method, we give a new proof of the all-associativity of octonions. As some applications, the known Taylor theorem is improved, and a new definition and new properties of octonionic determinant are also obtained.展开更多
The interface associativity and energy absorption capability of composite structure with anti-vibration porous Al-MM（cerium-rich mischmetal）alloy core and iron alloy skin were investigated.Porous aluminum core/iron ...The interface associativity and energy absorption capability of composite structure with anti-vibration porous Al-MM（cerium-rich mischmetal）alloy core and iron alloy skin were investigated.Porous aluminum core/iron alloy skin structures were fabricated considering an iron alloy tube as its shell and closed-cell porous Al-MM alloy as its core.A peeling experiment was carried out to calculate the capacity of interfacial bonding and a compression test was carried out to determine the energy absorption capability.The results showed that the addition of MM significantly enhanced both the interfacial bonding and the energy absorption capacity.展开更多
BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for malignancy.AIM To explore the clinical characteristi...BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for malignancy.AIM To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were evaluated.Clinical data including laboratory results,colonoscopy findings,and pathology reports were collected.Key variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic regression.The performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve analysis.RESULTS The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin levels.The novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation groups.Calibration curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of AP.CONCLUSION The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.展开更多
This paper introduces part of the content in the association standard,T/CAAM0002–2020 Nomenclature and Location of Acupuncture Points for Laboratory Animals Part 2:Rat.This standard was released by the China Associat...This paper introduces part of the content in the association standard,T/CAAM0002–2020 Nomenclature and Location of Acupuncture Points for Laboratory Animals Part 2:Rat.This standard was released by the China Association of Acupuncture and Moxibustion on May 15,2020,implemented on October 31,2020,and published by Standards Press of China.The standard was drafted by the Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,and the Nanjing University of Chinese Medicine.Principal draftsmen:Xiang-hong JING and Xing-bang HUA.Participating draftsmen:Wan-Zhu BAI,Bin XU,Dong-sheng XU,Yi GUO,Tie-ming MA,Xin-jun WANG,and Sheng-feng LU.展开更多
AIM:To determine the therapeutic benefits of fenofibrate(Feno)on the dysfunction of high glucose(HG)-induced human retinal microvascular endothelial cells(HRMECs)and to elucidate the underlying molecular mechanism.MET...AIM:To determine the therapeutic benefits of fenofibrate(Feno)on the dysfunction of high glucose(HG)-induced human retinal microvascular endothelial cells(HRMECs)and to elucidate the underlying molecular mechanism.METHODS:HRMEC dysfunction model was established by 48h glucose(30 mmol/L)treatment and treated with Feno/NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome activator(Nigericin).Cell viability/apoptosis were assessed by cell counting kit-8(CCK-8)/terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay(TUNEL)staining and flow cytometry assays.Levels of apoptosis-(Bcl-2-associated X protein,Bax/B-cell lymphoma 2,Bcl-2),vascular permeability-(vascular endothelial growth factor,VEGF)and inflammasome activation-related proteins(NLRP3/cleaved caspase-1/apoptosis-associated speck-like protein containing a CARD,ASC),as well as inflammatory factors(interleukin,IL-6/IL-1β/tumor necrosis factor,TNF-α/IL-18)were determined with Western blot/enzyme linked immunosorbent assay(ELISA).Cell permeability/reactive oxygen species(ROS)level/superoxide dismutase(SOD)activity/malondialdehyde(MDA)content were assessed by Evans blue staining/2',7'-dichlorodihydrofluorescein diacetate(DCFH-DA)fluorescent probe/SOD kit/MDA kit.RESULTS:HRMEC dysfunction was successfully induced by HG,evidenced by decreased viability(P<0.001),increased apoptosis(P<0.001),permeability(P<0.001),and inflammatory factor levels(P<0.001).Feno treatment significantly ameliorated HG-induced HRMEC dysfunction(P<0.01).Meanwhile,HG induction increased ROS production(P<0.001)and MDA content(P<0.001)in HRMECs,while reducing SOD activity(P<0.001),indicative of oxidative stress.This was,however,abolished by Feno(P<0.05).Moreover,Feno eliminated activation of NLRP3 inflammasomes(P<0.05)in HG-induced HRMECs.Strikingly,activation of NLRP3 inflammasomes partially averted the inhibition of Feno on HG-induced HRMEC dysfunction(P<0.05).CONCLUSION:Feno represses oxidative stress and NLRP3 inflammasome activation,consequently alleviating HG-induced HRMEC dysfunction.展开更多
This article reviews the study,“Fanlian huazhuo formula alleviates high-fat-dietinduced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway”published in the World Journal o...This article reviews the study,“Fanlian huazhuo formula alleviates high-fat-dietinduced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway”published in the World Journal of Gastroenterology.The study explores the therapeutic potential of Fanlian Huazhuo formula(FLHZF)in treating metabolic-associated steatotic liver disease(MASLD),demonstrating that FLHZF reduces lipid accumulation,oxidative stress,and liver injury in MASLD models by modulating key signaling pathways involved in lipid metabolism and autophagy.This editorial emphasizes the potential of FLHZF as a treatment for MASLD and calls for further research to verify its clinical efficacy.展开更多
Objective:To evaluate the predictive value of the neutrophil⁃to⁃lymphocyte ratio(NLR)and the systemic immune⁃inflammation index(SII)in predicting patients with anti⁃melanoma differentiation⁃associated gene 5⁃positive(...Objective:To evaluate the predictive value of the neutrophil⁃to⁃lymphocyte ratio(NLR)and the systemic immune⁃inflammation index(SII)in predicting patients with anti⁃melanoma differentiation⁃associated gene 5⁃positive(anti⁃MDA5+)dermatomyositis(DM)develop into the rapidly progressive interstitial lung disease(RPILD).Methods:We retrospectively analyzed the clinical and laboratory data of 124 anti⁃MDA5+DM patients from the First Affiliated Hospital of Nanjing Medical University between March 2019 and September 2023.We identified independent risk factors associated with the development and mortality of RPILD with the Cox regression analysis,and determined the optimal cut⁃off values for predicting adverse outcomes with the receiver operating characteristic(ROC)curve analysis.Results:Among the 124 patients,36 patients(29.03%)developed RPILD,and 39 patients(31.45%)died during the follow⁃up period.The results of multivariate Cox regression analysis showed that the elevated NLR was an independent risk factor for RPILD development,while the elevated SII expression was independently associated with the increased mortality of RPILD.Based on the ROC curve analysis,NLR>6.12 was a predictor for RPILD,and SII>875.79 was associated with increased mortality risk of RPILD.Conclusion:Both NLR and SII are accessible,cost⁃effective,and reliable prognostic indicators for the prognosis of patients with anti⁃MDA5^(+)DM,providing a valuable guidance for clinical management and risk stratification of the disease.展开更多
This article examines an early 2nd century BC decree of an association worshipping Zeus Hyetios,“the provider of rain,”in the Koan deme of Antimacheia.Focusing on the prosopographical information of the five individ...This article examines an early 2nd century BC decree of an association worshipping Zeus Hyetios,“the provider of rain,”in the Koan deme of Antimacheia.Focusing on the prosopographical information of the five individuals mentioned in the decree,this article contextualizes the association’s activities within the broader framework of Hellenistic Kos,highlighting issues such as landownership,migration,and social structures,whilst exploring the association’s agricultural focus,its integration with local deme structures,and its strategies for managing the challenges of absentee landownership.This study also argues that the unusual name of the association reflects the frequent absence of its members from the central cult place,who therefore needed to travel a considerable distance in order to attend the cult’s rituals in Antimacheia.This case underscores the interplay between religious,social,and economic dynamics in rural communities.展开更多
Founded in 1929 by a group of pioneering Teochew immigrants,Teochew Poit Ip Huay Kuan is now the largest Teochew clan association in Singapore,representing more than 6,000 members.What began as a traditional clan orga...Founded in 1929 by a group of pioneering Teochew immigrants,Teochew Poit Ip Huay Kuan is now the largest Teochew clan association in Singapore,representing more than 6,000 members.What began as a traditional clan organization has transformed into a dynamic international platform that promotes cultural preservation,strengthens business networks,and supports people-to-people diplomacy between Singapore and China.With seven dedicated divisions including cultural education,youth engagement,international affairs,commerce,and public welfare,the association’s mission is to unite Teochew people worldwide,safeguard their heritage,and foster cooperation between Singapore and China.It played a founding role in several major federations including the Malaysian Federation of Teochew Poit It Huay Kuan and the Singapore Federation of Chinese Clan Associations.展开更多
From August 12 to 15,the 2025 China International Paper Technology Exhibition(hereina?t er referred to as“CIPTE”)was successfully held in Shanghai.Hosted by the China Paper Association,China Technical Association of...From August 12 to 15,the 2025 China International Paper Technology Exhibition(hereina?t er referred to as“CIPTE”)was successfully held in Shanghai.Hosted by the China Paper Association,China Technical Association of Paper Industry,and China National Pulp and Paper Research Institute Co.,Ltd.(below referred to as“CNPPRI”),and organized by China Pulp and Paper Magazines Publisher,this event received strong support and extensive attention from industry peers.展开更多
The 11th data release of the LAMOST survey provides fundamental stellar parameters but lacks detailed abundance measurements forα-elements,which are crucial for understanding stellar populations and Galactic chemical...The 11th data release of the LAMOST survey provides fundamental stellar parameters but lacks detailed abundance measurements forα-elements,which are crucial for understanding stellar populations and Galactic chemical evolution.In this study,we derive the abundances of oxygen(O),magnesium(Mg),silicon(Si),calcium(Ca),and titanium(Ti)for over 6.8 million stars using LAMOST DR11 low-resolution spectra.To ensure reliable measurements,we select 760 open clusters spanning a broad range of ages and apply Monte Carlo sampling for accurate abundance estimates.Additionally,we utilize over 30,000 stars from the GALAH DR4 catalog to train an XGBoost model for extractingα-element abundances from LAMOST DR11 spectra.Bayesian linear regression is employed to analyze the compositional distribution across the Galactic disk and infer chemical gradients as a function of Galactocentric distance.Our results indicate a general increase in chemical abundances with Galactocentric distance,with oxygen showing the steepest gradient.Our results confirm the overall increase ofα-element abundances with Galactocentric distance,consistent with previous studies,while minor discrepancies in Mg,Ca,and Ti gradients likely arise from differences in sample selection,observational sensitivity,or Galactic enrichment processes.展开更多
The potential of induced pluripotent stem cells(iPSCs)for modeling and treating metabolic associated fatty liver disease(MAFLD)and metabolic associated steatohepatitis(MASH)is emerging.MAFLD is a growing global health...The potential of induced pluripotent stem cells(iPSCs)for modeling and treating metabolic associated fatty liver disease(MAFLD)and metabolic associated steatohepatitis(MASH)is emerging.MAFLD is a growing global health concern,currently with limited treatment options.While primary mesenchymal stem cells hold promise,iPSCs offer a versatile alternative due to their ability to differentiate into various cell types,including iPSC-derived mesenchymal stem cells.However,challenges remain,including optimizing differentiation protocols,ensuring cell safety,and addressing potential tumorigenicity risks.In addition,iPSCs offer the possibility to generate complex cellular models,including three-dimensional organoid models,which are closer representations of the human disease than animal models.Those models would also be valuable for drug discovery and personalized medicine approaches.Overall,iPSCs and their derivatives offer new perspectives for advancing MAFLD/MASH research and developing novel therapeutic strategies.Further research is needed to overcome current limitations and translate this potential into effective clinical applications.展开更多
BACKGROUND MURCS association,an acronym for Müllerian duct aplasia/hypoplasia,congenital renal agenesis/ectopia,and cervical somite dysplasia,presents unique anaesthetic challenges,particularly for airway control...BACKGROUND MURCS association,an acronym for Müllerian duct aplasia/hypoplasia,congenital renal agenesis/ectopia,and cervical somite dysplasia,presents unique anaesthetic challenges,particularly for airway control due to cervical spine anomalies.This case report adds to the limited literature by detailing airway management strategies in a paediatric patient with MURCS,emphasising the need for thorough preoperative evaluation and curated planning.CASE SUMMARY This report describes the successful anaesthetic and airway management of a 6-year-old girl with MURCS undergoing dental extraction.To address the complexities of the patient’s condition,a multidisciplinary approach involving comprehensive preoperative assessment,meticulous planning,and advanced airway management techniques was adopted.CONCLUSION This report emphasizes individualized anesthetic strategies and interprofessional collaboration for managing rare congenital syndromes.展开更多
Introduction: Foot amputation in a diabetic patient is a real public health problem due to its functional and psychological repercussions. The objective was to study the factors associated with amputation in patients ...Introduction: Foot amputation in a diabetic patient is a real public health problem due to its functional and psychological repercussions. The objective was to study the factors associated with amputation in patients monitored for a diabetic foot in the internal medicine hospitalization of the Abass Ndao University Hospital Center (CHU) in Dakar. Methods: This was a retrospective, descriptive and analytical study conducted from the records of hospitalized patients over a 24-month period. The analysis included a descriptive phase, followed by a bivariate phase completed by logistic modeling following a descending procedure. Results: Of 1499 hospitalized patients, 224 cases had diabetic foot (14.9%). Among the cases of diabetic foot, 198 patients met the inclusion criteria. Their mean age was 61.7 ± 11.3 years, the sex ratio (M/F) was 1.2. Other associated cardiovascular risk factors were high blood pressure (54.0% 107 cases), and smoking (10.9% 21 cases). A history of lower limb amputation was found in 21.2% (42 cases). It was type 2 diabetes in 184 cases (92.9%) and the mean blood sugar was 2.7 ± 1.3 g/l. Chronic complications included neuropathy in 112 cases (78.3%), arteriopathy in 172 cases (86.9%), and chronic kidney disease in 167 cases (84.4%). The mean consultation time was 47.6 days. The main lesions were gangrene (64.6%), ulcer (24.7%), phlegmon (5.6%), and necrotizing fasciitis (5.1%). According to the University of Texas classification, patients presented with a stage D lesion (86.4%), grade 3 (51.0%). The hospital prevalence of amputation was 57.6% (114 cases), including major amputation in 55.1% (109 cases). The mortality rate was 36.4% (72 cases). Risk factors for amputation were peripheral arterial disease (ORa = 4.96 [1.33 - 18.43] p = 0.017), foot gangrene (Ora = 3.16 [1.24 - 8.04] p = 0.016) and Texas classification grade 3 (ORa = 17.49 [1.67 - 190] p = 0.019). Conclusion: The prevalence of foot and amputations remains a health problem. Reducing amputations will necessarily require strengthening prevention through education and early monitoring of diabetic patients.展开更多
Inclusive fitness theory posits that altruistic behaviors,which are directed more likely towards relatives,should be favored by natural selection.However,the prevalence of alternative parenting behaviors in offspring ...Inclusive fitness theory posits that altruistic behaviors,which are directed more likely towards relatives,should be favored by natural selection.However,the prevalence of alternative parenting behaviors in offspring selection,including rejecting their own offspring and accepting the offspring of others,remains poorly understood within the context of parental care evolution.In order to investigate the factors that prompt the occurrence of alternative parenting behaviors,we designed a series of experiments in the Azure-winged Magpie(Cyanopica cyanus).By manipulating the nest spatial position or offspring age/number and parent-offspring familiarity,we addressed how parents provided parental care for the manipulated offspring.In the nest resettlement experiment,the probability of parents rejecting their own offspring significantly increased with nest-moving distances while decreased with offspring ages.In the cross-fostering experiments,the probability of parents provisioning unrelated young significantly decreased with the age difference between cross-fostered chicks.In the nest duplication experiments,where parents were given a choice between familiar offspring and unfamiliar unrelated chicks or between unfamiliar offspring and familiar unrelated chicks,the probability of both alternative parenting behaviors was significantly influenced by the time when parental association with their offspring was deprived.We conclude that as offspring phenotypic traits become individualized and fixed at a special developmental stage,parents gradually acquire the capacity for offspring recognition by associating with them.Any factors that disrupt parent-offspring association or introduce unrelated young into the nest prior to this critical timeline can result in the occurrence of alternative parenting behaviors.展开更多
The study by Luo et al published in the World Journal of Gastrointestinal Oncology presents a thorough and scientific methodology.Pancreatic cancer is the most challenging malignancy in the digestive system,exhibiting...The study by Luo et al published in the World Journal of Gastrointestinal Oncology presents a thorough and scientific methodology.Pancreatic cancer is the most challenging malignancy in the digestive system,exhibiting one of the highest mortality rates associated with cancer globally.The delayed onset of symptoms and diagnosis often results in metastasis or local progression of the cancer,thereby constraining treatment options and outcomes.For these patients,prompt tumour identification and treatment strategising are crucial.The present objective of pancreatic cancer research is to examine the correlation between various pathological types and imaging data to facilitate therapeutic decision-making.This study aims to clarify the correlation between diverse pathological markers and imaging in pancreatic cancer patients,with prospective longitudinal studies potentially providing novel insights into the diagnosis and treatment of pancreatic cancer.展开更多
Brain-inspired intelligence is considered to be a computational model with the most promising potential to overcome the shortcomings of the von Neumann architecture,making it a current research hotspot.Due to advantag...Brain-inspired intelligence is considered to be a computational model with the most promising potential to overcome the shortcomings of the von Neumann architecture,making it a current research hotspot.Due to advantages such as nonvolatility,high density,low power consumption,and high response ratio,memristors are regarded as devices with promising applications in brain-inspired intelligence.This paper proposes a physical Ag/HfO_(x)/FeO_(x)/Pt memristor model.The Ag/HfO_(x)/FeO_(x)/Pt memristor is first fabricated using magnetron sputtering,and its internal principles and characteristics are then thoroughly analyzed.Furthermore,we construct a corresponding physical memristor model which achieves a simulation accuracy of up to 99.72%for the physical memristor.We design a fully functional Pavlovian associative memory circuit,realizing functions including generalization,primary differentiation,secondary differentiation,and forgetting.Finally,the circuit is validated through PSPICE simulation and analysis.展开更多
In this paper,we investigate a multi-UAV aided NOMA communication system,where multiple UAV-mounted aerial base stations are employed to serve ground users in the downlink NOMA communication,and each UAV serves its as...In this paper,we investigate a multi-UAV aided NOMA communication system,where multiple UAV-mounted aerial base stations are employed to serve ground users in the downlink NOMA communication,and each UAV serves its associated users on its own bandwidth.We aim at maximizing the overall common throughput in a finite time period.Such a problem is a typical mixed integer nonlinear problem,which involves both continuous-variable and combinatorial optimizations.To efficiently solve this problem,we propose a two-layer algorithm,which separately tackles continuous-variable and combinatorial optimization.Specifically,in the inner layer given one user association scheme,subproblems of bandwidth allocation,power allocation and trajectory design are solved based on alternating optimization.In the outer layer,a small number of candidate user association schemes are generated from an initial scheme and the best solution can be determined by comparing all the candidate schemes.In particular,a clustering algorithm based on K-means is applied to produce all candidate user association schemes,the successive convex optimization technique is adopted in the power allocation subproblem and a logistic function approximation approach is employed in the trajectory design subproblem.Simulation results show that the proposed NOMA scheme outperforms three baseline schemes in downlink common throughput,including one solution proposed in an existing literature.展开更多
基金Supported in part by the Doctoral Station Grant of Chinese Education Committee (20050574002), P. R. China
文摘Using an elementary method, we give a new proof of the all-associativity of octonions. As some applications, the known Taylor theorem is improved, and a new definition and new properties of octonionic determinant are also obtained.
基金supported by the National Natural Science Foundation of China(Grant No.20111061)
文摘The interface associativity and energy absorption capability of composite structure with anti-vibration porous Al-MM（cerium-rich mischmetal）alloy core and iron alloy skin were investigated.Porous aluminum core/iron alloy skin structures were fabricated considering an iron alloy tube as its shell and closed-cell porous Al-MM alloy as its core.A peeling experiment was carried out to calculate the capacity of interfacial bonding and a compression test was carried out to determine the energy absorption capability.The results showed that the addition of MM significantly enhanced both the interfacial bonding and the energy absorption capacity.
基金Supported by the National Natural Science Foundation of China,No.62375202Natural Science Foundation of Tianjin,No.23JCYBJC00950+1 种基金Tianjin Health Science and Technology Project Key Discipline Special,No.TJWJ2022XK034Research Project in Key Areas of Traditional Chinese Medicine in 2024,No.2024022.
文摘BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for malignancy.AIM To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were evaluated.Clinical data including laboratory results,colonoscopy findings,and pathology reports were collected.Key variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic regression.The performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve analysis.RESULTS The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin levels.The novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation groups.Calibration curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of AP.CONCLUSION The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.
文摘This paper introduces part of the content in the association standard,T/CAAM0002–2020 Nomenclature and Location of Acupuncture Points for Laboratory Animals Part 2:Rat.This standard was released by the China Association of Acupuncture and Moxibustion on May 15,2020,implemented on October 31,2020,and published by Standards Press of China.The standard was drafted by the Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,and the Nanjing University of Chinese Medicine.Principal draftsmen:Xiang-hong JING and Xing-bang HUA.Participating draftsmen:Wan-Zhu BAI,Bin XU,Dong-sheng XU,Yi GUO,Tie-ming MA,Xin-jun WANG,and Sheng-feng LU.
基金Supported by grants from the Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJYXZDXK-037A).
文摘AIM:To determine the therapeutic benefits of fenofibrate(Feno)on the dysfunction of high glucose(HG)-induced human retinal microvascular endothelial cells(HRMECs)and to elucidate the underlying molecular mechanism.METHODS:HRMEC dysfunction model was established by 48h glucose(30 mmol/L)treatment and treated with Feno/NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome activator(Nigericin).Cell viability/apoptosis were assessed by cell counting kit-8(CCK-8)/terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay(TUNEL)staining and flow cytometry assays.Levels of apoptosis-(Bcl-2-associated X protein,Bax/B-cell lymphoma 2,Bcl-2),vascular permeability-(vascular endothelial growth factor,VEGF)and inflammasome activation-related proteins(NLRP3/cleaved caspase-1/apoptosis-associated speck-like protein containing a CARD,ASC),as well as inflammatory factors(interleukin,IL-6/IL-1β/tumor necrosis factor,TNF-α/IL-18)were determined with Western blot/enzyme linked immunosorbent assay(ELISA).Cell permeability/reactive oxygen species(ROS)level/superoxide dismutase(SOD)activity/malondialdehyde(MDA)content were assessed by Evans blue staining/2',7'-dichlorodihydrofluorescein diacetate(DCFH-DA)fluorescent probe/SOD kit/MDA kit.RESULTS:HRMEC dysfunction was successfully induced by HG,evidenced by decreased viability(P<0.001),increased apoptosis(P<0.001),permeability(P<0.001),and inflammatory factor levels(P<0.001).Feno treatment significantly ameliorated HG-induced HRMEC dysfunction(P<0.01).Meanwhile,HG induction increased ROS production(P<0.001)and MDA content(P<0.001)in HRMECs,while reducing SOD activity(P<0.001),indicative of oxidative stress.This was,however,abolished by Feno(P<0.05).Moreover,Feno eliminated activation of NLRP3 inflammasomes(P<0.05)in HG-induced HRMECs.Strikingly,activation of NLRP3 inflammasomes partially averted the inhibition of Feno on HG-induced HRMEC dysfunction(P<0.05).CONCLUSION:Feno represses oxidative stress and NLRP3 inflammasome activation,consequently alleviating HG-induced HRMEC dysfunction.
文摘This article reviews the study,“Fanlian huazhuo formula alleviates high-fat-dietinduced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway”published in the World Journal of Gastroenterology.The study explores the therapeutic potential of Fanlian Huazhuo formula(FLHZF)in treating metabolic-associated steatotic liver disease(MASLD),demonstrating that FLHZF reduces lipid accumulation,oxidative stress,and liver injury in MASLD models by modulating key signaling pathways involved in lipid metabolism and autophagy.This editorial emphasizes the potential of FLHZF as a treatment for MASLD and calls for further research to verify its clinical efficacy.
文摘Objective:To evaluate the predictive value of the neutrophil⁃to⁃lymphocyte ratio(NLR)and the systemic immune⁃inflammation index(SII)in predicting patients with anti⁃melanoma differentiation⁃associated gene 5⁃positive(anti⁃MDA5+)dermatomyositis(DM)develop into the rapidly progressive interstitial lung disease(RPILD).Methods:We retrospectively analyzed the clinical and laboratory data of 124 anti⁃MDA5+DM patients from the First Affiliated Hospital of Nanjing Medical University between March 2019 and September 2023.We identified independent risk factors associated with the development and mortality of RPILD with the Cox regression analysis,and determined the optimal cut⁃off values for predicting adverse outcomes with the receiver operating characteristic(ROC)curve analysis.Results:Among the 124 patients,36 patients(29.03%)developed RPILD,and 39 patients(31.45%)died during the follow⁃up period.The results of multivariate Cox regression analysis showed that the elevated NLR was an independent risk factor for RPILD development,while the elevated SII expression was independently associated with the increased mortality of RPILD.Based on the ROC curve analysis,NLR>6.12 was a predictor for RPILD,and SII>875.79 was associated with increased mortality risk of RPILD.Conclusion:Both NLR and SII are accessible,cost⁃effective,and reliable prognostic indicators for the prognosis of patients with anti⁃MDA5^(+)DM,providing a valuable guidance for clinical management and risk stratification of the disease.
文摘This article examines an early 2nd century BC decree of an association worshipping Zeus Hyetios,“the provider of rain,”in the Koan deme of Antimacheia.Focusing on the prosopographical information of the five individuals mentioned in the decree,this article contextualizes the association’s activities within the broader framework of Hellenistic Kos,highlighting issues such as landownership,migration,and social structures,whilst exploring the association’s agricultural focus,its integration with local deme structures,and its strategies for managing the challenges of absentee landownership.This study also argues that the unusual name of the association reflects the frequent absence of its members from the central cult place,who therefore needed to travel a considerable distance in order to attend the cult’s rituals in Antimacheia.This case underscores the interplay between religious,social,and economic dynamics in rural communities.
文摘Founded in 1929 by a group of pioneering Teochew immigrants,Teochew Poit Ip Huay Kuan is now the largest Teochew clan association in Singapore,representing more than 6,000 members.What began as a traditional clan organization has transformed into a dynamic international platform that promotes cultural preservation,strengthens business networks,and supports people-to-people diplomacy between Singapore and China.With seven dedicated divisions including cultural education,youth engagement,international affairs,commerce,and public welfare,the association’s mission is to unite Teochew people worldwide,safeguard their heritage,and foster cooperation between Singapore and China.It played a founding role in several major federations including the Malaysian Federation of Teochew Poit It Huay Kuan and the Singapore Federation of Chinese Clan Associations.
文摘From August 12 to 15,the 2025 China International Paper Technology Exhibition(hereina?t er referred to as“CIPTE”)was successfully held in Shanghai.Hosted by the China Paper Association,China Technical Association of Paper Industry,and China National Pulp and Paper Research Institute Co.,Ltd.(below referred to as“CNPPRI”),and organized by China Pulp and Paper Magazines Publisher,this event received strong support and extensive attention from industry peers.
基金supported by the National Natural Science Foundation of China under program Nos.12090040,12090043,12473031,and 12003025as well as the Basic Research Program of Yunnan Province(No.202401AT070142)+2 种基金the International Center of Supernovae,Yunnan Key Laboratory(No.202302AN360001)the Natural Science Foundation of Yunnan Province(No.202201BC070003)the support of the Postdoctoral Fellowship Program of CPSF under grant Nos.GZC20240124 and 2024M760242.
文摘The 11th data release of the LAMOST survey provides fundamental stellar parameters but lacks detailed abundance measurements forα-elements,which are crucial for understanding stellar populations and Galactic chemical evolution.In this study,we derive the abundances of oxygen(O),magnesium(Mg),silicon(Si),calcium(Ca),and titanium(Ti)for over 6.8 million stars using LAMOST DR11 low-resolution spectra.To ensure reliable measurements,we select 760 open clusters spanning a broad range of ages and apply Monte Carlo sampling for accurate abundance estimates.Additionally,we utilize over 30,000 stars from the GALAH DR4 catalog to train an XGBoost model for extractingα-element abundances from LAMOST DR11 spectra.Bayesian linear regression is employed to analyze the compositional distribution across the Galactic disk and infer chemical gradients as a function of Galactocentric distance.Our results indicate a general increase in chemical abundances with Galactocentric distance,with oxygen showing the steepest gradient.Our results confirm the overall increase ofα-element abundances with Galactocentric distance,consistent with previous studies,while minor discrepancies in Mg,Ca,and Ti gradients likely arise from differences in sample selection,observational sensitivity,or Galactic enrichment processes.
基金American Heart Association Award,No.24IVPHA1288417and FCT Fellowships,No.2022.13253.BDANA.
文摘The potential of induced pluripotent stem cells(iPSCs)for modeling and treating metabolic associated fatty liver disease(MAFLD)and metabolic associated steatohepatitis(MASH)is emerging.MAFLD is a growing global health concern,currently with limited treatment options.While primary mesenchymal stem cells hold promise,iPSCs offer a versatile alternative due to their ability to differentiate into various cell types,including iPSC-derived mesenchymal stem cells.However,challenges remain,including optimizing differentiation protocols,ensuring cell safety,and addressing potential tumorigenicity risks.In addition,iPSCs offer the possibility to generate complex cellular models,including three-dimensional organoid models,which are closer representations of the human disease than animal models.Those models would also be valuable for drug discovery and personalized medicine approaches.Overall,iPSCs and their derivatives offer new perspectives for advancing MAFLD/MASH research and developing novel therapeutic strategies.Further research is needed to overcome current limitations and translate this potential into effective clinical applications.
基金Supported by Far-Eastern Memorial Hospital,No.FEMH-2025-C-016.
文摘BACKGROUND MURCS association,an acronym for Müllerian duct aplasia/hypoplasia,congenital renal agenesis/ectopia,and cervical somite dysplasia,presents unique anaesthetic challenges,particularly for airway control due to cervical spine anomalies.This case report adds to the limited literature by detailing airway management strategies in a paediatric patient with MURCS,emphasising the need for thorough preoperative evaluation and curated planning.CASE SUMMARY This report describes the successful anaesthetic and airway management of a 6-year-old girl with MURCS undergoing dental extraction.To address the complexities of the patient’s condition,a multidisciplinary approach involving comprehensive preoperative assessment,meticulous planning,and advanced airway management techniques was adopted.CONCLUSION This report emphasizes individualized anesthetic strategies and interprofessional collaboration for managing rare congenital syndromes.
文摘Introduction: Foot amputation in a diabetic patient is a real public health problem due to its functional and psychological repercussions. The objective was to study the factors associated with amputation in patients monitored for a diabetic foot in the internal medicine hospitalization of the Abass Ndao University Hospital Center (CHU) in Dakar. Methods: This was a retrospective, descriptive and analytical study conducted from the records of hospitalized patients over a 24-month period. The analysis included a descriptive phase, followed by a bivariate phase completed by logistic modeling following a descending procedure. Results: Of 1499 hospitalized patients, 224 cases had diabetic foot (14.9%). Among the cases of diabetic foot, 198 patients met the inclusion criteria. Their mean age was 61.7 ± 11.3 years, the sex ratio (M/F) was 1.2. Other associated cardiovascular risk factors were high blood pressure (54.0% 107 cases), and smoking (10.9% 21 cases). A history of lower limb amputation was found in 21.2% (42 cases). It was type 2 diabetes in 184 cases (92.9%) and the mean blood sugar was 2.7 ± 1.3 g/l. Chronic complications included neuropathy in 112 cases (78.3%), arteriopathy in 172 cases (86.9%), and chronic kidney disease in 167 cases (84.4%). The mean consultation time was 47.6 days. The main lesions were gangrene (64.6%), ulcer (24.7%), phlegmon (5.6%), and necrotizing fasciitis (5.1%). According to the University of Texas classification, patients presented with a stage D lesion (86.4%), grade 3 (51.0%). The hospital prevalence of amputation was 57.6% (114 cases), including major amputation in 55.1% (109 cases). The mortality rate was 36.4% (72 cases). Risk factors for amputation were peripheral arterial disease (ORa = 4.96 [1.33 - 18.43] p = 0.017), foot gangrene (Ora = 3.16 [1.24 - 8.04] p = 0.016) and Texas classification grade 3 (ORa = 17.49 [1.67 - 190] p = 0.019). Conclusion: The prevalence of foot and amputations remains a health problem. Reducing amputations will necessarily require strengthening prevention through education and early monitoring of diabetic patients.
基金provided by the National Natural Sciences Foundation of China (Grant 32071491,31772465,31672299,31572271,and 32260128)。
文摘Inclusive fitness theory posits that altruistic behaviors,which are directed more likely towards relatives,should be favored by natural selection.However,the prevalence of alternative parenting behaviors in offspring selection,including rejecting their own offspring and accepting the offspring of others,remains poorly understood within the context of parental care evolution.In order to investigate the factors that prompt the occurrence of alternative parenting behaviors,we designed a series of experiments in the Azure-winged Magpie(Cyanopica cyanus).By manipulating the nest spatial position or offspring age/number and parent-offspring familiarity,we addressed how parents provided parental care for the manipulated offspring.In the nest resettlement experiment,the probability of parents rejecting their own offspring significantly increased with nest-moving distances while decreased with offspring ages.In the cross-fostering experiments,the probability of parents provisioning unrelated young significantly decreased with the age difference between cross-fostered chicks.In the nest duplication experiments,where parents were given a choice between familiar offspring and unfamiliar unrelated chicks or between unfamiliar offspring and familiar unrelated chicks,the probability of both alternative parenting behaviors was significantly influenced by the time when parental association with their offspring was deprived.We conclude that as offspring phenotypic traits become individualized and fixed at a special developmental stage,parents gradually acquire the capacity for offspring recognition by associating with them.Any factors that disrupt parent-offspring association or introduce unrelated young into the nest prior to this critical timeline can result in the occurrence of alternative parenting behaviors.
基金Supported by the National Health Commission’s Key Laboratory of Gastrointestinal Tumor Diagnosis and Treatment for The Year 2022,National Health Commission’s Master’s and Doctoral/Postdoctoral Fund Project,No.NHCDP2022001Gansu Provincial People’s Hospital Doctoral Supervisor Training Project,No.22GSSYA-3.
文摘The study by Luo et al published in the World Journal of Gastrointestinal Oncology presents a thorough and scientific methodology.Pancreatic cancer is the most challenging malignancy in the digestive system,exhibiting one of the highest mortality rates associated with cancer globally.The delayed onset of symptoms and diagnosis often results in metastasis or local progression of the cancer,thereby constraining treatment options and outcomes.For these patients,prompt tumour identification and treatment strategising are crucial.The present objective of pancreatic cancer research is to examine the correlation between various pathological types and imaging data to facilitate therapeutic decision-making.This study aims to clarify the correlation between diverse pathological markers and imaging in pancreatic cancer patients,with prospective longitudinal studies potentially providing novel insights into the diagnosis and treatment of pancreatic cancer.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.62476230 and 61976246)the Natural Science Foundation of Chongqing(Grant No.CSTB2023NSCQ-MSX0018)Fundamental Research Funds for the Central Universities(Grant No.SWUKR22046)。
文摘Brain-inspired intelligence is considered to be a computational model with the most promising potential to overcome the shortcomings of the von Neumann architecture,making it a current research hotspot.Due to advantages such as nonvolatility,high density,low power consumption,and high response ratio,memristors are regarded as devices with promising applications in brain-inspired intelligence.This paper proposes a physical Ag/HfO_(x)/FeO_(x)/Pt memristor model.The Ag/HfO_(x)/FeO_(x)/Pt memristor is first fabricated using magnetron sputtering,and its internal principles and characteristics are then thoroughly analyzed.Furthermore,we construct a corresponding physical memristor model which achieves a simulation accuracy of up to 99.72%for the physical memristor.We design a fully functional Pavlovian associative memory circuit,realizing functions including generalization,primary differentiation,secondary differentiation,and forgetting.Finally,the circuit is validated through PSPICE simulation and analysis.
基金supported by Beijing Natural Science Fund–Haidian Original Innovation Joint Fund(L232040 and L232045).
文摘In this paper,we investigate a multi-UAV aided NOMA communication system,where multiple UAV-mounted aerial base stations are employed to serve ground users in the downlink NOMA communication,and each UAV serves its associated users on its own bandwidth.We aim at maximizing the overall common throughput in a finite time period.Such a problem is a typical mixed integer nonlinear problem,which involves both continuous-variable and combinatorial optimizations.To efficiently solve this problem,we propose a two-layer algorithm,which separately tackles continuous-variable and combinatorial optimization.Specifically,in the inner layer given one user association scheme,subproblems of bandwidth allocation,power allocation and trajectory design are solved based on alternating optimization.In the outer layer,a small number of candidate user association schemes are generated from an initial scheme and the best solution can be determined by comparing all the candidate schemes.In particular,a clustering algorithm based on K-means is applied to produce all candidate user association schemes,the successive convex optimization technique is adopted in the power allocation subproblem and a logistic function approximation approach is employed in the trajectory design subproblem.Simulation results show that the proposed NOMA scheme outperforms three baseline schemes in downlink common throughput,including one solution proposed in an existing literature.
