He CEL-3是一个高温、高压、高流量的氦气冷却实验回路,主要用于聚变堆包层部件热工水力实验。根据实验回路的系统设计与布局参数,运用APROS软件对回路建模,模拟氦气在不同工况下的温度、压力、流量等重要工艺参数分布与变化,以及重要...He CEL-3是一个高温、高压、高流量的氦气冷却实验回路,主要用于聚变堆包层部件热工水力实验。根据实验回路的系统设计与布局参数,运用APROS软件对回路建模,模拟氦气在不同工况下的温度、压力、流量等重要工艺参数分布与变化,以及重要设备如印刷电路板式换热器(PCHE)和风机等在运行或状态切换过程中的瞬态参数,以获得热工特性曲线。目前He CEL-3实验回路已建设完工,回路已完成部分运行状态的实验研究工作。通过对模拟获取的热工特性与调试实验参数进行对比,以验证APROS模拟方法的有效性与适用性,为未来运用该方法设计和运行聚变堆氦气冷却回路提供参考。展开更多
The non-coding RNAs(ncRNAs)are a family of single-stranded RNAs that have become recognized as crucial gene expression regulators in normal and cancer cell biology.The gut microbiota,which consists of several differen...The non-coding RNAs(ncRNAs)are a family of single-stranded RNAs that have become recognized as crucial gene expression regulators in normal and cancer cell biology.The gut microbiota,which consists of several different bacteria,can actively contribute to the regulation of host metabolism,immunity,and inflammation.Roles of ncRNAs and gut microbiota could significantly interact with each other to regulate the growth of various types of cancer.In particular,a causal relationship among ncRNAs,gut microbiota,and immune cells has been shown for their potential importance in the development of breast cancer.Alteration of ncRNA expression and/or gut microbiota profiles could also influence several intracellular signaling pathways with the function of anti-proliferative(APRO)family proteins associated with the malignancy.Targeting ncRNAs and/or APRO family proteins for the treatment of various cancers has been revealed with novel immune therapies.Here,the most recent studies to underline the key role of ncRNAs,APRO family proteins,and gut microbiota in breast cancer progression have been discussed.For more effective breast cancer therapy,it would be imperative to figure out the collective mechanism of ncRNAs,APRO family proteins,and gut microbiota.展开更多
文摘The non-coding RNAs(ncRNAs)are a family of single-stranded RNAs that have become recognized as crucial gene expression regulators in normal and cancer cell biology.The gut microbiota,which consists of several different bacteria,can actively contribute to the regulation of host metabolism,immunity,and inflammation.Roles of ncRNAs and gut microbiota could significantly interact with each other to regulate the growth of various types of cancer.In particular,a causal relationship among ncRNAs,gut microbiota,and immune cells has been shown for their potential importance in the development of breast cancer.Alteration of ncRNA expression and/or gut microbiota profiles could also influence several intracellular signaling pathways with the function of anti-proliferative(APRO)family proteins associated with the malignancy.Targeting ncRNAs and/or APRO family proteins for the treatment of various cancers has been revealed with novel immune therapies.Here,the most recent studies to underline the key role of ncRNAs,APRO family proteins,and gut microbiota in breast cancer progression have been discussed.For more effective breast cancer therapy,it would be imperative to figure out the collective mechanism of ncRNAs,APRO family proteins,and gut microbiota.
