With the transformation from websites to Internet platforms, Chinese young netizens (born in 1990-2005) have become key subjects in the evolution of cyber-nationalism. Based on survey data, this study classifies their...With the transformation from websites to Internet platforms, Chinese young netizens (born in 1990-2005) have become key subjects in the evolution of cyber-nationalism. Based on survey data, this study classifies their nationalism into four types and explores its transformation alongside globalization cognition. The result shows that moderate nationalism is the mainstream. This has raised their attention to globalization, with greater focus on relations between China and developing countries, and nations along the Belt and Road Initiative. Their personal experiences and cultural exposure foster a more inclusive global vision, shaping the evolution of nationalism and global dialogue.展开更多
The integration of High-Altitude Platform Stations(HAPS)with Reconfigurable Intelligent Surfaces(RIS)represents a critical advancement for next-generation wireless networks,offering unprecedented opportunities for ubi...The integration of High-Altitude Platform Stations(HAPS)with Reconfigurable Intelligent Surfaces(RIS)represents a critical advancement for next-generation wireless networks,offering unprecedented opportunities for ubiquitous connectivity.However,existing research reveals significant gaps in dynamic resource allocation,joint optimization,and equitable service provisioning under varying channel conditions,limiting practical deployment of these technologies.This paper addresses these challenges by proposing a novel Fairness-Aware Deep Q-Learning(FAIRDQL)framework for joint resource management and phase configuration in HAPS-RIS systems.Our methodology employs a comprehensive three-tier algorithmic architecture integrating adaptive power control,priority-based user scheduling,and dynamic learning mechanisms.The FAIR-DQL approach utilizes advanced reinforcement learning with experience replay and fairness-aware reward functions to balance competing objectives while adapting to dynamic environments.Key findings demonstrate substantial improvements:9.15 dB SINR gain,12.5 bps/Hz capacity,78%power efficiency,and 0.82 fairness index.The framework achieves rapid 40-episode convergence with consistent delay performance.These contributions establish new benchmarks for fairness-aware resource allocation in aerial communications,enabling practical HAPS-RIS deployments in rural connectivity,emergency communications,and urban networks.展开更多
The construction of centralized and standardized material databases is essential to support both scientific innovation and industrial application.However,for rare and precious metal materials,existing data resources a...The construction of centralized and standardized material databases is essential to support both scientific innovation and industrial application.However,for rare and precious metal materials,existing data resources are often decentralized.This results in persistent issues such as data silos and fragmentation,which significantly hinder efficient data utilization and collaboration.In response to these challenges,this study investigates the development of an integrated platform for sharing genetic data of rare and precious metal materials.The research begins by analyzing current trends in material data platforms,both domestically and internationally.These insights help inform the architectural design.The core of the platform consists of several key modules.Data resource integration is designed to aggregate and harmonize heterogeneous data from diverse sources.A structured data management system supports efficient storage and retrieval.A computational environment enables data analysis and modeling.A trusted sharing mechanism ensures security and access control.By integrating these functionalities,the platform aims to provide a unified ecosystem.This system facilitates open yet secure data exchange,promotes reproducibility,and enhances research efficiency.Finally,the article summarizes the initial implementation of the platform.It discusses its potential limitations and outlines future directions for development,including the integration of artificial intelligence tools and the expansion of data coverage.展开更多
Under the current background of an information society,the digital transformation of enterprises has become a necessary means to enhance the competitiveness of enterprises.This article is based on the industrial Inter...Under the current background of an information society,the digital transformation of enterprises has become a necessary means to enhance the competitiveness of enterprises.This article is based on the industrial Internet platform,the digital planning and architecture of enterprises research.First,we analyze the current challenges of digital transformation and the development opportunities brought by the industrial Internet.Then,we propose a digital planning method based on the industrial Internet platform,which takes the full connectivity of people,machine and things and intelligent decision making as the core,takes data collection,processing,analysis and application as the main line,and finally forms the top-level design of the digital transformation of enterprises.At the same time,we also built an industrial Internet platform architecture model,including the previous end perception layer,network transmission layer,platform service layer,and application innovation layer for four levels,to support enterprises in innovative applications and decision support under the industrial Internet environment.Research shows that this kind of enterprise digital planning and architecture based on an industrial Internet platform can effectively promote enterprises to achieve business model innovation,system innovation,and strengthen the flexibility and agility of enterprises to respond to market changes.The results of this research not only have important theoretical and practical significance for guiding enterprises to carry out digital planning and build an industrial Internet platform,but also provide useful reference for relevant policy formulation.展开更多
Portable ratiometric fluorescent platforms have emerged as promising tools for multifarious detection,yet remain unexplored for point-of-care monitoring doxorubicin(DOX),one of clinically antineoplastic drugs.To this ...Portable ratiometric fluorescent platforms have emerged as promising tools for multifarious detection,yet remain unexplored for point-of-care monitoring doxorubicin(DOX),one of clinically antineoplastic drugs.To this end,we herein develop a portable self-calibrating platform namely carbon dots(C-dots)-embedded hydrogel sensors with a smartphone-assisted high-throughput imaging device,for DOX sensing.The prepared green-emitting(λ_(em)=508 nm)and negatively-charged C-dots(−11.40±1.21 mV),which have sufficient spectral overlap with the absorption band of DOX(∼500 nm),can strongly bind with positively-charged DOX molecules by electrostatic attraction effects.As a result,DOX molecules are selectively and rapid(20 s)determined with a detection limit of 10.26 nmol/L via Förster resonance energy transfer processes,demonstrating a remarkably chromatic shift from green to red.Further integrated with a 3D-printed smartphone-assisted device,the platform enabled high-throughput quantification,achieving recoveries of 96.40%-101.85%in human urine/serum(RSDs<2.94%,n=3).Notably,the dual linear detection ranges of the platform align with the reported clinical DOX concentrations in urine and plasma(0-4 h post-administration),validating their capability for direct quantification of DOX in clinical samples without special pre-treatment processes.By virtue of attractive analytical performances and robust feasibility,this platform bridges laboratory precision and point-of-care testing needs,offering promising potential for personalized chemotherapy and multiplexed analyte screening.展开更多
Amidst evolving user behavior driven by the development of the internet,enhancing the operational quality of trade publishing knowledge service platforms has become a significant challenge for publishing institutions....Amidst evolving user behavior driven by the development of the internet,enhancing the operational quality of trade publishing knowledge service platforms has become a significant challenge for publishing institutions.To address this issue,this paper employs a combined approach of theoretical analysis and case study,introducing the SICAS(Sense-Interest-Connection-Action-Share)user consumption behavior analysis model and selecting“CITIC Academy”as the case study subject.It systematically examines and summarizes the platform’s operational practices and specific strategies,aiming to offer strategic insights and practical references for the operational improvement and sustainable,high-quality development of trade publishing knowledge service platforms.展开更多
We are sorry for the mistakes of Affiliation,"a State Key Laboratory of Advanced Fiber Materials,Center for Advanced Low-Dimension Materials,Donghua University,Shanghai 201620,China"should be replaced by&quo...We are sorry for the mistakes of Affiliation,"a State Key Laboratory of Advanced Fiber Materials,Center for Advanced Low-Dimension Materials,Donghua University,Shanghai 201620,China"should be replaced by"a State Key Laboratory of Advanced Fiber Materials,Center for Advanced Low-Dimension Materials,College of Materials Science and Engineering,Donghua University,Shanghai 201620,China".We apologized for the inconvenience caused by this error.展开更多
Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells,which is involved in retinal ganglion cell apopt...Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells,which is involved in retinal ganglion cell apoptosis in glaucoma.Modulation of Kir4.1 expression in Müller cells may therefore be a potential strategy for attenuating retinal ganglion cell damage in glaucoma.In this study,we identified seven predicted phosphorylation sites in Kir4.1 and constructed lentiviral expression systems expressing Kir4.1 mutated at each site to prevent phosphorylation.Following this,we treated Müller glial cells in vitro and in vivo with the m Glu R I agonist DHPG to induce Kir4.1 or Kir4.1 Tyr^(9)Asp overexpression.We found that both Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression inhibited activation of Müller glial cells.Subsequently,we established a rat model of chronic ocular hypertension by injecting microbeads into the anterior chamber and overexpressed Kir4.1 or Kir4.1 Tyr^(9)Asp in the eye,and observed similar results in Müller cells in vivo as those seen in vitro.Both Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression inhibited Müller cell activation,regulated the balance of Bax/Bcl-2,and reduced the m RNA and protein levels of pro-inflammatory factors,including interleukin-1βand tumor necrosis factor-α.Furthermore,we investigated the regulatory effects of Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression on the release of pro-inflammatory factors in a co-culture system of Müller glial cells and microglia.In this co-culture system,we observed elevated adenosine triphosphate concentrations in activated Müller cells,increased levels of translocator protein(a marker of microglial activation),and elevated interleukin-1βm RNA and protein levels in microglia induced by activated Müller cells.These changes could be reversed by Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression in Müller cells.Kir4.1 overexpression,but not Kir4.1 Tyr^(9)Asp overexpression,reduced the number of proliferative and migratory microglia induced by activated Müller cells.Collectively,these results suggest that the tyrosine residue at position nine in Kir4.1 may serve as a functional modulation site in the retina in an experimental model of glaucoma.Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression attenuated Müller cell activation,reduced ATP/P2X receptor–mediated interactions between glial cells,inhibited microglial activation,and decreased the synthesis and release of pro-inflammatory factors,consequently ameliorating retinal ganglion cell apoptosis in glaucoma.展开更多
文摘With the transformation from websites to Internet platforms, Chinese young netizens (born in 1990-2005) have become key subjects in the evolution of cyber-nationalism. Based on survey data, this study classifies their nationalism into four types and explores its transformation alongside globalization cognition. The result shows that moderate nationalism is the mainstream. This has raised their attention to globalization, with greater focus on relations between China and developing countries, and nations along the Belt and Road Initiative. Their personal experiences and cultural exposure foster a more inclusive global vision, shaping the evolution of nationalism and global dialogue.
基金supported by the Princess Nourah bint Abdulrahman University Researchers Supporting Project,number PNURSP2025R757Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.
文摘The integration of High-Altitude Platform Stations(HAPS)with Reconfigurable Intelligent Surfaces(RIS)represents a critical advancement for next-generation wireless networks,offering unprecedented opportunities for ubiquitous connectivity.However,existing research reveals significant gaps in dynamic resource allocation,joint optimization,and equitable service provisioning under varying channel conditions,limiting practical deployment of these technologies.This paper addresses these challenges by proposing a novel Fairness-Aware Deep Q-Learning(FAIRDQL)framework for joint resource management and phase configuration in HAPS-RIS systems.Our methodology employs a comprehensive three-tier algorithmic architecture integrating adaptive power control,priority-based user scheduling,and dynamic learning mechanisms.The FAIR-DQL approach utilizes advanced reinforcement learning with experience replay and fairness-aware reward functions to balance competing objectives while adapting to dynamic environments.Key findings demonstrate substantial improvements:9.15 dB SINR gain,12.5 bps/Hz capacity,78%power efficiency,and 0.82 fairness index.The framework achieves rapid 40-episode convergence with consistent delay performance.These contributions establish new benchmarks for fairness-aware resource allocation in aerial communications,enabling practical HAPS-RIS deployments in rural connectivity,emergency communications,and urban networks.
基金funded by the Major Science and Technology Projects in Yunnan Province(202502AD080002)Yunnan Fundamental Research Projects(202201AT070161)Yunnan Province High-Level Talent Introduction Program(C619300A023).
文摘The construction of centralized and standardized material databases is essential to support both scientific innovation and industrial application.However,for rare and precious metal materials,existing data resources are often decentralized.This results in persistent issues such as data silos and fragmentation,which significantly hinder efficient data utilization and collaboration.In response to these challenges,this study investigates the development of an integrated platform for sharing genetic data of rare and precious metal materials.The research begins by analyzing current trends in material data platforms,both domestically and internationally.These insights help inform the architectural design.The core of the platform consists of several key modules.Data resource integration is designed to aggregate and harmonize heterogeneous data from diverse sources.A structured data management system supports efficient storage and retrieval.A computational environment enables data analysis and modeling.A trusted sharing mechanism ensures security and access control.By integrating these functionalities,the platform aims to provide a unified ecosystem.This system facilitates open yet secure data exchange,promotes reproducibility,and enhances research efficiency.Finally,the article summarizes the initial implementation of the platform.It discusses its potential limitations and outlines future directions for development,including the integration of artificial intelligence tools and the expansion of data coverage.
文摘Under the current background of an information society,the digital transformation of enterprises has become a necessary means to enhance the competitiveness of enterprises.This article is based on the industrial Internet platform,the digital planning and architecture of enterprises research.First,we analyze the current challenges of digital transformation and the development opportunities brought by the industrial Internet.Then,we propose a digital planning method based on the industrial Internet platform,which takes the full connectivity of people,machine and things and intelligent decision making as the core,takes data collection,processing,analysis and application as the main line,and finally forms the top-level design of the digital transformation of enterprises.At the same time,we also built an industrial Internet platform architecture model,including the previous end perception layer,network transmission layer,platform service layer,and application innovation layer for four levels,to support enterprises in innovative applications and decision support under the industrial Internet environment.Research shows that this kind of enterprise digital planning and architecture based on an industrial Internet platform can effectively promote enterprises to achieve business model innovation,system innovation,and strengthen the flexibility and agility of enterprises to respond to market changes.The results of this research not only have important theoretical and practical significance for guiding enterprises to carry out digital planning and build an industrial Internet platform,but also provide useful reference for relevant policy formulation.
基金supported by the National NaturalScience Foundation of China(No.22274001)the Key Project of Natural Science Research of the Education Department of Anhui Province(No.2022AH051032)the Excellent Research and Innovation Team of Universities in Anhui Province(No.2024AH010016).
文摘Portable ratiometric fluorescent platforms have emerged as promising tools for multifarious detection,yet remain unexplored for point-of-care monitoring doxorubicin(DOX),one of clinically antineoplastic drugs.To this end,we herein develop a portable self-calibrating platform namely carbon dots(C-dots)-embedded hydrogel sensors with a smartphone-assisted high-throughput imaging device,for DOX sensing.The prepared green-emitting(λ_(em)=508 nm)and negatively-charged C-dots(−11.40±1.21 mV),which have sufficient spectral overlap with the absorption band of DOX(∼500 nm),can strongly bind with positively-charged DOX molecules by electrostatic attraction effects.As a result,DOX molecules are selectively and rapid(20 s)determined with a detection limit of 10.26 nmol/L via Förster resonance energy transfer processes,demonstrating a remarkably chromatic shift from green to red.Further integrated with a 3D-printed smartphone-assisted device,the platform enabled high-throughput quantification,achieving recoveries of 96.40%-101.85%in human urine/serum(RSDs<2.94%,n=3).Notably,the dual linear detection ranges of the platform align with the reported clinical DOX concentrations in urine and plasma(0-4 h post-administration),validating their capability for direct quantification of DOX in clinical samples without special pre-treatment processes.By virtue of attractive analytical performances and robust feasibility,this platform bridges laboratory precision and point-of-care testing needs,offering promising potential for personalized chemotherapy and multiplexed analyte screening.
文摘Amidst evolving user behavior driven by the development of the internet,enhancing the operational quality of trade publishing knowledge service platforms has become a significant challenge for publishing institutions.To address this issue,this paper employs a combined approach of theoretical analysis and case study,introducing the SICAS(Sense-Interest-Connection-Action-Share)user consumption behavior analysis model and selecting“CITIC Academy”as the case study subject.It systematically examines and summarizes the platform’s operational practices and specific strategies,aiming to offer strategic insights and practical references for the operational improvement and sustainable,high-quality development of trade publishing knowledge service platforms.
文摘We are sorry for the mistakes of Affiliation,"a State Key Laboratory of Advanced Fiber Materials,Center for Advanced Low-Dimension Materials,Donghua University,Shanghai 201620,China"should be replaced by"a State Key Laboratory of Advanced Fiber Materials,Center for Advanced Low-Dimension Materials,College of Materials Science and Engineering,Donghua University,Shanghai 201620,China".We apologized for the inconvenience caused by this error.
基金supported by the National Natural Science Foundation of China,Nos.32271043(to ZW)and 82171047(to YM)the both Science and Technology Major Project of Shanghai,No.2018SHZDZX01 and ZJLabShanghai Center for Brain Science and Brain-Inspired Technology(to ZW)。
文摘Downregulation of the inwardly rectifying potassium channel Kir4.1 is a key step for inducing retinal Müller cell activation and interaction with other glial cells,which is involved in retinal ganglion cell apoptosis in glaucoma.Modulation of Kir4.1 expression in Müller cells may therefore be a potential strategy for attenuating retinal ganglion cell damage in glaucoma.In this study,we identified seven predicted phosphorylation sites in Kir4.1 and constructed lentiviral expression systems expressing Kir4.1 mutated at each site to prevent phosphorylation.Following this,we treated Müller glial cells in vitro and in vivo with the m Glu R I agonist DHPG to induce Kir4.1 or Kir4.1 Tyr^(9)Asp overexpression.We found that both Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression inhibited activation of Müller glial cells.Subsequently,we established a rat model of chronic ocular hypertension by injecting microbeads into the anterior chamber and overexpressed Kir4.1 or Kir4.1 Tyr^(9)Asp in the eye,and observed similar results in Müller cells in vivo as those seen in vitro.Both Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression inhibited Müller cell activation,regulated the balance of Bax/Bcl-2,and reduced the m RNA and protein levels of pro-inflammatory factors,including interleukin-1βand tumor necrosis factor-α.Furthermore,we investigated the regulatory effects of Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression on the release of pro-inflammatory factors in a co-culture system of Müller glial cells and microglia.In this co-culture system,we observed elevated adenosine triphosphate concentrations in activated Müller cells,increased levels of translocator protein(a marker of microglial activation),and elevated interleukin-1βm RNA and protein levels in microglia induced by activated Müller cells.These changes could be reversed by Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression in Müller cells.Kir4.1 overexpression,but not Kir4.1 Tyr^(9)Asp overexpression,reduced the number of proliferative and migratory microglia induced by activated Müller cells.Collectively,these results suggest that the tyrosine residue at position nine in Kir4.1 may serve as a functional modulation site in the retina in an experimental model of glaucoma.Kir4.1 and Kir4.1 Tyr^(9)Asp overexpression attenuated Müller cell activation,reduced ATP/P2X receptor–mediated interactions between glial cells,inhibited microglial activation,and decreased the synthesis and release of pro-inflammatory factors,consequently ameliorating retinal ganglion cell apoptosis in glaucoma.
