Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food mater...Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.展开更多
Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food mater...Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.展开更多
Background:The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease.Transgenic approaches hold promise in addressing this com...Background:The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease.Transgenic approaches hold promise in addressing this complex problem.One such model,the Oncopig,has been reported to develop tumors of up to 4 cm in diameter within 7-14 days at sites of in situ vector inoculation.However,the resulting lesions reportedly contained an extensive inflammatory component that has not been evaluated in detail.Methods:Herein,we describe our results from multiparametric characterization of the lesions generated using liver biopsy cores incubated in vector solution and re-placed in the tissue.The study consisted of 3 animals in 3 cohorts(total of 9 animals)that were evaluated at 14,21,and 28 days.CT imaging,immunohistochemistry,multiplex immunofluorescence,and comprehensive blood analyses were used to quantify composition of the hepatic masses that developed following AdCre inoculation.Results:The tumors were hypovascular on CT and predominantly composed of CD45+cells with a strong lymphohistiocytic component,with no carcinomas identified.Ki-67 staining showed proliferation of CD45+immune cells but no neoplastic component.To provide further insight,the results are evaluated in the context of tumor growth kinetics.Conclusion:While progress has been made in generating targetable lesions,achieving a robust large animal model of liver cancer that faithfully recapitulates the human disease remains a challenging goal.展开更多
Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food mater...Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.The research scope includes the quality and processing characteristics of food raw materials,the relationships of nutritional components and bioactive substances with human health,product flavor and sensory characteristics,the control of harmful substances during processing or cooking,product preservation,storage and packaging;microorganisms and fermentation,illegal drug residues and food safety detection;authenticity identification;cell-cultured meat,regulations and standards.展开更多
Neurodegenerative diseases are increasing in prevalence due largely to aging populations worldwide and improved medical care for the elderly.Currently approved drugs can reduce some of the symptoms of neurodegenerativ...Neurodegenerative diseases are increasing in prevalence due largely to aging populations worldwide and improved medical care for the elderly.Currently approved drugs can reduce some of the symptoms of neurodegenerative diseases but cannot cure them.Inflammation is involved in the development and progression of neurodegenerative diseases,and oxidative stress is implicated in neurodegeneration associated with cognitive decline and age-related cognitive impairment.Polyphenols such as curcumin,quercetin,and resveratrol possess potent anti-inflammatory and antioxidant properties.Nanoformulations of curcumin and quercetin can optimize their pharmacological effects in the treatment of neurodegenerative diseases.Nanocarriers play a crucial role in delivering drugs across the blood-brain barrier,thereby lowering the risk of peripheral side effects.Various nanoforms have been developed to induce bioavailability and solubility of curcumin and quercetin,including nanoparticles and nanoemulsions.The studies reviewed included 17 using curcumin nanoformulations and seven with quercetin nanoformulations and were tested in widely used animal models of Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and multiple sclerosis.Many of the curcumin and quercetin nanoformulations brought about improvements in learning and memory in behavioral tests of Alzheimer’s disease models and were effective in reducing oxidative stress in the brain.Both nanocurcumin and nanoquercetin decreased the levels of inflammatory markers in the brain.Nanocurcumin formulations improved motor behavior,gait,and memory in Parkinson’s disease models and increased dopaminergic neurons in the striatum and substantia nigra.Furthermore,nanocurcumin improved locomotor activity,memory,and learning,and the number of dendrites of medium spiny neurons in Huntington’s disease models.Nanocurcumin formulations decreased oxidative stress and inflammation in a model of demyelination.Several important limitations were identified in the studies reviewed and these need to be considered in future studies.Also,clinical trials could be performed using the currently available nanoforms of curcumin and quercetin.展开更多
Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecul...Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecular mechanisms involved in these types of scars and developing effective treatments requires the use of controlled ex-perimental models,especially animals,to overcome the limitations of clinical studies.The aim of this sistematic review is to critically analyze the animal models used in the last five years(2020-2025)for the study of pathological scars,highlighting their advantages,limitations and applicability in the development of new therapeutic strat-egies.Murine,rabbit and porcine models,as well as alternative models,offer varied perspectives on the formation and treatment of HTS and KS,with an emphasis on histological and molecular correlations with human pathology.By synthesizing recent data,the paper highlights the essential role of preclinical research in optimizing an-tifibrotic treatments and in advancing the translation of data into the clinical sphere.Overall,animal models remain essential for bridging mechanistic insights with clinical translation,supporting the development of more effective and personalized anti-scar therapies.展开更多
Bisphenol F(BPF)and Bisphenol S(BPS)are widely used substitutes for Bisphenol A(BPA).However,growing evidence indicated that BPF and BPS may induce physiological effects similar to those of BPA.Furthermore,chemical ma...Bisphenol F(BPF)and Bisphenol S(BPS)are widely used substitutes for Bisphenol A(BPA).However,growing evidence indicated that BPF and BPS may induce physiological effects similar to those of BPA.Furthermore,chemical management and control is primarily focus on the risk assessment of individual compounds,often overlooking the implications of chemical mixtures.We hypothesize that exposure to a mixture of BPA and its substitutes will enhance their endocrine-disruptive effects,disrupt steroid hormone homeostasis,and further impair reproductive system functionality.In the animal study,both female and male mice were exposed to 333μg/kg of BPA,BPF,BPS,their mixture(333μg/kg(MIXL),and 1 mg/kg(MIXH))via gavage daily for four weeks.The study demonstrated that bisphenols(BPs)affected the expression of genes related to steroid hormone synthesis.The MIXL group of female mice exhibited an increasing trend in estradiol(E2)levels and a decreasing trend in progesterone(Pg)and testosterone(TT)levels.Additionally,follicular development was impacted,resulting in an increased number of atretic follicles.In contrast,a significant increase in E2 concentration and disruption of testicular morphology were observed in the MIXH group of male mice,accompanied by a decline in sperm quality.Importantly,these results were corroborated by a population-based investigation.Collectively,the animal experiments indicate that mixed exposure to BPs disrupts hormone levels and adversely affects reproductive function,while epidemiological evidence further establishes correlative links between bisphenols and hormone levels.These findings underscore the necessity of considering chemical mixtures during testing and risk assessment.展开更多
This study summarizes the theoretical basis,modeling strategies,pathological mechanisms,and therapeutic advances related to high-altitude qi-deficiency and blood-stasis pattern.Traditional concepts such as“qi drives ...This study summarizes the theoretical basis,modeling strategies,pathological mechanisms,and therapeutic advances related to high-altitude qi-deficiency and blood-stasis pattern.Traditional concepts such as“qi drives blood”and“deficiency leads to stasis”closely align with modern evidence demonstrating that hypoxia disrupts energy metabolism,impairs microcirculation,and amplifies inflammation and oxidative stress.Current animal models commonly use hypobaric hypoxia combined with fatigue loading,dietary restriction,ice-water stimulation,or adrenaline injection to mimic the combined effects of qi deficiency,blood stasis,and hypoxic injury.These composite approaches reproduce systemic abnormalities,including reduced arterial oxygen partial pressure,increased blood viscosity,impaired cardiac and pulmonary function,microcirculatory obstruction,and mitochondrial dysfunction.Enhanced inflammatory signaling,oxidative stress,and disturbances in metabolic and epigenetic networks further characterize the pattern.The findings indicate that its pathogenesis arises from multi-system,multi-target interactions rather than a single pathway.Representative herbal formulas,such as Buyang Huanwu decoction,Xuefu Zhuyu decoction,and prescriptions rich in Astragalus membranaceus(Fisch.)Bunge(A.membranaceus,Huang qi)or Salvia miltiorrhiza Bunge(S.miltiorrhiza,Dan Shen)have demonstrated the ability to improve energy metabolism,attenuate endothelial injury,enhance microcirculation,and suppress inflammation through network-level regulation.Future research should focus on standardizing exposure parameters,developing quantitative syndrome evaluation systems,and integrating multi-omics,systems biology and artificial intelligence to improve model reproducibility and mechanistic precision.These efforts may help establish objective criteria for high-altitude qi-deficiency and blood-stasis pattern and support the development of targeted therapeutic strategies.展开更多
Zinc,an essential trace element,plays a pivotal role in maintaining animal health and physiological functions.This review comprehensively examines zinc metabolism—including absorption dynamics across species(poultry,...Zinc,an essential trace element,plays a pivotal role in maintaining animal health and physiological functions.This review comprehensively examines zinc metabolism—including absorption dynamics across species(poultry,ruminants,and non-ruminants),transport mechanisms,storage in tissues,e.g.,the liver,and excretion pathways—and its multifaceted effects on animal health.Zinc critically regulates aspects of growth and development,particularly bone formation,as its deficiency induces skeletal deformities in young animals.It modulates immune function through zinc finger proteins,influencing immune organ integrity,lymphocyte proliferation,and cytokine expression.Reproductive performance is significantly affected by zinc,with its deficiency causing impaired spermatogenesis;delayed sexual maturity in males;and reduced litter size,embryonic survival,and placental function in females.At the molecular level,zinc regulates the activity of enzymes(e.g.,SOD),signaling pathways(MAPK,NF-κB),and transcription factors(MTF-1,Sp1)to maintain homeostasis.Both zinc deficiency(due to dietary insufficiency,malabsorption,or physiological stress)and zinc excess(from environmental pollution or feed oversupplementation)adversely affect health,disrupting mineral balance,enzyme function,and gut microbiota.In animal production,inorganic(zinc oxide,zinc sulfate)and organic(zinc methionine)sources of zinc increase growth,immunity,and productivity,although sustainable strategies are needed to mitigate environmental risks.Future research should focus on novel zinc formulations,precision nutrition,and interactions with gut microbiota to optimize livestock health and sustainable husbandry.展开更多
The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention a...The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention and treatment methods.Animal models serve as essential tools for investigating disease mechanisms and assessing novel therapeutic strategies,and the scientific rigor of their construction and validation significantly impacts the reliability of research findings.This paper systematically reviews the research progress and evaluation systems of BAS animal models over the past decade,aiming to provide a robust foundation for the optimized construction of BAS models,intervention studies,and clinical translation.This effort is intended to facilitate the innovation and advancement in BAS prevention and treatment strategies.展开更多
Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in ...Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in their serum, targeting acetylcholine receptor, muscle-specific kinase, or related proteins. Current treatment for myasthenia gravis involves symptomatic therapy, immunosuppressive drugs such as corticosteroids, azathioprine, and mycophenolate mofetil, and thymectomy, which is primarily indicated in patients with thymoma or thymic hyperplasia. However, this condition continues to pose significant challenges including an unpredictable and variable disease progression, differing response to individual therapies, and substantial longterm side effects associated with standard treatments(including an increased risk of infections, osteoporosis, and diabetes), underscoring the necessity for a more personalized approach to treatment. Furthermore, about fifteen percent of patients, called “refractory myasthenia gravis patients”, do not respond adequately to standard therapies. In this context, the introduction of molecular therapies has marked a significant advance in myasthenia gravis management. Advances in understanding myasthenia gravis pathogenesis, especially the role of pathogenic antibodies, have driven the development of these biological drugs, which offer more selective, rapid, and safer alternatives to traditional immunosuppressants. This review aims to provide a comprehensive overview of emerging therapeutic strategies targeting specific immune pathways in myasthenia gravis, with a particular focus on preclinical evidence, therapeutic rationale, and clinical translation of B-cell depletion therapies, neonatal Fc receptor inhibitors, and complement inhibitors.展开更多
Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food mater...Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.展开更多
Food Science of Animal Products (ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food mate...Food Science of Animal Products (ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.展开更多
Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food mater...Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.展开更多
Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food mater...Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.展开更多
As the Philippines celebrated the 2nd Asia Laboratory Animal Day(ALAD)last November 29,2025,the Philippine Association for Laboratory Animal Sciences(PALAS)reflected on a year marked by growth,collaboration,and renewe...As the Philippines celebrated the 2nd Asia Laboratory Animal Day(ALAD)last November 29,2025,the Philippine Association for Laboratory Animal Sciences(PALAS)reflected on a year marked by growth,collaboration,and renewed commitment to ethical and scientific excellence in animal-based research.Throughout 2025,PALAS has continued to strengthen the laboratory animal science community by advancing education,capacity building,policy advocacy,and regional cooperation.These efforts underscore PALAS’vital role in shaping a culture of responsible animal research aligned with international standards.展开更多
Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food mater...Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.The research scope includes the quality and processing characteristics of food raw materials,the relationships of nutritional components and bioactive substances with human health,product flavor and sensory characteristics,the control of harmful substances during processing or cooking,product preservation,storage and packaging;microorganisms and fermentation,illegal drug residues and food safety detection;authenticity identification;cell-cultured meat,regulations and standards.展开更多
Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food mater...Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.The research scope includes the quality and processing characteristics of food raw materials,the relationships of nutritional components and bioactive substances with human health,product flavor and sensory characteristics,the control of harmful substances during processing or cooking,product preservation,storage and packaging;microorganisms and fermentation,illegal drug residues and food safety detection;authenticity identification;cell-cultured meat,regulations and standards.展开更多
Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food mater...Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.The research scope includes the quality and processing characteristics of food raw materials,the relationships of nutritional components and bioactive substances with human health,product flavor and sensory characteristics,the control of harmful substances during processing or cooking,product preservation,storage and packaging;microorganisms and fermentation,illegal drug residues and food safety detection;authenticity identifi cation;cell-cultured meat,regulations and standards.展开更多
Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research fi ndings in the fi eld of animal-origin foods,involving food mat...Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research fi ndings in the fi eld of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.The research scope includes the quality and processing characteristics of food raw materials,the relationships of nutritional components and bioactive substances with human health,product fl avor and sensory characteristics,the control of harmful substances during processing or cooking,product preservation,storage and packaging;microorganisms and fermentation,illegal drug residues and food safety detection;authenticity identifi cation;cell-cultured meat,regulations and standards.展开更多
文摘Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.
文摘Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.
基金Institutional Research Grant,MD Anderson Cancer CenterUPWARDS Training Program(Undergraduate Students Working Towards Research in Science),Grant/Award Number:1R25CA240137-01A1the CPRIT Research Training Award CPRIT Training Program,Grant/Award Number:RP210028。
文摘Background:The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease.Transgenic approaches hold promise in addressing this complex problem.One such model,the Oncopig,has been reported to develop tumors of up to 4 cm in diameter within 7-14 days at sites of in situ vector inoculation.However,the resulting lesions reportedly contained an extensive inflammatory component that has not been evaluated in detail.Methods:Herein,we describe our results from multiparametric characterization of the lesions generated using liver biopsy cores incubated in vector solution and re-placed in the tissue.The study consisted of 3 animals in 3 cohorts(total of 9 animals)that were evaluated at 14,21,and 28 days.CT imaging,immunohistochemistry,multiplex immunofluorescence,and comprehensive blood analyses were used to quantify composition of the hepatic masses that developed following AdCre inoculation.Results:The tumors were hypovascular on CT and predominantly composed of CD45+cells with a strong lymphohistiocytic component,with no carcinomas identified.Ki-67 staining showed proliferation of CD45+immune cells but no neoplastic component.To provide further insight,the results are evaluated in the context of tumor growth kinetics.Conclusion:While progress has been made in generating targetable lesions,achieving a robust large animal model of liver cancer that faithfully recapitulates the human disease remains a challenging goal.
文摘Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.The research scope includes the quality and processing characteristics of food raw materials,the relationships of nutritional components and bioactive substances with human health,product flavor and sensory characteristics,the control of harmful substances during processing or cooking,product preservation,storage and packaging;microorganisms and fermentation,illegal drug residues and food safety detection;authenticity identification;cell-cultured meat,regulations and standards.
文摘Neurodegenerative diseases are increasing in prevalence due largely to aging populations worldwide and improved medical care for the elderly.Currently approved drugs can reduce some of the symptoms of neurodegenerative diseases but cannot cure them.Inflammation is involved in the development and progression of neurodegenerative diseases,and oxidative stress is implicated in neurodegeneration associated with cognitive decline and age-related cognitive impairment.Polyphenols such as curcumin,quercetin,and resveratrol possess potent anti-inflammatory and antioxidant properties.Nanoformulations of curcumin and quercetin can optimize their pharmacological effects in the treatment of neurodegenerative diseases.Nanocarriers play a crucial role in delivering drugs across the blood-brain barrier,thereby lowering the risk of peripheral side effects.Various nanoforms have been developed to induce bioavailability and solubility of curcumin and quercetin,including nanoparticles and nanoemulsions.The studies reviewed included 17 using curcumin nanoformulations and seven with quercetin nanoformulations and were tested in widely used animal models of Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and multiple sclerosis.Many of the curcumin and quercetin nanoformulations brought about improvements in learning and memory in behavioral tests of Alzheimer’s disease models and were effective in reducing oxidative stress in the brain.Both nanocurcumin and nanoquercetin decreased the levels of inflammatory markers in the brain.Nanocurcumin formulations improved motor behavior,gait,and memory in Parkinson’s disease models and increased dopaminergic neurons in the striatum and substantia nigra.Furthermore,nanocurcumin improved locomotor activity,memory,and learning,and the number of dendrites of medium spiny neurons in Huntington’s disease models.Nanocurcumin formulations decreased oxidative stress and inflammation in a model of demyelination.Several important limitations were identified in the studies reviewed and these need to be considered in future studies.Also,clinical trials could be performed using the currently available nanoforms of curcumin and quercetin.
基金Ministry of Research,Innovation and Digitization,CCCDI-UEFISCDI,Grant/Award Number:PN-IV-P7-7.1-PED-2024-1578,within PNCDI Ⅳ.
文摘Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecular mechanisms involved in these types of scars and developing effective treatments requires the use of controlled ex-perimental models,especially animals,to overcome the limitations of clinical studies.The aim of this sistematic review is to critically analyze the animal models used in the last five years(2020-2025)for the study of pathological scars,highlighting their advantages,limitations and applicability in the development of new therapeutic strat-egies.Murine,rabbit and porcine models,as well as alternative models,offer varied perspectives on the formation and treatment of HTS and KS,with an emphasis on histological and molecular correlations with human pathology.By synthesizing recent data,the paper highlights the essential role of preclinical research in optimizing an-tifibrotic treatments and in advancing the translation of data into the clinical sphere.Overall,animal models remain essential for bridging mechanistic insights with clinical translation,supporting the development of more effective and personalized anti-scar therapies.
基金supported by the National Science Foundation of China(Nos.U23A20103,22476120 and 22106098)Shanxi Province Higher Education"Billion Project"Science and Technology Guidance Project,Youth Science and Technology Research Foundation of Shanxi Province(No.20210302124298)+2 种基金the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(No.2020L0174)the Startup Foundation for Doctors of Shanxi Province(No.SD1917)the Startup Foundation for Doctors of Shanxi Medical University(No.XD1917).
文摘Bisphenol F(BPF)and Bisphenol S(BPS)are widely used substitutes for Bisphenol A(BPA).However,growing evidence indicated that BPF and BPS may induce physiological effects similar to those of BPA.Furthermore,chemical management and control is primarily focus on the risk assessment of individual compounds,often overlooking the implications of chemical mixtures.We hypothesize that exposure to a mixture of BPA and its substitutes will enhance their endocrine-disruptive effects,disrupt steroid hormone homeostasis,and further impair reproductive system functionality.In the animal study,both female and male mice were exposed to 333μg/kg of BPA,BPF,BPS,their mixture(333μg/kg(MIXL),and 1 mg/kg(MIXH))via gavage daily for four weeks.The study demonstrated that bisphenols(BPs)affected the expression of genes related to steroid hormone synthesis.The MIXL group of female mice exhibited an increasing trend in estradiol(E2)levels and a decreasing trend in progesterone(Pg)and testosterone(TT)levels.Additionally,follicular development was impacted,resulting in an increased number of atretic follicles.In contrast,a significant increase in E2 concentration and disruption of testicular morphology were observed in the MIXH group of male mice,accompanied by a decline in sperm quality.Importantly,these results were corroborated by a population-based investigation.Collectively,the animal experiments indicate that mixed exposure to BPs disrupts hormone levels and adversely affects reproductive function,while epidemiological evidence further establishes correlative links between bisphenols and hormone levels.These findings underscore the necessity of considering chemical mixtures during testing and risk assessment.
基金supported by the National Key Research and Development Program,China(2022YFC3502103,2022YFC3502102)the National Natural Science Foundation of China,China(82204751).
文摘This study summarizes the theoretical basis,modeling strategies,pathological mechanisms,and therapeutic advances related to high-altitude qi-deficiency and blood-stasis pattern.Traditional concepts such as“qi drives blood”and“deficiency leads to stasis”closely align with modern evidence demonstrating that hypoxia disrupts energy metabolism,impairs microcirculation,and amplifies inflammation and oxidative stress.Current animal models commonly use hypobaric hypoxia combined with fatigue loading,dietary restriction,ice-water stimulation,or adrenaline injection to mimic the combined effects of qi deficiency,blood stasis,and hypoxic injury.These composite approaches reproduce systemic abnormalities,including reduced arterial oxygen partial pressure,increased blood viscosity,impaired cardiac and pulmonary function,microcirculatory obstruction,and mitochondrial dysfunction.Enhanced inflammatory signaling,oxidative stress,and disturbances in metabolic and epigenetic networks further characterize the pattern.The findings indicate that its pathogenesis arises from multi-system,multi-target interactions rather than a single pathway.Representative herbal formulas,such as Buyang Huanwu decoction,Xuefu Zhuyu decoction,and prescriptions rich in Astragalus membranaceus(Fisch.)Bunge(A.membranaceus,Huang qi)or Salvia miltiorrhiza Bunge(S.miltiorrhiza,Dan Shen)have demonstrated the ability to improve energy metabolism,attenuate endothelial injury,enhance microcirculation,and suppress inflammation through network-level regulation.Future research should focus on standardizing exposure parameters,developing quantitative syndrome evaluation systems,and integrating multi-omics,systems biology and artificial intelligence to improve model reproducibility and mechanistic precision.These efforts may help establish objective criteria for high-altitude qi-deficiency and blood-stasis pattern and support the development of targeted therapeutic strategies.
基金supported by the Natural Science Foundation of Heilongjiang Province(LH2023C028)。
文摘Zinc,an essential trace element,plays a pivotal role in maintaining animal health and physiological functions.This review comprehensively examines zinc metabolism—including absorption dynamics across species(poultry,ruminants,and non-ruminants),transport mechanisms,storage in tissues,e.g.,the liver,and excretion pathways—and its multifaceted effects on animal health.Zinc critically regulates aspects of growth and development,particularly bone formation,as its deficiency induces skeletal deformities in young animals.It modulates immune function through zinc finger proteins,influencing immune organ integrity,lymphocyte proliferation,and cytokine expression.Reproductive performance is significantly affected by zinc,with its deficiency causing impaired spermatogenesis;delayed sexual maturity in males;and reduced litter size,embryonic survival,and placental function in females.At the molecular level,zinc regulates the activity of enzymes(e.g.,SOD),signaling pathways(MAPK,NF-κB),and transcription factors(MTF-1,Sp1)to maintain homeostasis.Both zinc deficiency(due to dietary insufficiency,malabsorption,or physiological stress)and zinc excess(from environmental pollution or feed oversupplementation)adversely affect health,disrupting mineral balance,enzyme function,and gut microbiota.In animal production,inorganic(zinc oxide,zinc sulfate)and organic(zinc methionine)sources of zinc increase growth,immunity,and productivity,although sustainable strategies are needed to mitigate environmental risks.Future research should focus on novel zinc formulations,precision nutrition,and interactions with gut microbiota to optimize livestock health and sustainable husbandry.
基金National Natural Science Foundation of China,Grant/Award Number:82000102 and 82270112。
文摘The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention and treatment methods.Animal models serve as essential tools for investigating disease mechanisms and assessing novel therapeutic strategies,and the scientific rigor of their construction and validation significantly impacts the reliability of research findings.This paper systematically reviews the research progress and evaluation systems of BAS animal models over the past decade,aiming to provide a robust foundation for the optimized construction of BAS models,intervention studies,and clinical translation.This effort is intended to facilitate the innovation and advancement in BAS prevention and treatment strategies.
文摘Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in their serum, targeting acetylcholine receptor, muscle-specific kinase, or related proteins. Current treatment for myasthenia gravis involves symptomatic therapy, immunosuppressive drugs such as corticosteroids, azathioprine, and mycophenolate mofetil, and thymectomy, which is primarily indicated in patients with thymoma or thymic hyperplasia. However, this condition continues to pose significant challenges including an unpredictable and variable disease progression, differing response to individual therapies, and substantial longterm side effects associated with standard treatments(including an increased risk of infections, osteoporosis, and diabetes), underscoring the necessity for a more personalized approach to treatment. Furthermore, about fifteen percent of patients, called “refractory myasthenia gravis patients”, do not respond adequately to standard therapies. In this context, the introduction of molecular therapies has marked a significant advance in myasthenia gravis management. Advances in understanding myasthenia gravis pathogenesis, especially the role of pathogenic antibodies, have driven the development of these biological drugs, which offer more selective, rapid, and safer alternatives to traditional immunosuppressants. This review aims to provide a comprehensive overview of emerging therapeutic strategies targeting specific immune pathways in myasthenia gravis, with a particular focus on preclinical evidence, therapeutic rationale, and clinical translation of B-cell depletion therapies, neonatal Fc receptor inhibitors, and complement inhibitors.
文摘Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.
文摘Food Science of Animal Products (ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.
文摘Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.
文摘Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.
文摘As the Philippines celebrated the 2nd Asia Laboratory Animal Day(ALAD)last November 29,2025,the Philippine Association for Laboratory Animal Sciences(PALAS)reflected on a year marked by growth,collaboration,and renewed commitment to ethical and scientific excellence in animal-based research.Throughout 2025,PALAS has continued to strengthen the laboratory animal science community by advancing education,capacity building,policy advocacy,and regional cooperation.These efforts underscore PALAS’vital role in shaping a culture of responsible animal research aligned with international standards.
文摘Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.The research scope includes the quality and processing characteristics of food raw materials,the relationships of nutritional components and bioactive substances with human health,product flavor and sensory characteristics,the control of harmful substances during processing or cooking,product preservation,storage and packaging;microorganisms and fermentation,illegal drug residues and food safety detection;authenticity identification;cell-cultured meat,regulations and standards.
文摘Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.The research scope includes the quality and processing characteristics of food raw materials,the relationships of nutritional components and bioactive substances with human health,product flavor and sensory characteristics,the control of harmful substances during processing or cooking,product preservation,storage and packaging;microorganisms and fermentation,illegal drug residues and food safety detection;authenticity identification;cell-cultured meat,regulations and standards.
文摘Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research findings in the field of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.The research scope includes the quality and processing characteristics of food raw materials,the relationships of nutritional components and bioactive substances with human health,product flavor and sensory characteristics,the control of harmful substances during processing or cooking,product preservation,storage and packaging;microorganisms and fermentation,illegal drug residues and food safety detection;authenticity identifi cation;cell-cultured meat,regulations and standards.
文摘Food Science of Animal Products(ISSN:2958-4124,e-ISSN:2958-3780)is a peer-reviewed,open access international journal that publishes the latest research fi ndings in the fi eld of animal-origin foods,involving food materials such as meat,aquatic products,milk,eggs,animal offals and edible insects.The research scope includes the quality and processing characteristics of food raw materials,the relationships of nutritional components and bioactive substances with human health,product fl avor and sensory characteristics,the control of harmful substances during processing or cooking,product preservation,storage and packaging;microorganisms and fermentation,illegal drug residues and food safety detection;authenticity identifi cation;cell-cultured meat,regulations and standards.
