Existing evidence suggests residential greenness is beneficial to human,while no research to date explored the associations of greenness with age-related macular degeneration(AMD).To evaluate the association of greenn...Existing evidence suggests residential greenness is beneficial to human,while no research to date explored the associations of greenness with age-related macular degeneration(AMD).To evaluate the association of greenness with AMD,modification and mediation effect of air pollution,we conducted this prospective study.We con-structed weighted quantile sum(WQS)index as co-exposure to nitrogen oxides(NO_(x)),particulate matter<2.5μm(PM_(2.5)),particulate matter<10μm(PM10).Stratified Cox regression models were applied to test the effect of exposure.Effect modification of air pollution was assessed.Stratified Cox models through the indirect method and Aalen additive risk models were used in mediation analysis.Over median follow-up of 11.67 years,4596 AMD events were ascertained.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)of incident AMD for pollution per interquartile range(IQR)increment were 1.10(1.04–1.16)for nitrogen dioxide(NO_(2)),1.09(1.03–1.15)for NO_(x),1.14(1.05–1.24)for PM_(2.5),1.13(1.05–1.21)for PM10.The HR(95%CI)of AMD associated with greenness 1000 m buffer per IQR increment was 0.91(0.86–0.97),300 m buffer was 0.94(0.89–0.99).The as-sociation between greenness 1000 m and AMD was 28.59%,44.77%,35.59%,32.31%and 27.08%mediated by the decreased WQS index,NO_(2),NO_(x),PM_(2.5) and PM10,respectively.Increased greenness was associated with lower AMD incidence,and air pollution partly mediate it,which implies that interventions aimed at improving air quality and increasing greenness could have a dual benefit in mitigating AMD risk.展开更多
AMD:年龄相关性黄斑变性(age-related macular degeneration)ANOVA:方差分析(analysis of variance)BUT:泪膜破裂时间(breakup time of tear film)DR:糖尿病视网膜病变(diabetic retinopathy)EAU:实验性自身免疫性葡萄膜炎(experimental...AMD:年龄相关性黄斑变性(age-related macular degeneration)ANOVA:方差分析(analysis of variance)BUT:泪膜破裂时间(breakup time of tear film)DR:糖尿病视网膜病变(diabetic retinopathy)EAU:实验性自身免疫性葡萄膜炎(experimental autoimmune uveitis)EGF:表皮生长因子(epidermal growth factor)ELISA:酶联免疫吸附测定(enzyme-linked immunosorbent assay)ERG:视网膜电图(electroretinogram)FFA:荧光素眼底血管造影(fundus fluorescein angiography).展开更多
AMD:年龄相关性黄斑变性(age-related macular degeneration)ANOVA:方差分析(analysis of variance)BUT:泪膜破裂时间(breakup time of tear film)DR:糖尿病视网膜病变(diabetic retinopathy)EAU:实验性自身免疫性葡萄膜炎(experimental...AMD:年龄相关性黄斑变性(age-related macular degeneration)ANOVA:方差分析(analysis of variance)BUT:泪膜破裂时间(breakup time of tear film)DR:糖尿病视网膜病变(diabetic retinopathy)EAU:实验性自身免疫性葡萄膜炎(experimental autoimmune uveitis)。展开更多
The fusion dynamics of ^(6)Li and ^(7)Li projectiles incident on the ^(13)C and ^(12)C targets,respectively,near the Coulomb barrier,were investigated theoretically using the antisymmetrized molecular dynamics(AMD)mod...The fusion dynamics of ^(6)Li and ^(7)Li projectiles incident on the ^(13)C and ^(12)C targets,respectively,near the Coulomb barrier,were investigated theoretically using the antisymmetrized molecular dynamics(AMD)model.Within the AMD framework,the ground-state configurations of ^(6)Li and ^(7)Li exhibit pronounced deformation characterized by well-developed d+α and t+α clustering structures,respectively.Reaction simulations were performed across a center-of-mass energy range of 3−7.6MeV,encompassing the fusion barrier region.The total fusion cross sections computed as a function of collision energy demon-strate favorable quantitative agreement with the experimental values at energies above the Coulomb barrier.Additionally,a detailed comparison was made of the partial cross sections into specific residual fragments predicted by AMD at different center-of-mass energies.The AMD model provides a robust microscopic description of light-heavy-ion fusion dynamics and captures the role of extended density distributions and cluster correlations within interacting nuclei.展开更多
基金supported by the High-level Talents Introduction Plan from Central South University(No.502045003)the National Natural Science Foundation of China(No.42277438)Hunan Provincial Natural Science Foundation for Distinguished Young Scholars(No.2024JJ2082)to Fang Xiao,and the Postgraduate Independent Exploration and Innovation Project of Central South University,China(Nos.2024ZZTS0557 and 2023ZZTS0993)。
文摘Existing evidence suggests residential greenness is beneficial to human,while no research to date explored the associations of greenness with age-related macular degeneration(AMD).To evaluate the association of greenness with AMD,modification and mediation effect of air pollution,we conducted this prospective study.We con-structed weighted quantile sum(WQS)index as co-exposure to nitrogen oxides(NO_(x)),particulate matter<2.5μm(PM_(2.5)),particulate matter<10μm(PM10).Stratified Cox regression models were applied to test the effect of exposure.Effect modification of air pollution was assessed.Stratified Cox models through the indirect method and Aalen additive risk models were used in mediation analysis.Over median follow-up of 11.67 years,4596 AMD events were ascertained.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)of incident AMD for pollution per interquartile range(IQR)increment were 1.10(1.04–1.16)for nitrogen dioxide(NO_(2)),1.09(1.03–1.15)for NO_(x),1.14(1.05–1.24)for PM_(2.5),1.13(1.05–1.21)for PM10.The HR(95%CI)of AMD associated with greenness 1000 m buffer per IQR increment was 0.91(0.86–0.97),300 m buffer was 0.94(0.89–0.99).The as-sociation between greenness 1000 m and AMD was 28.59%,44.77%,35.59%,32.31%and 27.08%mediated by the decreased WQS index,NO_(2),NO_(x),PM_(2.5) and PM10,respectively.Increased greenness was associated with lower AMD incidence,and air pollution partly mediate it,which implies that interventions aimed at improving air quality and increasing greenness could have a dual benefit in mitigating AMD risk.
文摘AMD:年龄相关性黄斑变性(age-related macular degeneration)ANOVA:方差分析(analysis of variance)BUT:泪膜破裂时间(breakup time of tear film)DR:糖尿病视网膜病变(diabetic retinopathy)EAU:实验性自身免疫性葡萄膜炎(experimental autoimmune uveitis)。
基金supported by the National Natural Science Foundation of China(Nos.12465024 and 12365018)Natural Science Foundation of Inner Mongolia(Nos.2024ZD23,2024FX30 and 2023MS01005)+1 种基金the program of Innovative Research Team and Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(Nos.NMGIRT2217 and NJYT23109)the Central Government Guidance for Local Science and Technology Development Funds Project(No.2025ZY0067).
文摘The fusion dynamics of ^(6)Li and ^(7)Li projectiles incident on the ^(13)C and ^(12)C targets,respectively,near the Coulomb barrier,were investigated theoretically using the antisymmetrized molecular dynamics(AMD)model.Within the AMD framework,the ground-state configurations of ^(6)Li and ^(7)Li exhibit pronounced deformation characterized by well-developed d+α and t+α clustering structures,respectively.Reaction simulations were performed across a center-of-mass energy range of 3−7.6MeV,encompassing the fusion barrier region.The total fusion cross sections computed as a function of collision energy demon-strate favorable quantitative agreement with the experimental values at energies above the Coulomb barrier.Additionally,a detailed comparison was made of the partial cross sections into specific residual fragments predicted by AMD at different center-of-mass energies.The AMD model provides a robust microscopic description of light-heavy-ion fusion dynamics and captures the role of extended density distributions and cluster correlations within interacting nuclei.
