Recently,Tian et al.published a research paper with significant breakthroughs in Cell[1].The study found that targeting the signalling pathways named Serpine2-lowdensity lipoprotein receptor-related protein 1(Lrp1)and...Recently,Tian et al.published a research paper with significant breakthroughs in Cell[1].The study found that targeting the signalling pathways named Serpine2-lowdensity lipoprotein receptor-related protein 1(Lrp1)and ectonucleoside triphosphate diphosphohydrolase 1(CD39)-adenosine A_(3)receptor(A_(3)AR)is a promising strategy for the treatment of vascular dementia.The Serpine2-Lrp1 signalling pathway primarily exerts its therapeutic effects on myelin regeneration by regulating the differentiation of oligodendrocyte precursor cells.Serpine2 is a secretory serine protease inhibitor regulates proteolytic homeostasis.It may also bind to cell surface receptors such as Lrp1 to directly activate signalling pathways.As a transmembrane glycoprotein receptor,Lrpl mediates the endocytic clearance of ligands.展开更多
AR Aur A+B is a close binary of astrophysical interest because dissimilar surface compositions are reported between similar late B-type dwarfs.A new spectroscopic study on this system was carried out based on the dise...AR Aur A+B is a close binary of astrophysical interest because dissimilar surface compositions are reported between similar late B-type dwarfs.A new spectroscopic study on this system was carried out based on the disentangled spectra,in order to determine their atmospheric parameters and elemental abundances.The effective temperature and microturbulence(determined from the equivalent widths of Fe II lines)turned out to be(11,150 K,0.9 km s^(-1))and(10,650 K,0.1 km s^(-1))for A and B,respectively.The chemical abundances of 28 elements were then derived while taking into account the non-LTE effect for Z≤15 elements(Z:atomic number).The following trends were elucidated for[X/H](abundance of X relative to the Sun):(1)Qualitatively,[X/H]shows a rough global tendency to increase with Z,with the gradient steeper for A than for B.(2)However,considerable dispersion is involved for A,since prominently large peculiarities are seen in specific elements reflecting the characteristics of HgMn stars(e.g.,very deficient N,Al,Sc,Ni;markedly overabundant P,Mn).(3)In contrast,the Z-dependence of[X/H]for B tends to be nearly linear with only a small dispersion.These observational facts may serve as a key to understanding the critical condition for the emergence of the chemical anomaly.展开更多
Lip language provides a silent,intuitive,and efficient mode of communication,offering a promising solution for individuals with speech impairments.Its articulation relies on complex movements of the jaw and the muscle...Lip language provides a silent,intuitive,and efficient mode of communication,offering a promising solution for individuals with speech impairments.Its articulation relies on complex movements of the jaw and the muscles surrounding it.However,the accurate and real-time acquisition and decoding of these movements into reliable silent speech signals remains a significant challenge.In this work,we propose a real-time silent speech recognition system,which integrates a triboelectric nanogenerator-based flexible pressure sensor(FPS)with a deep learning framework.The FPS employs a porous pyramid-structured silicone film as the negative triboelectric layer,enabling highly sensitive pressure detection in the low-force regime(1 V N^(-1) for 0-10 N and 4.6 V N^(-1) for 10-24 N).This allows it to precisely capture jaw movements during speech and convert them into electrical signals.To decode the signals,we proposed a convolutional neural networklong short-term memory(CNN-LSTM)hybrid network,combining CNN and LSTM model to extract both local spatial features and temporal dynamics.The model achieved 95.83%classification accuracy in 30 categories of daily words.Furthermore,the decoded silent speech signals can be directly translated into executable commands for contactless and precise control of the smartphone.The system can also be connected to AR glasses,offering a novel human-machine interaction approach with promising potential in AR/VR applications.展开更多
目的:探讨膜肾方对特发性膜性肾病大鼠血浆诱导损伤足细胞的干预作用及其机制。方法:建立特发性膜性肾病大鼠模型,用肝素钠作为抗凝剂收集其血浆样品并诱导足细胞损伤,分对照组、模型组、膜肾方组、膜肾方+C3a受体(C3aR)拮抗剂组、C3aR...目的:探讨膜肾方对特发性膜性肾病大鼠血浆诱导损伤足细胞的干预作用及其机制。方法:建立特发性膜性肾病大鼠模型,用肝素钠作为抗凝剂收集其血浆样品并诱导足细胞损伤,分对照组、模型组、膜肾方组、膜肾方+C3a受体(C3aR)拮抗剂组、C3aR拮抗剂组。采用Western blotting检测各组足细胞C3aR、磷脂酶A2受体(PLA2R)、磷酸化细胞外信号调节激酶1/2(p-ERK1/2)、磷酸化细胞浆型磷脂酶A2(p-cPLA2)蛋白表达水平;酶联免疫吸附试验(ELISA)检测上清液C3a表达水平;Real-time PCR测定Synaptopodin mRNA、C3aR m RNA、PLA2R mRNA表达水平;细胞计数试剂盒-8(CCK-8)检测各组足细胞活力。结果:与对照组比较,模型组足细胞C3aR、PLA2R、p-ERK1/2、p-cPLA2表达水平均升高,上清液C3a水平升高,Synaptopodin m RNA水平下降,C3aR mRNA、PLA2R mRNA水平升高,足细胞活力下降,差异均有统计学意义(P<0.01);与模型组比较,膜肾方组足细胞C3aR、PLA2R、p-ERK1/2、p-cPLA2表达水平均下降,上清液C3a水平下降,Synaptopodin m RNA水平升高,C3aR mRNA、PLA2R mRNA水平下降,足细胞活力改善,差异均有统计学意义(P<0.01);与膜肾方组比较,膜肾方+C3aR拮抗剂组及C3aR拮抗剂组足细胞C3aR、PLA2R、p-ERK1/2、p-cPLA2表达水平均下降,上清液C3a水平下降,Synaptopodin mRNA水平升高,C3aR m RNA、PLA2R mRNA水平下降,足细胞活力改善,膜肾方+C3aR拮抗剂组更明显,差异均有统计学意义(P<0.01)。结论:膜肾方可能通过调控C3a/C3aR通路,下调PLA2R水平,稳定足细胞骨架,改善足细胞活力,从而发挥对足细胞的保护作用。展开更多
基金support from the Sichuan Science and Technology Program(2024JDHJ0043 and 2025YFHZ0121).
文摘Recently,Tian et al.published a research paper with significant breakthroughs in Cell[1].The study found that targeting the signalling pathways named Serpine2-lowdensity lipoprotein receptor-related protein 1(Lrp1)and ectonucleoside triphosphate diphosphohydrolase 1(CD39)-adenosine A_(3)receptor(A_(3)AR)is a promising strategy for the treatment of vascular dementia.The Serpine2-Lrp1 signalling pathway primarily exerts its therapeutic effects on myelin regeneration by regulating the differentiation of oligodendrocyte precursor cells.Serpine2 is a secretory serine protease inhibitor regulates proteolytic homeostasis.It may also bind to cell surface receptors such as Lrp1 to directly activate signalling pathways.As a transmembrane glycoprotein receptor,Lrpl mediates the endocytic clearance of ligands.
文摘AR Aur A+B is a close binary of astrophysical interest because dissimilar surface compositions are reported between similar late B-type dwarfs.A new spectroscopic study on this system was carried out based on the disentangled spectra,in order to determine their atmospheric parameters and elemental abundances.The effective temperature and microturbulence(determined from the equivalent widths of Fe II lines)turned out to be(11,150 K,0.9 km s^(-1))and(10,650 K,0.1 km s^(-1))for A and B,respectively.The chemical abundances of 28 elements were then derived while taking into account the non-LTE effect for Z≤15 elements(Z:atomic number).The following trends were elucidated for[X/H](abundance of X relative to the Sun):(1)Qualitatively,[X/H]shows a rough global tendency to increase with Z,with the gradient steeper for A than for B.(2)However,considerable dispersion is involved for A,since prominently large peculiarities are seen in specific elements reflecting the characteristics of HgMn stars(e.g.,very deficient N,Al,Sc,Ni;markedly overabundant P,Mn).(3)In contrast,the Z-dependence of[X/H]for B tends to be nearly linear with only a small dispersion.These observational facts may serve as a key to understanding the critical condition for the emergence of the chemical anomaly.
基金supported by the Natural Science Foundation of Fujian Province under Grant No.2024J010016Fujian Province Young and Middle aged Teacher Education Research Project No.JAT241317the Mindu Innovation Laboratory Project under Grant No.2020ZZ113.
文摘Lip language provides a silent,intuitive,and efficient mode of communication,offering a promising solution for individuals with speech impairments.Its articulation relies on complex movements of the jaw and the muscles surrounding it.However,the accurate and real-time acquisition and decoding of these movements into reliable silent speech signals remains a significant challenge.In this work,we propose a real-time silent speech recognition system,which integrates a triboelectric nanogenerator-based flexible pressure sensor(FPS)with a deep learning framework.The FPS employs a porous pyramid-structured silicone film as the negative triboelectric layer,enabling highly sensitive pressure detection in the low-force regime(1 V N^(-1) for 0-10 N and 4.6 V N^(-1) for 10-24 N).This allows it to precisely capture jaw movements during speech and convert them into electrical signals.To decode the signals,we proposed a convolutional neural networklong short-term memory(CNN-LSTM)hybrid network,combining CNN and LSTM model to extract both local spatial features and temporal dynamics.The model achieved 95.83%classification accuracy in 30 categories of daily words.Furthermore,the decoded silent speech signals can be directly translated into executable commands for contactless and precise control of the smartphone.The system can also be connected to AR glasses,offering a novel human-machine interaction approach with promising potential in AR/VR applications.
文摘目的:探讨膜肾方对特发性膜性肾病大鼠血浆诱导损伤足细胞的干预作用及其机制。方法:建立特发性膜性肾病大鼠模型,用肝素钠作为抗凝剂收集其血浆样品并诱导足细胞损伤,分对照组、模型组、膜肾方组、膜肾方+C3a受体(C3aR)拮抗剂组、C3aR拮抗剂组。采用Western blotting检测各组足细胞C3aR、磷脂酶A2受体(PLA2R)、磷酸化细胞外信号调节激酶1/2(p-ERK1/2)、磷酸化细胞浆型磷脂酶A2(p-cPLA2)蛋白表达水平;酶联免疫吸附试验(ELISA)检测上清液C3a表达水平;Real-time PCR测定Synaptopodin mRNA、C3aR m RNA、PLA2R mRNA表达水平;细胞计数试剂盒-8(CCK-8)检测各组足细胞活力。结果:与对照组比较,模型组足细胞C3aR、PLA2R、p-ERK1/2、p-cPLA2表达水平均升高,上清液C3a水平升高,Synaptopodin m RNA水平下降,C3aR mRNA、PLA2R mRNA水平升高,足细胞活力下降,差异均有统计学意义(P<0.01);与模型组比较,膜肾方组足细胞C3aR、PLA2R、p-ERK1/2、p-cPLA2表达水平均下降,上清液C3a水平下降,Synaptopodin m RNA水平升高,C3aR mRNA、PLA2R mRNA水平下降,足细胞活力改善,差异均有统计学意义(P<0.01);与膜肾方组比较,膜肾方+C3aR拮抗剂组及C3aR拮抗剂组足细胞C3aR、PLA2R、p-ERK1/2、p-cPLA2表达水平均下降,上清液C3a水平下降,Synaptopodin mRNA水平升高,C3aR m RNA、PLA2R mRNA水平下降,足细胞活力改善,膜肾方+C3aR拮抗剂组更明显,差异均有统计学意义(P<0.01)。结论:膜肾方可能通过调控C3a/C3aR通路,下调PLA2R水平,稳定足细胞骨架,改善足细胞活力,从而发挥对足细胞的保护作用。
