Objective:To investigate the potential of hydro-alcoholic extract of Gentiana lutea roots(GLE)in scopolamine-induced amnesia model in mice.Methods:The active chemical constituents were determined by GC-MS analysis.In ...Objective:To investigate the potential of hydro-alcoholic extract of Gentiana lutea roots(GLE)in scopolamine-induced amnesia model in mice.Methods:The active chemical constituents were determined by GC-MS analysis.In vitro antioxidant activity was performed by the DPPH free radical scavenging method.Ex vivo anti-acetylcholinesterase assay was conducted to investigate the effect on the cholinergic system.A scopolamine-induced memory impairment model was used.The levels of beta-amyloid(Aβ)and tau protein were measured.The behavioral studies were performed through Morris water maze and passive avoidance learning tests,followed by estimation of biochemical markers(GSH and MDA),immunohistochemistry,and histopathological studies on isolated brain tissues.Results:GLE exhibited DPPH free radical scavenging activity with an IC50 value of(76.68±2.28)μg/mL.GLE also manifested inhibitory effect on acetylcholinesterase[IC50(36.58±0.73)μg/mL]to upregulate the cholinergic system.GLE at 200 mg/kg and 400 mg/kg significantly restored the memory impairment induced by scopolamine.GLE at 200 mg/kg and 400 mg/kg significantly reduced brain oxidative stress(P<0.001).Immunohistochemistry investigation showed a significant reduction in Aβdeposition and p-tau protein expression in the GLE treatment groups(P<0.001).Administration of GLE effectively reduced scopolamine-induced neuronal damage in a dose-dependent manner.Conclusions:The study demonstrates that GLE ameliorates scopolamine-induced memory impairment by alleviating Aβ/p-tau protein accumulation and upregulation in the cholinergic system to improve cognitive dysfunction and behavioral problems.展开更多
BACKGROUND Stroke is an important cause of maternal morbidity and mortality during pregnancy and puerperium.Isolated amnesia is a rare clinical symptom caused by ischemic stroke during pregnancy.We present the first d...BACKGROUND Stroke is an important cause of maternal morbidity and mortality during pregnancy and puerperium.Isolated amnesia is a rare clinical symptom caused by ischemic stroke during pregnancy.We present the first documented case of acute amnesia during pregnancy due to bilateral fornix infarction.CASE SUMMARY A 32-year-old nullipara presented at 35 wk of gestation with acute amnesia and headache.Brain magnetic resonance imaging and angiography revealed acute infarction in the bilateral anterior fornix.There was no evidence of causative abnormality after extensive work-up,including for vascular abnormality,cardiac disease,coagulopathy,and pregnancy-related conditions.The patient was diagnosed with cryptogenic stroke.Aspirin was administered immediately,and the patient recovered fully without recurrence.CONCLUSION Acute isolated amnesia due to stroke is rare during pregnancy.Early diagnosis of stroke and immediate treatment prevent neurologic sequelae.展开更多
In the present study we investigated the anti-amnesic activity of Vitex negundo in scopolamine induced amnesia in rats. Wistar rats (180-200 g) were trained on active avoidance task. Each animal received session of 15...In the present study we investigated the anti-amnesic activity of Vitex negundo in scopolamine induced amnesia in rats. Wistar rats (180-200 g) were trained on active avoidance task. Each animal received session of 15 trials with inter trial duration of 15 s for 5 days. Scopolamine (3 mg/kg, i.p) was administered at different time periods on the basis of stages of memory i.e acquisition, consolidation and retention in different groups (n = 6). Effect of Vitex negundo extract was evaluated and compared to a standard drug, Donepezil. Significant (p 【0.05) increase in the avoidance response on the 5th session has been observed as compared to 1st session in control group. Scopolamine treatment significantly (p 【0.05) reduced the avoidance response compared to control. Extract treated groups shown significant (p 【0.05) increase in number of avoidance responses as compared to scopolamine treated groups. Increased oxidative stress in brain after scopolamine treatment, as observed by increase in MDA &decrease in GSH &SOD, was lowered in the groups treated with extracts. AChE activity was also improved after V. negundo treatment. Results of the study have shown that V. negundo treated groups decrease the phenomenon of amnesia by increasing learning of memory through antioxidant effect and decreasing AChE activity.展开更多
In Marilynne Robinson's Gilead,the first John Ames is the memory-individual whose personal memory serves as the living memory to combat the collective historical amnesia of Iowa’s antislavery movement.For all his...In Marilynne Robinson's Gilead,the first John Ames is the memory-individual whose personal memory serves as the living memory to combat the collective historical amnesia of Iowa’s antislavery movement.For all his efforts,memory is framed by the present.Gilead has forgotten its abolitionist root and anti-racial discrimination tradition.The individual effort to resist collective historical amnesia fails.Through the first Ames’s failure,Robinson presents the politics of memory,particularly the struggle between individual memory and collective historical amnesia.The historical amnesia of abolitionism over Gilead is Robinson’s criticism of the present societal betrayal of the pursuit of racial equality as epitomized in the historical antislavery movement.Robinson’s memory writing in Gilead is also her literary endeavor to remember the forgotten history and to reflect upon the racial issue pervading present American society.展开更多
To facilitate gathering information during a psychiatric interview, some psychiatrists advocate augmenting the interview using drugs. Rather than barbiturates, benzodiazepines have been used for drug-assisted intervie...To facilitate gathering information during a psychiatric interview, some psychiatrists advocate augmenting the interview using drugs. Rather than barbiturates, benzodiazepines have been used for drug-assisted interviews. Dissociative amnesia is one of the indications for these interviews. Herein, we present the case of a 15-year-old female who was diagnosed as having dissociative amnesia because of conflicts with her friends. She was administered a Iorazepam-assisted interview to aid recovery of her memories. In this case, a small dose of Iorazepam was sufficient to recover her memories without any adverse effects.展开更多
It has been known that peripheral adverse event is caused by peripheral antimuscarinic action, from hyoscine butylbromide (Buscopan; Boehringer Ingelheim, Germany) used as a premedication for endoscopy. However, sympt...It has been known that peripheral adverse event is caused by peripheral antimuscarinic action, from hyoscine butylbromide (Buscopan; Boehringer Ingelheim, Germany) used as a premedication for endoscopy. However, symptoms or signs associated with the central nervous system are rarely reported in the field of anesthesiology and peripartum labor. This central anticholinergic syndrome is likely caused by blockade of muscarinic cholinergic receptors in the central nervous system. There is no report on Buscopan-induced central anticholinergic syndrome in endoscopy room so far. Three middle-aged females unexpectedly suffered from anterograde amnesia after intramuscular injection of hyoscine butylbromide as an antispasmodic premedication for endoscopy at our endoscopy unit in the Health Promotion Center.展开更多
Epiduroscopy (EDS) allows diagnosis and treatment of spinal nerve root pathology by a fiberoptic device inserted percutaneously in the epidural space. Transient global amnesia syndrome (TGA) is defined by an abrupt on...Epiduroscopy (EDS) allows diagnosis and treatment of spinal nerve root pathology by a fiberoptic device inserted percutaneously in the epidural space. Transient global amnesia syndrome (TGA) is defined by an abrupt onset of an anterograde and retrograde amnesia that lasts up to 24 h, although mild subclinical neuropsychological deficits, with concomitant vegetative symptoms, can last for days after the episode. To our knowledge no cases of TGA in association with EDS have been recognized. We present a case of a 54-year-old man who was admitted for EDS, having experienced two times the failed surgery for spinal and left leg pain. During the EDS, 10 ml of non-ionic contrast media (CM) was injected to confirm the inside lesions. The epidural adhesions were gently broken down and drugs were injected around any inflamed nerve roots. Immediately after EDS, the patient experienced a TGA with loss of memory for the recent procedure and an impaired ability to retain new information. There were no signs of confusion or altered conscious level or seizure activities and neurological examination was normal. At 24 h a cranial computerized tomography (cCT) without CM showed “abnormal contrast enhancement at subarachnoid liquoral spaces levels”, then at 72 h cCT control was normal. The patient was discharged on the seventh day with perioperative lacunar amnesia persisting at this time. Herein, we sought a possible relationship between neurotoxic effect of CM and TGA in a patient emotionally stressed, even if the CM dose was given as a normal clinical range.展开更多
This case study addresses episodic memory impairment or focal retrograde amnesia related to limbic encephalitis. The patient in question was a right-handed man in his 60s who developed focal retrograde amnesia due to ...This case study addresses episodic memory impairment or focal retrograde amnesia related to limbic encephalitis. The patient in question was a right-handed man in his 60s who developed focal retrograde amnesia due to limbic encephalitis. An abnormal MRI signal was observed in the right medial temporal lobe. Immediately after the encephalitis onset, mental symptoms—including impaired consciousness, disorientation, hallucinations, and delusions—appeared;however, his condition improved with medical treatment. After transfer to a convalescent and rehabilitation hospital, various neuropsychological tests were conducted but no apparent functional decline was observed in intellectual function, attention, memorization, or retention. However, the patient exhibited impairments related to autobiographical memory and memory of events 4?-?5 years before the onset of limbic encephalitis. Based on these observations, the patient was considered to exhibit focal retrograde amnesia due to limbic encephalitis. Despite exhibiting retrograde amnesia, he had no difficulty in his daily life in the ward. Moreover, after discharge from hospital, smooth work reinstatement was possible. This case demonstrates that, even after exhibiting retrograde amnesia, if its duration is relatively short and physical function and other higher-order brain functions are sustained, social rehabilitation—including work reinstatement—is feasible.展开更多
Although there have been a limited number of case reports of human bilateral hippocampal injury, none of these have addressed the impact of such injuries on medical decision making capacity. The authors present a case...Although there have been a limited number of case reports of human bilateral hippocampal injury, none of these have addressed the impact of such injuries on medical decision making capacity. The authors present a case of an elderly man with discrete bilateral hippocampal injury. As a result of his injury, the patient was hopelessly “lost in the present” and only retained the basic cognitive functions necessary to have decision making capacity for a limited period of time. He was unable to appreciate the nature of his injury, the potential risks involved in his decisions, and the recommended course of treatment longer than a few minutes. The patient’s resultant neurocognitive deficits left him lacking medical decision making capacity, a likely outcome for patients with persistent anterograde amnesia.展开更多
It is becoming more and more common in modern life that people forget words when they write. Based on the Logistics model, this study conducts a systematic empirical analysis on the influencing factors and heterogenei...It is becoming more and more common in modern life that people forget words when they write. Based on the Logistics model, this study conducts a systematic empirical analysis on the influencing factors and heterogeneity of this phenomenon through a questionnaire survey of college students in Kaifeng City, He’nan Province. The results show that students professional differences, Chinese character use habits, environmental edification and attitude towards this phenomenon have an effect of 2.2%~5.4%. The higher the frequency of learning and output using electronic devices, the more likely it is that the phenomenon of character amnesia will appear. Moreover, this effect has both gender and grade heterogeneity.展开更多
OBJECTIVE: To study cognitive function and cerebral metabolic changes in patients with transient global amnesia (TGA). METHODS: Three patients with TGA were given mini-mental state examination (MMSE), revised Wechsler...OBJECTIVE: To study cognitive function and cerebral metabolic changes in patients with transient global amnesia (TGA). METHODS: Three patients with TGA were given mini-mental state examination (MMSE), revised Wechsler memory scale (WMS-R) examination and magnetic resonance imaging (MRI) scans after they had been diagnosed as TGA. Using (18)F labelled deoxyglucose as tracer, patients were given a positron emission tomography (PET) examination at different periods during recovery. RESULTS: No obvious abnormality was found in MMSE and MRI scans in the three patients. However, WMS-R examination and cerebral PET imaging displayed cognitive dysfunction of varying degrees and low metabolism in local areas related to memory in 2 of 3 patients. CONCLUSIONS: In TGA patients, cognitive function and cerebral metabolic levels are closely correlated with duration of symptoms. It is necessary to stop the TGA attack as quickly as possible early time.展开更多
The moment we open our eyes,we experience a rich and detailed visual world,but the amount of information available to report is rather limited.This dissociation relates to a major debate regarding the nature of visual...The moment we open our eyes,we experience a rich and detailed visual world,but the amount of information available to report is rather limited.This dissociation relates to a major debate regarding the nature of visual consciousness.The overflow argument suggests that our conscious experience is quite rich and far beyond what can be reported,standing in sharp contrast to the nooverflow argument that visual consciousness is severely impoverished and limited to what can be reported.In this paper,we systematically reviewed existing evidence in favor of the overflow argument,including studies of several variations of the iconic memory paradigm and the divided attention paradigm,as well as studies of neural correlates of consciousness.Simultaneously,we expounded some critical objections and alternative interpretations to such evidence,as well as some opposing evidence.Finally,we introduced a series of our recent studies based on a striking phenomenon of attribute amnesia,which we believe could provide new insight into the overflow view of visual consciousness.展开更多
目的观察柔肝调神针刺法联合认知训练治疗肝郁血虚型帕金森病轻度认知障碍(Parkinson’sdisease with mild cog-nitive impairment,PD-MCI)的临床效果。方法临床收集62例肝郁血虚型PD-MCI患者,随机分为观察组和对照组。观察组予以柔肝...目的观察柔肝调神针刺法联合认知训练治疗肝郁血虚型帕金森病轻度认知障碍(Parkinson’sdisease with mild cog-nitive impairment,PD-MCI)的临床效果。方法临床收集62例肝郁血虚型PD-MCI患者,随机分为观察组和对照组。观察组予以柔肝调神针刺法联合认知训练治疗,对照组予以认知训练治疗。2组均采用简明精神状态检查表(MMSE)、蒙特利尔认知评估量表(MoCA)和帕金森病生活质量量表(PDQ-39)进行评价。结果治疗后,2组肝郁血虚型PD-MCI患者MMSE评分和MoCA评分均提高,PDQ-39评分均降低,且观察组各项评分均明显优于对照组(P<0.05)。结论柔肝调神针刺法联合认知训练治疗肝郁血虚型PD-MCI效果明显,能有效改善患者认知功能,提高患者生活质量,值得临床推广运用。展开更多
文摘Objective:To investigate the potential of hydro-alcoholic extract of Gentiana lutea roots(GLE)in scopolamine-induced amnesia model in mice.Methods:The active chemical constituents were determined by GC-MS analysis.In vitro antioxidant activity was performed by the DPPH free radical scavenging method.Ex vivo anti-acetylcholinesterase assay was conducted to investigate the effect on the cholinergic system.A scopolamine-induced memory impairment model was used.The levels of beta-amyloid(Aβ)and tau protein were measured.The behavioral studies were performed through Morris water maze and passive avoidance learning tests,followed by estimation of biochemical markers(GSH and MDA),immunohistochemistry,and histopathological studies on isolated brain tissues.Results:GLE exhibited DPPH free radical scavenging activity with an IC50 value of(76.68±2.28)μg/mL.GLE also manifested inhibitory effect on acetylcholinesterase[IC50(36.58±0.73)μg/mL]to upregulate the cholinergic system.GLE at 200 mg/kg and 400 mg/kg significantly restored the memory impairment induced by scopolamine.GLE at 200 mg/kg and 400 mg/kg significantly reduced brain oxidative stress(P<0.001).Immunohistochemistry investigation showed a significant reduction in Aβdeposition and p-tau protein expression in the GLE treatment groups(P<0.001).Administration of GLE effectively reduced scopolamine-induced neuronal damage in a dose-dependent manner.Conclusions:The study demonstrates that GLE ameliorates scopolamine-induced memory impairment by alleviating Aβ/p-tau protein accumulation and upregulation in the cholinergic system to improve cognitive dysfunction and behavioral problems.
文摘BACKGROUND Stroke is an important cause of maternal morbidity and mortality during pregnancy and puerperium.Isolated amnesia is a rare clinical symptom caused by ischemic stroke during pregnancy.We present the first documented case of acute amnesia during pregnancy due to bilateral fornix infarction.CASE SUMMARY A 32-year-old nullipara presented at 35 wk of gestation with acute amnesia and headache.Brain magnetic resonance imaging and angiography revealed acute infarction in the bilateral anterior fornix.There was no evidence of causative abnormality after extensive work-up,including for vascular abnormality,cardiac disease,coagulopathy,and pregnancy-related conditions.The patient was diagnosed with cryptogenic stroke.Aspirin was administered immediately,and the patient recovered fully without recurrence.CONCLUSION Acute isolated amnesia due to stroke is rare during pregnancy.Early diagnosis of stroke and immediate treatment prevent neurologic sequelae.
文摘In the present study we investigated the anti-amnesic activity of Vitex negundo in scopolamine induced amnesia in rats. Wistar rats (180-200 g) were trained on active avoidance task. Each animal received session of 15 trials with inter trial duration of 15 s for 5 days. Scopolamine (3 mg/kg, i.p) was administered at different time periods on the basis of stages of memory i.e acquisition, consolidation and retention in different groups (n = 6). Effect of Vitex negundo extract was evaluated and compared to a standard drug, Donepezil. Significant (p 【0.05) increase in the avoidance response on the 5th session has been observed as compared to 1st session in control group. Scopolamine treatment significantly (p 【0.05) reduced the avoidance response compared to control. Extract treated groups shown significant (p 【0.05) increase in number of avoidance responses as compared to scopolamine treated groups. Increased oxidative stress in brain after scopolamine treatment, as observed by increase in MDA &decrease in GSH &SOD, was lowered in the groups treated with extracts. AChE activity was also improved after V. negundo treatment. Results of the study have shown that V. negundo treated groups decrease the phenomenon of amnesia by increasing learning of memory through antioxidant effect and decreasing AChE activity.
基金funded by Guangdong Polytechnic Normal University(2021SDKYB087).
文摘In Marilynne Robinson's Gilead,the first John Ames is the memory-individual whose personal memory serves as the living memory to combat the collective historical amnesia of Iowa’s antislavery movement.For all his efforts,memory is framed by the present.Gilead has forgotten its abolitionist root and anti-racial discrimination tradition.The individual effort to resist collective historical amnesia fails.Through the first Ames’s failure,Robinson presents the politics of memory,particularly the struggle between individual memory and collective historical amnesia.The historical amnesia of abolitionism over Gilead is Robinson’s criticism of the present societal betrayal of the pursuit of racial equality as epitomized in the historical antislavery movement.Robinson’s memory writing in Gilead is also her literary endeavor to remember the forgotten history and to reflect upon the racial issue pervading present American society.
文摘To facilitate gathering information during a psychiatric interview, some psychiatrists advocate augmenting the interview using drugs. Rather than barbiturates, benzodiazepines have been used for drug-assisted interviews. Dissociative amnesia is one of the indications for these interviews. Herein, we present the case of a 15-year-old female who was diagnosed as having dissociative amnesia because of conflicts with her friends. She was administered a Iorazepam-assisted interview to aid recovery of her memories. In this case, a small dose of Iorazepam was sufficient to recover her memories without any adverse effects.
文摘It has been known that peripheral adverse event is caused by peripheral antimuscarinic action, from hyoscine butylbromide (Buscopan; Boehringer Ingelheim, Germany) used as a premedication for endoscopy. However, symptoms or signs associated with the central nervous system are rarely reported in the field of anesthesiology and peripartum labor. This central anticholinergic syndrome is likely caused by blockade of muscarinic cholinergic receptors in the central nervous system. There is no report on Buscopan-induced central anticholinergic syndrome in endoscopy room so far. Three middle-aged females unexpectedly suffered from anterograde amnesia after intramuscular injection of hyoscine butylbromide as an antispasmodic premedication for endoscopy at our endoscopy unit in the Health Promotion Center.
文摘Epiduroscopy (EDS) allows diagnosis and treatment of spinal nerve root pathology by a fiberoptic device inserted percutaneously in the epidural space. Transient global amnesia syndrome (TGA) is defined by an abrupt onset of an anterograde and retrograde amnesia that lasts up to 24 h, although mild subclinical neuropsychological deficits, with concomitant vegetative symptoms, can last for days after the episode. To our knowledge no cases of TGA in association with EDS have been recognized. We present a case of a 54-year-old man who was admitted for EDS, having experienced two times the failed surgery for spinal and left leg pain. During the EDS, 10 ml of non-ionic contrast media (CM) was injected to confirm the inside lesions. The epidural adhesions were gently broken down and drugs were injected around any inflamed nerve roots. Immediately after EDS, the patient experienced a TGA with loss of memory for the recent procedure and an impaired ability to retain new information. There were no signs of confusion or altered conscious level or seizure activities and neurological examination was normal. At 24 h a cranial computerized tomography (cCT) without CM showed “abnormal contrast enhancement at subarachnoid liquoral spaces levels”, then at 72 h cCT control was normal. The patient was discharged on the seventh day with perioperative lacunar amnesia persisting at this time. Herein, we sought a possible relationship between neurotoxic effect of CM and TGA in a patient emotionally stressed, even if the CM dose was given as a normal clinical range.
文摘This case study addresses episodic memory impairment or focal retrograde amnesia related to limbic encephalitis. The patient in question was a right-handed man in his 60s who developed focal retrograde amnesia due to limbic encephalitis. An abnormal MRI signal was observed in the right medial temporal lobe. Immediately after the encephalitis onset, mental symptoms—including impaired consciousness, disorientation, hallucinations, and delusions—appeared;however, his condition improved with medical treatment. After transfer to a convalescent and rehabilitation hospital, various neuropsychological tests were conducted but no apparent functional decline was observed in intellectual function, attention, memorization, or retention. However, the patient exhibited impairments related to autobiographical memory and memory of events 4?-?5 years before the onset of limbic encephalitis. Based on these observations, the patient was considered to exhibit focal retrograde amnesia due to limbic encephalitis. Despite exhibiting retrograde amnesia, he had no difficulty in his daily life in the ward. Moreover, after discharge from hospital, smooth work reinstatement was possible. This case demonstrates that, even after exhibiting retrograde amnesia, if its duration is relatively short and physical function and other higher-order brain functions are sustained, social rehabilitation—including work reinstatement—is feasible.
文摘Although there have been a limited number of case reports of human bilateral hippocampal injury, none of these have addressed the impact of such injuries on medical decision making capacity. The authors present a case of an elderly man with discrete bilateral hippocampal injury. As a result of his injury, the patient was hopelessly “lost in the present” and only retained the basic cognitive functions necessary to have decision making capacity for a limited period of time. He was unable to appreciate the nature of his injury, the potential risks involved in his decisions, and the recommended course of treatment longer than a few minutes. The patient’s resultant neurocognitive deficits left him lacking medical decision making capacity, a likely outcome for patients with persistent anterograde amnesia.
文摘It is becoming more and more common in modern life that people forget words when they write. Based on the Logistics model, this study conducts a systematic empirical analysis on the influencing factors and heterogeneity of this phenomenon through a questionnaire survey of college students in Kaifeng City, He’nan Province. The results show that students professional differences, Chinese character use habits, environmental edification and attitude towards this phenomenon have an effect of 2.2%~5.4%. The higher the frequency of learning and output using electronic devices, the more likely it is that the phenomenon of character amnesia will appear. Moreover, this effect has both gender and grade heterogeneity.
文摘OBJECTIVE: To study cognitive function and cerebral metabolic changes in patients with transient global amnesia (TGA). METHODS: Three patients with TGA were given mini-mental state examination (MMSE), revised Wechsler memory scale (WMS-R) examination and magnetic resonance imaging (MRI) scans after they had been diagnosed as TGA. Using (18)F labelled deoxyglucose as tracer, patients were given a positron emission tomography (PET) examination at different periods during recovery. RESULTS: No obvious abnormality was found in MMSE and MRI scans in the three patients. However, WMS-R examination and cerebral PET imaging displayed cognitive dysfunction of varying degrees and low metabolism in local areas related to memory in 2 of 3 patients. CONCLUSIONS: In TGA patients, cognitive function and cerebral metabolic levels are closely correlated with duration of symptoms. It is necessary to stop the TGA attack as quickly as possible early time.
基金supported by the National Natural Science Foundation of China(31771201)National Science Foundation for Distinguished Young Scholars of Zhejiang Province,China(LR19C090002)Humanities and Social Sciences Foundation of the Ministry of Education of China(17YJA190001)。
文摘The moment we open our eyes,we experience a rich and detailed visual world,but the amount of information available to report is rather limited.This dissociation relates to a major debate regarding the nature of visual consciousness.The overflow argument suggests that our conscious experience is quite rich and far beyond what can be reported,standing in sharp contrast to the nooverflow argument that visual consciousness is severely impoverished and limited to what can be reported.In this paper,we systematically reviewed existing evidence in favor of the overflow argument,including studies of several variations of the iconic memory paradigm and the divided attention paradigm,as well as studies of neural correlates of consciousness.Simultaneously,we expounded some critical objections and alternative interpretations to such evidence,as well as some opposing evidence.Finally,we introduced a series of our recent studies based on a striking phenomenon of attribute amnesia,which we believe could provide new insight into the overflow view of visual consciousness.
文摘目的观察柔肝调神针刺法联合认知训练治疗肝郁血虚型帕金森病轻度认知障碍(Parkinson’sdisease with mild cog-nitive impairment,PD-MCI)的临床效果。方法临床收集62例肝郁血虚型PD-MCI患者,随机分为观察组和对照组。观察组予以柔肝调神针刺法联合认知训练治疗,对照组予以认知训练治疗。2组均采用简明精神状态检查表(MMSE)、蒙特利尔认知评估量表(MoCA)和帕金森病生活质量量表(PDQ-39)进行评价。结果治疗后,2组肝郁血虚型PD-MCI患者MMSE评分和MoCA评分均提高,PDQ-39评分均降低,且观察组各项评分均明显优于对照组(P<0.05)。结论柔肝调神针刺法联合认知训练治疗肝郁血虚型PD-MCI效果明显,能有效改善患者认知功能,提高患者生活质量,值得临床推广运用。
