In this study,thyme essential oil(TEO)nanoemulsion(tPTNs)was constructed with transglutaminase(TGase)-modified potato protein,and its antibacterial activity and mechanism of action were evaluated and explored.Results ...In this study,thyme essential oil(TEO)nanoemulsion(tPTNs)was constructed with transglutaminase(TGase)-modified potato protein,and its antibacterial activity and mechanism of action were evaluated and explored.Results indicated that tPTNs exhibited great antibacterial activity against both Staphylococcus aureus and Escherichia coli,with minimal inhibitory concentration(MIC)and minimum bactericidal concentration(MBC)of 2.5 and 5.0 mg/mL,respectively.Also,the antibacterial effects of tPTNs were concentration-dependent.We observed a significant decrease in the absolute value of the zeta potential,and significant increases in particle size,cell membrane hydrophobicity,conductivity,the release of metal ions,and the leakage of nucleic acid as the concentration of tPTNs increased from 0 mg/mL to MBC.Furthermore,sodium dodecyl sulphate-polyacrylamide gel electrophoresis(SDS-PAGE)demonstrated that protein synthesis was inhibited or even disrupted.Analysis by liquid chromatography-mass spectrometry(LC-MS)indicated that treatment with tPTNs caused significant changes in bacterial metabolites,1117 and 692 differential metabolites being found for S.aureus and E.coli,respectively.The differential metabolites were involved in nucleotide metabolism,amino acid metabolism,tricarboxylic acid cycle and other metabolic pathways.These findings provide valuable insights for the application of thyme essential oil as an efficient antibacterial agent and for the understanding of its mechanism of action.展开更多
Chitosan(CTS)was grafted onto the surface of amino‑functionalized silver chloride silicon dioxide(AgCl@SiO_(2)‑NH_(2))cores to obtain AgCl@SiO_(2)/CTS hybrid nanoparticles.The as‑obtained AgCl@SiO_(2)/CTS nanoparticle...Chitosan(CTS)was grafted onto the surface of amino‑functionalized silver chloride silicon dioxide(AgCl@SiO_(2)‑NH_(2))cores to obtain AgCl@SiO_(2)/CTS hybrid nanoparticles.The as‑obtained AgCl@SiO_(2)/CTS nanoparticles were chlorinated by NaClO solution to get AgCl@SiO_(2)/CTS‑based chloramine nano‑hybrid materials,denoted as AgCl@SiO_(2)/CTS‑Cl.A transmission electron microscope was used to observe the morphology of the as‑prepared samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.At the same time,an X‑ray diffractometer and an infrared spectroscope were utilized to characterize their crystal and chemical structures.Besides,ζpotentials were measured to elucidate the surface modification of AgCl nanoparticles by—NH_(2),the antibacterial mechanism of AgCl@SiO_(2)/CTS‑Cl was investigated by scanning electron microscopy,and Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)were used as the to‑be‑tested strains to evaluate the antimicrobial activity of samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.Findings demonstrate that sample AgCl@SiO_(2)/CTS exhibits a chain‑like structure ascribed to the interaction between—NH_(2),and each AgCl@SiO_(2)/CTS hybrid nanoparticle contains several AgCl cores.In the meantime,sample AgCl@SiO_(2)/CTS‑Cl exhibits excellent antibacterial activity against E.coli and S.aureus,which is attributed to the synergistic antibacterial effect of Ag^(+)and Cl^(-).Sample AgCl@SiO_(2)/CTS‑Cl with a dosage of 640.00μg·mL^(-1) could completely kill the two kinds of tested bacteria in 12 h of incubation;it retains a high antibacterial efficiency even after 10 cycles of antibacterial tests.展开更多
Herein,antibacterial silver‑doped fluorescent carbon dots(Ag‑CDs)were synthesized through a stepwise hydrothermal method,with polyethyleneimine(PEI),citric acid(CA),and silver nitrate(AgNO3)serving as precursors.The a...Herein,antibacterial silver‑doped fluorescent carbon dots(Ag‑CDs)were synthesized through a stepwise hydrothermal method,with polyethyleneimine(PEI),citric acid(CA),and silver nitrate(AgNO3)serving as precursors.The applicability and antimicrobial efficacy of these nanomaterials were systematically investigated for metal ion sensing.Experimental evidence demonstrated that the Ag‑CDs exhibited a pronounced fluorescence quenching response toward ferric ions(Fe^(3+)),enabling their quantitative determination via a linear concentration‑dependent relationship.These Ag‑CDs exhibited significant inhibitory effects on biofilm growth and disruption for both Escherichia coli and Staphylococcus aureus.Mechanism investigations indicate that Ag‑CDs induced the death of Escherichia coli and Pseudomonas aeruginosa by disrupting their bacterial morphology and structure,triggering the generation of intracellular reactive oxygen species(ROS),and impairing their antioxidant defense system.展开更多
The effect of antibacterial adhesive on the biological corrosion resistance of mortar in seawater environment was studied by means of scanning electron microscope,thermogravimetric analysis,X-ray diffraction,Fourier t...The effect of antibacterial adhesive on the biological corrosion resistance of mortar in seawater environment was studied by means of scanning electron microscope,thermogravimetric analysis,X-ray diffraction,Fourier transform infrared spectroscopy,and ultra-depth microscope.The results show that the antibacterial adhesive can effectively inhibit the growth of sulfur-oxidizing bacteria in seawater,hinder their metabolism to produce biological sulfate,and reduce the formation of destructive product gypsum.The mineral composition and thermal analysis showed that the peak value of plaster diffraction peak and the mass loss of plaster dehydration in antibacterial adhesive group were significantly lower than those in blank group(without protective coating group).In addition,the electric flux of chloride ions(>400 C)in the blank group of mortar samples was higher than that in the antibacterial adhesive group(<200 C),indicating that the antibacterial adhesive can effectively reduce the permeability of chloride ions in mortar,and thus hinder the Cl-erosion in seawater.展开更多
The photothermal effect enhances the antibacterial activity by generating localized heat that disrupts microbial cells,leading to increased bacterial inactivation.The objective of this study was to develop and evaluat...The photothermal effect enhances the antibacterial activity by generating localized heat that disrupts microbial cells,leading to increased bacterial inactivation.The objective of this study was to develop and evaluate the antibacterial and photothermal applications of polydopamine-berberine nanoparticles(PDA-BBR-NPs),incorporating them into a sodium alginate matrix for food preservation.The self-assembled PDA-BBR-NPs were synthesized using a solution oxidation method and characterized by scanning electron microscopy,Fourier transform infrared spectroscopy,and nanoparticle size analysis.The results demonstrated that PDA-BBR-NPs were uniform spheres with an average diameter of 177.1 nm.Drug loading and encapsulation efficiency tests showed that the optimal formulation had a drug loading capacity of 48.4%and an encapsulation efficiency of 84.70%.Antibacterial activity against Escherichia coli and Staphylococcus aureus was evaluated using the dilution coating plate method,showing an inhibition rate of over 98%.Photothermal testing under 808 nm near-infrared irradiation revealed a maximum photothermal conversion efficiency of 32.65%.To assess the practical application of the nanoparticles,they were incorporated into a sodium alginate-based coating for the preservation of Kyoho grapes.Key parameters such as weight loss rate,pH,titratable acidity,and soluble solids content were monitored over a 12-day storage period at room temperature.The PDA-BBR-near-infrared spectroscopy-treated group exhibited significantly reduced weight loss rate(6.08%lower than the control group)and a slower decrease in pH.The coating effectively inhibited microbial activity and extended the shelf life of the grapes by 3-6 days compared to the control group.These findings demonstrated the potential of PDA-BBR-NPs to enhance the preservation of fresh produce through their combined antibacterial and photothermal effects,offering a promising method for extending fruit shelf life.展开更多
Plant bacterial diseases cause significant harm to agricultural production because of their frequent,intermittent and regional outbreaks.Currently,chemical control is still a more effective method for bacterial diseas...Plant bacterial diseases cause significant harm to agricultural production because of their frequent,intermittent and regional outbreaks.Currently,chemical control is still a more effective method for bacterial disease.To develop new,efficient and safe antibacterial agrochemicals,we summarize the research progress of compounds with antibacterial activities in the past ten years,classify them according to their active skeletons,and discuss their structure-activity relationships and mechanisms of action.Finally,the development trend of antibacterial agrochemicals was prospected.This review provides valuable information for the development of antibacterial agrochemicals.展开更多
Novel antibacterial strategies such as antibacterial photodynamic therapy(aPDT)and photothermal therapy(PTT)have gained significant attention,however,relying on a single-treatment approach still faces challenges of in...Novel antibacterial strategies such as antibacterial photodynamic therapy(aPDT)and photothermal therapy(PTT)have gained significant attention,however,relying on a single-treatment approach still faces challenges of insufficient therapeutic efficiency and the potential for drug resistance.In this study,a multimodal synergistic antibacterial nanoplatform by coupling a carbon monoxide(CO)donor(4-(3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid(4-BA))with carbon dots(CDs)is developed,referred to as CDs-CO,which integrates multiple antibacterial modes of aPDT,PTT,and gas therapy.This nanoplatform is designed for highly efficient antibacterial action with a low risk of inducing drug resistance.CDs are engineered to possess tailored functions,including deep-red light-triggered heat and singlet oxygen(^(1)O_(2))production.After modification with 4-BA and exposure to 660 nm laser irradiation,CDs-CO exhibits favorable photothermal conversion efficiency(η=52.7%),robust ^(1)O_(2) generation,and ^(1)O_(2)-activated CO release.Antibacterial experiments demonstrated the excellent sterilization effects of CDs-CO against both Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus),underscoring the enhanced antibacterial efficiency of this multimodal nanoplatform.This study offers a rational approach for designing multimodal synergistic antibacterial platforms,highlighting their potential for effectively treating bacterial infections.展开更多
[Objectives]To evaluate the in vitro antibacterial,antioxidant,andα-glucosidase inhibitory activities of the ethanol total extract and four different polarity fractions(n-butanol,ethyl acetate,petroleum ether,and wat...[Objectives]To evaluate the in vitro antibacterial,antioxidant,andα-glucosidase inhibitory activities of the ethanol total extract and four different polarity fractions(n-butanol,ethyl acetate,petroleum ether,and water)of Pilea peltata Hance,so as to provide a reference for its further development and research.[Methods]The antibacterial activity of P.peltata was evaluated in vitro by determining the minimum inhibitory concentration(MIC)and minimum bactericidal concentration(MBC)of its ethanol total extract and four different polarity fractions against seven test bacterial strains using the broth microdilution method.The in vitro antioxidant activity was investigated through DPPH radical,hydroxyl radical,and superoxide anion radical scavenging assays,with vitamin C(Vit C)as the positive control and the half maximal scavenging concentration(IC 50)as the evaluation indicator.The in vitroα-glucosidase inhibitory activity was assessed by measuring the peak area of p-nitrophenol(PNP),the hydrolysis product of 4-nitrophenylα-D-glucopyranoside(PNPG),via high-performance liquid chromatography(HPLC),using the half maximal inhibitory concentration(IC 50)as the evaluation indicator.[Results]Both the ethanol total extract and the four different polarity fractions of P.peltata exhibited significant in vitro anti-Streptococcus pneumoniae activity.The DPPH radical scavenging capacities of the ethanol total extract and the various fractions were all weaker than that of VitC,with the order of efficacy being:n-butanol fraction>ethanol total extract>ethyl acetate fraction>petroleum ether fraction>aqueous fraction.For hydroxyl radical scavenging activity,the efficacy order of P.peltata fractions was:n-butanol extract>ethyl acetate extract>ethanol total extract>petroleum ether extract>aqueous extract.Notably,the n-butanol fraction(IC 50=0.068±0.001)demonstrated stronger activity than VitC(IC 50=0.097±0.001).The activity of the ethyl acetate fraction(IC 50=0.096±0.004)was comparable to that of VitC(IC 50=0.097±0.001).The superoxide anion scavenging capacities of the ethanol total extract and different polarity fractions from P.peltata were all weaker than that of VitC,with the order of efficacy being:n-butanol fraction>ethyl acetate fraction>ethanol total extract>petroleum ether fraction>aqueous fraction.The ethanol total extract and aqueous fraction of Pilea peltata showed no significant in vitroα-glucosidase inhibitory activity.Compared with the acarbose group,the IC 50 values of the ethyl acetate fraction and the n-butanol fraction both showed highly significant differences(P<0.01).[Conclusions]This study provides an experimental basis for the pharmacodynamic study and active component study of P.peltata.展开更多
Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial property.However,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are...Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial property.However,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water pollution.In this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing agent.Experimental analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag NPs.The surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their aggregation.After the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite hydrogel.The inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag NPs.The prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.展开更多
Nano-zinc oxides(ZnO)demonstrate remarkable antibacterial properties.To further enhance the corrosion resistance and antibacterial efficiency of magnesium alloy micro-arc oxidation(MAO)coatings,this study investigates...Nano-zinc oxides(ZnO)demonstrate remarkable antibacterial properties.To further enhance the corrosion resistance and antibacterial efficiency of magnesium alloy micro-arc oxidation(MAO)coatings,this study investigates the preparation of ZnO-containing micro-arc oxidation coatings with dual functionality by incorporating nano-ZnO into MAO electrolyte.The influence of varying ZnO concentrations on the microstructure,corrosion resistance,and antibacterial properties of the coating was examined through microstructure analysis,immersion tests,electrochemical experiments,and antibacterial assays.The findings revealed that the addition of nano-ZnO significantly enhanced the corrosion resistance of the MAO-coated alloy.Specifically,when the ZnO concentration in the electrolyte was 5 g/L,the corrosion rate was more than ten times lower compared to the MAO coatings without ZnO.Moreover,the antibacterial efficacy of ZnO+MAO coating,prepared with a ZnO concentration of 5 g/L,surpassed 95%after 24 h of co-culturing with Staphylococcus aureus(S.aureus).The nano-ZnO+MAO-coated alloy exhibited exceptional degradation resistance,corrosion resistance,and antibacterial effectiveness.展开更多
The defect regulation and p-n heterojunction of composites have gained significant attention due to their potential applications.Nitrogen(N)as doping heteroatoms and perylene-3,4,9,10-tetracarboximide(PDINH)as an appr...The defect regulation and p-n heterojunction of composites have gained significant attention due to their potential applications.Nitrogen(N)as doping heteroatoms and perylene-3,4,9,10-tetracarboximide(PDINH)as an appropriate n-type semiconductor were innovatively and reasonably selected to enhance the photocatalytic performance of pristine p-type cuprous oxide(Cu_(2)O).In this study,the defect regula-tion of N doping(1)achieved the small-size effect of Cu_(2)O,(2)optimized the electron features,and(3)improved the kinetics of reactive oxygen species.The p-n heterojunction with PDINH was developed to sharply improve the light utilization of Cu_(2)O,from the UV region to the near-infrared region.As expected,the optimized Cu_(2)N_(x)O_(1–x)/PDINH(x=0.02)exhibited excellent long-term photocatalytic antibacterial ac-tivities,with antibacterial rates exceeding 91%against Staphylococcus aureus and Pseudomonas aeruginosa.Defect regulation and p-n heterojunction of Cu_(2)O-based composites thus provide a great deal of potential for future advancements in photocatalysis.展开更多
Fiber fabrics have been wildly utilized for solar interracial evaporators to address freshwater scarcity.However,the complex and expensive manufacturing processes remain limited to their scalable development.Herein,a ...Fiber fabrics have been wildly utilized for solar interracial evaporators to address freshwater scarcity.However,the complex and expensive manufacturing processes remain limited to their scalable development.Herein,a fabric-based Janus interracial evaporator is efficiently fabricated on a large scale by integrating an extremely innovative self-designed melt-centrifugal spinning technology with spray coating technology.The prepared fabric-based Janus interfacial evaporator has differential hydrophilicity,uneven surfaces,and channels that allow moisture escape.Benefiting from the excellent photothermai conversion of graphene oxide and the charge transfer actions of titanium dioxide,such a multifunction evaporator can reach a high evaporation rate of 1.72 kg m^(-2)h^(-1)under 1 sun irradiation,a superior antibacterial rate of 99%,excellent photocatalytic degradation,and effective thermoelectric ability simultaneously.Moreover,it also shows fantastic performance in salt resistance,recyclable evaporation,and real desalination,This work demonstrates a high-efficiency,cost-effective,multifunctional,and scalable strategy for high-performance fiber fabrics solar interfacial evaporation.展开更多
Superhydrophobic surface is a promising strategy for antibacterial and corrosion protection.However,the use of harmful fluorine-containing materials,poor mechano-chemical stability,the addition of fungicides and poor ...Superhydrophobic surface is a promising strategy for antibacterial and corrosion protection.However,the use of harmful fluorine-containing materials,poor mechano-chemical stability,the addition of fungicides and poor corrosion resistance often limit its practical application.In this paper,a high-robustness pho-tothermal self-healing superhydrophobic coating is prepared by simply spraying a mixture of hydropho-bically modified epoxy resin and two kinds of modified nanofillers(carbon nanotubes and SiO2)for long-term anticorrosion and antibacterial applications.Multi-scale network and lubrication structures formed by cross-linking of modified carbon nanotubes and repeatable roughness endow coating with high ro-bustness,so that the coating maintains superhydrophobicity even after 100 Taber abrasion cycles,20 m sandpaper abrasion and 100 tape peeling cycles.The synergistic effect of antibacterial adhesion and pho-tothermal bactericidal activity endows coating with excellent antibacterial efficiency,which against Es-cherichia coli(E.coli)and Staphylococcus aureus(S.aureus)separately reaches 99.6% and 99.8%.Moreover,the influence of modified epoxy resin,superhydrophobicity,organic coating and coating thicknesses on the anticorrosion of magnesium(Mg)alloy is systematically studied and analyzed.More importantly,the prepared coating still exhibits excellent self-cleaning,anticorrosion and antibacterial abilities after 20 m abrasion.Furthermore,the coating exhibits excellent adhesion(level 4B),chemical stability,UV radiation resistance,high-low temperature alternation resistance,stable heat production capacity and photother-mal self-healing ability.All these excellent performances can promote its application in a wider range of fields.展开更多
Fast electron-hole recombination issues during titanium dioxide(TiO_(2))photocatalysis limit its application in preventing bacterial infection during bone defect repair.In this study,TiO_(2)@reduced graphene oxide(rGO...Fast electron-hole recombination issues during titanium dioxide(TiO_(2))photocatalysis limit its application in preventing bacterial infection during bone defect repair.In this study,TiO_(2)@reduced graphene oxide(rGO)composites were synthesized using a hydrothermal method in which rGO,which possesses very high electrical conductivity,promotes the separation of photoelectron-hole pairs of TiO_(2),thus improving the efficiency of photocatalytic production of reactive oxygen species(ROS).Subsequently,TiO_(2)@rGO composites were introduced into poly-L-lactic acid(PLLA)to prepare bone scaffolds with photocatalytic antibacterial function via selective laser sintering.The results showed that TiO_(2)grew on the surface of rGO and formed a covalent bond connection(Ti-O-C)with rGO.A decreased electrochemical impedance of TiO_(2)@rGO composites was observed,and the transient photocurrent intensity increased from 0.05 to 0.5μA/cm^(2).Analysis of electron spin resonance found that the photocatalytic products of TiO_(2)were·OH and·O^(2-),two kinds of ROS capable of killing bacteria via disrupting the structure of the bacterial membrane in vitro.Antibacterial experiments showed that the PLLA/TiO_(2)@rGO scaffolds had good antibacterial properties against Escherichia coli and Staphylococcus aureus.Finally,we report that these scaffolds exhibited both enhanced mechanical properties due to the addition of TiO_(2)@rGO as a reinforcement material and good biocompatibility during cell proliferation.展开更多
Two Gd_(2)complexes,namely[Gd_(2)(dbm)_(2)(HL_(1))_(2)(CH_(3)OH)_(2)]·4CH_(3)OH(1)and[Gd_(2)(dbm)_(2)(L_(2))_(2)(CH_(3)OH)_(2)]·2CH_(3)OH(2),where H_(3)L_(1)=(Z)-N'-[4-(diethylamino)-2-hydroxybenzylidene...Two Gd_(2)complexes,namely[Gd_(2)(dbm)_(2)(HL_(1))_(2)(CH_(3)OH)_(2)]·4CH_(3)OH(1)and[Gd_(2)(dbm)_(2)(L_(2))_(2)(CH_(3)OH)_(2)]·2CH_(3)OH(2),where H_(3)L_(1)=(Z)-N'-[4-(diethylamino)-2-hydroxybenzylidene]-2-hydroxyacetohydrazide,H_(2)L_(2)=(E)-N'-(5-bromo-2-hydroxy-3-methoxybenzylidene)nicotinohydrazide,Hdbm=dibenzoylmethane,have been constructed by adopting the solvothermal method.Structural characterization unveils that both complexes 1 and 2 are constituted by two Gd^(3+)ions,two dbm-ions,two CH_(3)OH molecules,and two polydentate Schiff-base ligands(HL_(1)^(2-)or L_(2)^(2-)).In addition,complex 1 contains four free methanol molecules,whereas complex 2 harbors two free methanol molecules.By investigating the interactions between complexes 1 and 2 and four types of bacteria(Bacillus subtilis,Escherichia coli,Staphylococcus aureus,Candida albicans),it was found that both complexes 1 and 2 exhibited potent antibacte-rial activities.The interaction mechanisms between the ligands H_(3)L_(1),H_(2)L_(2),complexes 1 and 2,and calf thymus DNA(CT-DNA)were studied using ultraviolet-visible spectroscopy,fluorescence titration,and cyclic voltammetry.The results demonstrated that both complexes 1 and 2 can intercalate into CT-DNA molecules,thereby inhibiting bacterial proliferation to achieve the antibacterial effects.CCDC:2401116,1;2401117,2.展开更多
A novel 3D metal-organic framework(MOF)[Pr_(2)(L)_(3)(H_(2)O)5·H_(2)O]n(Pr-1),(H_(2)L=4,4'-oxybis(benzoic acid))with a rare structure of broken layer net,was constructed under the condition of solvothermal sy...A novel 3D metal-organic framework(MOF)[Pr_(2)(L)_(3)(H_(2)O)5·H_(2)O]n(Pr-1),(H_(2)L=4,4'-oxybis(benzoic acid))with a rare structure of broken layer net,was constructed under the condition of solvothermal synthesis.The struc-ture and crystal net were analyzed and characterized.This rod net of Pr-1 is new to both RCSR and ToposPro data-bases,and is named as rn-12 as suggested.Due to the luminescent properties of H_(2)L and Pr(Ⅲ),the solid-state fluo-rescence property and sensing performance(solvents and metal ions)of Pr-1 were investigated.The sensing experi-ments indicated that Pr-1 could act as a fluorescence sensor to detect Cd^(2+)ions with good sensitivity.In addition,antibacterial activities show that Pr-1 exhibited stronger antibacterial activity against Escherichia coli(E.coli),Staphylococcus aureus(S.aureus),and Bacillus subtilis(B.subtilis)compared to synthetic materials.展开更多
Infections associated with titanium(Ti)-based implants present significant challenges in clinical treatments,especially when biofilms already form on the implant surface.Many antimicrobial agents,including antibiotics...Infections associated with titanium(Ti)-based implants present significant challenges in clinical treatments,especially when biofilms already form on the implant surface.Many antimicrobial agents,including antibiotics,metallic nanoparticles and antimicrobial peptides,have been extensively used to deal with Ti implant infections.However,these chemical approaches suffer from potential toxicity,antibiotic resistance and poor long-term antibacterial performance.Hence,physical antibacterial surfaces on Ti-based implants have attracted increasing attention.The antibacterial behavior of different surfaces on Ti-based biomaterials against various bacteria only by physical properties of the implants themselves(e.g.,nanotopography)or exogenous physical stimulus(e.g.,photocatalysis)was reviewed,as well as parameters influencing the physical antibacterial processes,such as size,shape and density of the surface nanotextures,and bacterial growth phases.Besides,mechanisms of different fabrication techniques for the physical antibacterial surfaces on Ti-based biomaterials were also summarized.展开更多
Magnesium alloys are promising candidates for bio-implant applications due to their biodegradability and biocompati-bility.However,their rapid corrosion remains a critical limitation.This study presents the developmen...Magnesium alloys are promising candidates for bio-implant applications due to their biodegradability and biocompati-bility.However,their rapid corrosion remains a critical limitation.This study presents the development of a multifunctional nanocomposite coating designed to enhance the corrosion resistance and antibacterial properties of magnesium alloy im-plants.The coating comprisedγ-cyclodextrin metal-organic frameworks(γ-CD MOFs)decorated with TiO_(2)@Ag core-shell nanoparticles,embedded in a polycaprolactone(PCL)matrix.Immersion tests in a simulated body fluid(SBF)revealed an initially higher corrosion rate for the PCL-TiO_(2)@Ag/γ-CD MOF coating compared to the coating without TiO_(2)@Ag nanopar-ticles;however,it demonstrated significant improvement over time.After five days,the corrosion inhibition reached 95.44%,with the corrosion rate decreasing to 1.70 mpy.Additionally,the composite coating exhibited strong antibacterial activity against Escherichia coli,Pseudomonas,and Staphylococcus aureus.Furthermore,MTT assays indicated that the coating facili-tated the growth and proliferation of osteoblast-like MC3T3-E1 cells,confirming its nontoxicity and biocompatibility.These findings highlight the potential of the PCL-TiO_(2)@Ag/γ-CD MOF nanocomposite as a biocompatible,antibacterial,and cor-rosion-resistant coating for biodegradable magnesium implants,offering a promising solution for biomedical applications.展开更多
[Objectives]To explore the antibacterial activity of Gouteng Foot Bath Concentrated Liquid.[Methods]The inhibitory activity against Staphylococcus aureus,Escherichia coli,Candida albicans,and Trichophyton rubrum was d...[Objectives]To explore the antibacterial activity of Gouteng Foot Bath Concentrated Liquid.[Methods]The inhibitory activity against Staphylococcus aureus,Escherichia coli,Candida albicans,and Trichophyton rubrum was determined using the mycelial growth rate method.The inhibitory effects of different concentrations of Gouteng Concentrated Liquid on these four microbial strains were analyzed.[Results]Gouteng Foot Bath Concentrated Liquid showed certain antibacterial activity against the above bacteria,and the antibacterial activity against S.aureus,T.rubrum and C.albicans was more significant.[Conclusions]This study provides experimental evidence supporting the application of Gouteng(Uncariae Ramulus Cum Uncis)in antimicrobial foot care products.展开更多
Corresponding author’s name was incorrectly written as“Dadang Guo”instead of“Dagang Guo”.The correct author name should be“Dagang Guo”.The authors would like to apologise for any inconvenience caused.
文摘In this study,thyme essential oil(TEO)nanoemulsion(tPTNs)was constructed with transglutaminase(TGase)-modified potato protein,and its antibacterial activity and mechanism of action were evaluated and explored.Results indicated that tPTNs exhibited great antibacterial activity against both Staphylococcus aureus and Escherichia coli,with minimal inhibitory concentration(MIC)and minimum bactericidal concentration(MBC)of 2.5 and 5.0 mg/mL,respectively.Also,the antibacterial effects of tPTNs were concentration-dependent.We observed a significant decrease in the absolute value of the zeta potential,and significant increases in particle size,cell membrane hydrophobicity,conductivity,the release of metal ions,and the leakage of nucleic acid as the concentration of tPTNs increased from 0 mg/mL to MBC.Furthermore,sodium dodecyl sulphate-polyacrylamide gel electrophoresis(SDS-PAGE)demonstrated that protein synthesis was inhibited or even disrupted.Analysis by liquid chromatography-mass spectrometry(LC-MS)indicated that treatment with tPTNs caused significant changes in bacterial metabolites,1117 and 692 differential metabolites being found for S.aureus and E.coli,respectively.The differential metabolites were involved in nucleotide metabolism,amino acid metabolism,tricarboxylic acid cycle and other metabolic pathways.These findings provide valuable insights for the application of thyme essential oil as an efficient antibacterial agent and for the understanding of its mechanism of action.
文摘Chitosan(CTS)was grafted onto the surface of amino‑functionalized silver chloride silicon dioxide(AgCl@SiO_(2)‑NH_(2))cores to obtain AgCl@SiO_(2)/CTS hybrid nanoparticles.The as‑obtained AgCl@SiO_(2)/CTS nanoparticles were chlorinated by NaClO solution to get AgCl@SiO_(2)/CTS‑based chloramine nano‑hybrid materials,denoted as AgCl@SiO_(2)/CTS‑Cl.A transmission electron microscope was used to observe the morphology of the as‑prepared samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.At the same time,an X‑ray diffractometer and an infrared spectroscope were utilized to characterize their crystal and chemical structures.Besides,ζpotentials were measured to elucidate the surface modification of AgCl nanoparticles by—NH_(2),the antibacterial mechanism of AgCl@SiO_(2)/CTS‑Cl was investigated by scanning electron microscopy,and Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)were used as the to‑be‑tested strains to evaluate the antimicrobial activity of samples AgCl@SiO_(2)/CTS and AgCl@SiO_(2)/CTS‑Cl.Findings demonstrate that sample AgCl@SiO_(2)/CTS exhibits a chain‑like structure ascribed to the interaction between—NH_(2),and each AgCl@SiO_(2)/CTS hybrid nanoparticle contains several AgCl cores.In the meantime,sample AgCl@SiO_(2)/CTS‑Cl exhibits excellent antibacterial activity against E.coli and S.aureus,which is attributed to the synergistic antibacterial effect of Ag^(+)and Cl^(-).Sample AgCl@SiO_(2)/CTS‑Cl with a dosage of 640.00μg·mL^(-1) could completely kill the two kinds of tested bacteria in 12 h of incubation;it retains a high antibacterial efficiency even after 10 cycles of antibacterial tests.
文摘Herein,antibacterial silver‑doped fluorescent carbon dots(Ag‑CDs)were synthesized through a stepwise hydrothermal method,with polyethyleneimine(PEI),citric acid(CA),and silver nitrate(AgNO3)serving as precursors.The applicability and antimicrobial efficacy of these nanomaterials were systematically investigated for metal ion sensing.Experimental evidence demonstrated that the Ag‑CDs exhibited a pronounced fluorescence quenching response toward ferric ions(Fe^(3+)),enabling their quantitative determination via a linear concentration‑dependent relationship.These Ag‑CDs exhibited significant inhibitory effects on biofilm growth and disruption for both Escherichia coli and Staphylococcus aureus.Mechanism investigations indicate that Ag‑CDs induced the death of Escherichia coli and Pseudomonas aeruginosa by disrupting their bacterial morphology and structure,triggering the generation of intracellular reactive oxygen species(ROS),and impairing their antioxidant defense system.
基金Funded by the National Natural Science Foundation of China(Nos.52278269,52278268,52178264)Tianjin Outstanding Young Scholars Science Fund Project(No.22JCJQJC00020)Key Project of Tianjin Natural Science Foundation(No.23JCZDJC00430)。
文摘The effect of antibacterial adhesive on the biological corrosion resistance of mortar in seawater environment was studied by means of scanning electron microscope,thermogravimetric analysis,X-ray diffraction,Fourier transform infrared spectroscopy,and ultra-depth microscope.The results show that the antibacterial adhesive can effectively inhibit the growth of sulfur-oxidizing bacteria in seawater,hinder their metabolism to produce biological sulfate,and reduce the formation of destructive product gypsum.The mineral composition and thermal analysis showed that the peak value of plaster diffraction peak and the mass loss of plaster dehydration in antibacterial adhesive group were significantly lower than those in blank group(without protective coating group).In addition,the electric flux of chloride ions(>400 C)in the blank group of mortar samples was higher than that in the antibacterial adhesive group(<200 C),indicating that the antibacterial adhesive can effectively reduce the permeability of chloride ions in mortar,and thus hinder the Cl-erosion in seawater.
基金supported by Research Projects of Liaoning Provincial Department of Education(LJ212410163008)the National Training Program of Innovation and Entrepreneurship for Undergraduates of Shenyang Pharmaceutical University(202410163042)。
文摘The photothermal effect enhances the antibacterial activity by generating localized heat that disrupts microbial cells,leading to increased bacterial inactivation.The objective of this study was to develop and evaluate the antibacterial and photothermal applications of polydopamine-berberine nanoparticles(PDA-BBR-NPs),incorporating them into a sodium alginate matrix for food preservation.The self-assembled PDA-BBR-NPs were synthesized using a solution oxidation method and characterized by scanning electron microscopy,Fourier transform infrared spectroscopy,and nanoparticle size analysis.The results demonstrated that PDA-BBR-NPs were uniform spheres with an average diameter of 177.1 nm.Drug loading and encapsulation efficiency tests showed that the optimal formulation had a drug loading capacity of 48.4%and an encapsulation efficiency of 84.70%.Antibacterial activity against Escherichia coli and Staphylococcus aureus was evaluated using the dilution coating plate method,showing an inhibition rate of over 98%.Photothermal testing under 808 nm near-infrared irradiation revealed a maximum photothermal conversion efficiency of 32.65%.To assess the practical application of the nanoparticles,they were incorporated into a sodium alginate-based coating for the preservation of Kyoho grapes.Key parameters such as weight loss rate,pH,titratable acidity,and soluble solids content were monitored over a 12-day storage period at room temperature.The PDA-BBR-near-infrared spectroscopy-treated group exhibited significantly reduced weight loss rate(6.08%lower than the control group)and a slower decrease in pH.The coating effectively inhibited microbial activity and extended the shelf life of the grapes by 3-6 days compared to the control group.These findings demonstrated the potential of PDA-BBR-NPs to enhance the preservation of fresh produce through their combined antibacterial and photothermal effects,offering a promising method for extending fruit shelf life.
基金The financial support from the National Natural Science Foundation of China (No.31972290)National Key Research and Development Program of China (No.2022YFD1700300)。
文摘Plant bacterial diseases cause significant harm to agricultural production because of their frequent,intermittent and regional outbreaks.Currently,chemical control is still a more effective method for bacterial disease.To develop new,efficient and safe antibacterial agrochemicals,we summarize the research progress of compounds with antibacterial activities in the past ten years,classify them according to their active skeletons,and discuss their structure-activity relationships and mechanisms of action.Finally,the development trend of antibacterial agrochemicals was prospected.This review provides valuable information for the development of antibacterial agrochemicals.
基金supported by the National Natural Science Foundation of China(No.52173126)China Postdoctoral Science Foundation(No.2024M751152).
文摘Novel antibacterial strategies such as antibacterial photodynamic therapy(aPDT)and photothermal therapy(PTT)have gained significant attention,however,relying on a single-treatment approach still faces challenges of insufficient therapeutic efficiency and the potential for drug resistance.In this study,a multimodal synergistic antibacterial nanoplatform by coupling a carbon monoxide(CO)donor(4-(3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid(4-BA))with carbon dots(CDs)is developed,referred to as CDs-CO,which integrates multiple antibacterial modes of aPDT,PTT,and gas therapy.This nanoplatform is designed for highly efficient antibacterial action with a low risk of inducing drug resistance.CDs are engineered to possess tailored functions,including deep-red light-triggered heat and singlet oxygen(^(1)O_(2))production.After modification with 4-BA and exposure to 660 nm laser irradiation,CDs-CO exhibits favorable photothermal conversion efficiency(η=52.7%),robust ^(1)O_(2) generation,and ^(1)O_(2)-activated CO release.Antibacterial experiments demonstrated the excellent sterilization effects of CDs-CO against both Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus),underscoring the enhanced antibacterial efficiency of this multimodal nanoplatform.This study offers a rational approach for designing multimodal synergistic antibacterial platforms,highlighting their potential for effectively treating bacterial infections.
基金Supported by Scientific Research Project of the Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine(GXZYA20220105).
文摘[Objectives]To evaluate the in vitro antibacterial,antioxidant,andα-glucosidase inhibitory activities of the ethanol total extract and four different polarity fractions(n-butanol,ethyl acetate,petroleum ether,and water)of Pilea peltata Hance,so as to provide a reference for its further development and research.[Methods]The antibacterial activity of P.peltata was evaluated in vitro by determining the minimum inhibitory concentration(MIC)and minimum bactericidal concentration(MBC)of its ethanol total extract and four different polarity fractions against seven test bacterial strains using the broth microdilution method.The in vitro antioxidant activity was investigated through DPPH radical,hydroxyl radical,and superoxide anion radical scavenging assays,with vitamin C(Vit C)as the positive control and the half maximal scavenging concentration(IC 50)as the evaluation indicator.The in vitroα-glucosidase inhibitory activity was assessed by measuring the peak area of p-nitrophenol(PNP),the hydrolysis product of 4-nitrophenylα-D-glucopyranoside(PNPG),via high-performance liquid chromatography(HPLC),using the half maximal inhibitory concentration(IC 50)as the evaluation indicator.[Results]Both the ethanol total extract and the four different polarity fractions of P.peltata exhibited significant in vitro anti-Streptococcus pneumoniae activity.The DPPH radical scavenging capacities of the ethanol total extract and the various fractions were all weaker than that of VitC,with the order of efficacy being:n-butanol fraction>ethanol total extract>ethyl acetate fraction>petroleum ether fraction>aqueous fraction.For hydroxyl radical scavenging activity,the efficacy order of P.peltata fractions was:n-butanol extract>ethyl acetate extract>ethanol total extract>petroleum ether extract>aqueous extract.Notably,the n-butanol fraction(IC 50=0.068±0.001)demonstrated stronger activity than VitC(IC 50=0.097±0.001).The activity of the ethyl acetate fraction(IC 50=0.096±0.004)was comparable to that of VitC(IC 50=0.097±0.001).The superoxide anion scavenging capacities of the ethanol total extract and different polarity fractions from P.peltata were all weaker than that of VitC,with the order of efficacy being:n-butanol fraction>ethyl acetate fraction>ethanol total extract>petroleum ether fraction>aqueous fraction.The ethanol total extract and aqueous fraction of Pilea peltata showed no significant in vitroα-glucosidase inhibitory activity.Compared with the acarbose group,the IC 50 values of the ethyl acetate fraction and the n-butanol fraction both showed highly significant differences(P<0.01).[Conclusions]This study provides an experimental basis for the pharmacodynamic study and active component study of P.peltata.
基金financially supported by the National Natural Science Foundation of China(No.52203209)the State Key Laboratory of Solid Waste Reuse for Building Materials,China(No.SWR-2022-009)the Fundamental Research Funds for the Central Universities,China(No.FRF-IDRY22-012)。
文摘Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial property.However,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water pollution.In this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing agent.Experimental analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag NPs.The surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their aggregation.After the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite hydrogel.The inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag NPs.The prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.
基金supported by the National Natural Science Foundation of China(No.52001034)the China Postdoctoral Science Foundation(No.2023M731677)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX23_3032).
文摘Nano-zinc oxides(ZnO)demonstrate remarkable antibacterial properties.To further enhance the corrosion resistance and antibacterial efficiency of magnesium alloy micro-arc oxidation(MAO)coatings,this study investigates the preparation of ZnO-containing micro-arc oxidation coatings with dual functionality by incorporating nano-ZnO into MAO electrolyte.The influence of varying ZnO concentrations on the microstructure,corrosion resistance,and antibacterial properties of the coating was examined through microstructure analysis,immersion tests,electrochemical experiments,and antibacterial assays.The findings revealed that the addition of nano-ZnO significantly enhanced the corrosion resistance of the MAO-coated alloy.Specifically,when the ZnO concentration in the electrolyte was 5 g/L,the corrosion rate was more than ten times lower compared to the MAO coatings without ZnO.Moreover,the antibacterial efficacy of ZnO+MAO coating,prepared with a ZnO concentration of 5 g/L,surpassed 95%after 24 h of co-culturing with Staphylococcus aureus(S.aureus).The nano-ZnO+MAO-coated alloy exhibited exceptional degradation resistance,corrosion resistance,and antibacterial effectiveness.
基金supported by the National Natural Science Foundation Joint Fund(Nos.U1806223 and U2106226)the National Natural Science Foundation of China(No.52371081)the Key Technology Research and Development Program of Shandong Province(No.2020CXGC010703).
文摘The defect regulation and p-n heterojunction of composites have gained significant attention due to their potential applications.Nitrogen(N)as doping heteroatoms and perylene-3,4,9,10-tetracarboximide(PDINH)as an appropriate n-type semiconductor were innovatively and reasonably selected to enhance the photocatalytic performance of pristine p-type cuprous oxide(Cu_(2)O).In this study,the defect regula-tion of N doping(1)achieved the small-size effect of Cu_(2)O,(2)optimized the electron features,and(3)improved the kinetics of reactive oxygen species.The p-n heterojunction with PDINH was developed to sharply improve the light utilization of Cu_(2)O,from the UV region to the near-infrared region.As expected,the optimized Cu_(2)N_(x)O_(1–x)/PDINH(x=0.02)exhibited excellent long-term photocatalytic antibacterial ac-tivities,with antibacterial rates exceeding 91%against Staphylococcus aureus and Pseudomonas aeruginosa.Defect regulation and p-n heterojunction of Cu_(2)O-based composites thus provide a great deal of potential for future advancements in photocatalysis.
基金the National Key Research and Development Program of China(Grant No.2022YFC3901902)the National Natural Science Foundation of China(Grant Nos.52203037,52103031,and 52073107)。
文摘Fiber fabrics have been wildly utilized for solar interracial evaporators to address freshwater scarcity.However,the complex and expensive manufacturing processes remain limited to their scalable development.Herein,a fabric-based Janus interracial evaporator is efficiently fabricated on a large scale by integrating an extremely innovative self-designed melt-centrifugal spinning technology with spray coating technology.The prepared fabric-based Janus interfacial evaporator has differential hydrophilicity,uneven surfaces,and channels that allow moisture escape.Benefiting from the excellent photothermai conversion of graphene oxide and the charge transfer actions of titanium dioxide,such a multifunction evaporator can reach a high evaporation rate of 1.72 kg m^(-2)h^(-1)under 1 sun irradiation,a superior antibacterial rate of 99%,excellent photocatalytic degradation,and effective thermoelectric ability simultaneously.Moreover,it also shows fantastic performance in salt resistance,recyclable evaporation,and real desalination,This work demonstrates a high-efficiency,cost-effective,multifunctional,and scalable strategy for high-performance fiber fabrics solar interfacial evaporation.
基金the National Natural Science Foundation of China(Nos.U2106226,52105297)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.52021003)the Science and Technology Development Project of Jilin Province(Nos.20210203022SF,20210508029RQ).
文摘Superhydrophobic surface is a promising strategy for antibacterial and corrosion protection.However,the use of harmful fluorine-containing materials,poor mechano-chemical stability,the addition of fungicides and poor corrosion resistance often limit its practical application.In this paper,a high-robustness pho-tothermal self-healing superhydrophobic coating is prepared by simply spraying a mixture of hydropho-bically modified epoxy resin and two kinds of modified nanofillers(carbon nanotubes and SiO2)for long-term anticorrosion and antibacterial applications.Multi-scale network and lubrication structures formed by cross-linking of modified carbon nanotubes and repeatable roughness endow coating with high ro-bustness,so that the coating maintains superhydrophobicity even after 100 Taber abrasion cycles,20 m sandpaper abrasion and 100 tape peeling cycles.The synergistic effect of antibacterial adhesion and pho-tothermal bactericidal activity endows coating with excellent antibacterial efficiency,which against Es-cherichia coli(E.coli)and Staphylococcus aureus(S.aureus)separately reaches 99.6% and 99.8%.Moreover,the influence of modified epoxy resin,superhydrophobicity,organic coating and coating thicknesses on the anticorrosion of magnesium(Mg)alloy is systematically studied and analyzed.More importantly,the prepared coating still exhibits excellent self-cleaning,anticorrosion and antibacterial abilities after 20 m abrasion.Furthermore,the coating exhibits excellent adhesion(level 4B),chemical stability,UV radiation resistance,high-low temperature alternation resistance,stable heat production capacity and photother-mal self-healing ability.All these excellent performances can promote its application in a wider range of fields.
基金supported by the following funds:The National Natural Science Foundation of China(Nos.52275393,51935014,and 82072084)Jiangxi Provincial Natural Science Foundation of China(No.20224ACB204013)+2 种基金The Project of State Key Laboratory of Precision Manufacturing for Extreme Service Performancethe National Key Research and Development Program of China(No.2023YFB4605800)the Independent Exploration and Innovation Project of Central South University(No.1053320221707).
文摘Fast electron-hole recombination issues during titanium dioxide(TiO_(2))photocatalysis limit its application in preventing bacterial infection during bone defect repair.In this study,TiO_(2)@reduced graphene oxide(rGO)composites were synthesized using a hydrothermal method in which rGO,which possesses very high electrical conductivity,promotes the separation of photoelectron-hole pairs of TiO_(2),thus improving the efficiency of photocatalytic production of reactive oxygen species(ROS).Subsequently,TiO_(2)@rGO composites were introduced into poly-L-lactic acid(PLLA)to prepare bone scaffolds with photocatalytic antibacterial function via selective laser sintering.The results showed that TiO_(2)grew on the surface of rGO and formed a covalent bond connection(Ti-O-C)with rGO.A decreased electrochemical impedance of TiO_(2)@rGO composites was observed,and the transient photocurrent intensity increased from 0.05 to 0.5μA/cm^(2).Analysis of electron spin resonance found that the photocatalytic products of TiO_(2)were·OH and·O^(2-),two kinds of ROS capable of killing bacteria via disrupting the structure of the bacterial membrane in vitro.Antibacterial experiments showed that the PLLA/TiO_(2)@rGO scaffolds had good antibacterial properties against Escherichia coli and Staphylococcus aureus.Finally,we report that these scaffolds exhibited both enhanced mechanical properties due to the addition of TiO_(2)@rGO as a reinforcement material and good biocompatibility during cell proliferation.
文摘Two Gd_(2)complexes,namely[Gd_(2)(dbm)_(2)(HL_(1))_(2)(CH_(3)OH)_(2)]·4CH_(3)OH(1)and[Gd_(2)(dbm)_(2)(L_(2))_(2)(CH_(3)OH)_(2)]·2CH_(3)OH(2),where H_(3)L_(1)=(Z)-N'-[4-(diethylamino)-2-hydroxybenzylidene]-2-hydroxyacetohydrazide,H_(2)L_(2)=(E)-N'-(5-bromo-2-hydroxy-3-methoxybenzylidene)nicotinohydrazide,Hdbm=dibenzoylmethane,have been constructed by adopting the solvothermal method.Structural characterization unveils that both complexes 1 and 2 are constituted by two Gd^(3+)ions,two dbm-ions,two CH_(3)OH molecules,and two polydentate Schiff-base ligands(HL_(1)^(2-)or L_(2)^(2-)).In addition,complex 1 contains four free methanol molecules,whereas complex 2 harbors two free methanol molecules.By investigating the interactions between complexes 1 and 2 and four types of bacteria(Bacillus subtilis,Escherichia coli,Staphylococcus aureus,Candida albicans),it was found that both complexes 1 and 2 exhibited potent antibacte-rial activities.The interaction mechanisms between the ligands H_(3)L_(1),H_(2)L_(2),complexes 1 and 2,and calf thymus DNA(CT-DNA)were studied using ultraviolet-visible spectroscopy,fluorescence titration,and cyclic voltammetry.The results demonstrated that both complexes 1 and 2 can intercalate into CT-DNA molecules,thereby inhibiting bacterial proliferation to achieve the antibacterial effects.CCDC:2401116,1;2401117,2.
文摘A novel 3D metal-organic framework(MOF)[Pr_(2)(L)_(3)(H_(2)O)5·H_(2)O]n(Pr-1),(H_(2)L=4,4'-oxybis(benzoic acid))with a rare structure of broken layer net,was constructed under the condition of solvothermal synthesis.The struc-ture and crystal net were analyzed and characterized.This rod net of Pr-1 is new to both RCSR and ToposPro data-bases,and is named as rn-12 as suggested.Due to the luminescent properties of H_(2)L and Pr(Ⅲ),the solid-state fluo-rescence property and sensing performance(solvents and metal ions)of Pr-1 were investigated.The sensing experi-ments indicated that Pr-1 could act as a fluorescence sensor to detect Cd^(2+)ions with good sensitivity.In addition,antibacterial activities show that Pr-1 exhibited stronger antibacterial activity against Escherichia coli(E.coli),Staphylococcus aureus(S.aureus),and Bacillus subtilis(B.subtilis)compared to synthetic materials.
基金National Natural Science Foundation of China(52171114)。
文摘Infections associated with titanium(Ti)-based implants present significant challenges in clinical treatments,especially when biofilms already form on the implant surface.Many antimicrobial agents,including antibiotics,metallic nanoparticles and antimicrobial peptides,have been extensively used to deal with Ti implant infections.However,these chemical approaches suffer from potential toxicity,antibiotic resistance and poor long-term antibacterial performance.Hence,physical antibacterial surfaces on Ti-based implants have attracted increasing attention.The antibacterial behavior of different surfaces on Ti-based biomaterials against various bacteria only by physical properties of the implants themselves(e.g.,nanotopography)or exogenous physical stimulus(e.g.,photocatalysis)was reviewed,as well as parameters influencing the physical antibacterial processes,such as size,shape and density of the surface nanotextures,and bacterial growth phases.Besides,mechanisms of different fabrication techniques for the physical antibacterial surfaces on Ti-based biomaterials were also summarized.
文摘Magnesium alloys are promising candidates for bio-implant applications due to their biodegradability and biocompati-bility.However,their rapid corrosion remains a critical limitation.This study presents the development of a multifunctional nanocomposite coating designed to enhance the corrosion resistance and antibacterial properties of magnesium alloy im-plants.The coating comprisedγ-cyclodextrin metal-organic frameworks(γ-CD MOFs)decorated with TiO_(2)@Ag core-shell nanoparticles,embedded in a polycaprolactone(PCL)matrix.Immersion tests in a simulated body fluid(SBF)revealed an initially higher corrosion rate for the PCL-TiO_(2)@Ag/γ-CD MOF coating compared to the coating without TiO_(2)@Ag nanopar-ticles;however,it demonstrated significant improvement over time.After five days,the corrosion inhibition reached 95.44%,with the corrosion rate decreasing to 1.70 mpy.Additionally,the composite coating exhibited strong antibacterial activity against Escherichia coli,Pseudomonas,and Staphylococcus aureus.Furthermore,MTT assays indicated that the coating facili-tated the growth and proliferation of osteoblast-like MC3T3-E1 cells,confirming its nontoxicity and biocompatibility.These findings highlight the potential of the PCL-TiO_(2)@Ag/γ-CD MOF nanocomposite as a biocompatible,antibacterial,and cor-rosion-resistant coating for biodegradable magnesium implants,offering a promising solution for biomedical applications.
基金Supported by Guizhou Province Science and Technology Planning Program for Industrial Enterprises above Designated Size Without R&D Activities(QKTY[2024]No.456).
文摘[Objectives]To explore the antibacterial activity of Gouteng Foot Bath Concentrated Liquid.[Methods]The inhibitory activity against Staphylococcus aureus,Escherichia coli,Candida albicans,and Trichophyton rubrum was determined using the mycelial growth rate method.The inhibitory effects of different concentrations of Gouteng Concentrated Liquid on these four microbial strains were analyzed.[Results]Gouteng Foot Bath Concentrated Liquid showed certain antibacterial activity against the above bacteria,and the antibacterial activity against S.aureus,T.rubrum and C.albicans was more significant.[Conclusions]This study provides experimental evidence supporting the application of Gouteng(Uncariae Ramulus Cum Uncis)in antimicrobial foot care products.
文摘Corresponding author’s name was incorrectly written as“Dadang Guo”instead of“Dagang Guo”.The correct author name should be“Dagang Guo”.The authors would like to apologise for any inconvenience caused.
