利用Norton Ghost工具制作映像文件来快速备份、恢复操作系统已成为业内的通行做法,但具体情况还需具体分析,巧妙的方法能取得事半功倍的效果。描述了并行计算机群的安装方法,着重讲述了基于新近出品的Redhat L inux Advanced Server 4....利用Norton Ghost工具制作映像文件来快速备份、恢复操作系统已成为业内的通行做法,但具体情况还需具体分析,巧妙的方法能取得事半功倍的效果。描述了并行计算机群的安装方法,着重讲述了基于新近出品的Redhat L inux Advanced Server 4.0操作系统下如何高效地安装、配置并行计算机群。展开更多
Objective： To investigate the As4S4 induced growth inhibition and apoptosis in HeLa cells and its possible relationship with cyclooxygenase-2 （COX-2）. Methods： HeLa cells were treated with various concentrations ...Objective： To investigate the As4S4 induced growth inhibition and apoptosis in HeLa cells and its possible relationship with cyclooxygenase-2 （COX-2）. Methods： HeLa cells were treated with various concentrations （7.5, 15, 30, 60 mg/L） of As4S4 at different times （12, 24, 36, 48, 60 h）. Cell growth was measured by MTT. Apoptosis was detected by double staining flow cytometry （FCM）. Levels of PGE2 were measured by radioimmunoassay. The expression of COX-2 protein was examined by Western blot analysis. Results： After treated with different concentrations of As4S4, the growth of HeLa cells was suppressed significantly in a dose-and time-dependent manner. The IC50 of 24 h was 30 mg/L （P〈0.01）. As4S4 induced apoptosis with apoptosis rates at 8.13%-62.36% by flow cytometry （FCM） in a dose-dependent manners. The release of PGE2 was reduced in HeLa cells with the values being （70.56±2.03）, （48.58±2.28）, （29.25±1.57） and （18.02±1.04） respectively, significantly different compared with control group （3.15±0.01） （P〈0.01）. As4S4 also inhibited the activity and expression of COX-2 in a dose dependent manner and down-regulated the expression of COX-2 protein greatly. Conclusion： As4S4 could inhibit the proliferation and increase apoptosis in human HeLa cells. These effects may depend on the inhibition of the expression of COX-2 and PGE2 by As4S4.展开更多
以前笔者一直使用zhcon作为Linux Shell下的中文平台，可是自从将系统升级到Red HatLinux AS 4(下文简称AS4)之后就不能再使用zhcon了。因为AS4使用了UTF-8编码，但zhcon并不支持UTF-8。虽然可以使用CCE作为AS4下的中文Shell平台，但是...以前笔者一直使用zhcon作为Linux Shell下的中文平台，可是自从将系统升级到Red HatLinux AS 4(下文简称AS4)之后就不能再使用zhcon了。因为AS4使用了UTF-8编码，但zhcon并不支持UTF-8。虽然可以使用CCE作为AS4下的中文Shell平台，但是在安装CCE时需要修改部分源代码，、这对初学者来说还是比较麻烦的。其实只需要将AS4的字体编码更改一下就可以正常使用zhcon了，具体步骤如下：展开更多
Mineral medicine,especially those containing heavy metals,is one of the characteristics of traditional Chinese medicine.A famous mineral medicine,realgar,containing heavy metal arsenic with a chemical formula of As4S4...Mineral medicine,especially those containing heavy metals,is one of the characteristics of traditional Chinese medicine.A famous mineral medicine,realgar,containing heavy metal arsenic with a chemical formula of As4S4,has the function of detoxification,killing bacteria and viruses,and eliminating dampness and phlegm.Different As4S4 isomers are likely to have different drug effects and pharmacological actions.Therefore,it is of great scientific significance to find more stable As4S4 isomers.In view of this,ab initio molecular orbital theory and density functional theory(DFT)have been used to study ten isomers of As4S4 at the B3LYP/6-31 G*,B3LYP/6-311+G*,B3LYP/6-311+G(3 df,2 p)and MP2/(6-311+G*,LanL2 MB)levels of theory.In addition to the two isomers having been studied previously,eight new isomers were investigated in the present paper.All the ten As4S4 isomers were proved to be true local minima on their potential energy surfaces.The calculated NICS values and molecular orbital analyses showed that,the D2d symmetric As4S4,isomer 1,may be s-aromatic.The study proves that ten As4S4 isomers are stable thermodynamically,and are highly desirable for the future theoretical study of realgar.展开更多
Low-temperature specific heat(SH)is measured for the 12442-type KCa2Fe4As4F2 single crystal under different magnetic fields.A clear SH jump with the height of?C/T|Tc=130 mJ mol-1 K-2 is observed at the superconducting...Low-temperature specific heat(SH)is measured for the 12442-type KCa2Fe4As4F2 single crystal under different magnetic fields.A clear SH jump with the height of?C/T|Tc=130 mJ mol-1 K-2 is observed at the superconducting transition temperature Tc.It is found that the electronic SH coefficient?γ(H)quickly increases when the field is in the low-field region below 3T and then considerably slows down the increase with a further increase in the field,which indicates a rather strong anisotropy or multi-gap feature with a small minimum in the superconducting gap(s).The temperature-dependent SH data indicate the presence of the T2 term,which supplies further information and supports the picture with a line-nodal gap structure.Moreover,the onset point of the SH transition remains almost unchanged under the field as high as 9 T,which is similar to that observed in cuprates,and places this system in the middle between the BCS limit and the Bose-Einstein condensation.展开更多
文摘利用Norton Ghost工具制作映像文件来快速备份、恢复操作系统已成为业内的通行做法,但具体情况还需具体分析,巧妙的方法能取得事半功倍的效果。描述了并行计算机群的安装方法,着重讲述了基于新近出品的Redhat L inux Advanced Server 4.0操作系统下如何高效地安装、配置并行计算机群。
文摘Objective： To investigate the As4S4 induced growth inhibition and apoptosis in HeLa cells and its possible relationship with cyclooxygenase-2 （COX-2）. Methods： HeLa cells were treated with various concentrations （7.5, 15, 30, 60 mg/L） of As4S4 at different times （12, 24, 36, 48, 60 h）. Cell growth was measured by MTT. Apoptosis was detected by double staining flow cytometry （FCM）. Levels of PGE2 were measured by radioimmunoassay. The expression of COX-2 protein was examined by Western blot analysis. Results： After treated with different concentrations of As4S4, the growth of HeLa cells was suppressed significantly in a dose-and time-dependent manner. The IC50 of 24 h was 30 mg/L （P〈0.01）. As4S4 induced apoptosis with apoptosis rates at 8.13%-62.36% by flow cytometry （FCM） in a dose-dependent manners. The release of PGE2 was reduced in HeLa cells with the values being （70.56±2.03）, （48.58±2.28）, （29.25±1.57） and （18.02±1.04） respectively, significantly different compared with control group （3.15±0.01） （P〈0.01）. As4S4 also inhibited the activity and expression of COX-2 in a dose dependent manner and down-regulated the expression of COX-2 protein greatly. Conclusion： As4S4 could inhibit the proliferation and increase apoptosis in human HeLa cells. These effects may depend on the inhibition of the expression of COX-2 and PGE2 by As4S4.
文摘以前笔者一直使用zhcon作为Linux Shell下的中文平台，可是自从将系统升级到Red HatLinux AS 4(下文简称AS4)之后就不能再使用zhcon了。因为AS4使用了UTF-8编码，但zhcon并不支持UTF-8。虽然可以使用CCE作为AS4下的中文Shell平台，但是在安装CCE时需要修改部分源代码，、这对初学者来说还是比较麻烦的。其实只需要将AS4的字体编码更改一下就可以正常使用zhcon了，具体步骤如下：
基金supported by the National Natural Science Foundation of China(No.81403069)the Research and Development Fund of Beijing University of Chinese Medicine(No.2020072120050)。
文摘Mineral medicine,especially those containing heavy metals,is one of the characteristics of traditional Chinese medicine.A famous mineral medicine,realgar,containing heavy metal arsenic with a chemical formula of As4S4,has the function of detoxification,killing bacteria and viruses,and eliminating dampness and phlegm.Different As4S4 isomers are likely to have different drug effects and pharmacological actions.Therefore,it is of great scientific significance to find more stable As4S4 isomers.In view of this,ab initio molecular orbital theory and density functional theory(DFT)have been used to study ten isomers of As4S4 at the B3LYP/6-31 G*,B3LYP/6-311+G*,B3LYP/6-311+G(3 df,2 p)and MP2/(6-311+G*,LanL2 MB)levels of theory.In addition to the two isomers having been studied previously,eight new isomers were investigated in the present paper.All the ten As4S4 isomers were proved to be true local minima on their potential energy surfaces.The calculated NICS values and molecular orbital analyses showed that,the D2d symmetric As4S4,isomer 1,may be s-aromatic.The study proves that ten As4S4 isomers are stable thermodynamically,and are highly desirable for the future theoretical study of realgar.
基金the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Grant No.2015187)the National Natural Science Foundation of China(Grant Nos.11204338,and 11927807)the“Strategic Priority Research Program(B)”of the Chinese Academy of Sciences(Grant No.XDB04040300).Wei Li also acknowledges the start-up funding from Fudan University.
文摘Low-temperature specific heat(SH)is measured for the 12442-type KCa2Fe4As4F2 single crystal under different magnetic fields.A clear SH jump with the height of?C/T|Tc=130 mJ mol-1 K-2 is observed at the superconducting transition temperature Tc.It is found that the electronic SH coefficient?γ(H)quickly increases when the field is in the low-field region below 3T and then considerably slows down the increase with a further increase in the field,which indicates a rather strong anisotropy or multi-gap feature with a small minimum in the superconducting gap(s).The temperature-dependent SH data indicate the presence of the T2 term,which supplies further information and supports the picture with a line-nodal gap structure.Moreover,the onset point of the SH transition remains almost unchanged under the field as high as 9 T,which is similar to that observed in cuprates,and places this system in the middle between the BCS limit and the Bose-Einstein condensation.
