Owing to its low cost, free chlorine is one of the most common disinfectants for wastewater and drinking water treatment. However, the formation of disinfection byproducts has been found to occur after free chlorine d...Owing to its low cost, free chlorine is one of the most common disinfectants for wastewater and drinking water treatment. However, the formation of disinfection byproducts has been found to occur after free chlorine disinfection in recent decades. Antipyrine （ANT）, an anti-inflammatory analgesic, has been frequently detected in the aquatic environment. In this work, the removal efficiency of ANT by free chlorine oxidation in ultrapure water was investigated with batch experiments. The influencing factors on the removal of ANT were explored at initial concentrations of ANT from 0.04 to 0.64 rag/L, free chlorine dosage from 0.30 to 1.31 rag/L, and pH from 1.5 to 9.0. The main degradation products were identified by solid phase extraction-gas chromatography-mass spectrometry. The results showed that ANT reacted rapidly with free chlorine in ultrapure water systems and up to 90.6% removal efficiency of ANT was achieved after 25 sec （initial free chlorine 1 mg/L, ANT 0.5 mg/L, pH 7.0）. Higher oxidant dosage, lower ANT initial concentration and low pH favor the ANT removal. The main degradation product in ANT chlorination was a monochlorine substitution product （4-chloro-l,2-dihydro- 1,5-dimethyl-2-phenyl-3H-pyrazol-3-one）, which can be further chlorinated by free chlorine. In addition, the total organic carbon result indicated that ANT is difficult to be mineralized using chlorine.展开更多
Six new rare earth complexes with Schiff base from 2,6 diformylpyridine N oxide and 4 amino antipyrine were synthesized. These complexes with general formula REL(NO 3) 3 (RE=La, Pr, Eu, Tb, Er, Y) were character...Six new rare earth complexes with Schiff base from 2,6 diformylpyridine N oxide and 4 amino antipyrine were synthesized. These complexes with general formula REL(NO 3) 3 (RE=La, Pr, Eu, Tb, Er, Y) were characterized by elemental analysis, IR, UV, molar conductance measurements and antimicrobial activity.展开更多
Novel 4-thiazolidione and 1,4-bis-thiazolidinone derivatives bearing antipyrine moiety have been obtained from condensation of 4-aminoantipyrine 1 with aromatic/heteroaldehydes followed by cycloaddition with mercaptoa...Novel 4-thiazolidione and 1,4-bis-thiazolidinone derivatives bearing antipyrine moiety have been obtained from condensation of 4-aminoantipyrine 1 with aromatic/heteroaldehydes followed by cycloaddition with mercaptoacetic acid in nonpolar solvents. Structure of the products has been deduced upon their elemental analysis and spectral measurements. Most of the targets evaluated as enzymatic effect towards some bacteria (E. coli) in compare with Xanthine oxidase (from buttermilk) where the role of compounds is an inhibition of purine metabolism enzymes caused by E. coli.展开更多
Solid state photochemical reactions of antipyrine with 5-formyl-1,3- dimethyluracil,p-nitrobenzaldehyde and p-hydroxybenzaldehyde have been described.The structures of 4 hey compounds obtained were determined by IR,UV...Solid state photochemical reactions of antipyrine with 5-formyl-1,3- dimethyluracil,p-nitrobenzaldehyde and p-hydroxybenzaldehyde have been described.The structures of 4 hey compounds obtained were determined by IR,UV,\+1HNHR,ns and elemental analysis.展开更多
The aim of this study was to synthesize a novel lanthanum(La)doped catalyst and to investigate antipyrine removal in wastewater using the Fenton-like process with the catalyst.The La-doped Co-Cu-Fe catalyst was synthe...The aim of this study was to synthesize a novel lanthanum(La)doped catalyst and to investigate antipyrine removal in wastewater using the Fenton-like process with the catalyst.The La-doped Co-Cu-Fe catalyst was synthesized using the modified hydrothermal method.Results showed that the Ladoped catalyst had higher specific surface area and lower particle size than the catalyst without La doping(i.e.,the control)(267 vs.163 m2/g and 14 vs.32 nm,respectively).Under the conditions of catalyst dosage 0.5 g/L,H2O2 concentration 1.70 g/L,and NaHCO3 0.1g/L,the antipyrine removal within 60 min using the Fenton-like process with the La-doped catalyst was much higher than that with the control(95%vs.54%).The hydroxyl radical concentration with the La-doped catalyst within 60 min was two times higher than that with the control(49.2 vs.22.1 gg/L).The high catalytic activity of La-doped catalyst was mainly attributed to its high specific surface area based on the X-ray photoelectron spectroscopy result.Our La-doped catalyst should have great potential to remove antipyrine in wastewater using the heterogeneous Fenton-like process.展开更多
Coupling of dimedone with the diazonium salt of 4-aminoantipyrine afforded 2,3-dimethyl-4-[2-（5,5-dimethyl- 2,6-dioxocyclohex-2-ylidend）-hydrazino]-5-oxo-1-phenylpyrazoline （3）. Reaction of 3 with excess phenylhyd...Coupling of dimedone with the diazonium salt of 4-aminoantipyrine afforded 2,3-dimethyl-4-[2-（5,5-dimethyl- 2,6-dioxocyclohex-2-ylidend）-hydrazino]-5-oxo-1-phenylpyrazoline （3）. Reaction of 3 with excess phenylhydrazine gave the mixed trishydrazone derivative 4. Treatment of 3 with hydroxylamine produced the bisoxime 5 which upon dehydrative cyclization with acetic anhydride gave the corrsponding tetrahydrobenzo[d][1,2,3]triazole derivative 7. A one-pot synthesis of 7 was done by reacting 3 with hydroxylamine hydrochloride in pyridine, followed by heatment with acetic anhydride.展开更多
Based on the phase equilibrium study of the system Sm(ClO4)3-4-monochloroace-tylantipyrine (C13H13ClN2O2)-H2O at 30℃, we have synthesized the title complex [Sm(C13H13Cl. N2O2)3(H2O)4](C1O4)3.4H2O. The single crystal ...Based on the phase equilibrium study of the system Sm(ClO4)3-4-monochloroace-tylantipyrine (C13H13ClN2O2)-H2O at 30℃, we have synthesized the title complex [Sm(C13H13Cl. N2O2)3(H2O)4](C1O4)3.4H2O. The single crystal structure analysis on RASA-IIS Rigaku diffrac-tometer shows that the coordination number of the metal ion is nine and the geometry of the complex is tricapped trigonal prism. Two of the three molecules of organic ligand act as bidentate chelated through both carbonyl oxygens to the metal ion, but the other one as a monodentate coordinated only through the ring carbonyl oxygen, the side chain carbonyl is far away from the central ion. The crystal is monoclinic, space group P21, a = 18.013(4), 6 = 14.709(3), c = 10.536(3) A, β=94.69(2)°, V=2782(1) A3, Z=2.展开更多
A new azo Schiff-base ligand,(N^(1)Z,N^(2)Z)-N^(1),N^(2)-bis(4-((Z)4-hydroxy naphthalen-1-yl)diazenyl)-(1,5-dimethy-2-phenyl-^(1)H-pyrazol-3(2H)-ylidene)benzene-1,2-diamine,has been synthesized from coupling(N^(1)Z,N^...A new azo Schiff-base ligand,(N^(1)Z,N^(2)Z)-N^(1),N^(2)-bis(4-((Z)4-hydroxy naphthalen-1-yl)diazenyl)-(1,5-dimethy-2-phenyl-^(1)H-pyrazol-3(2H)-ylidene)benzene-1,2-diamine,has been synthesized from coupling(N^(1)Z,N^(2)Z)-N^(1),N^(2)-bis(4-amino-1,5-dimethyl-2-phenyl-^(1)H-pyrazol-3(2H)-ylidene)benzene-1,2-diamine with 1-naphthol.Fourier-transform infrared spectroscopy(FTIR),proton nuclear magnetic resonance(^(1)H-NMR),carbon nuclear magnetic resonance(^(13)C-NMR)technique,ultraviolet-visible spectroscopy(UV-Vis),mass analysis,molar conductance and magnetic susceptibility were used to characterize the structures of the new ligand and their transition metal complexes.The complexes were found to have the general formula(M)(L)Cl_(2) where M=Co(Ⅱ),Ni(Ⅱ),Cu(Ⅱ),Zn(Ⅱ),Cd(Ⅱ)and Hg(Ⅱ),(M)(L)Cl_(3) where M=Au(Ⅲ),and(M)(L)Cl_(2)Cl where M=Fe(Ⅲ).The FTIR results demonstrated that the coordination sites were the azomethine nitrogen and azo nitrogen atoms of the azo Schiff-base ligand.The electronic spectral and magnetic measurement data indicated that the complexes exhibited octahedral geometry,except the Au(Ⅲ)complex suggested a square planar geometry around the central metal ion.The results showed the highest inhibitory effect for gold the complex.The effect of biological screening of the gold complex on human colon cancer cell line LS-174 was investigated.The gold complex was observed to have the highest inhibitory effect.展开更多
The title compound C18H16N4O3 （Mr = 336.35） has been synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The Schiff base compound is a derivative of 4-aminoantipyrine. As expect...The title compound C18H16N4O3 （Mr = 336.35） has been synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The Schiff base compound is a derivative of 4-aminoantipyrine. As expected, the molecular structure adopts a trans configuration about the central C=N double bond. It crystallizes in orthorhombic, space group P2dc with a = 7.632（1）, b = 7.816（1）, c = 28.082（5） A,β = 96.18（1）°, V= 1665.48（51） A^3, Z= 4, Dc = 1.341 g/cm^3, F（000） = 704,μ = 0.094 mm^-1, the final R = 0.0448 and wR = 0.1058. Of the total 3748 collections, 3105 were unique. In the molecule there exist two different planes of pyrazoline and C（11）-C（16） phenyl ring, which are approximately coplanar （r.m.s. de deviation from the combined mean plane is 0.03 A） with the dihedral angle between them of 9.8%.展开更多
The title compound （C20H21N3O4, Mr = 367.40） has been synthesized and its crystal structure was determined by single-crystal X-ray diffraction. The crystal is of orthorhombic, space group P212121 with a = 7.5143（15...The title compound （C20H21N3O4, Mr = 367.40） has been synthesized and its crystal structure was determined by single-crystal X-ray diffraction. The crystal is of orthorhombic, space group P212121 with a = 7.5143（15）, b = 13.901（3）, c = 18.545（4）A , V = 1937.1（7） A^3, Z = 4, Dc = 1.260 g/cm^3, μ = 0.089 mm^-1, F（000） = 776, the final R = 0.0616 and wR = 0.0912. X-ray diffraction reveals that the molecule adopts an E configuration about the central C=N double bond. The intermolecular O-H…O hydrogen bond stabilizes the crystal structure by causing the formation of a supramolecular architecture.展开更多
The title Schiff base compound, C19H19N3O3, a derivative of antipyrine, has been synthesized and characterized by elemental analysis, IR, and single-crystal X-ray diffraction. The crystal belongs to the monoclinic sys...The title Schiff base compound, C19H19N3O3, a derivative of antipyrine, has been synthesized and characterized by elemental analysis, IR, and single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group C2/c, with α = 27.935（5）, b = 7.553（1）, c = 16.692（3） A, β = 105.810（3）°, Z = 8, V= 3388.7（10） A^3, Dc = 1.323 g/cm^3, Mr = 337.37, λ（MoKα） = 0.71073 A,μ= 0.091 mm^-1, F（000） = 1424, R = 0.0630 and wR = 0.1273. A total of 3513 unique reflections were collected, of which 2112 with I 〉 2σ（I） were observed. The molecular structure adopts a trans configuration about the C=N double bond. The pyrazoline and C（1）-C（6） phenyl ring are approximately coplanar （mean deviation from the combined plane is 0.069（3） A）, with the dihedral angle of 9.7（2）°. The preliminary biological tests show that the compound has high antibacterial activities.展开更多
The title compound （C16H15N3O2, Mr= 281.31） has been synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The Schiff base compound is a derivative of 4-aminoantipyrine. As expect...The title compound （C16H15N3O2, Mr= 281.31） has been synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The Schiff base compound is a derivative of 4-aminoantipyrine. As expected, the molecular structure adopts a trans configuration about the C=N double bond. It crystallizes in the monoclinic system, space group P2 1/c with a = 11.150（3）, b = 9.906（3）, c = 13.624（4） A, β = 106.360（4）°, V= 1443.9（7） ,A^3, Z = 4, Dc = 1.294 g/cm^3, F（000） = 592,μ（MoKa） = 0.088 mm ^-1, R = 0.0577 and wR = 0.1214. Of the 5766 total reflections, 2540 were unique. In the molecule there exist two different planes of pyrazoline and O（2）-C（10） phenyl ring, which are approximately coplanar （r.m.s. de deviation from the combined mean plane is 0026 A） with the dihedral angle between them of 6.3°.展开更多
Cutaneous leishmaniasis(CL)is a parasitic disease transmitted by biting of the sandfly;it is a severe health problem in many regions of the world.The disease is endemic in Iraq and other countries.In Iraq,there are tw...Cutaneous leishmaniasis(CL)is a parasitic disease transmitted by biting of the sandfly;it is a severe health problem in many regions of the world.The disease is endemic in Iraq and other countries.In Iraq,there are two main species of the genus Leishmania causing the infection:L.tropica and L.major.Previous studies suggested that a genetic makeup of host also had an essential role in the outcome of the disease.The present study investigated the association between CL and functionally active polymorphisms in the macrophage migration inhibitory factor(MIF gene).Samples of peripheral blood were collected from 60 patients with CL and 32 apparently healthy controls.MIF-173G>C polymorphism was detected in patients and control groups by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)technique.There was no statistically significant difference in the MIF-173G>C polymorphism between the CL patients and the healthy controls(P=0.234),as well as no association between MIF-173G>C polymorphisms and CL;the frequency of allele C showed a trend towards lower frequency in patients as compared to that observed in the control group(P=0.512).展开更多
基金supported by the Research Funds for the Central Universities (No. YX2011-12, BLJC200903,TD2011-22)the National Natural Science Foundation of China (No. 51178046)+1 种基金the Program for New Century Excellent Talents in University of China (No.NCET-08-0732)the National High Technology Research and Development Program (863) of China (No.2008AA06Z309)
文摘Owing to its low cost, free chlorine is one of the most common disinfectants for wastewater and drinking water treatment. However, the formation of disinfection byproducts has been found to occur after free chlorine disinfection in recent decades. Antipyrine （ANT）, an anti-inflammatory analgesic, has been frequently detected in the aquatic environment. In this work, the removal efficiency of ANT by free chlorine oxidation in ultrapure water was investigated with batch experiments. The influencing factors on the removal of ANT were explored at initial concentrations of ANT from 0.04 to 0.64 rag/L, free chlorine dosage from 0.30 to 1.31 rag/L, and pH from 1.5 to 9.0. The main degradation products were identified by solid phase extraction-gas chromatography-mass spectrometry. The results showed that ANT reacted rapidly with free chlorine in ultrapure water systems and up to 90.6% removal efficiency of ANT was achieved after 25 sec （initial free chlorine 1 mg/L, ANT 0.5 mg/L, pH 7.0）. Higher oxidant dosage, lower ANT initial concentration and low pH favor the ANT removal. The main degradation product in ANT chlorination was a monochlorine substitution product （4-chloro-l,2-dihydro- 1,5-dimethyl-2-phenyl-3H-pyrazol-3-one）, which can be further chlorinated by free chlorine. In addition, the total organic carbon result indicated that ANT is difficult to be mineralized using chlorine.
文摘Six new rare earth complexes with Schiff base from 2,6 diformylpyridine N oxide and 4 amino antipyrine were synthesized. These complexes with general formula REL(NO 3) 3 (RE=La, Pr, Eu, Tb, Er, Y) were characterized by elemental analysis, IR, UV, molar conductance measurements and antimicrobial activity.
文摘Novel 4-thiazolidione and 1,4-bis-thiazolidinone derivatives bearing antipyrine moiety have been obtained from condensation of 4-aminoantipyrine 1 with aromatic/heteroaldehydes followed by cycloaddition with mercaptoacetic acid in nonpolar solvents. Structure of the products has been deduced upon their elemental analysis and spectral measurements. Most of the targets evaluated as enzymatic effect towards some bacteria (E. coli) in compare with Xanthine oxidase (from buttermilk) where the role of compounds is an inhibition of purine metabolism enzymes caused by E. coli.
文摘Solid state photochemical reactions of antipyrine with 5-formyl-1,3- dimethyluracil,p-nitrobenzaldehyde and p-hydroxybenzaldehyde have been described.The structures of 4 hey compounds obtained were determined by IR,UV,\+1HNHR,ns and elemental analysis.
基金grants from the National Key R&D Program of China(Nos.2017YFB0903700 and 2017YFB0903703)the National Natural Science Foundation of China(Grant Nos.51608547,51278500 and 51308557)the Fundamental Research Funds for the Central Universities(181gpy43).
文摘The aim of this study was to synthesize a novel lanthanum(La)doped catalyst and to investigate antipyrine removal in wastewater using the Fenton-like process with the catalyst.The La-doped Co-Cu-Fe catalyst was synthesized using the modified hydrothermal method.Results showed that the Ladoped catalyst had higher specific surface area and lower particle size than the catalyst without La doping(i.e.,the control)(267 vs.163 m2/g and 14 vs.32 nm,respectively).Under the conditions of catalyst dosage 0.5 g/L,H2O2 concentration 1.70 g/L,and NaHCO3 0.1g/L,the antipyrine removal within 60 min using the Fenton-like process with the La-doped catalyst was much higher than that with the control(95%vs.54%).The hydroxyl radical concentration with the La-doped catalyst within 60 min was two times higher than that with the control(49.2 vs.22.1 gg/L).The high catalytic activity of La-doped catalyst was mainly attributed to its high specific surface area based on the X-ray photoelectron spectroscopy result.Our La-doped catalyst should have great potential to remove antipyrine in wastewater using the heterogeneous Fenton-like process.
文摘Coupling of dimedone with the diazonium salt of 4-aminoantipyrine afforded 2,3-dimethyl-4-[2-（5,5-dimethyl- 2,6-dioxocyclohex-2-ylidend）-hydrazino]-5-oxo-1-phenylpyrazoline （3）. Reaction of 3 with excess phenylhydrazine gave the mixed trishydrazone derivative 4. Treatment of 3 with hydroxylamine produced the bisoxime 5 which upon dehydrative cyclization with acetic anhydride gave the corrsponding tetrahydrobenzo[d][1,2,3]triazole derivative 7. A one-pot synthesis of 7 was done by reacting 3 with hydroxylamine hydrochloride in pyridine, followed by heatment with acetic anhydride.
文摘Based on the phase equilibrium study of the system Sm(ClO4)3-4-monochloroace-tylantipyrine (C13H13ClN2O2)-H2O at 30℃, we have synthesized the title complex [Sm(C13H13Cl. N2O2)3(H2O)4](C1O4)3.4H2O. The single crystal structure analysis on RASA-IIS Rigaku diffrac-tometer shows that the coordination number of the metal ion is nine and the geometry of the complex is tricapped trigonal prism. Two of the three molecules of organic ligand act as bidentate chelated through both carbonyl oxygens to the metal ion, but the other one as a monodentate coordinated only through the ring carbonyl oxygen, the side chain carbonyl is far away from the central ion. The crystal is monoclinic, space group P21, a = 18.013(4), 6 = 14.709(3), c = 10.536(3) A, β=94.69(2)°, V=2782(1) A3, Z=2.
文摘A new azo Schiff-base ligand,(N^(1)Z,N^(2)Z)-N^(1),N^(2)-bis(4-((Z)4-hydroxy naphthalen-1-yl)diazenyl)-(1,5-dimethy-2-phenyl-^(1)H-pyrazol-3(2H)-ylidene)benzene-1,2-diamine,has been synthesized from coupling(N^(1)Z,N^(2)Z)-N^(1),N^(2)-bis(4-amino-1,5-dimethyl-2-phenyl-^(1)H-pyrazol-3(2H)-ylidene)benzene-1,2-diamine with 1-naphthol.Fourier-transform infrared spectroscopy(FTIR),proton nuclear magnetic resonance(^(1)H-NMR),carbon nuclear magnetic resonance(^(13)C-NMR)technique,ultraviolet-visible spectroscopy(UV-Vis),mass analysis,molar conductance and magnetic susceptibility were used to characterize the structures of the new ligand and their transition metal complexes.The complexes were found to have the general formula(M)(L)Cl_(2) where M=Co(Ⅱ),Ni(Ⅱ),Cu(Ⅱ),Zn(Ⅱ),Cd(Ⅱ)and Hg(Ⅱ),(M)(L)Cl_(3) where M=Au(Ⅲ),and(M)(L)Cl_(2)Cl where M=Fe(Ⅲ).The FTIR results demonstrated that the coordination sites were the azomethine nitrogen and azo nitrogen atoms of the azo Schiff-base ligand.The electronic spectral and magnetic measurement data indicated that the complexes exhibited octahedral geometry,except the Au(Ⅲ)complex suggested a square planar geometry around the central metal ion.The results showed the highest inhibitory effect for gold the complex.The effect of biological screening of the gold complex on human colon cancer cell line LS-174 was investigated.The gold complex was observed to have the highest inhibitory effect.
文摘The title compound C18H16N4O3 （Mr = 336.35） has been synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The Schiff base compound is a derivative of 4-aminoantipyrine. As expected, the molecular structure adopts a trans configuration about the central C=N double bond. It crystallizes in orthorhombic, space group P2dc with a = 7.632（1）, b = 7.816（1）, c = 28.082（5） A,β = 96.18（1）°, V= 1665.48（51） A^3, Z= 4, Dc = 1.341 g/cm^3, F（000） = 704,μ = 0.094 mm^-1, the final R = 0.0448 and wR = 0.1058. Of the total 3748 collections, 3105 were unique. In the molecule there exist two different planes of pyrazoline and C（11）-C（16） phenyl ring, which are approximately coplanar （r.m.s. de deviation from the combined mean plane is 0.03 A） with the dihedral angle between them of 9.8%.
基金This work was supported by the Foundation of Science and Technology Department of Guangdong Province (2004B30101007)Taishan University (No.Y04-2-02)
文摘The title compound （C20H21N3O4, Mr = 367.40） has been synthesized and its crystal structure was determined by single-crystal X-ray diffraction. The crystal is of orthorhombic, space group P212121 with a = 7.5143（15）, b = 13.901（3）, c = 18.545（4）A , V = 1937.1（7） A^3, Z = 4, Dc = 1.260 g/cm^3, μ = 0.089 mm^-1, F（000） = 776, the final R = 0.0616 and wR = 0.0912. X-ray diffraction reveals that the molecule adopts an E configuration about the central C=N double bond. The intermolecular O-H…O hydrogen bond stabilizes the crystal structure by causing the formation of a supramolecular architecture.
基金This work was supported by the Qufu Normal University
文摘The title Schiff base compound, C19H19N3O3, a derivative of antipyrine, has been synthesized and characterized by elemental analysis, IR, and single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group C2/c, with α = 27.935（5）, b = 7.553（1）, c = 16.692（3） A, β = 105.810（3）°, Z = 8, V= 3388.7（10） A^3, Dc = 1.323 g/cm^3, Mr = 337.37, λ（MoKα） = 0.71073 A,μ= 0.091 mm^-1, F（000） = 1424, R = 0.0630 and wR = 0.1273. A total of 3513 unique reflections were collected, of which 2112 with I 〉 2σ（I） were observed. The molecular structure adopts a trans configuration about the C=N double bond. The pyrazoline and C（1）-C（6） phenyl ring are approximately coplanar （mean deviation from the combined plane is 0.069（3） A）, with the dihedral angle of 9.7（2）°. The preliminary biological tests show that the compound has high antibacterial activities.
基金This work was supported by the Phytochemistry Key Laboratory of Shaanxi Province (No. 02js40)
文摘The title compound （C16H15N3O2, Mr= 281.31） has been synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. The Schiff base compound is a derivative of 4-aminoantipyrine. As expected, the molecular structure adopts a trans configuration about the C=N double bond. It crystallizes in the monoclinic system, space group P2 1/c with a = 11.150（3）, b = 9.906（3）, c = 13.624（4） A, β = 106.360（4）°, V= 1443.9（7） ,A^3, Z = 4, Dc = 1.294 g/cm^3, F（000） = 592,μ（MoKa） = 0.088 mm ^-1, R = 0.0577 and wR = 0.1214. Of the 5766 total reflections, 2540 were unique. In the molecule there exist two different planes of pyrazoline and O（2）-C（10） phenyl ring, which are approximately coplanar （r.m.s. de deviation from the combined mean plane is 0026 A） with the dihedral angle between them of 6.3°.
文摘Cutaneous leishmaniasis(CL)is a parasitic disease transmitted by biting of the sandfly;it is a severe health problem in many regions of the world.The disease is endemic in Iraq and other countries.In Iraq,there are two main species of the genus Leishmania causing the infection:L.tropica and L.major.Previous studies suggested that a genetic makeup of host also had an essential role in the outcome of the disease.The present study investigated the association between CL and functionally active polymorphisms in the macrophage migration inhibitory factor(MIF gene).Samples of peripheral blood were collected from 60 patients with CL and 32 apparently healthy controls.MIF-173G>C polymorphism was detected in patients and control groups by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)technique.There was no statistically significant difference in the MIF-173G>C polymorphism between the CL patients and the healthy controls(P=0.234),as well as no association between MIF-173G>C polymorphisms and CL;the frequency of allele C showed a trend towards lower frequency in patients as compared to that observed in the control group(P=0.512).
