Accurate satellite data assimilation under all-sky conditions requires enhanced parameterization of scattering properties for frozen hydrometeors in clouds.This study aims to develop a nonspherical scattering look-up ...Accurate satellite data assimilation under all-sky conditions requires enhanced parameterization of scattering properties for frozen hydrometeors in clouds.This study aims to develop a nonspherical scattering look-up table that contains the optical properties of five hydrometeor types—rain,cloud water,cloud ice,graupel,and snow—for the Advanced Radiative Transfer Modeling System(ARMS)at frequencies below 220 GHz.The discrete dipole approximation(DDA)method is employed to compute the single-scattering properties of solid cloud particles,modeling these particles as aggregated roughened bullet rosettes.The bulk optical properties of the cloud layer are derived by integrating the singlescattering properties with a modified Gamma size distribution,specifically for distributions with 18 effective radii.The bulk phase function is then projected onto a series of generalized spherical functions,applying the delta-M method for truncation.The results indicate that simulations using the newly developed nonspherical scattering look-up table exhibit significant consistency with observations under deep convection conditions.In contrast,assuming spherical solid cloud particles leads to excessive scattering at mid-frequency channels and insufficient scattering at high-frequency channels.This improvement in radiative transfer simulation accuracy for cloudy conditions will better support the assimilation of allsky microwave observations into numerical weather prediction models.·Frozen cloud particles were modeled as aggregates of bullet rosettes and the optical properties at microwave range were computed by DDA.·A complete process and technical details for constructing a look-up table of ARMS are provided.·The ARMS simulations generally show agreement with observations of MWTS and MWHS under typhoon conditions using the new look-up table.展开更多
This commentary critically appraises the study by Li et al which pioneered the exploration of the triglyceride-glucose(TyG)index as a prognostic marker in hepatitis B virus-related advanced hepatocellular carcinoma pa...This commentary critically appraises the study by Li et al which pioneered the exploration of the triglyceride-glucose(TyG)index as a prognostic marker in hepatitis B virus-related advanced hepatocellular carcinoma patients undergoing combined camrelizumab and lenvatinib therapy.While we acknowledge the study’s clinical relevance in proposing an easily accessible metabolic biomarker,we delve into the mechanistic plausibility linking insulin resistance to immunotherapy response and angiogenic inhibition.We further critically examine the methodological limitations,including the retrospective design,the populationspecific TyG cut-off value,and unaddressed metabolic confounders.We highlight the imperative for future research to validate its utility across diverse etiologies and treatment settings,and to unravel the underlying immunometabolic pathways.展开更多
Recent years have witnessed transformative changes brought about by artificial intelligence(AI)techniques with billions of parameters for the realization of high accuracy,proposing high demand for the advanced and AI ...Recent years have witnessed transformative changes brought about by artificial intelligence(AI)techniques with billions of parameters for the realization of high accuracy,proposing high demand for the advanced and AI chip to solve these AI tasks efficiently and powerfully.Rapid progress has been made in the field of advanced chips recently,such as the development of photonic computing,the advancement of the quantum processors,the boost of the biomimetic chips,and so on.Designs tactics of the advanced chips can be conducted with elaborated consideration of materials,algorithms,models,architectures,and so on.Though a few reviews present the development of the chips from their unique aspects,reviews in the view of the latest design for advanced and AI chips are few.Here,the newest development is systematically reviewed in the field of advanced chips.First,background and mechanisms are summarized,and subsequently most important considerations for co-design of the software and hardware are illustrated.Next,strategies are summed up to obtain advanced and AI chips with high excellent performance by taking the important information processing steps into consideration,after which the design thought for the advanced chips in the future is proposed.Finally,some perspectives are put forward.展开更多
BACKGROUND Paternal perinatal depression(PPD)is closely associated with maternal mental health challenges,marital strain,and adverse child developmental outcomes.Despite its significant impact,PPD remains under-recogn...BACKGROUND Paternal perinatal depression(PPD)is closely associated with maternal mental health challenges,marital strain,and adverse child developmental outcomes.Despite its significant impact,PPD remains under-recognized in family-centered clinical practice.Concurrently,against the backdrop of rising rates of delayed marriage and China’s Maternity Incentive Policy,the proportion of women giving birth at an advanced maternal age is increasing.Nevertheless,research specifically examining PPD among spouses of older mothers remains critically scarce,both in China and globally.AIM To investigate PPD and its influencing factors in Chinese advanced maternal age families.METHODS This cross-sectional study included 358 participants;it was conducted among fathers of pregnant women of advanced maternal age at five hospitals in the Pearl River Delta region of China from September 2023 to June 2024.Data were collected via a general information questionnaire,the Social Support Rating Scale,and the Edinburgh Postnatal Depression Scale.Latent profile analysis and regression mixture models(RMMs)were adopted to analyze the latent PPD types and factors that influenced PPD.RESULTS The incidence of PPD was 16.48%,and three profiles were identified:Low-symptomatic(175 cases,48.89%),monophasic(140 cases,39.10%),and high-symptomatic(43 cases,12.01%).The RMM analysis revealed that first pregnancy,low income(<¥3000/month),part-time work,and a history of abnormal pregnancy were positively associated with the high-symptomatic type(P<0.05).Conversely,high subjective support and support utilization were negatively associated with the high-symptomatic type compared with the low-symptomatic type(P<0.05).Good couple relationships,high objective and subjective support,and high support utilization were negatively associated with monophasic disorder(P<0.05).CONCLUSION PPD incidence is high among Chinese fathers with advanced maternal age partners,and the characteristics of depression are varied.Healthcare practitioners should prioritize individuals with low levels of social support.展开更多
Clinical pharmacists specialized in oncology contributed to the safe and effective chemotherapy treatment for advanced esophageal carcinoma patients complicated with hypertension by participating in medication practic...Clinical pharmacists specialized in oncology contributed to the safe and effective chemotherapy treatment for advanced esophageal carcinoma patients complicated with hypertension by participating in medication practice. Optimal therapeutic regimen was proposed, and pharmaceutical care and health education were provided based on the condition of each patient. By providing pharmaceutical care for cancer patients with their pharmacy knowledge, clinical pharmacists specialized in oncology can not only reduce the potential risks of chemotherapy, but also take into account of other accompanying diseases, thus improving the comprehensive treatment of patients. Furthermore, it deepened the understanding of the role of clinical pharmacy practice by patients and other medical workers. Involvement of clinical pharmacist in therapeutic practice could improve the outcome of pharmacotherapy.展开更多
In recent years, the use of advanced high strength steels in automotive industry has been increased remarkably. Among advanced high strength steels, dual phase （DP） steels have gained a great attention owing to a co...In recent years, the use of advanced high strength steels in automotive industry has been increased remarkably. Among advanced high strength steels, dual phase （DP） steels have gained a great attention owing to a combination of high strength and good formability. However, high strength usually increases the spring-back behavior of the material, which creates problems for the parts during the assembly. Thus, the uniaxial tensile deformation and spring-back behaviors of DP600 advanced high strength steel were investigated in rolling （0°）, diagonal （45°） , and transverse （90°） directions in the temperature range from room temperature （RT） to 300 ℃. All tests were performed at a deformation speed of 25 mm/min. A V-shaped die （60°） was used for the spring-back measurements. The results indicated that the formability and spring-back of the material were decreased with increasing the temperatures. The material showed complex behaviors in different directions and at different temperatures.展开更多
To improve the computational efficiency of the reliability-based design optimization(RBDO) of flexible mechanism, particle swarm optimization-advanced extremum response surface method(PSO-AERSM) was proposed by integr...To improve the computational efficiency of the reliability-based design optimization(RBDO) of flexible mechanism, particle swarm optimization-advanced extremum response surface method(PSO-AERSM) was proposed by integrating particle swarm optimization(PSO) algorithm and advanced extremum response surface method(AERSM). Firstly, the AERSM was developed and its mathematical model was established based on artificial neural network, and the PSO algorithm was investigated. And then the RBDO model of flexible mechanism was presented based on AERSM and PSO. Finally, regarding cross-sectional area as design variable, the reliability optimization of flexible mechanism was implemented subject to reliability degree and uncertainties based on the proposed approach. The optimization results show that the cross-section sizes obviously reduce by 22.96 mm^2 while keeping reliability degree. Through the comparison of methods, it is demonstrated that the AERSM holds high computational efficiency while keeping computational precision for the RBDO of flexible mechanism, and PSO algorithm minimizes the response of the objective function. The efforts of this work provide a useful sight for the reliability optimization of flexible mechanism, and enrich and develop the reliability theory as well.展开更多
In this study, an advanced probabilistic neural network （APNN） method is proposed to reflect the global probability density function （PDF） by summing up the heterogeneous local PDF which is automatically determine...In this study, an advanced probabilistic neural network （APNN） method is proposed to reflect the global probability density function （PDF） by summing up the heterogeneous local PDF which is automatically determined in the individual standard deviation of variables. The APNN is applied to predict the stability number of armor blocks of breakwaters using the experimental data of＇ van der Meet, and the estimated results of the APNN are compared with those of an empirical formula and a previous artificial neural network （ANN） model. The APNN shows better results in predicting the stability number of armor bilks of breakwater and it provided the promising probabilistic viewpoints by using the individual standard deviation in a variable.展开更多
基金supported by the National Key Research and Development Program of China(Grant No.2021YFB3900400)the National Natural Science Foundation of China(Grant Nos.U2142212 and 42361074)。
文摘Accurate satellite data assimilation under all-sky conditions requires enhanced parameterization of scattering properties for frozen hydrometeors in clouds.This study aims to develop a nonspherical scattering look-up table that contains the optical properties of five hydrometeor types—rain,cloud water,cloud ice,graupel,and snow—for the Advanced Radiative Transfer Modeling System(ARMS)at frequencies below 220 GHz.The discrete dipole approximation(DDA)method is employed to compute the single-scattering properties of solid cloud particles,modeling these particles as aggregated roughened bullet rosettes.The bulk optical properties of the cloud layer are derived by integrating the singlescattering properties with a modified Gamma size distribution,specifically for distributions with 18 effective radii.The bulk phase function is then projected onto a series of generalized spherical functions,applying the delta-M method for truncation.The results indicate that simulations using the newly developed nonspherical scattering look-up table exhibit significant consistency with observations under deep convection conditions.In contrast,assuming spherical solid cloud particles leads to excessive scattering at mid-frequency channels and insufficient scattering at high-frequency channels.This improvement in radiative transfer simulation accuracy for cloudy conditions will better support the assimilation of allsky microwave observations into numerical weather prediction models.·Frozen cloud particles were modeled as aggregates of bullet rosettes and the optical properties at microwave range were computed by DDA.·A complete process and technical details for constructing a look-up table of ARMS are provided.·The ARMS simulations generally show agreement with observations of MWTS and MWHS under typhoon conditions using the new look-up table.
文摘This commentary critically appraises the study by Li et al which pioneered the exploration of the triglyceride-glucose(TyG)index as a prognostic marker in hepatitis B virus-related advanced hepatocellular carcinoma patients undergoing combined camrelizumab and lenvatinib therapy.While we acknowledge the study’s clinical relevance in proposing an easily accessible metabolic biomarker,we delve into the mechanistic plausibility linking insulin resistance to immunotherapy response and angiogenic inhibition.We further critically examine the methodological limitations,including the retrospective design,the populationspecific TyG cut-off value,and unaddressed metabolic confounders.We highlight the imperative for future research to validate its utility across diverse etiologies and treatment settings,and to unravel the underlying immunometabolic pathways.
基金supported by the Hong Kong Polytechnic University(1-WZ1Y,1-W34U,4-YWER).
文摘Recent years have witnessed transformative changes brought about by artificial intelligence(AI)techniques with billions of parameters for the realization of high accuracy,proposing high demand for the advanced and AI chip to solve these AI tasks efficiently and powerfully.Rapid progress has been made in the field of advanced chips recently,such as the development of photonic computing,the advancement of the quantum processors,the boost of the biomimetic chips,and so on.Designs tactics of the advanced chips can be conducted with elaborated consideration of materials,algorithms,models,architectures,and so on.Though a few reviews present the development of the chips from their unique aspects,reviews in the view of the latest design for advanced and AI chips are few.Here,the newest development is systematically reviewed in the field of advanced chips.First,background and mechanisms are summarized,and subsequently most important considerations for co-design of the software and hardware are illustrated.Next,strategies are summed up to obtain advanced and AI chips with high excellent performance by taking the important information processing steps into consideration,after which the design thought for the advanced chips in the future is proposed.Finally,some perspectives are put forward.
基金Supported by High-level Professional Groups in Gangdong Province,No.GSPZYQ2020101Guangdong Province Educational Research Planning Project,No.2024GXJK742。
文摘BACKGROUND Paternal perinatal depression(PPD)is closely associated with maternal mental health challenges,marital strain,and adverse child developmental outcomes.Despite its significant impact,PPD remains under-recognized in family-centered clinical practice.Concurrently,against the backdrop of rising rates of delayed marriage and China’s Maternity Incentive Policy,the proportion of women giving birth at an advanced maternal age is increasing.Nevertheless,research specifically examining PPD among spouses of older mothers remains critically scarce,both in China and globally.AIM To investigate PPD and its influencing factors in Chinese advanced maternal age families.METHODS This cross-sectional study included 358 participants;it was conducted among fathers of pregnant women of advanced maternal age at five hospitals in the Pearl River Delta region of China from September 2023 to June 2024.Data were collected via a general information questionnaire,the Social Support Rating Scale,and the Edinburgh Postnatal Depression Scale.Latent profile analysis and regression mixture models(RMMs)were adopted to analyze the latent PPD types and factors that influenced PPD.RESULTS The incidence of PPD was 16.48%,and three profiles were identified:Low-symptomatic(175 cases,48.89%),monophasic(140 cases,39.10%),and high-symptomatic(43 cases,12.01%).The RMM analysis revealed that first pregnancy,low income(<¥3000/month),part-time work,and a history of abnormal pregnancy were positively associated with the high-symptomatic type(P<0.05).Conversely,high subjective support and support utilization were negatively associated with the high-symptomatic type compared with the low-symptomatic type(P<0.05).Good couple relationships,high objective and subjective support,and high support utilization were negatively associated with monophasic disorder(P<0.05).CONCLUSION PPD incidence is high among Chinese fathers with advanced maternal age partners,and the characteristics of depression are varied.Healthcare practitioners should prioritize individuals with low levels of social support.
基金Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents(Grant No.2010-190-4)
文摘Clinical pharmacists specialized in oncology contributed to the safe and effective chemotherapy treatment for advanced esophageal carcinoma patients complicated with hypertension by participating in medication practice. Optimal therapeutic regimen was proposed, and pharmaceutical care and health education were provided based on the condition of each patient. By providing pharmaceutical care for cancer patients with their pharmacy knowledge, clinical pharmacists specialized in oncology can not only reduce the potential risks of chemotherapy, but also take into account of other accompanying diseases, thus improving the comprehensive treatment of patients. Furthermore, it deepened the understanding of the role of clinical pharmacy practice by patients and other medical workers. Involvement of clinical pharmacist in therapeutic practice could improve the outcome of pharmacotherapy.
基金Item Sponsored by Scientific and Technological Research Council of Turkey(107 M596)
文摘In recent years, the use of advanced high strength steels in automotive industry has been increased remarkably. Among advanced high strength steels, dual phase （DP） steels have gained a great attention owing to a combination of high strength and good formability. However, high strength usually increases the spring-back behavior of the material, which creates problems for the parts during the assembly. Thus, the uniaxial tensile deformation and spring-back behaviors of DP600 advanced high strength steel were investigated in rolling （0°）, diagonal （45°） , and transverse （90°） directions in the temperature range from room temperature （RT） to 300 ℃. All tests were performed at a deformation speed of 25 mm/min. A V-shaped die （60°） was used for the spring-back measurements. The results indicated that the formability and spring-back of the material were decreased with increasing the temperatures. The material showed complex behaviors in different directions and at different temperatures.
基金Projects(51275138,51475025)supported by the National Natural Science Foundation of ChinaProject(12531109)supported by the Science Foundation of Heilongjiang Provincial Department of Education,China+1 种基金Projects(XJ2015002,G-YZ90)supported by Hong Kong Scholars Program,ChinaProject(2015M580037)supported by Postdoctoral Science Foundation of China
文摘To improve the computational efficiency of the reliability-based design optimization(RBDO) of flexible mechanism, particle swarm optimization-advanced extremum response surface method(PSO-AERSM) was proposed by integrating particle swarm optimization(PSO) algorithm and advanced extremum response surface method(AERSM). Firstly, the AERSM was developed and its mathematical model was established based on artificial neural network, and the PSO algorithm was investigated. And then the RBDO model of flexible mechanism was presented based on AERSM and PSO. Finally, regarding cross-sectional area as design variable, the reliability optimization of flexible mechanism was implemented subject to reliability degree and uncertainties based on the proposed approach. The optimization results show that the cross-section sizes obviously reduce by 22.96 mm^2 while keeping reliability degree. Through the comparison of methods, it is demonstrated that the AERSM holds high computational efficiency while keeping computational precision for the RBDO of flexible mechanism, and PSO algorithm minimizes the response of the objective function. The efforts of this work provide a useful sight for the reliability optimization of flexible mechanism, and enrich and develop the reliability theory as well.
基金This work was supported by grant PM484400 PM41500 from"High-Tech Port Research Program"founded by Ministry of Maritime Affairs and Fisheries of Korean Government.
文摘In this study, an advanced probabilistic neural network （APNN） method is proposed to reflect the global probability density function （PDF） by summing up the heterogeneous local PDF which is automatically determined in the individual standard deviation of variables. The APNN is applied to predict the stability number of armor blocks of breakwaters using the experimental data of＇ van der Meet, and the estimated results of the APNN are compared with those of an empirical formula and a previous artificial neural network （ANN） model. The APNN shows better results in predicting the stability number of armor bilks of breakwater and it provided the promising probabilistic viewpoints by using the individual standard deviation in a variable.
