By using c-Ha-ras-1, N-ras Wigler (left sequence) and P52C.(right sequence), c-sis, v-erbB, c-myc and v-fos oncogenes as probes, restriction fragment length polymorphisms (RFLPs) of tumor tissue DNAs of 95 patients wi...By using c-Ha-ras-1, N-ras Wigler (left sequence) and P52C.(right sequence), c-sis, v-erbB, c-myc and v-fos oncogenes as probes, restriction fragment length polymorphisms (RFLPs) of tumor tissue DNAs of 95 patients with gastric carcinoma, primary hepatic carcinoma and brain tumor, and those of 90 normal individuals were studied with the techniques of Southern blot and dot blot. Gene amplification and recombination were also examined in some tumors simultaneously. Some alleles of oncogene are reported in Chinese population for the first time. Moreover, the characteristic frequency of some "rare" alleles and genotypes occurred in some tumor samples is significantly higher than that occured in normal individuals. Pedigree analysis for 2 patients showed that some "rare" alleles are also abandant. Besides, gene amplification and recombination were found in some tumors.展开更多
The pulse amplification in the dispersion-decreasing fiber （DDF） is investigated via symbolic computation to solve the variable-coefficient higher-order nonlinear Schrfdinger equation with the effects of third-order...The pulse amplification in the dispersion-decreasing fiber （DDF） is investigated via symbolic computation to solve the variable-coefficient higher-order nonlinear Schrfdinger equation with the effects of third-order dispersion, self-steepening, and stimulated Raman scattering. The analytic one-soliton solution of this model is obtained with a set of parametric conditions. Based on this solution, the fundamental soliton is shown to be amplified in the DDF. The comparison of the amplitude of pulses for different dispersion profiles of the DDF is also performed through the graphical analysis. The results of this paper would be of certain value to the study of signal amplification and pulse compression.展开更多
Due to its low latency,byte-addressable,non-volatile,and high density,persistent memory(PM)is expected to be used to design a high-performance storage system.However,PM also has disadvantages such as limited endurance...Due to its low latency,byte-addressable,non-volatile,and high density,persistent memory(PM)is expected to be used to design a high-performance storage system.However,PM also has disadvantages such as limited endurance,thereby proposing challenges to traditional index technologies such as B(+)tree.B(+)tree is originally designed for dynamic random access memory(DRAM)-based or disk-based systems and has a large write amplification problem.The high write amplification is detrimental to a PM-based system.This paper proposes WO-tree,a write-optimized B(+)tree for PM.WO-tree adopts an unordered write mechanism for the leaf nodes,and the unordered write mechanism can reduce a large number of write operations caused by maintaining the entry order in the leaf nodes.When the leaf node is split,WO-tree performs the cache line flushing operation after all write operations are completed,which can reduce frequent data flushing operations.WO-tree adopts a partial logging mechanism and it only writes the log for the leaf node.The inner node recognizes the data inconsistency by the read operation and the data can be recovered using the leaf node information,thereby significantly reducing the logging overhead.Furthermore,WO-tree adopts a lock-free search for inner nodes,which reduces the locking overhead for concurrency operation.We evaluate WO-tree using the Yahoo!Cloud Serving Benchmark(YCSB)workloads.Compared with traditional B(+)tree,wB-tree,and Fast-Fair,the number of cache line flushes caused by WO-tree insertion operations is reduced by 84.7%,22.2%,and 30.8%,respectively,and the execution time is reduced by 84.3%,27.3%,and 44.7%,respectively.展开更多
文摘By using c-Ha-ras-1, N-ras Wigler (left sequence) and P52C.(right sequence), c-sis, v-erbB, c-myc and v-fos oncogenes as probes, restriction fragment length polymorphisms (RFLPs) of tumor tissue DNAs of 95 patients with gastric carcinoma, primary hepatic carcinoma and brain tumor, and those of 90 normal individuals were studied with the techniques of Southern blot and dot blot. Gene amplification and recombination were also examined in some tumors simultaneously. Some alleles of oncogene are reported in Chinese population for the first time. Moreover, the characteristic frequency of some "rare" alleles and genotypes occurred in some tumor samples is significantly higher than that occured in normal individuals. Pedigree analysis for 2 patients showed that some "rare" alleles are also abandant. Besides, gene amplification and recombination were found in some tumors.
基金Supported by the National Natural Science Foundation of China under Grant No.60772023the Open Fund of the State Key Laboratory of Software Development Environment under Grant No.BUAA-SKLSDE-09KF-04+3 种基金Beijing University of Aeronautics and Astronauticsthe National Basic Research Program of China (973 Program) under Grant No.2005CB321901the Specialized Research Fund for the Doctoral Program of Higher Education under Grant Nos.20060006024 and 20080013006Chinese Ministry of Education
文摘The pulse amplification in the dispersion-decreasing fiber （DDF） is investigated via symbolic computation to solve the variable-coefficient higher-order nonlinear Schrfdinger equation with the effects of third-order dispersion, self-steepening, and stimulated Raman scattering. The analytic one-soliton solution of this model is obtained with a set of parametric conditions. Based on this solution, the fundamental soliton is shown to be amplified in the DDF. The comparison of the amplitude of pulses for different dispersion profiles of the DDF is also performed through the graphical analysis. The results of this paper would be of certain value to the study of signal amplification and pulse compression.
基金supported in part by the National Natural Science Foundation of China under Grant Nos.U1709220,U2001203,61821003,61872413,and 61902137in part by the National Key Research and Development Program of China under Grant No.2018YFB1003305in part by the Key-Area Research and Development Program of Guangdong Province of China under Grant No.2019B010107001.
文摘Due to its low latency,byte-addressable,non-volatile,and high density,persistent memory(PM)is expected to be used to design a high-performance storage system.However,PM also has disadvantages such as limited endurance,thereby proposing challenges to traditional index technologies such as B(+)tree.B(+)tree is originally designed for dynamic random access memory(DRAM)-based or disk-based systems and has a large write amplification problem.The high write amplification is detrimental to a PM-based system.This paper proposes WO-tree,a write-optimized B(+)tree for PM.WO-tree adopts an unordered write mechanism for the leaf nodes,and the unordered write mechanism can reduce a large number of write operations caused by maintaining the entry order in the leaf nodes.When the leaf node is split,WO-tree performs the cache line flushing operation after all write operations are completed,which can reduce frequent data flushing operations.WO-tree adopts a partial logging mechanism and it only writes the log for the leaf node.The inner node recognizes the data inconsistency by the read operation and the data can be recovered using the leaf node information,thereby significantly reducing the logging overhead.Furthermore,WO-tree adopts a lock-free search for inner nodes,which reduces the locking overhead for concurrency operation.We evaluate WO-tree using the Yahoo!Cloud Serving Benchmark(YCSB)workloads.Compared with traditional B(+)tree,wB-tree,and Fast-Fair,the number of cache line flushes caused by WO-tree insertion operations is reduced by 84.7%,22.2%,and 30.8%,respectively,and the execution time is reduced by 84.3%,27.3%,and 44.7%,respectively.
