This commentary critically appraises the study by Li et al which pioneered the exploration of the triglyceride-glucose(TyG)index as a prognostic marker in hepatitis B virus-related advanced hepatocellular carcinoma pa...This commentary critically appraises the study by Li et al which pioneered the exploration of the triglyceride-glucose(TyG)index as a prognostic marker in hepatitis B virus-related advanced hepatocellular carcinoma patients undergoing combined camrelizumab and lenvatinib therapy.While we acknowledge the study’s clinical relevance in proposing an easily accessible metabolic biomarker,we delve into the mechanistic plausibility linking insulin resistance to immunotherapy response and angiogenic inhibition.We further critically examine the methodological limitations,including the retrospective design,the populationspecific TyG cut-off value,and unaddressed metabolic confounders.We highlight the imperative for future research to validate its utility across diverse etiologies and treatment settings,and to unravel the underlying immunometabolic pathways.展开更多
The Southern Advanced Photon Source(SAPS)is a diffraction-limited synchrotron light source under design,which employs longitudinal injection as its primary injection scheme.This kind of injection scheme requires that ...The Southern Advanced Photon Source(SAPS)is a diffraction-limited synchrotron light source under design,which employs longitudinal injection as its primary injection scheme.This kind of injection scheme requires that the injected beam has a short bunch length and low emittance,and the preferred injector should offer high stability and low cost.Therefore,an injector based on a booster synchrotron was developed.The proposed injector includes a 250 MeV linac,a booster synchrotron that ramps the beam energy to 3.5 GeV,and two beam transport lines to ensure efficient beam delivery and beam quality preservation.The linac utilizes a thermionic high-voltage DC gun for reliable operation and features a bunching system with an advanced focusing system to preserve the emittance.To meet the injection requirements of the SAPS,a comprehensive design for the booster has been conducted.The booster synchrotron employs a threefold lattice structure,incorporating modified theoretical minimum emittance cells with a small momentum compaction factor and a high voltage to achieve an emittance of 3.98 nm rad and a bunch length of 4.8 mm.The injector has the potential to deliver a high charge,reducing the injection period of the storage ring to less than 1 min.Simulations demonstrated the expected performance,with a transmission efficiency of 90%,confirming its capability to meet the injection requirement of the SAPS storage ring.This design offers a stable and efficient solution for the SAPS.展开更多
Recent years have witnessed transformative changes brought about by artificial intelligence(AI)techniques with billions of parameters for the realization of high accuracy,proposing high demand for the advanced and AI ...Recent years have witnessed transformative changes brought about by artificial intelligence(AI)techniques with billions of parameters for the realization of high accuracy,proposing high demand for the advanced and AI chip to solve these AI tasks efficiently and powerfully.Rapid progress has been made in the field of advanced chips recently,such as the development of photonic computing,the advancement of the quantum processors,the boost of the biomimetic chips,and so on.Designs tactics of the advanced chips can be conducted with elaborated consideration of materials,algorithms,models,architectures,and so on.Though a few reviews present the development of the chips from their unique aspects,reviews in the view of the latest design for advanced and AI chips are few.Here,the newest development is systematically reviewed in the field of advanced chips.First,background and mechanisms are summarized,and subsequently most important considerations for co-design of the software and hardware are illustrated.Next,strategies are summed up to obtain advanced and AI chips with high excellent performance by taking the important information processing steps into consideration,after which the design thought for the advanced chips in the future is proposed.Finally,some perspectives are put forward.展开更多
Background:The long-term outcomes of robotic-assisted surgery and the prognostic significance of the pretreatment neutrophil-to-lymphocyte ratio(NLR)in locally advanced rectal cancer(LARC)remain uncertain.This study a...Background:The long-term outcomes of robotic-assisted surgery and the prognostic significance of the pretreatment neutrophil-to-lymphocyte ratio(NLR)in locally advanced rectal cancer(LARC)remain uncertain.This study aimed to assess the long-term outcomes of patients with LARC undergoing robotic-assisted surgery and to determine the prognostic value of pretreatment NLR.Methods:We retrospectively reviewed 252 patients with LARC who were treated at a single medical center in Taiwan between January 2012 and January 2023.All patients underwent neoadjuvant concurrent chemoradiotherapy(CRT)followed by robotic-assisted surgery with total mesorectal excision(TME).Patients were stratified into four groups on the basis of pretreatment NLRs and carcinoembryonic antigen(CEA)levels.Univariate and multivariate analyses were conducted to identify prognostic indicators for overall survival(OS)and disease-free survival(DFS).Results:Patients with a pretreatment NLR of≥3.2 exhibited significantly worse OS and DFS compared with those with an NLR of<3.2(OS:94.4 vs.116.5 months,p=0.001;DFS:78.8 vs.101.7 months,p=0.003).Group A exhibited the poorest prognosis,whereas Group D had the most favorable outcomes.Multivariate analysis revealed NLR≥3.2 as an independent predictor of poor OS(hazard ratio[HR]=2.306,95%CI:1.149-3.747;p=0.001)and DFS(HR=2.055,95%CI:1.341-3.148;p=0.001).Conclusion:Neoadjuvant concurrent CRT followed by robotic-assisted TME is an effective treatment strategy for LARC.A higher pretreatment NLR(≥3.2)independently predicted worse OS and DFS.Stratification using the NLR in combination with CEA levels may enhance prognostic accuracy for patients undergoing robotic-assisted surgery for LARC.展开更多
Yunhe County in Lishui City,southwestern Zhejiang Province,doesn’t have any Disney castles.Instead,it has built bridges to the world with wood.Known as“China’s town of wooden toys,”accounting for about 40 percent ...Yunhe County in Lishui City,southwestern Zhejiang Province,doesn’t have any Disney castles.Instead,it has built bridges to the world with wood.Known as“China’s town of wooden toys,”accounting for about 40 percent of the global wooden toy market,Yunhe’s story began with a small factory established in 1970.Today,it has grown into a distinctive industrial cluster with an annual output value exceeding 8 billion yuan($1.15 billion),exporting products to 82 countries and regions.展开更多
BACKGROUND Paternal perinatal depression(PPD)is closely associated with maternal mental health challenges,marital strain,and adverse child developmental outcomes.Despite its significant impact,PPD remains under-recogn...BACKGROUND Paternal perinatal depression(PPD)is closely associated with maternal mental health challenges,marital strain,and adverse child developmental outcomes.Despite its significant impact,PPD remains under-recognized in family-centered clinical practice.Concurrently,against the backdrop of rising rates of delayed marriage and China’s Maternity Incentive Policy,the proportion of women giving birth at an advanced maternal age is increasing.Nevertheless,research specifically examining PPD among spouses of older mothers remains critically scarce,both in China and globally.AIM To investigate PPD and its influencing factors in Chinese advanced maternal age families.METHODS This cross-sectional study included 358 participants;it was conducted among fathers of pregnant women of advanced maternal age at five hospitals in the Pearl River Delta region of China from September 2023 to June 2024.Data were collected via a general information questionnaire,the Social Support Rating Scale,and the Edinburgh Postnatal Depression Scale.Latent profile analysis and regression mixture models(RMMs)were adopted to analyze the latent PPD types and factors that influenced PPD.RESULTS The incidence of PPD was 16.48%,and three profiles were identified:Low-symptomatic(175 cases,48.89%),monophasic(140 cases,39.10%),and high-symptomatic(43 cases,12.01%).The RMM analysis revealed that first pregnancy,low income(<¥3000/month),part-time work,and a history of abnormal pregnancy were positively associated with the high-symptomatic type(P<0.05).Conversely,high subjective support and support utilization were negatively associated with the high-symptomatic type compared with the low-symptomatic type(P<0.05).Good couple relationships,high objective and subjective support,and high support utilization were negatively associated with monophasic disorder(P<0.05).CONCLUSION PPD incidence is high among Chinese fathers with advanced maternal age partners,and the characteristics of depression are varied.Healthcare practitioners should prioritize individuals with low levels of social support.展开更多
The momentum with which we begin defines the trajectory of our achievements.As we celebrate the fifth anniversary of Advanced Photonics Nexus(APNexus),we are delighted to share several important milestones.The journal...The momentum with which we begin defines the trajectory of our achievements.As we celebrate the fifth anniversary of Advanced Photonics Nexus(APNexus),we are delighted to share several important milestones.The journal has earned its first Impact Factor of 6.0,positioning it in the Q1 zone among 125 optics journals in Journal Citation Reports.Over 90%of articles published during its first Impact Factor calculation window have already garnered citations.In 2025,APNexus experienced a 43%increase in total submissions from 33 countries,publishing close to 100 articles in the form of original research and reviews.Dedicated to providing an open platform for emerging directions and innovative paradigms,APNexus continues to demonstrate robust and dynamic growth.展开更多
Synchronous reluctance motors(SynRM)are widely employed in industrial applications due to their high robustness,low cost,and absence of permanent magnets.In recent years,significant research efforts have focused on im...Synchronous reluctance motors(SynRM)are widely employed in industrial applications due to their high robustness,low cost,and absence of permanent magnets.In recent years,significant research efforts have focused on improving the controllability and efficiency of SynRM.Accurate rotor position information is essential for the controller to generate appropriate current and voltage references corresponding to the desired speed and load torque.Shaft-mounted position sensors are generally undesirable because of their high cost,sensitivity to harsh operating conditions,maintenance requirements,and reduced reliability in environments characterized by high vibration.Consequently,sensorless control techniques that estimate rotor position using measured stator currents and voltages have attracted increasing attention.However,magnetic saturation,parameter nonlinearities,and cross-coupling effects significantly degrade position estimation accuracy and may compromise the stability of sensorless SynRM drives.In this paper,a nonlinear SynRM model is developed using finite element analysis(FEA)to accurately capture magnetic saturation and cross-coupling effects,thereby providing a precise representation of the machine’s electromagnetic behavior under varying load and flux conditions.A series of magnetostatic FEA simulations is performed.To reduce computational complexity,only one motor pole is analyzed by applying anti-periodic boundary conditions along the domain sides and enforcing a zero magnetic vector potential on the external stator boundary.Nonlinear iron material properties are modeled using the appropriate B-H curve.The simulations are carried out by imposing d-and q-axis current components and computing the corresponding flux linkages and electromagnetic torque.Based on these results,both apparent and incremental inductances are extracted and incorporated into the control algorithm.An advanced fictitious flux linkage method combined with a phase-locked loop(PLL)is employed for accurate rotor position estimation.Simulation results confirm that the proposed sensorless control strategy ensures stable operation and high position estimation accuracy over the entire speed range.展开更多
Background:Locally advanced laryngeal squamous cell carcinoma(LA-LSCC)presents clinical challenges due to the lack of reliable non-invasive biomarkers.This study aimed to evaluate miR-449a as a diagnostic and prognost...Background:Locally advanced laryngeal squamous cell carcinoma(LA-LSCC)presents clinical challenges due to the lack of reliable non-invasive biomarkers.This study aimed to evaluate miR-449a as a diagnostic and prognostic biomarker in LA-LSCC.Methods:miR-449a expression was analyzed in tumor tissues,adjacent normal tissues,and serum from 81 LA-LSCC patients and 50 controls using quantitative real-time reverse transcription polymerase chain reaction(qRT-PCR).We assessed the diagnostic accuracy by Receiver Operating Characteristic curve(ROC curves),clinicopathological associations,survival outcomes(Kaplan-Meier),and treatment response dynamics.Results:miR-449a was significantly downregulated in LA-LSCC tissues(p<0.0001)and serum(p<0.0001),with a strong tissue-serum correlation(R^(2)=0.988).Tissue miR-449a demonstrated a diagnostic accuracy(Area Under the Curve,AUC=0.857),while serum showed moderate accuracy(AUC=0.734).High miR-449a expression correlated with favorable clinicopathological features and improved survival(median overall survival:67.82 vs.23.74 months;p=0.0012).Multivariate analysis confirmed miR-449a as an independent prognostic factor(p<0.001).miR-449a levels increased post-treatment,particularly in responders to chemotherapy/radiation(p<0.0001).Conclusion:miR-449a serves as a non-invasive biomarker for LA-LSCC diagnosis,prognosis,and treatment monitoring.Its dynamic expression highlights potential for risk stratification and therapy response prediction,warranting further validation in larger cohorts.展开更多
文摘This commentary critically appraises the study by Li et al which pioneered the exploration of the triglyceride-glucose(TyG)index as a prognostic marker in hepatitis B virus-related advanced hepatocellular carcinoma patients undergoing combined camrelizumab and lenvatinib therapy.While we acknowledge the study’s clinical relevance in proposing an easily accessible metabolic biomarker,we delve into the mechanistic plausibility linking insulin resistance to immunotherapy response and angiogenic inhibition.We further critically examine the methodological limitations,including the retrospective design,the populationspecific TyG cut-off value,and unaddressed metabolic confounders.We highlight the imperative for future research to validate its utility across diverse etiologies and treatment settings,and to unravel the underlying immunometabolic pathways.
基金supported by the Guangdong Basic and Applied Basic Research Foundation,China(No.2021B1515140007).
文摘The Southern Advanced Photon Source(SAPS)is a diffraction-limited synchrotron light source under design,which employs longitudinal injection as its primary injection scheme.This kind of injection scheme requires that the injected beam has a short bunch length and low emittance,and the preferred injector should offer high stability and low cost.Therefore,an injector based on a booster synchrotron was developed.The proposed injector includes a 250 MeV linac,a booster synchrotron that ramps the beam energy to 3.5 GeV,and two beam transport lines to ensure efficient beam delivery and beam quality preservation.The linac utilizes a thermionic high-voltage DC gun for reliable operation and features a bunching system with an advanced focusing system to preserve the emittance.To meet the injection requirements of the SAPS,a comprehensive design for the booster has been conducted.The booster synchrotron employs a threefold lattice structure,incorporating modified theoretical minimum emittance cells with a small momentum compaction factor and a high voltage to achieve an emittance of 3.98 nm rad and a bunch length of 4.8 mm.The injector has the potential to deliver a high charge,reducing the injection period of the storage ring to less than 1 min.Simulations demonstrated the expected performance,with a transmission efficiency of 90%,confirming its capability to meet the injection requirement of the SAPS storage ring.This design offers a stable and efficient solution for the SAPS.
基金supported by the Hong Kong Polytechnic University(1-WZ1Y,1-W34U,4-YWER).
文摘Recent years have witnessed transformative changes brought about by artificial intelligence(AI)techniques with billions of parameters for the realization of high accuracy,proposing high demand for the advanced and AI chip to solve these AI tasks efficiently and powerfully.Rapid progress has been made in the field of advanced chips recently,such as the development of photonic computing,the advancement of the quantum processors,the boost of the biomimetic chips,and so on.Designs tactics of the advanced chips can be conducted with elaborated consideration of materials,algorithms,models,architectures,and so on.Though a few reviews present the development of the chips from their unique aspects,reviews in the view of the latest design for advanced and AI chips are few.Here,the newest development is systematically reviewed in the field of advanced chips.First,background and mechanisms are summarized,and subsequently most important considerations for co-design of the software and hardware are illustrated.Next,strategies are summed up to obtain advanced and AI chips with high excellent performance by taking the important information processing steps into consideration,after which the design thought for the advanced chips in the future is proposed.Finally,some perspectives are put forward.
基金supported by grants through funding from the National Science and Technology Council(NSTC112-2314-B-037-050-MY3,NSTC114-2314-B-037-103-MY3,NSTC114-2321-B-037-003)the Ministry of Health and Welfare(MOHW113-TDU-B-222-134014)+2 种基金funded by the health and welfare surcharge of on tobacco products,and the Kaohsiung Medical University Hospital(KMUH113-3R31,KMUH113-3R32,KMUH113-3R33,KMUH113-3M58,KMUH113-3M59,KMUH-S11412,KMUH-SH11403)Kaohsiung Medical University Research Center Grant(KMU-TC113A04)supported by the Grant of Taiwan Precision Medicine Initiative and Taiwan Biobank,Academia Sinica,Taiwan.
文摘Background:The long-term outcomes of robotic-assisted surgery and the prognostic significance of the pretreatment neutrophil-to-lymphocyte ratio(NLR)in locally advanced rectal cancer(LARC)remain uncertain.This study aimed to assess the long-term outcomes of patients with LARC undergoing robotic-assisted surgery and to determine the prognostic value of pretreatment NLR.Methods:We retrospectively reviewed 252 patients with LARC who were treated at a single medical center in Taiwan between January 2012 and January 2023.All patients underwent neoadjuvant concurrent chemoradiotherapy(CRT)followed by robotic-assisted surgery with total mesorectal excision(TME).Patients were stratified into four groups on the basis of pretreatment NLRs and carcinoembryonic antigen(CEA)levels.Univariate and multivariate analyses were conducted to identify prognostic indicators for overall survival(OS)and disease-free survival(DFS).Results:Patients with a pretreatment NLR of≥3.2 exhibited significantly worse OS and DFS compared with those with an NLR of<3.2(OS:94.4 vs.116.5 months,p=0.001;DFS:78.8 vs.101.7 months,p=0.003).Group A exhibited the poorest prognosis,whereas Group D had the most favorable outcomes.Multivariate analysis revealed NLR≥3.2 as an independent predictor of poor OS(hazard ratio[HR]=2.306,95%CI:1.149-3.747;p=0.001)and DFS(HR=2.055,95%CI:1.341-3.148;p=0.001).Conclusion:Neoadjuvant concurrent CRT followed by robotic-assisted TME is an effective treatment strategy for LARC.A higher pretreatment NLR(≥3.2)independently predicted worse OS and DFS.Stratification using the NLR in combination with CEA levels may enhance prognostic accuracy for patients undergoing robotic-assisted surgery for LARC.
文摘Yunhe County in Lishui City,southwestern Zhejiang Province,doesn’t have any Disney castles.Instead,it has built bridges to the world with wood.Known as“China’s town of wooden toys,”accounting for about 40 percent of the global wooden toy market,Yunhe’s story began with a small factory established in 1970.Today,it has grown into a distinctive industrial cluster with an annual output value exceeding 8 billion yuan($1.15 billion),exporting products to 82 countries and regions.
基金Supported by High-level Professional Groups in Gangdong Province,No.GSPZYQ2020101Guangdong Province Educational Research Planning Project,No.2024GXJK742。
文摘BACKGROUND Paternal perinatal depression(PPD)is closely associated with maternal mental health challenges,marital strain,and adverse child developmental outcomes.Despite its significant impact,PPD remains under-recognized in family-centered clinical practice.Concurrently,against the backdrop of rising rates of delayed marriage and China’s Maternity Incentive Policy,the proportion of women giving birth at an advanced maternal age is increasing.Nevertheless,research specifically examining PPD among spouses of older mothers remains critically scarce,both in China and globally.AIM To investigate PPD and its influencing factors in Chinese advanced maternal age families.METHODS This cross-sectional study included 358 participants;it was conducted among fathers of pregnant women of advanced maternal age at five hospitals in the Pearl River Delta region of China from September 2023 to June 2024.Data were collected via a general information questionnaire,the Social Support Rating Scale,and the Edinburgh Postnatal Depression Scale.Latent profile analysis and regression mixture models(RMMs)were adopted to analyze the latent PPD types and factors that influenced PPD.RESULTS The incidence of PPD was 16.48%,and three profiles were identified:Low-symptomatic(175 cases,48.89%),monophasic(140 cases,39.10%),and high-symptomatic(43 cases,12.01%).The RMM analysis revealed that first pregnancy,low income(<¥3000/month),part-time work,and a history of abnormal pregnancy were positively associated with the high-symptomatic type(P<0.05).Conversely,high subjective support and support utilization were negatively associated with the high-symptomatic type compared with the low-symptomatic type(P<0.05).Good couple relationships,high objective and subjective support,and high support utilization were negatively associated with monophasic disorder(P<0.05).CONCLUSION PPD incidence is high among Chinese fathers with advanced maternal age partners,and the characteristics of depression are varied.Healthcare practitioners should prioritize individuals with low levels of social support.
文摘The momentum with which we begin defines the trajectory of our achievements.As we celebrate the fifth anniversary of Advanced Photonics Nexus(APNexus),we are delighted to share several important milestones.The journal has earned its first Impact Factor of 6.0,positioning it in the Q1 zone among 125 optics journals in Journal Citation Reports.Over 90%of articles published during its first Impact Factor calculation window have already garnered citations.In 2025,APNexus experienced a 43%increase in total submissions from 33 countries,publishing close to 100 articles in the form of original research and reviews.Dedicated to providing an open platform for emerging directions and innovative paradigms,APNexus continues to demonstrate robust and dynamic growth.
文摘Synchronous reluctance motors(SynRM)are widely employed in industrial applications due to their high robustness,low cost,and absence of permanent magnets.In recent years,significant research efforts have focused on improving the controllability and efficiency of SynRM.Accurate rotor position information is essential for the controller to generate appropriate current and voltage references corresponding to the desired speed and load torque.Shaft-mounted position sensors are generally undesirable because of their high cost,sensitivity to harsh operating conditions,maintenance requirements,and reduced reliability in environments characterized by high vibration.Consequently,sensorless control techniques that estimate rotor position using measured stator currents and voltages have attracted increasing attention.However,magnetic saturation,parameter nonlinearities,and cross-coupling effects significantly degrade position estimation accuracy and may compromise the stability of sensorless SynRM drives.In this paper,a nonlinear SynRM model is developed using finite element analysis(FEA)to accurately capture magnetic saturation and cross-coupling effects,thereby providing a precise representation of the machine’s electromagnetic behavior under varying load and flux conditions.A series of magnetostatic FEA simulations is performed.To reduce computational complexity,only one motor pole is analyzed by applying anti-periodic boundary conditions along the domain sides and enforcing a zero magnetic vector potential on the external stator boundary.Nonlinear iron material properties are modeled using the appropriate B-H curve.The simulations are carried out by imposing d-and q-axis current components and computing the corresponding flux linkages and electromagnetic torque.Based on these results,both apparent and incremental inductances are extracted and incorporated into the control algorithm.An advanced fictitious flux linkage method combined with a phase-locked loop(PLL)is employed for accurate rotor position estimation.Simulation results confirm that the proposed sensorless control strategy ensures stable operation and high position estimation accuracy over the entire speed range.
基金The authors extend their appreciation to Taif University,Saudi Arabia,for supporting this work through project No.(TU-DSPP-2024-54).
文摘Background:Locally advanced laryngeal squamous cell carcinoma(LA-LSCC)presents clinical challenges due to the lack of reliable non-invasive biomarkers.This study aimed to evaluate miR-449a as a diagnostic and prognostic biomarker in LA-LSCC.Methods:miR-449a expression was analyzed in tumor tissues,adjacent normal tissues,and serum from 81 LA-LSCC patients and 50 controls using quantitative real-time reverse transcription polymerase chain reaction(qRT-PCR).We assessed the diagnostic accuracy by Receiver Operating Characteristic curve(ROC curves),clinicopathological associations,survival outcomes(Kaplan-Meier),and treatment response dynamics.Results:miR-449a was significantly downregulated in LA-LSCC tissues(p<0.0001)and serum(p<0.0001),with a strong tissue-serum correlation(R^(2)=0.988).Tissue miR-449a demonstrated a diagnostic accuracy(Area Under the Curve,AUC=0.857),while serum showed moderate accuracy(AUC=0.734).High miR-449a expression correlated with favorable clinicopathological features and improved survival(median overall survival:67.82 vs.23.74 months;p=0.0012).Multivariate analysis confirmed miR-449a as an independent prognostic factor(p<0.001).miR-449a levels increased post-treatment,particularly in responders to chemotherapy/radiation(p<0.0001).Conclusion:miR-449a serves as a non-invasive biomarker for LA-LSCC diagnosis,prognosis,and treatment monitoring.Its dynamic expression highlights potential for risk stratification and therapy response prediction,warranting further validation in larger cohorts.
