0 INTRODUCTION.The global availability of digital elevation model(DEM)data,such as 90-m Shuttle Radar Topography Mission(SRTM)DEM and 30-m Advanced Spaceborne Thermal Emission and Reflection Radiometer Global Digital ...0 INTRODUCTION.The global availability of digital elevation model(DEM)data,such as 90-m Shuttle Radar Topography Mission(SRTM)DEM and 30-m Advanced Spaceborne Thermal Emission and Reflection Radiometer Global Digital Elevation Model(ASTER GDEM),has been extensively utilized in morphotectonic analyses(e.g.,Wang et al.,2024;Cheng et al.,2018;Pérez-Pe?a et al.,2010;El Hamdouni et al.,2008).展开更多
Climate change and environmental degradation threaten the world and global economic conditions.As one of countries’most important economic components,the financial sector might be an effective tool for reducing and e...Climate change and environmental degradation threaten the world and global economic conditions.As one of countries’most important economic components,the financial sector might be an effective tool for reducing and even reversing environmental degradation.The financial sector can affect sustainability through its lending and investment practices.The sector can play a role in financing sustainable projects and businesses,helping reduce CO_(2) emissions.By aligning its financial objectives with environmental protection,the financial sector can support the transition to a more sustainable future by helping reduce environmental degradation’s negative impacts.This paper examines the domestic financial sector’s impact on CO_(2) emissions in the United States over the 1990:Q1–2022:Q3 period.In this research,the nexus between the domestic financial sector(total debt securities,loans,liabilities,and total financial assets)and Carbon dioxide emissions in the U.S.is investigated by Morlet wavelet analysis.Rest of the world:sector discrepancy transactions,rest of the world:debt securities and loans,gross domestic product,and the square of the gross domestic product,are control variables in the estimated models.Partial wavelet coherency analyses prove that the financial sector reduces CO_(2) emissions at the 5–8-year frequency band during different subsample periods.The financial sector’s instruments can be effective in struggling with climate change.展开更多
Osteoporosis is a known risk factor for rotator cuff tears(RCTs),but the causal correlation and underlying mechanisms remain unclear.This study aims to evaluate the impact of osteoporosis on RCT risk and investigate t...Osteoporosis is a known risk factor for rotator cuff tears(RCTs),but the causal correlation and underlying mechanisms remain unclear.This study aims to evaluate the impact of osteoporosis on RCT risk and investigate their genetic associations.Using data from the UK Biobank(n=457871),cross-sectional analyses demonstrated that osteoporosis was significantly associated with an increased risk of RCTs(adjusted OR[95%CI]=1.38[1.25–1.52]).A longitudinal analysis of a subset of patients(n=268117)over 11 years revealed that osteoporosis increased the risk of RCTs(adjusted HR[95%CI]=1.56[1.29–1.87]),which is notably varied between sexes in sex-stratified analysis.Causal inference methods,including propensity score matching,inverse probability weighting,causal random forest and survival random forest models further confirmed the causal effect,both from cross-sectional and longitudinal perspectives.展开更多
Background Social media listening is a new approach for gathering insights from social media platforms about users experiences.This approach has not been applied to analyse discussions about Alzheimer's disease(AD...Background Social media listening is a new approach for gathering insights from social media platforms about users experiences.This approach has not been applied to analyse discussions about Alzheimer's disease(AD)in China.Aims We aimed to leverage multisource Chinese data to gain deeper insights into the current state of the daily management of Chinese patients with AD and the burdens faced by their caregivers.Methods We searched ninemainstreampublic onlineplatforms in China fromSeptember2010 to March 2024.Natural language processing tools were used to identify patients and caregivers,and categorise patients by disease stage forfurther analysis.We analysed the current state of patient daily management,including diagnosis and treatment,choice oftreatment scenarios,patient safetyand caregiverconcerns.Results Atotal of 1211patientswithAD(66% female,82% aged 60-90)and 756caregiversfor patients with AD were identified from 107556 online sources.Most patients were derived from online consultation platforms(43%),followed by bulletin board system platforms(24%).Among the patients categorised into specific disease stages(n=382),42% were in the moderate stage.The most frequent diagnostic tools included medical history(97%)and symptoms(84%).Treatment options for patients with AD primarily included cholinesterase inhibitors,N-methyl-D-aspartate receptor antagonists and antipsychotics.Both quantitative and qualitative analysis of patients whoexperiencedwandering(n=92)indicated a higher incidence of wandering during the moderate stage of the disease.Most caregivers were family members,with their primary concerns focusing on disease management and treatment(90%),followed by daily life care(37%)and psychosocial support(25%).Conclusions Online platform data provide a broad spectrum of real-world insights into individuals affected byAD in China.This study enhances our understanding of the experiences of patients with AD and their caregivers,providing guidance for developing personalised interventions,providing advicefor caregivers and improving care for patients with AD.展开更多
BACKGROUND Myocardial ischemia/reperfusion(I/R)injury,which is associated with high morbidity and mortality,is a main cause of unexpected myocardial injury after acute myocardial infarction.However,the underlying mech...BACKGROUND Myocardial ischemia/reperfusion(I/R)injury,which is associated with high morbidity and mortality,is a main cause of unexpected myocardial injury after acute myocardial infarction.However,the underlying mechanism remains unclear.Circular RNAs(circRNAs),which are formed from protein-coding genes,can sequester microRNAs or proteins,modulate transcription and interfere with splicing.Authoritative studies suggest that circRNAs may play an important role in myocardial I/R injury.AIM To explore the role and mechanism of circRNAs in myocardial I/R injury.METHODS We constructed a myocardial I/R injury model using ligation of the left anterior descending coronary artery,and evaluated the success of the validated model using triphenyltetrazolium chloride and hematoxylin-eosin staining.Then,left ventricular samples from different groups were selected for mRNA-sequence,and differential gene screening was performed on the obtained results.The differentially obtained mRNAs were divided into up-regulated and down-regulated according to their expression levels,and Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)functional enrichment analysis were performed,respectively.Then,the obtained circRNA and microRNA(miRNA)were paired for analysis,and the binding sites of miRNA and mRNA were virtual screened.Finally,the obtained circRNA,miRNA and mRNA were constructed by ceRNA mutual most useful network.RESULTS We used an RNA sequencing array to investigate the expression signatures of circRNAs in myocardial I/R injury using three samples from the I/R group and three samples from the sham group.A total of 142 upregulated and 121 downregulated circRNAs were found to be differentially expressed(fold change≥2,P<0.05).GO and KEGG functional analyses of these circRNAs were performed.GO analysis revealed that these circRNAs were involved mainly in cellular and intracellular processes.KEGG analysis demonstrated that 6 of the top 20 pathways were correlated with cell apoptosis.Furthermore,a circRNA-miRNA coexpression network and ceRNA network based on these genes were constructed,revealing that mmu-circ-0001452,mmu-circ-0001637,and mmu-circ-0000870 might be key regulators of myocardial I/R injury.CONCLUSION This research provides new insights into the mechanism of myocardial I/R,which mmu-circ-0001452,mmu-circ-0001637,and mmu-circ-0000870 are expected to be new therapeutic targets for myocardial I/R injury.展开更多
This paper employs the Direct Finite Element Squared(DFE2)method to develop Sparse Polynomial Chaos Expansions(SPCE)models for analyzing the electromechanical properties of multiscale piezoelectric structures.By incor...This paper employs the Direct Finite Element Squared(DFE2)method to develop Sparse Polynomial Chaos Expansions(SPCE)models for analyzing the electromechanical properties of multiscale piezoelectric structures.By incorporating variations in piezoelectric and elastic constants,the DFE2 method is utilized to simulate the statistical characteristics—such as expected values and standard deviations—of electromechanical properties,including Mises stress,maximum in-plane principal strain,electric potential gradient,and electric potential,under varying parameters.This approach achieves a balance between computational efficiency and accuracy.Different SPCE models are used to investigate the influence of piezoelectric and elastic constants on multiscale piezoelectric materials.Additionally,the multiscale parameterization study investigates how microscale material properties affect the macroscopic response of these structures and materials.展开更多
The world-class Jiaodong gold province in the North China Craton hosts over 5000 t of Au resource and is characterized by abundant visible gold mineralization.However,the critical processes controlling the formation o...The world-class Jiaodong gold province in the North China Craton hosts over 5000 t of Au resource and is characterized by abundant visible gold mineralization.However,the critical processes controlling the formation of visible gold in this province remain poorly understood.To solve this problem,integrated microtextural,trace elemental,and sulfur isotopic analyses of pyrite from the high-grade Linglong gold deposit in the Jiaodong gold province were conducted in this study.Two distinct pyrite types were identified within auriferous quartz-sulfide veins:(1)Py1 aggregates in quartz-pyrite veins(hydrothermal stageⅡ),and(2)euhedral to subhedral,coarse-grained Py2 crystals in quartz-polymetallic sulfide veins(hydrothermal stageⅢ).Microtextural and elemental analyses revealed that visible gold predominantly occurs as intergranular particles between primary pyrite crystals within Py1 aggregates.The Py1 exhibits complex microtextures with abundant mineral inclusions of polymetallic sulfides and has low concentrations of Au(median:0.032 ppm)with a narrowδ^(34)S range(4.86‰-6.75‰),indicative of rapid crystallization under unstable,disequilibrium conditions.By contrast,the Py2 is texturally homogeneous and contains higher Au concentrations(median:0.304 ppm)with progressively increasingδ^(34)S values(5.25‰-10.14‰)over time,suggesting slow crystal growth under more stable,near-equilibrium conditions.Based on the microtextural and geochemical information,it is proposed that fluid boiling occurred only during the hydrothermal stage Ⅱ,which resulted in the unstable physicochemical environment and rapid deposition of gold.During the boiling processes,gold colloids likely occurred and promoted the formation of visible gold.展开更多
The deep seabed is known for its abundant reserves of various mineral resources.Notably,the Clarion Clipperton(C-C)mining area in the northeast Pacific Ocean,where China holds exploration rights,is particularly rich i...The deep seabed is known for its abundant reserves of various mineral resources.Notably,the Clarion Clipperton(C-C)mining area in the northeast Pacific Ocean,where China holds exploration rights,is particularly rich in deep-sea polymetallic nodules.These nodules,which are nodular and unevenly distributed in seafloor sediments,have significant industrial exploitation value.Over the decades,the deep-sea mining industry has increasingly adopted systems that combine rigid and flexible risers supported by large surface mining vessels.However,current systems face economic and structural stability challenges,hindering the development of deep-sea mining technology.This paper proposes a new structural design for a deep-sea mining system based on flexible risers,validated through numerical simulations and experimental research.The system composition,function and operational characteristics are comprehensively introduced.Detailed calculations determine the production capacity of the deep-sea mining system and the dimensions of the seabed mining subsystem.Finite element numerical simulations analyze the morphological changes of flexible risers and the stress conditions at key connection points under different ocean current incident angles.Experimental research verifies the feasibility of collaborative movement between two tethered underwater devices.The proposed deep-sea mining system,utilizing flexible risers,significantly advances the establishment of a commercial deep-sea mining system.The production calculations and parameter determinations provide essential references for the system’s future detailed design.Furthermore,the finite element simulation model established in this paper provides a research basis,and the method established in this paper offers a foundation for subsequent research under more complex ocean conditions.The control strategy for the collaborative movement between two tethered underwater devices provides an effective solution for deep-sea mining control systems.展开更多
This study proposes a three-dimensional(3D)coupled magneto-electro-elastic problem for the static analysis of multilayered plates embedding piezomagnetic and piezoelectric layers by considering both sensor and actuato...This study proposes a three-dimensional(3D)coupled magneto-electro-elastic problem for the static analysis of multilayered plates embedding piezomagnetic and piezoelectric layers by considering both sensor and actuator configurations.The 3D governing equations for the magneto-electro-elastic static behavior of plates are explicitly show that are made by the three 3D equilibrium equations,the 3D divergence equation for magnetic induction,and the 3D divergence equation for the electric displacement.The proposed solution involves the exponential matrix in the thickness direction and primary variables’harmonic forms in the in-plane ones.A closed-form solution is performed considering simply-supported boundary conditions.Interlaminar continuity conditions are imposed for displacements,magnetic potential,electric potential,transverse shear/normal stresses,transverse normal magnetic induction and transverse normal electric displacement.Therefore,a layerwise approach is adopted.The results section is composed of an assessment part,where the present model is compared to past 3D electro-elastic or magneto-elastic formulations and a new benchmark part.Benchmarks consider sensor and actuator plate configurations for the fully coupled magneto-electro-elastic cases for different thickness ratios.Tabular and graphical results are presented for displacements,stresses,magnetic potential,electric potential,transverse normal magnetic induction and transverse normal electric displacement.For each presented benchmark,magneto-electro-elastic coupling and thickness and material layer effects are discussed in depth.展开更多
The accurate characterization of thermoelectric properties at low temperatures is crucial for the development of high-performance thermoelectric cooling devices. While measurement errors of thermoelectric properties a...The accurate characterization of thermoelectric properties at low temperatures is crucial for the development of high-performance thermoelectric cooling devices. While measurement errors of thermoelectric properties at temperatures above room temperature have been extensively discussed, there is a lack of standard measurement protocols and error analyses for low-temperature transport properties. In this study, we present a measurement system capable of characterizing all three key thermoelectric parameters, i.e., Seebeck coefficient, electrical conductivity, and thermal conductivity, for a single sample across a temperature range of 10 K to 300 K. We investigated six representative commercial Bi_(2)Te_(3)-based samples(three N-type and three P-type). Using an error propagation model, we systematically analyzed the measurement uncertainties of the three intrinsic parameters and the resulting thermoelectric figure of merit. Our findings reveal that measurement uncertainties for both N-type and P-type Bi_(2)Te_(3)-based materials can be effectively maintained below 5% in the temperature range of 40 K to 300 K. However, the uncertainties increase to over 10% at lower temperatures, primarily due to the relatively smaller values of electrical resistivity and Seebeck coefficients in this regime. This work establishes foundational data for Bi_(2)Te_(3)-based thermoelectric materials and provides a framework for broader investigations of advanced low-temperature thermoelectrics.展开更多
To accomplish the reliability analyses of the correlation of multi-analytical objectives,an innovative framework of Dimensional Synchronous Modeling(DSM)and correlation analysis is developed based on the stepwise mode...To accomplish the reliability analyses of the correlation of multi-analytical objectives,an innovative framework of Dimensional Synchronous Modeling(DSM)and correlation analysis is developed based on the stepwise modeling strategy,cell array operation principle,and Copula theory.Under this framework,we propose a DSM-based Enhanced Kriging(DSMEK)algorithm to synchronously derive the modeling of multi-objective,and explore an adaptive Copula function approach to analyze the correlation among multiple objectives and to assess the synthetical reliability level.In the proposed DSMEK and adaptive Copula methods,the Kriging model is treated as the basis function of DSMEK model,the Multi-Objective Snake Optimizer(MOSO)algorithm is used to search the optimal values of hyperparameters of basis functions,the cell array operation principle is adopted to establish a whole model of multiple objectives,the goodness of fit is utilized to determine the forms of Copula functions,and the determined Copula functions are employed to perform the reliability analyses of the correlation of multi-analytical objectives.Furthermore,three examples,including multi-objective complex function approximation,aeroengine turbine bladeddisc multi-failure mode reliability analyses and aircraft landing gear system brake temperature reliability analyses,are performed to verify the effectiveness of the proposed methods,from the viewpoints of mathematics and engineering.The results show that the DSMEK and adaptive Copula approaches hold obvious advantages in terms of modeling features and simulation performance.The efforts of this work provide a useful way for the modeling of multi-analytical objectives and synthetical reliability analyses of complex structure/system with multi-output responses.展开更多
With the increment of the complexity of structural systems and the span of spatial structures, the interactions between parts of the structures, especially between some flexible substructures, become too complex to be...With the increment of the complexity of structural systems and the span of spatial structures, the interactions between parts of the structures, especially between some flexible substructures, become too complex to be analyzed clearly. In this paper, taking an actual gymnasium of a long-span spatial steel-cable-membrane hybrid structure as the calculation model, the static and dynamic analyses of the hybrid structures are performed by employing the global analysis of the whole hybrid structure and the substructural analysis of the truss arch substructure, the cable-membrane substructure, etc. In addition, the comparison of stresses and displacements of structural members in the global and substructural analyses is made. The numerical results show that serious errors exist in the substructural analysis of the hybrid structure, and the global analysis is necessary for the hybrid structure under the excitation of static loads and seismic loads.展开更多
The thermodynamic(energy and exergy)analysis of a condensate heating system,its segments,and components from a marine steam propulsion plant with steam reheating is performed in this paper.It is found that energy anal...The thermodynamic(energy and exergy)analysis of a condensate heating system,its segments,and components from a marine steam propulsion plant with steam reheating is performed in this paper.It is found that energy analysis of any condensate heating system should be avoided because it is highly influenced by the measuring equipment accuracy and precision.All the components from the observed marine condensate heating system have energy destructions lower than 3 kW,while the energy efficiencies of this system are higher than 99%.The exergy efficiency of closed condensate heaters continuously increases from the lowest to the highest steam pressures(from 70.10%to 92.29%).The ambient temperature variation between 5℃and 45℃notably influences the exergy efficiency change of both low pressure heaters and the low pressure segment equal to 31.61%,12.37%,and 18.35%,respectively.展开更多
This paper summarizes a few spatial statistical analysis methods for to measuring spatial autocorrelation and spatial association, discusses the criteria for the identification of spatial association by the use of glo...This paper summarizes a few spatial statistical analysis methods for to measuring spatial autocorrelation and spatial association, discusses the criteria for the identification of spatial association by the use of global Moran Coefficient, Local Moran and Local Geary. Furthermore, a user-friendly statistical module, combining spatial statistical analysis methods with GIS visual techniques, is developed in Arcview using Avenue. An example is also given to show the usefulness of this module in identifying and quantifying the underlying spatial association patterns between economic units.展开更多
In-vessel components are important parts of the EAST superconducting tokamak. They include the plasma facing components, passive plates, cryo-pumps, in-vessel coils, etc. The structural design, analysis and related R...In-vessel components are important parts of the EAST superconducting tokamak. They include the plasma facing components, passive plates, cryo-pumps, in-vessel coils, etc. The structural design, analysis and related R＆D have been completed. The divertor is designed in an up-down symmetric configuration to accommodate both double null and single null plasma operation. Passive plates are used for plasma movement control. In-vessel coils are used for the active control of plasma vertical movements. Each cryo-pump can provide an approximately 45 m^3/s pumping rate at a pressure of 10^-1 Pa for particle exhaust. Analysis shows that, when a plasma current of 1 MA disrupts in 3 ms, the EM loads caused by the eddy current and the halo current in a vertical displacement event （VDE） will not generate an unacceptable stress on the divertor structure. The bolted divertor thermal structure with an active cooling system can sustain a load of 2 MW/m^2 up to a 60 s operation if the plasma facing surface temperature is limited to 1500 ℃. Thermal testing and structural optimization testing were conducted to demonstrate the analysis results.展开更多
Ultrasonic welding is an effective ways to achieve a non-reactive/immiscible heterogeneous metal connection, such as the connection of magnesium alloy and titanium alloy. But the thermal mechanism of magnesium alloy/t...Ultrasonic welding is an effective ways to achieve a non-reactive/immiscible heterogeneous metal connection, such as the connection of magnesium alloy and titanium alloy. But the thermal mechanism of magnesium alloy/titanium alloy ultrasonic welding has not been defined clearly. In this paper, the experimental and the finite element analysis were adopted to study the thermal mechanism during welding. Through the test, the temperature variation law during the welding process is obtained, and the accuracy of the finite element model is verified. The microscopic analysis indicates that at the welding time of 0.5 s, the magnesium alloy in the center of the solder joint is partially melted and generates the liquid phase. Through the finite element analysis, the friction coefficient of the magnesium–titanium ultrasonic welding interface can be considered as an average constant value of 0.28. The maximum temperature at the interface can exceed 600 ℃ to reach the melting point temperature of the magnesium alloy. The plastic deformation begins after 0.35 s and occurs at the magnesium side at the center of the interface.展开更多
Gene spectrum analysis has shown that gene expression and signaling pathways change dramatically after spinal cord injury,which may affect the microenvironment of the damaged site.Microarray analysis provides a new op...Gene spectrum analysis has shown that gene expression and signaling pathways change dramatically after spinal cord injury,which may affect the microenvironment of the damaged site.Microarray analysis provides a new opportunity for investigating diagnosis,treatment,and prognosis of spinal cord injury.However,differentially expressed genes are not consistent among studies,and many key genes and signaling pathways have not yet been accurately studied.GSE5296 was retrieved from the Gene Expression Omnibus DataSet.Differentially expressed genes were obtained using R/Bioconductor software(expression changed at least two-fold;P < 0.05).Database for Annotation,Visualization and Integrated Discovery was used for functional annotation of differentially expressed genes and Animal Transcription Factor Database for predicting potential transcription factors.The resulting transcription regulatory protein interaction network was mapped to screen representative genes and investigate their diagnostic and therapeutic value for disease.In total,this study identified 109 genes that were upregulated and 30 that were downregulated at 0.5,4,and 24 hours,and 3,7,and 28 days after spinal cord injury.The number of downregulated genes was smaller than the number of upregulated genes at each time point.Database for Annotation,Visualization and Integrated Discovery analysis found that many inflammation-related pathways were upregulated in injured spinal cord.Additionally,expression levels of these inflammation-related genes were maintained for at least 28 days.Moreover,399 regulation modes and 77 nodes were shown in the protein-protein interaction network of upregulated differentially expressed genes.Among the 10 upregulated differentially expressed genes with the highest degrees of distribution,six genes were transcription factors.Among these transcription factors,ATF3 showed the greatest change.ATF3 was upregulated within 30 minutes,and its expression levels remained high at28 days after spinal cord injury.These key genes screened by bioinformatics tools can be used as biological markers to diagnose diseases and provide a reference for identifying therapeutic targets.展开更多
A new instrument called capacitive drop analyser (CDA) for measuring the physical properties of liquid is developed.A delivery head with a specialized wetting design was constructed for forming drops.The capacitive tr...A new instrument called capacitive drop analyser (CDA) for measuring the physical properties of liquid is developed.A delivery head with a specialized wetting design was constructed for forming drops.The capacitive transducer uses the delivery head as one of its plates and a cylindrical ring plate.Excellent linearity is achieved by optimising the design,with an accuracy of drop volume measurement of approximately 2 μL.It is suitable for measuring both drops in equilibrium and those in the process of growing.Its capability of real time measurement makes it particularly useful for volatile liquids,in which instance the measurement of drop volume using a flowmeter or a pump is no longer reliable.The CDA can also be used to determine concentration.It is found that concentration curve is linear for aqueous glycerol solutions although not so for aqueous ethanol solution.The CDAs capability of measuring surface tension is also explored and experimental results are presented.展开更多
The application of the linear guideways is very extensive, such as automation equipment, heavy-duty carry equipment, heavy-cut machining tool, CNC grinding machine, large-scale planning machine and machining center wi...The application of the linear guideways is very extensive, such as automation equipment, heavy-duty carry equipment, heavy-cut machining tool, CNC grinding machine, large-scale planning machine and machining center with the demand of high rigidity and heavy load. By means of the study of contact behavior between the roller/guideway and roller/slider, roller type linear guideways can improve the machining accuracy. The goal of this paper is to construct the fatigue life model of the linear guideway, with the help of the contact mechanics of rollers. In beginning, the analyses of the rigidity of a single roller compressed between guideway and slider was conducted. Then, the normal contact pressure of linear guideways was obtained by using the superposition method, and verified by the FEM software (ANSYS workbench). Finally, the bearing life theory proposed by Lundberg and Palmgren was used to describe the contact fatigue life.展开更多
This paper deals with the validation and theoretical analyses of a simple method for calculating the intrinsic rate of increase, rm, of aphids and mites. This method does not require a detailed fecundity table data. T...This paper deals with the validation and theoretical analyses of a simple method for calculating the intrinsic rate of increase, rm, of aphids and mites. This method does not require a detailed fecundity table data. The value of rm can be estimated by the simple equation: rm=0.74ln (Md)/d, where d is the time from birth to first reproduction; Md is the number of female offspring produced per original female in 2d. This method was developed by Wyatt and White. We reached the following conclusions from our study: When the parameter, Md is less than 1, this equation is not appropriate for estimating rm of populations; When the parameter, Md is larger than 1 and about 70% or more of the reproductive contribution to the rm is achieved in 2d, the equation is appropriate for calculatng the rm of aphids and mites.As Md decreases, the required reproductive contribution to the rm in 2d corresponding to the constant 0.74 will increase. However, whether 70% or more of reproductive contribution to rm is achieved in 2d still is a problem for whole taxa of aphids and mites. Therefore, further siudy on reproductive distribution will be required for practical application of this method.展开更多
基金supported by the National Key Research and Development Project of China(No.2023YFC3007303)the Open Research Project of the Hubei Key Laboratory of Intelligent Geo-Information Processing(No.KLIGIP-2019B08)。
文摘0 INTRODUCTION.The global availability of digital elevation model(DEM)data,such as 90-m Shuttle Radar Topography Mission(SRTM)DEM and 30-m Advanced Spaceborne Thermal Emission and Reflection Radiometer Global Digital Elevation Model(ASTER GDEM),has been extensively utilized in morphotectonic analyses(e.g.,Wang et al.,2024;Cheng et al.,2018;Pérez-Pe?a et al.,2010;El Hamdouni et al.,2008).
文摘Climate change and environmental degradation threaten the world and global economic conditions.As one of countries’most important economic components,the financial sector might be an effective tool for reducing and even reversing environmental degradation.The financial sector can affect sustainability through its lending and investment practices.The sector can play a role in financing sustainable projects and businesses,helping reduce CO_(2) emissions.By aligning its financial objectives with environmental protection,the financial sector can support the transition to a more sustainable future by helping reduce environmental degradation’s negative impacts.This paper examines the domestic financial sector’s impact on CO_(2) emissions in the United States over the 1990:Q1–2022:Q3 period.In this research,the nexus between the domestic financial sector(total debt securities,loans,liabilities,and total financial assets)and Carbon dioxide emissions in the U.S.is investigated by Morlet wavelet analysis.Rest of the world:sector discrepancy transactions,rest of the world:debt securities and loans,gross domestic product,and the square of the gross domestic product,are control variables in the estimated models.Partial wavelet coherency analyses prove that the financial sector reduces CO_(2) emissions at the 5–8-year frequency band during different subsample periods.The financial sector’s instruments can be effective in struggling with climate change.
基金the Scientific Research Innovation Capability Support Project for Young Faculty(ZYGXQNJSKYCXNLZCXM-H8)Fundamental Research Funds for the Central Universities(2024ZYGXZR077)+3 种基金Guangdong Basic and Applied Basic Research Foundation(2023B1515120006)Guangzhou Basic and Applied Basic Research Foundation(2024A04J5776)the Research Fund(2023QN10Y421)Guangzhou Talent Recruitment Team Program(2024D03J0004),all related to this study.
文摘Osteoporosis is a known risk factor for rotator cuff tears(RCTs),but the causal correlation and underlying mechanisms remain unclear.This study aims to evaluate the impact of osteoporosis on RCT risk and investigate their genetic associations.Using data from the UK Biobank(n=457871),cross-sectional analyses demonstrated that osteoporosis was significantly associated with an increased risk of RCTs(adjusted OR[95%CI]=1.38[1.25–1.52]).A longitudinal analysis of a subset of patients(n=268117)over 11 years revealed that osteoporosis increased the risk of RCTs(adjusted HR[95%CI]=1.56[1.29–1.87]),which is notably varied between sexes in sex-stratified analysis.Causal inference methods,including propensity score matching,inverse probability weighting,causal random forest and survival random forest models further confirmed the causal effect,both from cross-sectional and longitudinal perspectives.
基金funded by the Ministry of Science and Technology of the People's Republic of China(2021ZD0201804,GW).
文摘Background Social media listening is a new approach for gathering insights from social media platforms about users experiences.This approach has not been applied to analyse discussions about Alzheimer's disease(AD)in China.Aims We aimed to leverage multisource Chinese data to gain deeper insights into the current state of the daily management of Chinese patients with AD and the burdens faced by their caregivers.Methods We searched ninemainstreampublic onlineplatforms in China fromSeptember2010 to March 2024.Natural language processing tools were used to identify patients and caregivers,and categorise patients by disease stage forfurther analysis.We analysed the current state of patient daily management,including diagnosis and treatment,choice oftreatment scenarios,patient safetyand caregiverconcerns.Results Atotal of 1211patientswithAD(66% female,82% aged 60-90)and 756caregiversfor patients with AD were identified from 107556 online sources.Most patients were derived from online consultation platforms(43%),followed by bulletin board system platforms(24%).Among the patients categorised into specific disease stages(n=382),42% were in the moderate stage.The most frequent diagnostic tools included medical history(97%)and symptoms(84%).Treatment options for patients with AD primarily included cholinesterase inhibitors,N-methyl-D-aspartate receptor antagonists and antipsychotics.Both quantitative and qualitative analysis of patients whoexperiencedwandering(n=92)indicated a higher incidence of wandering during the moderate stage of the disease.Most caregivers were family members,with their primary concerns focusing on disease management and treatment(90%),followed by daily life care(37%)and psychosocial support(25%).Conclusions Online platform data provide a broad spectrum of real-world insights into individuals affected byAD in China.This study enhances our understanding of the experiences of patients with AD and their caregivers,providing guidance for developing personalised interventions,providing advicefor caregivers and improving care for patients with AD.
基金Supported by Zhejiang Provincial Natural Science Foundation of China,No.LQ23H020004The Medical and Health Research Project of Zhejiang province,No.2024KY983Basic Medical Health Technology Project of Wenzhou Science and Technology Bureau,No.Y20210818 and No.Y20210140.
文摘BACKGROUND Myocardial ischemia/reperfusion(I/R)injury,which is associated with high morbidity and mortality,is a main cause of unexpected myocardial injury after acute myocardial infarction.However,the underlying mechanism remains unclear.Circular RNAs(circRNAs),which are formed from protein-coding genes,can sequester microRNAs or proteins,modulate transcription and interfere with splicing.Authoritative studies suggest that circRNAs may play an important role in myocardial I/R injury.AIM To explore the role and mechanism of circRNAs in myocardial I/R injury.METHODS We constructed a myocardial I/R injury model using ligation of the left anterior descending coronary artery,and evaluated the success of the validated model using triphenyltetrazolium chloride and hematoxylin-eosin staining.Then,left ventricular samples from different groups were selected for mRNA-sequence,and differential gene screening was performed on the obtained results.The differentially obtained mRNAs were divided into up-regulated and down-regulated according to their expression levels,and Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)functional enrichment analysis were performed,respectively.Then,the obtained circRNA and microRNA(miRNA)were paired for analysis,and the binding sites of miRNA and mRNA were virtual screened.Finally,the obtained circRNA,miRNA and mRNA were constructed by ceRNA mutual most useful network.RESULTS We used an RNA sequencing array to investigate the expression signatures of circRNAs in myocardial I/R injury using three samples from the I/R group and three samples from the sham group.A total of 142 upregulated and 121 downregulated circRNAs were found to be differentially expressed(fold change≥2,P<0.05).GO and KEGG functional analyses of these circRNAs were performed.GO analysis revealed that these circRNAs were involved mainly in cellular and intracellular processes.KEGG analysis demonstrated that 6 of the top 20 pathways were correlated with cell apoptosis.Furthermore,a circRNA-miRNA coexpression network and ceRNA network based on these genes were constructed,revealing that mmu-circ-0001452,mmu-circ-0001637,and mmu-circ-0000870 might be key regulators of myocardial I/R injury.CONCLUSION This research provides new insights into the mechanism of myocardial I/R,which mmu-circ-0001452,mmu-circ-0001637,and mmu-circ-0000870 are expected to be new therapeutic targets for myocardial I/R injury.
基金supported by the Zhumadian 2023 Major Science and Technology Special Project(Grant No.ZMDSZDZX2023002)the Postgraduate Education Reform and Quality Improvement Project of Henan Province(Grant No.YJS2023JD52).
文摘This paper employs the Direct Finite Element Squared(DFE2)method to develop Sparse Polynomial Chaos Expansions(SPCE)models for analyzing the electromechanical properties of multiscale piezoelectric structures.By incorporating variations in piezoelectric and elastic constants,the DFE2 method is utilized to simulate the statistical characteristics—such as expected values and standard deviations—of electromechanical properties,including Mises stress,maximum in-plane principal strain,electric potential gradient,and electric potential,under varying parameters.This approach achieves a balance between computational efficiency and accuracy.Different SPCE models are used to investigate the influence of piezoelectric and elastic constants on multiscale piezoelectric materials.Additionally,the multiscale parameterization study investigates how microscale material properties affect the macroscopic response of these structures and materials.
基金supported by the National Natural Science Foundation of China(Grant Nos.42302106 and 42102089)National Foundation for Guiding Local Science and Technology Development(Guizhou[2024]043)Innovation and Development Fund of Science and Technology of Institute of Geochemistry,Chinese Academy of Sciences(Grant No.2025-1).
文摘The world-class Jiaodong gold province in the North China Craton hosts over 5000 t of Au resource and is characterized by abundant visible gold mineralization.However,the critical processes controlling the formation of visible gold in this province remain poorly understood.To solve this problem,integrated microtextural,trace elemental,and sulfur isotopic analyses of pyrite from the high-grade Linglong gold deposit in the Jiaodong gold province were conducted in this study.Two distinct pyrite types were identified within auriferous quartz-sulfide veins:(1)Py1 aggregates in quartz-pyrite veins(hydrothermal stageⅡ),and(2)euhedral to subhedral,coarse-grained Py2 crystals in quartz-polymetallic sulfide veins(hydrothermal stageⅢ).Microtextural and elemental analyses revealed that visible gold predominantly occurs as intergranular particles between primary pyrite crystals within Py1 aggregates.The Py1 exhibits complex microtextures with abundant mineral inclusions of polymetallic sulfides and has low concentrations of Au(median:0.032 ppm)with a narrowδ^(34)S range(4.86‰-6.75‰),indicative of rapid crystallization under unstable,disequilibrium conditions.By contrast,the Py2 is texturally homogeneous and contains higher Au concentrations(median:0.304 ppm)with progressively increasingδ^(34)S values(5.25‰-10.14‰)over time,suggesting slow crystal growth under more stable,near-equilibrium conditions.Based on the microtextural and geochemical information,it is proposed that fluid boiling occurred only during the hydrothermal stage Ⅱ,which resulted in the unstable physicochemical environment and rapid deposition of gold.During the boiling processes,gold colloids likely occurred and promoted the formation of visible gold.
基金Supported by Finance Science and Technology Project of Hainan Province under Grant No.ZDKJ2021027the National Natural Science Foundation of China under Grant No.52231012.
文摘The deep seabed is known for its abundant reserves of various mineral resources.Notably,the Clarion Clipperton(C-C)mining area in the northeast Pacific Ocean,where China holds exploration rights,is particularly rich in deep-sea polymetallic nodules.These nodules,which are nodular and unevenly distributed in seafloor sediments,have significant industrial exploitation value.Over the decades,the deep-sea mining industry has increasingly adopted systems that combine rigid and flexible risers supported by large surface mining vessels.However,current systems face economic and structural stability challenges,hindering the development of deep-sea mining technology.This paper proposes a new structural design for a deep-sea mining system based on flexible risers,validated through numerical simulations and experimental research.The system composition,function and operational characteristics are comprehensively introduced.Detailed calculations determine the production capacity of the deep-sea mining system and the dimensions of the seabed mining subsystem.Finite element numerical simulations analyze the morphological changes of flexible risers and the stress conditions at key connection points under different ocean current incident angles.Experimental research verifies the feasibility of collaborative movement between two tethered underwater devices.The proposed deep-sea mining system,utilizing flexible risers,significantly advances the establishment of a commercial deep-sea mining system.The production calculations and parameter determinations provide essential references for the system’s future detailed design.Furthermore,the finite element simulation model established in this paper provides a research basis,and the method established in this paper offers a foundation for subsequent research under more complex ocean conditions.The control strategy for the collaborative movement between two tethered underwater devices provides an effective solution for deep-sea mining control systems.
文摘This study proposes a three-dimensional(3D)coupled magneto-electro-elastic problem for the static analysis of multilayered plates embedding piezomagnetic and piezoelectric layers by considering both sensor and actuator configurations.The 3D governing equations for the magneto-electro-elastic static behavior of plates are explicitly show that are made by the three 3D equilibrium equations,the 3D divergence equation for magnetic induction,and the 3D divergence equation for the electric displacement.The proposed solution involves the exponential matrix in the thickness direction and primary variables’harmonic forms in the in-plane ones.A closed-form solution is performed considering simply-supported boundary conditions.Interlaminar continuity conditions are imposed for displacements,magnetic potential,electric potential,transverse shear/normal stresses,transverse normal magnetic induction and transverse normal electric displacement.Therefore,a layerwise approach is adopted.The results section is composed of an assessment part,where the present model is compared to past 3D electro-elastic or magneto-elastic formulations and a new benchmark part.Benchmarks consider sensor and actuator plate configurations for the fully coupled magneto-electro-elastic cases for different thickness ratios.Tabular and graphical results are presented for displacements,stresses,magnetic potential,electric potential,transverse normal magnetic induction and transverse normal electric displacement.For each presented benchmark,magneto-electro-elastic coupling and thickness and material layer effects are discussed in depth.
基金supported by the National Natural Science Foundation of China (Grant No. 52172259)the National Key Research and Development Program of China (Grant Nos. 2021YFA0718700 and 2022YFB3803900)the Fundamental Research Funds for the Inner Mongolia Normal University (Grant No. 2022JBTD008)。
文摘The accurate characterization of thermoelectric properties at low temperatures is crucial for the development of high-performance thermoelectric cooling devices. While measurement errors of thermoelectric properties at temperatures above room temperature have been extensively discussed, there is a lack of standard measurement protocols and error analyses for low-temperature transport properties. In this study, we present a measurement system capable of characterizing all three key thermoelectric parameters, i.e., Seebeck coefficient, electrical conductivity, and thermal conductivity, for a single sample across a temperature range of 10 K to 300 K. We investigated six representative commercial Bi_(2)Te_(3)-based samples(three N-type and three P-type). Using an error propagation model, we systematically analyzed the measurement uncertainties of the three intrinsic parameters and the resulting thermoelectric figure of merit. Our findings reveal that measurement uncertainties for both N-type and P-type Bi_(2)Te_(3)-based materials can be effectively maintained below 5% in the temperature range of 40 K to 300 K. However, the uncertainties increase to over 10% at lower temperatures, primarily due to the relatively smaller values of electrical resistivity and Seebeck coefficients in this regime. This work establishes foundational data for Bi_(2)Te_(3)-based thermoelectric materials and provides a framework for broader investigations of advanced low-temperature thermoelectrics.
基金co-supported by the National Natural Science Foundation of China(Nos.52405293,52375237)China Postdoctoral Science Foundation(No.2024M754219)Shaanxi Province Postdoctoral Research Project Funding,China。
文摘To accomplish the reliability analyses of the correlation of multi-analytical objectives,an innovative framework of Dimensional Synchronous Modeling(DSM)and correlation analysis is developed based on the stepwise modeling strategy,cell array operation principle,and Copula theory.Under this framework,we propose a DSM-based Enhanced Kriging(DSMEK)algorithm to synchronously derive the modeling of multi-objective,and explore an adaptive Copula function approach to analyze the correlation among multiple objectives and to assess the synthetical reliability level.In the proposed DSMEK and adaptive Copula methods,the Kriging model is treated as the basis function of DSMEK model,the Multi-Objective Snake Optimizer(MOSO)algorithm is used to search the optimal values of hyperparameters of basis functions,the cell array operation principle is adopted to establish a whole model of multiple objectives,the goodness of fit is utilized to determine the forms of Copula functions,and the determined Copula functions are employed to perform the reliability analyses of the correlation of multi-analytical objectives.Furthermore,three examples,including multi-objective complex function approximation,aeroengine turbine bladeddisc multi-failure mode reliability analyses and aircraft landing gear system brake temperature reliability analyses,are performed to verify the effectiveness of the proposed methods,from the viewpoints of mathematics and engineering.The results show that the DSMEK and adaptive Copula approaches hold obvious advantages in terms of modeling features and simulation performance.The efforts of this work provide a useful way for the modeling of multi-analytical objectives and synthetical reliability analyses of complex structure/system with multi-output responses.
文摘With the increment of the complexity of structural systems and the span of spatial structures, the interactions between parts of the structures, especially between some flexible substructures, become too complex to be analyzed clearly. In this paper, taking an actual gymnasium of a long-span spatial steel-cable-membrane hybrid structure as the calculation model, the static and dynamic analyses of the hybrid structures are performed by employing the global analysis of the whole hybrid structure and the substructural analysis of the truss arch substructure, the cable-membrane substructure, etc. In addition, the comparison of stresses and displacements of structural members in the global and substructural analyses is made. The numerical results show that serious errors exist in the substructural analysis of the hybrid structure, and the global analysis is necessary for the hybrid structure under the excitation of static loads and seismic loads.
基金This research is supported by the Croatian Science Foundation under the project IP-2018-01-3739,CEEPUS network CIII-HR-0108,European Regional Development Fund under the grant KK.01.1.1.01.0009(DATACROSS)project CEKOM under the grant KK.01.2.2.03.0004,CEI project“COVIDAi”(305.6019-20)University of Rijeka Scientific Grants uniri-tehnic-18-275-1447,uniritehnic-18-18-1146 and uniri-tehnic-18-14.
文摘The thermodynamic(energy and exergy)analysis of a condensate heating system,its segments,and components from a marine steam propulsion plant with steam reheating is performed in this paper.It is found that energy analysis of any condensate heating system should be avoided because it is highly influenced by the measuring equipment accuracy and precision.All the components from the observed marine condensate heating system have energy destructions lower than 3 kW,while the energy efficiencies of this system are higher than 99%.The exergy efficiency of closed condensate heaters continuously increases from the lowest to the highest steam pressures(from 70.10%to 92.29%).The ambient temperature variation between 5℃and 45℃notably influences the exergy efficiency change of both low pressure heaters and the low pressure segment equal to 31.61%,12.37%,and 18.35%,respectively.
文摘This paper summarizes a few spatial statistical analysis methods for to measuring spatial autocorrelation and spatial association, discusses the criteria for the identification of spatial association by the use of global Moran Coefficient, Local Moran and Local Geary. Furthermore, a user-friendly statistical module, combining spatial statistical analysis methods with GIS visual techniques, is developed in Arcview using Avenue. An example is also given to show the usefulness of this module in identifying and quantifying the underlying spatial association patterns between economic units.
基金JSPS-CAS Core-University Program on Basic Research of Nuclear Fusion Reactor Engineering in 2007
文摘In-vessel components are important parts of the EAST superconducting tokamak. They include the plasma facing components, passive plates, cryo-pumps, in-vessel coils, etc. The structural design, analysis and related R＆D have been completed. The divertor is designed in an up-down symmetric configuration to accommodate both double null and single null plasma operation. Passive plates are used for plasma movement control. In-vessel coils are used for the active control of plasma vertical movements. Each cryo-pump can provide an approximately 45 m^3/s pumping rate at a pressure of 10^-1 Pa for particle exhaust. Analysis shows that, when a plasma current of 1 MA disrupts in 3 ms, the EM loads caused by the eddy current and the halo current in a vertical displacement event （VDE） will not generate an unacceptable stress on the divertor structure. The bolted divertor thermal structure with an active cooling system can sustain a load of 2 MW/m^2 up to a 60 s operation if the plasma facing surface temperature is limited to 1500 ℃. Thermal testing and structural optimization testing were conducted to demonstrate the analysis results.
基金Supported by National Natural Science Foundation of China(Grant Nos.U1764251,51775160)Fundamental Research Funds for the Central Universities of China(Grant No.DUT19LAB24)
文摘Ultrasonic welding is an effective ways to achieve a non-reactive/immiscible heterogeneous metal connection, such as the connection of magnesium alloy and titanium alloy. But the thermal mechanism of magnesium alloy/titanium alloy ultrasonic welding has not been defined clearly. In this paper, the experimental and the finite element analysis were adopted to study the thermal mechanism during welding. Through the test, the temperature variation law during the welding process is obtained, and the accuracy of the finite element model is verified. The microscopic analysis indicates that at the welding time of 0.5 s, the magnesium alloy in the center of the solder joint is partially melted and generates the liquid phase. Through the finite element analysis, the friction coefficient of the magnesium–titanium ultrasonic welding interface can be considered as an average constant value of 0.28. The maximum temperature at the interface can exceed 600 ℃ to reach the melting point temperature of the magnesium alloy. The plastic deformation begins after 0.35 s and occurs at the magnesium side at the center of the interface.
基金supported by the Natural Science Foundation of Shaanxi Province of China,No.2018JQ8029(to LG)
文摘Gene spectrum analysis has shown that gene expression and signaling pathways change dramatically after spinal cord injury,which may affect the microenvironment of the damaged site.Microarray analysis provides a new opportunity for investigating diagnosis,treatment,and prognosis of spinal cord injury.However,differentially expressed genes are not consistent among studies,and many key genes and signaling pathways have not yet been accurately studied.GSE5296 was retrieved from the Gene Expression Omnibus DataSet.Differentially expressed genes were obtained using R/Bioconductor software(expression changed at least two-fold;P < 0.05).Database for Annotation,Visualization and Integrated Discovery was used for functional annotation of differentially expressed genes and Animal Transcription Factor Database for predicting potential transcription factors.The resulting transcription regulatory protein interaction network was mapped to screen representative genes and investigate their diagnostic and therapeutic value for disease.In total,this study identified 109 genes that were upregulated and 30 that were downregulated at 0.5,4,and 24 hours,and 3,7,and 28 days after spinal cord injury.The number of downregulated genes was smaller than the number of upregulated genes at each time point.Database for Annotation,Visualization and Integrated Discovery analysis found that many inflammation-related pathways were upregulated in injured spinal cord.Additionally,expression levels of these inflammation-related genes were maintained for at least 28 days.Moreover,399 regulation modes and 77 nodes were shown in the protein-protein interaction network of upregulated differentially expressed genes.Among the 10 upregulated differentially expressed genes with the highest degrees of distribution,six genes were transcription factors.Among these transcription factors,ATF3 showed the greatest change.ATF3 was upregulated within 30 minutes,and its expression levels remained high at28 days after spinal cord injury.These key genes screened by bioinformatics tools can be used as biological markers to diagnose diseases and provide a reference for identifying therapeutic targets.
文摘A new instrument called capacitive drop analyser (CDA) for measuring the physical properties of liquid is developed.A delivery head with a specialized wetting design was constructed for forming drops.The capacitive transducer uses the delivery head as one of its plates and a cylindrical ring plate.Excellent linearity is achieved by optimising the design,with an accuracy of drop volume measurement of approximately 2 μL.It is suitable for measuring both drops in equilibrium and those in the process of growing.Its capability of real time measurement makes it particularly useful for volatile liquids,in which instance the measurement of drop volume using a flowmeter or a pump is no longer reliable.The CDA can also be used to determine concentration.It is found that concentration curve is linear for aqueous glycerol solutions although not so for aqueous ethanol solution.The CDAs capability of measuring surface tension is also explored and experimental results are presented.
文摘The application of the linear guideways is very extensive, such as automation equipment, heavy-duty carry equipment, heavy-cut machining tool, CNC grinding machine, large-scale planning machine and machining center with the demand of high rigidity and heavy load. By means of the study of contact behavior between the roller/guideway and roller/slider, roller type linear guideways can improve the machining accuracy. The goal of this paper is to construct the fatigue life model of the linear guideway, with the help of the contact mechanics of rollers. In beginning, the analyses of the rigidity of a single roller compressed between guideway and slider was conducted. Then, the normal contact pressure of linear guideways was obtained by using the superposition method, and verified by the FEM software (ANSYS workbench). Finally, the bearing life theory proposed by Lundberg and Palmgren was used to describe the contact fatigue life.
文摘This paper deals with the validation and theoretical analyses of a simple method for calculating the intrinsic rate of increase, rm, of aphids and mites. This method does not require a detailed fecundity table data. The value of rm can be estimated by the simple equation: rm=0.74ln (Md)/d, where d is the time from birth to first reproduction; Md is the number of female offspring produced per original female in 2d. This method was developed by Wyatt and White. We reached the following conclusions from our study: When the parameter, Md is less than 1, this equation is not appropriate for estimating rm of populations; When the parameter, Md is larger than 1 and about 70% or more of the reproductive contribution to the rm is achieved in 2d, the equation is appropriate for calculatng the rm of aphids and mites.As Md decreases, the required reproductive contribution to the rm in 2d corresponding to the constant 0.74 will increase. However, whether 70% or more of reproductive contribution to rm is achieved in 2d still is a problem for whole taxa of aphids and mites. Therefore, further siudy on reproductive distribution will be required for practical application of this method.
