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毒素清对肺炎痰热证大鼠肺组织Janus激酶/信号转导和转录激活因子信号通路的影响 被引量:5
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作者 梅雪 李建生 张艳霞 《中国中西医结合急救杂志》 CAS 北大核心 2010年第2期80-82,共3页
目的 观察肺炎痰热证大鼠肺组织Janus激酶/信号转导和转录激活因子(JAK/STAT)转导通路,探讨毒素清治疗肺炎痰热证的作用机制.方法 将Wistar大鼠按随机数字表法分为正常组、肺炎组、肺炎痰热证组、阳性对照组、毒素清组,每组12只.制备细... 目的 观察肺炎痰热证大鼠肺组织Janus激酶/信号转导和转录激活因子(JAK/STAT)转导通路,探讨毒素清治疗肺炎痰热证的作用机制.方法 将Wistar大鼠按随机数字表法分为正常组、肺炎组、肺炎痰热证组、阳性对照组、毒素清组,每组12只.制备细菌性肺炎痰热证大鼠模型,采用免疫组化法测定肺组织p-JAK2、p-STAT1、p-STAT3、细胞信号转导抑制蛋白3(SOCS3)表达,采用逆转录-聚合酶链反应(RT-PCR)测定肺组织SOCS3 mRNA表达.结果 与正常组比较,肺炎组、肺炎痰热证组肺组织p-JAK2、p-STAT1、p-STAT3、SOCS3蛋白及SOCS3 mRNA表达均显著升高(均P【0.01),且肺炎痰热证组较肺炎组升高明显(均P【0.05).与肺炎痰热证组相比,毒素清组、阳性对照组肺组织p-JAK2、p-STAT1、p-STAT3蛋白表达明显减弱(均P【0.01),SOCS3蛋白及mRNA表达明显增强(均P【0.01),其中,毒素清组肺组织p-JAK2、p-STAT1、p-STAT3蛋白表达较阳性对照组减弱尤为明显(均P【0.05).结论 JAK/STAT信号转导通路参与了肺炎痰热证肺组织的病理损伤过程;毒素清治疗肺炎痰热证的作用机制可能与上调SOCS3,阻断JAK/STAT信号通路,继而减少炎症因子的释放有关. 展开更多
关键词 毒素清 细菌性肺炎 痰热证 Wistar大鼠 肺组织 JanuS激酶 信号转导通路 转录激活因子 JAK/STAT信号通路 Influence signal transduction pathway SOCS3 P-STAT3 mRNA表达 对照组 作用机制 蛋白表达 阳性 细胞信号转导 聚合酶链反应
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基于MILP搜索的ANU算法积分分析
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作者 袁征 朱亮 +1 位作者 赵晨曦 刘宗甫 《计算机应用研究》 CSCD 北大核心 2021年第4期1171-1174,共4页
ANU算法是由Bansod等人发表在SCN 2016上的一种超轻量级的Feistel结构的分组密码算法。截至目前,没有人提出针对该算法的积分攻击。为了研究ANU算法抗积分攻击的安全性,根据ANU算法的结构建立起基于比特可分性的MILP模型。对该模型进行... ANU算法是由Bansod等人发表在SCN 2016上的一种超轻量级的Feistel结构的分组密码算法。截至目前,没有人提出针对该算法的积分攻击。为了研究ANU算法抗积分攻击的安全性,根据ANU算法的结构建立起基于比特可分性的MILP模型。对该模型进行求解,首次得到ANU算法的9轮积分区分器;利用搜索到的9轮区分器以及轮密钥之间的相关性,对128 bit密钥长度的ANU算法进行12轮密钥恢复攻击,能够恢复43 bit轮密钥。该攻击的数据复杂度为2^(63.58)个选择明文,时间复杂度为2^(88.42)次12轮算法加密,存储复杂度为2^(33)个存储单元。 展开更多
关键词 anu算法 积分区分器 比特可分性 混合整数线性规划
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适应职业发展需求的本科人才培养模式构建:ANU的经验考察
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作者 李林木 《南京财经大学学报》 2009年第6期95-97,共3页
通过在澳大利亚国立大学(ANU)为期半年的考察,笔者发现该校在本科人才培养模式上富有鲜明的职业导向特色,不少经验值得借鉴:在学位设置上,该校在单学位和双学位基础上设立了标识优秀毕业生的"荣誉学位"制度;在课程建设上,给... 通过在澳大利亚国立大学(ANU)为期半年的考察,笔者发现该校在本科人才培养模式上富有鲜明的职业导向特色,不少经验值得借鉴:在学位设置上,该校在单学位和双学位基础上设立了标识优秀毕业生的"荣誉学位"制度;在课程建设上,给学生提供相当大的选修空间,且实行选修课与必修课相同的学分和要求;在教学方法上,实行大班授课与小班辅导相结合的教学模式,注重创新和学术诚实性的严格考核制度。 展开更多
关键词 本科学生 职业发展 培养模式 anu
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ANU,ANU-II和LiCi算法的积分区分器搜索 被引量:2
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作者 王红艳 韦永壮 刘文芬 《小型微型计算机系统》 CSCD 北大核心 2020年第7期1470-1475,共6页
ANU,ANU-II和LiCi算法是近几年相继被提出的新轻量级分组密码算法.由于采用比特级的设计理念,相比于传统字节级更具有结构轻巧、扩散灵活和实现效率高等优点,因而其安全性备受关注.基于以上三个算法的结构特性,构建了新的比特可分性MIL... ANU,ANU-II和LiCi算法是近几年相继被提出的新轻量级分组密码算法.由于采用比特级的设计理念,相比于传统字节级更具有结构轻巧、扩散灵活和实现效率高等优点,因而其安全性备受关注.基于以上三个算法的结构特性,构建了新的比特可分性MILP模型,并给出了ANU,ANU-II和LiCi算法的积分区分器自动化搜索方法.通常而言,区分器轮数的高低能够较好的衡量密码算法的安全性.研究结果表明:ANU,ANU-II和LiCi算法分别存在9轮、8轮和12轮的积分区分器,所需的数据复杂度为263,260和261个选择明文,这是目前已知分析方法中轮数最高和选择明文量最优的区分器结果.另外,提出了一种新的LiCi算法的等价结构. 展开更多
关键词 轻量分组密码算法 anu anu-II LiCi 可分性 MILP(混合线性整数规划) 积分区分器
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Obstructive ileus due to a giant fibroepithelial polyp of the anus 被引量:2
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作者 Ioannis Galanis Dimitrios Dragoumis +3 位作者 Michail Tsolakis Konstantinos Zarampoukas Thomas Zarampoukas Konstantinos Atmatzidis 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第29期3687-3690,共4页
Fibroepithelial polyps or hypertrophied anal papillae are essentially skin tags that project up from the dentate line and the junction between the skin and the epithelial lining of the anus. They are usually small in ... Fibroepithelial polyps or hypertrophied anal papillae are essentially skin tags that project up from the dentate line and the junction between the skin and the epithelial lining of the anus. They are usually small in size, but sometimes they become enlarged, causing unexpected medical conditions. An extremely rare case of a giant hypertrophied anal papilla complicated by obstructive ileus is reported. Fibroepithelial anal polyp, despite its size, should be included in the differential diagnosis of a smooth mass located near the anal verge, especially in a patient with a history of chronic anal irritation or infection. 展开更多
关键词 anuS Fibroepithelial polyp Hypertrophiedanal papillae ILEUS Intestinal obstruction
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Education of Parents When a Child Born with an Imperforate Anus;Does It Improve the Health of the Child? 被引量:2
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作者 Thi Hoa Chu Thi Hoa Duong 《Open Journal of Pediatrics》 2015年第1期90-98,共9页
Objectives: To describe and investigate the value of an education program for parents of children born with an imperforate anus in order to help them cope with the new situation of having a stoma. A comparison is made... Objectives: To describe and investigate the value of an education program for parents of children born with an imperforate anus in order to help them cope with the new situation of having a stoma. A comparison is made with a group of parents following routine hospital. A secondary aim was to illuminate the parents’ feelings and concerns in the first month after the birth of the child. Subjects and methods: The program was tested in 20 Vietnamese mothers of babies born with an imperforate anus;10 followed an intervention comprising an education program and 10 the ordinary routine hospital. The study design is both qualitative and quantitative. The mothers were interviewed, using open-ended questions, within a week of their child’s birth and then repeatedly for up to one month. Finally, the conditions of children were accessed on their return to the hospital for the second operation after one month of care at home. The qualitative data were subjected to content analysis. Results: All mothers felt sad and worried in the beginning, but this quickly changed to confidence, particularly among mothers in the intervention group who received education. While at home, mothers in both groups had financial concerns, as they were unable to work as much as expected and also had to buy equipment for colostomy care. The mothers in the control group complained about a lack of knowledge and how it affected the care of their child. The mothers in the intervention group, however, felt confident in their caring even at home. When the families returned for the second operation, the children in the intervention group were significantly healthier, had increased more in weight, and had fewer complications and emergency return visits to hospital compared to the control group. In the control group skin problems around the stoma, diarrhea, bleeding or constipation while at home were reported (p < 0.01). Conclusion: The education improved the care at home resulting in healthier children and more confident parents. 展开更多
关键词 Imperforate anuS PARTICIPATION EDUCATION for PARENTS
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OBSERVATION ON THERAPEUTIC EFFECTS OF ACUPUNCTURE IN 206 CASES WITH POSTOPERATIVE COMPLICATION OF ANUS AND INTESTINE
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作者 李复明 李梅 《World Journal of Acupuncture-Moxibustion》 1997年第1期13-17,共5页
The authors have treated postoperative complication of anus and intestine by usingacupuncture at main point Chengshan(BL 57) with cool-producing needling manipulation. Therapeuticeffects of the treatment on postoperat... The authors have treated postoperative complication of anus and intestine by usingacupuncture at main point Chengshan(BL 57) with cool-producing needling manipulation. Therapeuticeffects of the treatment on postoperative severe pain, retention of urine, constipation, and bleedingwere observed clinically. Results indicated that the cure rate was 97. 6 % and the total effective ratewas 100%. Strong stimulation of Chengshan(BL 57) point improved mainly postoperative edema,spasm, local edema. The improvement of hyperemia and spasm is a ma jor factor of curing various postoperative complication of the anus and intestine. The therapeutic method has advantages of using lesspoints, rapidly producing effects, shorter therapeutic course, suffering little for patients, and no sideeffect. 展开更多
关键词 anuS Surgical operation POSTOPERATIVE COMPLICATION PAIN Uroschesis ACUPUNCTURE therapy
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Neurostimulation for fecal incontinence after correction of repair of imperforate anus
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作者 Alexandre Bougie Nathalie McFadden +2 位作者 Sandeep Mayer Michel Lebel Ghislain Devroede 《World Journal of Clinical Cases》 SCIE 2017年第3期124-127,共4页
We are reporting the case of a 32-year-old female who had suffered from fecal incontinence(FI). She was born with an imperforate anus and a recto-vaginal fistula; she underwent repair at 6 mo of age. At 29 years of ag... We are reporting the case of a 32-year-old female who had suffered from fecal incontinence(FI). She was born with an imperforate anus and a recto-vaginal fistula; she underwent repair at 6 mo of age. At 29 years of age, she was still fecally incontinent despite extensive pelvic floor reeducation. A magnetic resonance imaging and an anal electromyography were performed. Because her symptoms were considered to be probably due to extra-sphincteric implantation of the neo-anus, a redo was performed of the recto-neo-anal intra-sphincteric anastomosis. A neurostimulator device was subsequently implanted for persistent incontinence. Solid and liquid FI resolved, and her quality of life improved markedly. Combining surgery to correct the position of the neo-anus within the anal sphincter complex and neurostimulation could thus become a new approach in cases of refractory FI for patients with imperforate anus as a newborn. Follow-up into adulthood after pediatric imperforate anus surgery should be recommended for adult patients with persistent FI. 展开更多
关键词 FECAL INCONTINENCE Congenital MALFORMATION NEUROMODULATION NEUROSTIMULATION Imperforate anuS
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LOOSENING AND LENGTHENING OF INTESTINAL TRACT AFTER RECTAL ISOLATION IN ANUS-SAVING RESECTION FOR RECTAL CARCINOMA
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作者 张保宁 余宏迢 邵永孚 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1995年第2期127-129,共3页
In low rectal cancer surgery,the section of rectum destal to the lower tumor maigin is relaxed and lengthened after fully isolation of the organ. This would facilitate the adoption of anus saving operation.Before and ... In low rectal cancer surgery,the section of rectum destal to the lower tumor maigin is relaxed and lengthened after fully isolation of the organ. This would facilitate the adoption of anus saving operation.Before and after fully isolation of the rectum in low ratal cancer surgery, the distance between the lower tumor margin and the anorectal line was measured by the same rectuscope introduced through the anus.The two results were compared .The average lengthening was less than 1 cm if the lower tumor marginanorectal line distance was 5 cm.It was 1─2 cm if the lower tumor margin-anorectal distance was 6 cm.It was more than 2 cm if the distance was 7─9 cm.The loosening and lengthening of the rectal canal was related to the presence of lymphnode metastasis and the skill of the operator.The lengthening was also influenced by the body build of the patient,involvement of the rectal circumference and the Dukes stage. Modified Park's operation,trans abdominosacral resection with anastormosis of rectum,and anterior resection on transpubic approach are indicated for those in whom the lower tumor margin-anorectal line distance was 5 cm The rectectomy-anastomosis in the abdominal cavity(Dixon's operation)is indicated for those in whom the lower tumor margin-anorectal line was 6 cm.If manual anastomosis is difficult,stapling device may be used. The anus saving resection is easy if the distance was 7─9 cm. 展开更多
关键词 Rectal carcinoma Lateral ligament Isolation of rectum Loosening and lengthening of intestinal tract anus-saving resection.
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SAFETY MARGIN IN ANUS-SAVING RESECTION FOR LOW RECTAL CANCER
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作者 张保宁 李凌 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1995年第3期209-211,213,共4页
The length and method of measurement of the safety-margin below the rectal cancer, being of the utmost importance for its prognosis, is still under debate.The following study was designed and done for its solution.Lig... The length and method of measurement of the safety-margin below the rectal cancer, being of the utmost importance for its prognosis, is still under debate.The following study was designed and done for its solution.Light microscopic examination was done on 83 resected rectal cancer specimens to assess the extent of intramural invasion towards the anus.By use of a ruler,the distance between the lower tumour margin and the resection line or the dentate line was measured when the specimen was:l. freshly resected,2.after fixing in 10% formalin, and 3.after being mounted in sections. The measurements were compared. By the same method,the distance between the lower tumor margin and the intended resectyion line was measured immediately before resection.It was compared with the measurement immediately after the resection.In 83 rectal cancer specimens, the extent of intramural infiltration toward the anus was:≤0.5 cm in 75 cases (90.4%).≥l cm in 2 cases which showed highly malignant carcinomas.These 2 cases, however,should not have been indicated for anus-saving resection.In 46 fresh specimens,the tumor-resection line distances gave an average of 2.7 cm.After fixing in 10% formalin, they became shortened by 0.7 cm. And, mouting in sections further shortened them by another 0.5 cm,giving a total shortening of l.2 cm.The tumor-resection line distance in 7 of the 11 fresh specimens resected by the Dixon's operation was shortened,though never more than o.5 cm immediately the operation.In performin ganus-saving resection for the low rectal cancer, after full isolation the rectum and stretching it slightly,≥3 cm of the rectum distal to the lower tumor margin should be resected.A safety margin of more than 2.5 cm is necessary in the fresh specimen.If formalin fixed specimen is measured, the safety margin should be ≥2 cm. 展开更多
关键词 Rectal cancer Intramural invasion Pathologic processing anus-saving resection Safety margin.
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关于启用七号信令消息ANU的建议
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作者 汤庭龙 《邮电设计技术》 2002年第4期14-16,共3页
从电话计费合理性的角度出发,提出了启用七号信令的ANU的建议,最后介绍了ANU使用的场合。
关键词 七号信令消息 anu IP电话 应答信号
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THE FACTORS AND TREATMENT OF LOCAL RECURRENCE AFTER RADICAL RESECTION RESERVING THE ANUS IN THE PATIENTS WITH RECTAL CANCER
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作者 单吉贤 陈峻青 +1 位作者 张文范 齐春莲 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1989年第4期73-76,共4页
Of seventy-one patients with rectal cancer after radical resection retaining the anus, 15 developed local recurrence with a recurrence rate of 21.1%. Local recurrence was correlated with improper safety margin from th... Of seventy-one patients with rectal cancer after radical resection retaining the anus, 15 developed local recurrence with a recurrence rate of 21.1%. Local recurrence was correlated with improper safety margin from the lower edge of cancer to the anal end. There was statistical significant difference between 3 cm or more and 2 cm or less. The local recurrence was also related to the pathologic stage, histologic differentiation and implant of free cancer cells. It is suggested that the surgical indication of saving the anus be strict and without stretching, the safety margin from the lower edge of cancer to the anal end should not be less than 2 cm in early rectal cancer and not less than 4 cm in advanced lesions. During the operation, no touching tumor technique, thorough rinsing of the peritoneal cavity and pre- or post-operative radiotherapy are important for prevention of local recurrence. Early local recurrent rectal cancer can be detected by periodic examinations. 展开更多
关键词 THE FACTORS AND TREATMENT OF LOCAL RECURRENCE AFTER RADICAL RESECTION RESERVING THE anuS IN THE PATIENTS WITH RECTAL CANCER
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Extramammary Paget’s Disease Manifested by Intraepithelial Adenocarcinoma of the Vulva and Anus Combined with Invasive Adenocarcinoma of the Ampullary Part of the Rectum
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作者 Anastasija Kursisha 《Open Journal of Pathology》 2023年第3期109-125,共17页
The Object of the Study: The author of the given paper describes an unusual combination of two diseases: extramammary Paget’s disease manifested by intraepithelial adenocarcinoma of the vulva and anus combined with i... The Object of the Study: The author of the given paper describes an unusual combination of two diseases: extramammary Paget’s disease manifested by intraepithelial adenocarcinoma of the vulva and anus combined with invasive adenocarcinoma of the ampullary part of the rectum and describes the atypical manifestations of these diseases. The Content: The content of this research paper includes a description of the patient, an analysis of the clinical picture, diagnostic methods and therapeutic interventions used, a report of the following disease, and the result of the presented case. The Result of the Research Work: The result of the research work is the analysis of a clinical case with two different tumors, where such a combination of tumors is rarely described in the literature. Moreover, no large specific sample with this combination of diseases is available. Patient Characteristics: The given case report describes a patient of the Palliative Care Unit of the Gerontology Clinic with a primary diagnosis of C20-rectal adenocarcinoma in the background of the anal canal, perineal skin Paget’s disease, stage IV. The presented complications of the patient’s primary diagnosis are multiple metastases in the liver;status post palliative chemotherapy;hepatomegaly;metastases to abdominal lymph nodes, inguinal lymph nodes;metastases at Th12, L4 level;pain syndrome. The presented above combination of diagnosed diseases is very rare. Applied Diagnostics: In October 2021, it was performed diagnostic manipulation: biopsy and the pathologist have provided a microscopic description. The first tissue fragment had a pronounced electrothermal lesion and the epithelial structures were not valuable. The second skin tissue fragment was covered with hyperplastic and acanthotic epithelium;its basal and middle layers contained multiple large cells proliferates extending into the medial epidermis, and the cytoplasm of these cells reacted positively with PAS (Periodic Acid Schiff reaction). It needs to be noted that the patient had previously had several years of biopsies from the perineal and anal epidermis, where Paget’s disease had also been diagnosed. The performed immunohistochemistry showed these cells to be CK20 positive, CK7 rare positive and p16 negative. The following pathohistological findings were made: morphological and immunohistochemical picture is consistent with Paget’s disease. According to the ICD-10, the patient was diagnosed with C51 malignant neoplasm of the female external genitalia. Using imaging diagnostics, it became clear that the patient’s rectal adenocarcinoma had progressed to metastatic stage with distant liver metastases in the background of anal canal, perineal skin Paget’s disease. Therapeutic Plan of the Patient: Based on the patient’s main diagnoses, the complications of the principal diagnosis, the patient’s overall severe condition, pain syndrome, age and comorbidities, palliative chemotherapy was approved as a therapeutic option in council of doctors. Monitoring and Outcome of the Patient: The patient’s general condition was becoming worse over time, and she was diagnosed with exitus latalis in December 2022. At that time, the patient was discharged from hospital and was on palliative care at home under the control of her family physician. 展开更多
关键词 Extramammary Paget’s Disease Intraepithelial Adenocarcinoma of the Vulva and anus Invasive Adenocarcinoma of the Ampullary Part of the Rectum Biopsies from the Perineal and Anal Epidermis Malignant Neoplasm of the Female External Genitalia
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Non-Operative Management of Pilonidal Sinuses Located Around Anus
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作者 Kemal Arslan Osman Dogru +1 位作者 Erhan Aygen Ersin Turan 《Surgical Science》 2012年第12期588-591,共4页
Aim: Pilonidal disease is generally located at sacrococcygeal region whereas it is rarely located near anus. The aim of this study is to discuss the results of crystallized phenol application that we performed for pat... Aim: Pilonidal disease is generally located at sacrococcygeal region whereas it is rarely located near anus. The aim of this study is to discuss the results of crystallized phenol application that we performed for patients with sinus pilonidalis located near anus with 95% success rate. Patients and Methods: Patients admitted between 2005 to 2011 with sinuses located in 2 cm range of anus or were primarily located up to 2 cm to the anal verge were enrolled in the study. Patients’ demographic features, Body Mass Index (BMI), family history, skin color, hair thickness, number of sinus openings, and the status of the sinus (acute vs. chronic) were recorded. Crystallized phenol was applied into the sinus. The pa tients were followed-up after recovery during the first 6 months and annually afterwards. Results: A total of 25 sinus pilonidalis cases located near anus were encountered. All patients were male;crystallized phenol application was per formed on all patients a total of 115 times. The mean number of applications was 5.6 (between 4 and 8 times). The mean recovery period was 74.5 days (range: 31 - 154) and the mean follow-up period was 36.16 months (range: 18 - 48). No surgical intervention was required. Conclusion: Sinus pilonidalis cases located in perianal region can be successfully treated with the crystallized phenol application which is a simple and inexpensive method, that can easily be performed in an outpatient setting. 展开更多
关键词 Pilonidal Sinus around anus Non-Opretive Treatment Crystallized Phenol
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肛周坏死性筋膜炎52例的临床及病原学特征分析
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作者 邹菊英 崔姣 +1 位作者 陆文洪 刘小丽 《安徽医药》 2025年第12期2412-2415,共4页
目的 分析肛周坏死性筋膜炎病人的临床及病原学特征。方法 回顾性分析湖南中医药大学第二附属医院2019—2023年肛周坏死性筋膜炎52例的临床资料和病原菌培养结果。结果 纳入52例肛周坏死性筋膜炎有病原学资料的病人,其中男性45例(86.53... 目的 分析肛周坏死性筋膜炎病人的临床及病原学特征。方法 回顾性分析湖南中医药大学第二附属医院2019—2023年肛周坏死性筋膜炎52例的临床资料和病原菌培养结果。结果 纳入52例肛周坏死性筋膜炎有病原学资料的病人,其中男性45例(86.53%);年龄(51.98±16.59)岁,50岁及以上占比65.38%;所有病人均合并基础疾病。共分离出病原菌54株,包括革兰阴性菌37株(68.52%),其中大肠埃希菌比例最高,革兰阳性菌27.78%(15/54),真菌3.70%(2/54)。主要革兰阴性菌对美罗培南、阿米卡星、替加环素及黏菌素等敏感率较高。主要革兰阳性菌对大部分抗菌药物均比较敏感。结论 肛周坏死性筋膜炎是临床较为少见的疾病,其主要发生于中老年男性,主要病原菌是大肠埃希菌、肺炎克雷伯菌以及链球菌属。 展开更多
关键词 筋膜炎 坏死性 肛门 病原菌 耐药性 抗菌药物 临床特征
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普济痔疮栓对混合痔痔上黏膜套扎术后创面水肿及炎症状态的影响
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作者 杨锋 张胜威 +1 位作者 李晓洁 杨会举 《锦州医科大学学报》 2025年第1期75-80,共6页
目的观察中药栓剂纳肛对混合痔患者痔上黏膜套扎术后创面水肿及炎症状态的影响。方法选取自2022年2月至2024年1月在郑州人民医院接受治疗的需进行痔上黏膜套扎术的混合痔患者共计100例。为确保研究的科学性和公正性,采用随机数字表法将... 目的观察中药栓剂纳肛对混合痔患者痔上黏膜套扎术后创面水肿及炎症状态的影响。方法选取自2022年2月至2024年1月在郑州人民医院接受治疗的需进行痔上黏膜套扎术的混合痔患者共计100例。为确保研究的科学性和公正性,采用随机数字表法将这100例患者随机分为两组,即对照组和观察组,每组各包含50例患者。对照组将接受常规的治疗方案,而观察组则在常规治疗基础上加入特定的干预措施,以便对比两组患者的治疗效果和康复情况。对照组除常规止血、抗生素治疗外,采用中药熏洗进行术后治疗,观察组在对照组基础上行中药栓剂纳肛治疗。观察两组手术指标及创面愈合时间,比较两组术后第1、7、14天创面水肿、肛门出血情况,比较两组炎症状态,记录两组术后6个月复发情况。结果两组在手术时间及出血量方面的差异无统计学意义(P>0.05),表明两组在这两个指标上的表现基本相当,没有明显的区别。但在创面愈合时间的对比中,观察组的表现明显优于对照组,其创面愈合时间明显更短,差异有统计学意义(P<0.05),显示出观察组在创面愈合方面的明显优势。术后第1天两组创面水肿分布情况差异有统计学意义(U=0.032,P=0.974),在术后第7天和第14天的观察期间,研究组中创面呈现I度水肿的患者数量分布明显多于对照组,此结果表明在相同的时间节点上,观察组患者的创面水肿程度较轻的比例明显高于对照组,显示出治疗措施在减轻术后水肿方面的积极效果,差异有统计学意义(U=2.139、2.158,P=0.032、0.031)。术后第1天两组肛门出血分布情况差异无统计学意义(U=0.036,P=0.971),术后第7、14天观察组肛门出血I度患者分布高于对照组,差异有统计学意义(U=2.005、2.068,P=0.045、0.039)。在术后第1天,两组患者的炎症状态经过统计学分析,结果显示差异无统计学意义(P>0.05),表明在此时间点上,两组患者的炎症反应程度基本相当,没有明显的区别。但术后第14天,观察组的炎症指标相较于对照组出现明显降低,此变化通过统计学检验,结果显示差异有统计学意义(P<0.05),表明观察组的炎症恢复情况明显优于对照组。此外,在不良反应的发生情况以和术后6个月的复发率方面,两组患者之间的差异经过统计学分析,结果显示差异无统计学意义(P>0.05),表明在这两个指标上,两组患者的表现相当,没有明显差别。结论中药栓剂纳肛可以明显改善混合痔患者痔上黏膜套扎术后创面水肿、肛门出血情况以及患者炎症状态。 展开更多
关键词 混合痔 痔上黏膜套扎术 中药栓剂 纳肛 创面水肿 炎症状态
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直肠癌患者保肛术后健康信息寻求行为的影响因素调查
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作者 刘雯 张佳慧 徐战 《卫生职业教育》 2025年第16期109-114,共6页
目的 调查直肠癌患者保肛术后的健康信息寻求行为现状及其影响因素。方法 采取横断面研究,选用方便抽样法从上海某“三甲”医院胃肠外科门诊抽取直肠癌保肛术后患者93例,采用一般资料调查表、健康信息搜寻行为问卷收集资料,并进行统计... 目的 调查直肠癌患者保肛术后的健康信息寻求行为现状及其影响因素。方法 采取横断面研究,选用方便抽样法从上海某“三甲”医院胃肠外科门诊抽取直肠癌保肛术后患者93例,采用一般资料调查表、健康信息搜寻行为问卷收集资料,并进行统计分析。结果 直肠癌保肛术后患者健康信息寻求行为总分为(96.00±38.97)分;年龄、受教育程度、低位前切除术综合征了解程度是患者健康信息寻求行为总分及对健康信息需求行为的态度维度、信息需求维度、获取健康信息的障碍维度得分的影响因素(P<0.05),年龄、受教育程度、职业、低位前切除术综合征了解程度是信息来源维度的影响因素(P<0.05)。结论 直肠癌保肛术后患者的健康信息寻求行为处于中等水平,建议医护人员应该了解患者对于疾病信息的需求以及寻求信息的方法,为患者提供途径或平台来帮助其获取健康信息。 展开更多
关键词 直肠癌 健康信息寻求行为 保肛手术 影响因素
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影响直肠癌保肛根治术后发生LARS的相关因素分析
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作者 张芳弟 万雪 闫雪南 《黑龙江医学》 2025年第7期786-789,共4页
目的:探讨腹腔镜直肠癌保肛根治术后并发低位前切除综合征(LARS)的高危因素。方法:回顾性分析2019年1月—2023年12月河南宏力医院77例行腹腔镜直肠癌保肛根治术并顺利出院患者的临床资料,在随访过程中,根据患者是否发生LARS分为LARS组和... 目的:探讨腹腔镜直肠癌保肛根治术后并发低位前切除综合征(LARS)的高危因素。方法:回顾性分析2019年1月—2023年12月河南宏力医院77例行腹腔镜直肠癌保肛根治术并顺利出院患者的临床资料,在随访过程中,根据患者是否发生LARS分为LARS组和无LARS组。分析对比两组患者基础性疾病等资料及临床指标,将差异有统计学意义的变量的项目纳入logistics回归分析,获取腹腔镜直肠癌保肛根治术后并发LARS的独立危险因素。结果:LARS组BMI≥24 kg/m^(2)、肿瘤距肛缘距离≤7 cm、行新辅助化疗、吻合口瘘、术后恢复时间≤6个月的发生率均高于无LARS组,差异均有统计学意义(χ^(2)=5.427、8.920、12.585、10.073、5.898,P<0.05);logsitic回归分析结果显示,BMI≥24 kg/m^(2)、肿瘤距肛缘距离≤7 cm、行新辅助化疗、吻合口瘘、术后恢复时间≤6个月是腹腔镜直肠癌保肛根治术后并发LARS的高危因素(OR=3.048、4.267、5.867、4.838、3.200,P<0.05)。结论:腹腔镜直肠癌保肛根治术后并发LARS的风险极高,与患者肥胖或超重、肿瘤距肛缘距离、行新辅助化疗、吻合口瘘、术后恢复时间短有关,临床可根据上述因素及早采取干预措施。 展开更多
关键词 直肠癌保肛根治术 低位前切除综合征 肥胖 低位肿瘤 新辅助化疗 吻合口瘘
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儿童全结直肠重复畸形的临床特点与手术治疗探讨
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作者 闫俊 陈亚军 +2 位作者 彭春辉 庞文博 吴东阳 《临床小儿外科杂志》 北大核心 2025年第8期734-740,共7页
目的探讨儿童全结直肠重复畸形的临床特点、诊断与手术治疗策略。方法回顾性分析2010年1月至2024年12月于首都医科大学附属北京儿童医院明确诊断后接受手术治疗的全结直肠重复畸形患儿临床资料,并检索2000—2024年PubMed、万方医学网和... 目的探讨儿童全结直肠重复畸形的临床特点、诊断与手术治疗策略。方法回顾性分析2010年1月至2024年12月于首都医科大学附属北京儿童医院明确诊断后接受手术治疗的全结直肠重复畸形患儿临床资料,并检索2000—2024年PubMed、万方医学网和中国知网数据库收录的“儿童全结直肠重复畸形”相关文献报道。总结分析患儿临床表现、诊断方法与手术治疗方案。结果5例全结直肠重复畸形患儿中,女性3例、男性2例,手术中位年龄1.1岁(范围:0.6~11.6岁)。均于生后1个月内出现正位肛门排便伴女童前庭漏便、男童尿液含粪渣,3例用力排便时肛门膨出半球形肿物;术前经会阴部查体、超声、直肠与瘘管对比造影明确诊断;均采取重复结肠粪便转流、重复直肠瘘管封闭、正位直肠肛门原位保留的手术策略;术后中位随访时间8.2年(范围:0.3~14.5年),临床症状均消失,排便功能满意。经检索收集符合纳入与排除标准文献23篇,报道27例儿童全结直肠重复畸形病例,女性15例、男性12例。11例女童正位肛门排便伴前庭或会阴漏便、5例男童正位肛门排便伴尿液含粪渣或肛门肿物膨出,其余表现不一;15例主要经对比造影等检查,12例经结肠造瘘或剖腹探查手术确诊;25例行手术治疗,其中14例行粪便转流、6例行重复畸形病变全切或黏膜剥除、5例行肠管全程贯通;20例术后随访2个月至17年,整体预后良好。结论多数儿童全结直肠重复畸形临床表现有一定的特异性:正位肛门排便,伴女性前庭或男性泌尿生殖道漏便,用力排便时结直肠黏膜呈半球形自肛门膨出。手术前对比造影等检查可明确诊断和指导手术方案制定。“重复结肠粪便转流+重复直肠畸形矫治+正位肛门原位保留”的手术治疗策略,效果确切,预后良好。 展开更多
关键词 重复畸形 结直肠 肛门 手术 儿童
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寒武纪大爆发期间蜕皮动物躯体构型起源与演化
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作者 王邓 韩健 +1 位作者 郭俊锋 强亚琴 《自然杂志》 2025年第2期125-133,共9页
蜕皮动物是一类能周期性蜕掉和更换身体表皮的无脊椎动物,是动物界生物多样性最高、数量最多的类群,并且成功占据了地球生物圈的各种生态位。现存的蜕皮动物包含八个门,从躯体构型上可分为两大类:其一为具吻-躯干分化、有口有肛门的、... 蜕皮动物是一类能周期性蜕掉和更换身体表皮的无脊椎动物,是动物界生物多样性最高、数量最多的类群,并且成功占据了地球生物圈的各种生态位。现存的蜕皮动物包含八个门,从躯体构型上可分为两大类:其一为具吻-躯干分化、有口有肛门的、无附肢的蠕形蜕皮动物;其二为发育成对附肢型的泛节肢动物。最新研究发现,无“头-躯干分化”、外形呈囊状、有腹部口而无肛的,保存为微体化石的皱囊动物门代表了一类早期蜕皮动物更为原始的躯体构型,而有附肢型更为先进。三大躯体构型(囊型、蠕虫型、有附肢型)在寒武纪大爆发期间均已经出现,并独立演化。 展开更多
关键词 寒武纪 宽川铺生物群 蜕皮动物 皱囊动物门 肛门
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