Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and imp...Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and impaired perinatal and post-natal outcome of offspring, has been thoroughly investigated, and these aspectsare clinically applied during fertility and pregestational counseling. Male aging and reproductive outcome has gained relatively less attention. The purpose of this review is to evaluate updated and relevant literature on the effect of paternal age on reproductive outcome.展开更多
Introduction:Human immunodeficiency virus(HIV)and hepatitis C virus(HCV)represent two major public health threats worldwide.However,the impact of HCV co-infection on HIV antiretroviral therapy(ART)outcomes remains deb...Introduction:Human immunodeficiency virus(HIV)and hepatitis C virus(HCV)represent two major public health threats worldwide.However,the impact of HCV co-infection on HIV antiretroviral therapy(ART)outcomes remains debated.Methods:Using data from the National Free Antiretroviral Treatment Program database,we employed stratified matching methods to extract two cohorts:HIV/HCV co-infected individuals and HIV mono-infected individuals.We compared differences in their ART outcomes—mortality,virological failure,and attrition—through stratified Cox regression and conditional logistic regression analyses.Results:A total of 10,953 HIV/HCV co-infected and 17,348 HIV mono-infected individuals were included.Across all baseline CD4 strata,HIV/HCV co-infected individuals demonstrated a significantly higher risk of mortality,virological failure,and attrition compared to HIV mono-infected individuals.The risks were highest for all ART outcomes in the group with a baseline CD4 count of 200-349 cells/μL.Conclusion:Given the adverse impact of HCV coinfection on treatment outcomes among people living with HIV(PLWH),enhanced prevention,screening,and management(including treatment)of HCV within PLWH should be prioritized and strengthened as part of routine clinical care.展开更多
文摘Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and impaired perinatal and post-natal outcome of offspring, has been thoroughly investigated, and these aspectsare clinically applied during fertility and pregestational counseling. Male aging and reproductive outcome has gained relatively less attention. The purpose of this review is to evaluate updated and relevant literature on the effect of paternal age on reproductive outcome.
文摘Introduction:Human immunodeficiency virus(HIV)and hepatitis C virus(HCV)represent two major public health threats worldwide.However,the impact of HCV co-infection on HIV antiretroviral therapy(ART)outcomes remains debated.Methods:Using data from the National Free Antiretroviral Treatment Program database,we employed stratified matching methods to extract two cohorts:HIV/HCV co-infected individuals and HIV mono-infected individuals.We compared differences in their ART outcomes—mortality,virological failure,and attrition—through stratified Cox regression and conditional logistic regression analyses.Results:A total of 10,953 HIV/HCV co-infected and 17,348 HIV mono-infected individuals were included.Across all baseline CD4 strata,HIV/HCV co-infected individuals demonstrated a significantly higher risk of mortality,virological failure,and attrition compared to HIV mono-infected individuals.The risks were highest for all ART outcomes in the group with a baseline CD4 count of 200-349 cells/μL.Conclusion:Given the adverse impact of HCV coinfection on treatment outcomes among people living with HIV(PLWH),enhanced prevention,screening,and management(including treatment)of HCV within PLWH should be prioritized and strengthened as part of routine clinical care.
