目的分析急性一氧化氮中毒(Acute nitric oxide,NO)患者心肌肌钙蛋白1(Cardiac troponin I,cTnI)、淀粉酶(Amylase,AMS)、中性粒细胞/淋巴细胞比值(Neutrophil lymphocyte ratio,NLR)、涎液化糖链抗原(Krebs von den lungen-6,KL-6)水...目的分析急性一氧化氮中毒(Acute nitric oxide,NO)患者心肌肌钙蛋白1(Cardiac troponin I,cTnI)、淀粉酶(Amylase,AMS)、中性粒细胞/淋巴细胞比值(Neutrophil lymphocyte ratio,NLR)、涎液化糖链抗原(Krebs von den lungen-6,KL-6)水平变化及预后评估价值。方法选取大兴区人民医院急诊科2020年3月-2022年7月收治的97例急性NO中毒患者,治疗前,使用全自动免疫透射比浊法检测cTnⅠ,酶联免疫吸附法检测AMS,并用全自动血液细胞分析仪检测NLR。给予患者特效解毒剂或拮抗剂,结合患者中毒情况给予氧疗、支气管扩张剂、高压氧、糖皮质激素等治疗。采用电话随访30 d内预后情况,将其分为预后良好组和预后不良组,对比两组患者基础资料和血清学指标,分析cTnI、AMS、NLR影响急性NO中毒患者预后的因素及预测价值。结果97例急性NO中毒患者,预后不良患者有22例(22.68%)。预后不良组中毒程度为重度、涎液化糖链抗原(Krebs von den lungen-6,KL-6)、AMS、cTnⅠ、NLR水平高于预后良好组(P<0.05)。Logistic回归分析显示,中毒程度为重度[OR=3.401(95%CI:1.162~9.950)]、AMS[OR=3.904(95%CI:1.334~11.422)]、cTnⅠ[OR=4.035(95%CI:1.379~11.805)]、NLR[OR=4.559(95%CI:1.558~13.337)]、KL-6[OR=3.104(95%CI:2.602~22.277)]是急性NO中毒患者预后不良的影响因素(P<0.05)。ROC曲线分析发现,AMS、cTnⅠ、NLR、KL-6联合预测急性NO中毒患者预后不良的灵敏度、特异度、曲线下面积(Area under curve,AUC)均高于各指标单一预测(P均<0.05)。结论AMS、cTnⅠ、NLR、KL-6水平变化与急性NO中毒患者预后不良相关,联合检测能够早期预测和改善急性NO中毒患者预后不良。展开更多
AM 1 and PM 3 SCF MO calculation have been performed to obtain molecular geometries of 7 1 isopropyl silacyclohexane based liquid crystal compounds biphenyl ethane series by energy gradient completed optimization.For ...AM 1 and PM 3 SCF MO calculation have been performed to obtain molecular geometries of 7 1 isopropyl silacyclohexane based liquid crystal compounds biphenyl ethane series by energy gradient completed optimization.For all optimized configurations,there is no imaginary frequency in vibrational analysis.The stable configuration,electronic structure,and some molecular properties of title compounds(heat of formation,dipole moment and energy level of frontal molecule orbital,etc) are frist reported.The calculated results are fully discussed with rspect to the organic structure theory.展开更多
文摘目的分析急性一氧化氮中毒(Acute nitric oxide,NO)患者心肌肌钙蛋白1(Cardiac troponin I,cTnI)、淀粉酶(Amylase,AMS)、中性粒细胞/淋巴细胞比值(Neutrophil lymphocyte ratio,NLR)、涎液化糖链抗原(Krebs von den lungen-6,KL-6)水平变化及预后评估价值。方法选取大兴区人民医院急诊科2020年3月-2022年7月收治的97例急性NO中毒患者,治疗前,使用全自动免疫透射比浊法检测cTnⅠ,酶联免疫吸附法检测AMS,并用全自动血液细胞分析仪检测NLR。给予患者特效解毒剂或拮抗剂,结合患者中毒情况给予氧疗、支气管扩张剂、高压氧、糖皮质激素等治疗。采用电话随访30 d内预后情况,将其分为预后良好组和预后不良组,对比两组患者基础资料和血清学指标,分析cTnI、AMS、NLR影响急性NO中毒患者预后的因素及预测价值。结果97例急性NO中毒患者,预后不良患者有22例(22.68%)。预后不良组中毒程度为重度、涎液化糖链抗原(Krebs von den lungen-6,KL-6)、AMS、cTnⅠ、NLR水平高于预后良好组(P<0.05)。Logistic回归分析显示,中毒程度为重度[OR=3.401(95%CI:1.162~9.950)]、AMS[OR=3.904(95%CI:1.334~11.422)]、cTnⅠ[OR=4.035(95%CI:1.379~11.805)]、NLR[OR=4.559(95%CI:1.558~13.337)]、KL-6[OR=3.104(95%CI:2.602~22.277)]是急性NO中毒患者预后不良的影响因素(P<0.05)。ROC曲线分析发现,AMS、cTnⅠ、NLR、KL-6联合预测急性NO中毒患者预后不良的灵敏度、特异度、曲线下面积(Area under curve,AUC)均高于各指标单一预测(P均<0.05)。结论AMS、cTnⅠ、NLR、KL-6水平变化与急性NO中毒患者预后不良相关,联合检测能够早期预测和改善急性NO中毒患者预后不良。
文摘AM 1 and PM 3 SCF MO calculation have been performed to obtain molecular geometries of 7 1 isopropyl silacyclohexane based liquid crystal compounds biphenyl ethane series by energy gradient completed optimization.For all optimized configurations,there is no imaginary frequency in vibrational analysis.The stable configuration,electronic structure,and some molecular properties of title compounds(heat of formation,dipole moment and energy level of frontal molecule orbital,etc) are frist reported.The calculated results are fully discussed with rspect to the organic structure theory.
