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基于API-TOF的化学战剂无损检测
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作者 王新华 杨杰 +3 位作者 郑普 樊宇 何铁 安力 《核技术》 CAS CSCD 北大核心 2013年第10期59-64,共6页
化学战剂的快速、准确、实时、非破坏性检测和定量分析对防化、反恐和国家安全是非常重要的,伴随α粒子成像的快中子飞行时间法(API-TOF)可用于隐藏的化学战剂无损检测。利用内置伴随α粒子探测器的中子管、屏蔽体、阵列NaI(Tl)探测器... 化学战剂的快速、准确、实时、非破坏性检测和定量分析对防化、反恐和国家安全是非常重要的,伴随α粒子成像的快中子飞行时间法(API-TOF)可用于隐藏的化学战剂无损检测。利用内置伴随α粒子探测器的中子管、屏蔽体、阵列NaI(Tl)探测器、电子学系统和控制系统建立了一套化学战剂的移动式无损检测原型装置。并利用该装置对芥子气、沙林、梭曼、VX、和路易氏剂等战剂进行了检测,检测结果表明,该系统可用于化学战剂的快速、无损检测。 展开更多
关键词 化学战剂 快中子飞行时间法(API—TOF) 无损检测 特征γ射线
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Study of spatial resolution of the associated alpha particle imaging–time-of-flight method 被引量:1
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作者 Meng Huang Jian-Yu Zhu Jun Wu 《Nuclear Science and Techniques》 SCIE CAS CSCD 2019年第4期105-113,共9页
Associated alpha particle imaging based on the time-of-flight(API-TOF) technique is an advanced neutron analysis method, which is capable of discriminating material nuclides and three-dimensional imaging of the spatia... Associated alpha particle imaging based on the time-of-flight(API-TOF) technique is an advanced neutron analysis method, which is capable of discriminating material nuclides and three-dimensional imaging of the spatial distribution of material nuclei. In this paper, the spatial resolution of API-TOF and its effects are studied using mathematical analysis and Monte Carlo numerical simulation. The results can provide guidance and assist in designing of API-TOF detection devices. First, a mathematical analysis of the imaging principles of the API-TOF was carried out, and the calculation formulas of the spatial resolution of API-TOF were deduced. Next, the relationship between the device layout and the spatial resolution of the API-TOF detection device was studied. The concept of a typical API-TOF detection device with an optimized structure was proposed. Then, the spatial distribution of the spatial resolution of the typical API-TOF detection device was analyzed, and the effects of the time resolution and the neutron emission angle resolution on the spatial resolution were studied. The results show that spatial resolutions better than 1 cm can be achieved by improving the time resolution and the neutron emission angle resolution to appropriate levels. Finally, a Monte Carlo numerical simulation program was developed for the study of the APITOF and was used to calculate the spatial resolutions of the API-TOF. The comparison of the results shows that thespatial resolutions calculated based on the Monte Carlo numerical simulation are in good agreement with those calculated based on the mathematical analysis. This verifies the mathematical analysis and the evaluation of the effects of the spatial resolution of the API-TOF in this study. 展开更多
关键词 api-tof Spatial RESOLUTION MATHEMATICAL analysis MONTE Carlo numerical simulation
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UPLC-Q-TOF-MS研究依拉地平原料药的降解杂质 被引量:4
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作者 杨长花 王月茹 +1 位作者 刘峰 彭修娟 《华西药学杂志》 CAS CSCD 2019年第3期286-290,共5页
目的系统分析国产依拉地平原料药降解杂质谱的构成,通过对比国外药典,确定其原料药中杂质的降解路线、种类及限度。方法采用强制降解(光照、强酸碱及氧化)得到依拉地平原料药的降解杂质色谱峰,通过制备液相色谱纯化及高分辨率飞行时间质... 目的系统分析国产依拉地平原料药降解杂质谱的构成,通过对比国外药典,确定其原料药中杂质的降解路线、种类及限度。方法采用强制降解(光照、强酸碱及氧化)得到依拉地平原料药的降解杂质色谱峰,通过制备液相色谱纯化及高分辨率飞行时间质谱(UPLC-Q-TOF-MS)解析,并结合原料药合成路线对降解杂质结构及来源进行分析。结果明确了6个杂质的结构及类型,对比国外药典中质量标准杂质控制限度及国际人用药品注册技术要求国际协调会(ICH)相关指导原则,明确了国产依拉地平原料药的主要控制降解杂质种类。结论按照9.0版《欧洲药典》中色谱条件检测国产依拉地平原料中的相对保留时间为0.63、0.85的杂质是其主要降解杂质,对原料药的质量影响最明显。 展开更多
关键词 依拉地平 原料药 强制降解实验 制备液相 高分辨质谱 飞行时间质谱 降解杂质 国际人用药品注册技术要求国际协调会指导原则
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