The aim of the present study was to determine the effect of AS-101, a known immunomodulator, on the pattern of cytokine production in children with patchy alopecia areata (PAA). Ten previously untreated children with ...The aim of the present study was to determine the effect of AS-101, a known immunomodulator, on the pattern of cytokine production in children with patchy alopecia areata (PAA). Ten previously untreated children with PAA were compared to 10 healthy age-and sex-matched controls. Peripheral blood mononuclear cells (PBMC) were isolated from all participants. Unstimulated and phytohaemagglutinin (PHA)stimulated PBMC were tested with and without the addition of AS-101. The production of interferon gamma (IFNγ), soluble interleukin (IL)-2 receptor (IL-2R), IL-10, IL-5 and EL-6 was determined. The levels of soluble IL-2R, IL-5 and EL-6 were significantly higher in the PAA patients than the controls. AS-101 inhibited the production of IL-10, IFNγ,IL-2R and IL-5 in both PAA patients and controls, but there was a greater inhibitory effect in children with PAA.展开更多
文摘The aim of the present study was to determine the effect of AS-101, a known immunomodulator, on the pattern of cytokine production in children with patchy alopecia areata (PAA). Ten previously untreated children with PAA were compared to 10 healthy age-and sex-matched controls. Peripheral blood mononuclear cells (PBMC) were isolated from all participants. Unstimulated and phytohaemagglutinin (PHA)stimulated PBMC were tested with and without the addition of AS-101. The production of interferon gamma (IFNγ), soluble interleukin (IL)-2 receptor (IL-2R), IL-10, IL-5 and EL-6 was determined. The levels of soluble IL-2R, IL-5 and EL-6 were significantly higher in the PAA patients than the controls. AS-101 inhibited the production of IL-10, IFNγ,IL-2R and IL-5 in both PAA patients and controls, but there was a greater inhibitory effect in children with PAA.
