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DTI-ALPS联合gBOLD-CSF技术评估偏头痛患者类淋巴系统功能
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作者 张亚男 刘妮 +7 位作者 韩雪 任蒙蒙 张磊 吴浩然 陈远鹏 郭笑利 刘军莲 霍健伟 《CT理论与应用研究(中英文)》 2025年第6期1092-1098,共7页
目的:探讨无先兆偏头痛(MwoA)患者大脑类淋巴系统功能的变化及其与临床指标的相关性。方法:招募50名MwoA患者及49例匹配的健康对照组。采用3.0T MRI获取影像数据,计算两组沿血管周围间隙的扩散张量成像分析(DTI-ALPS)指数及全局血氧水... 目的:探讨无先兆偏头痛(MwoA)患者大脑类淋巴系统功能的变化及其与临床指标的相关性。方法:招募50名MwoA患者及49例匹配的健康对照组。采用3.0T MRI获取影像数据,计算两组沿血管周围间隙的扩散张量成像分析(DTI-ALPS)指数及全局血氧水平依赖性信号与脑脊液流入动力学之间的耦合强度(gBOLDCSF)的差异,进而评估MwoA患者类淋巴系统的功能变化,并分析其与临床量表评分的相关性。结果:相比健康对照组,MwoA患者左侧DTI-ALPS指数、gBOLD-CSF及-d(gBOLD)/dt-CSF耦合强度明显减低,且患者左侧ALPS指数与贝克焦虑量表评分呈弱负相关。结论:MwoA患者存在大脑类淋巴系统功能障碍,其异常可能参与偏头痛的病理生理过程并与焦虑症状相关,为深入理解偏头痛的发病机制提供新视角。 展开更多
关键词 磁共振 无先兆偏头痛 类淋巴系统 DTI-alps指数 gBOLD-CSF耦合强度
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单倍体造血干细胞移植治疗伴LRBA缺陷的ALPS样表型1例报告
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作者 王庆伟 周敏 +4 位作者 程生钦 肖佩芳 卢俊 李捷 胡绍燕 《临床儿科杂志》 北大核心 2025年第5期367-370,382,共5页
患儿男,1个月24天,诊断为免疫性血小板减少症(ITP)和自身免疫性溶血性贫血(AIHA)。全外显子基因测序显示LRBA复合杂合突变,诊断为LRBA缺陷伴自身免疫性淋巴细胞增生性综合征(ALPS)样表型。在皮质类固醇、新生儿样换血、利妥昔单抗、西... 患儿男,1个月24天,诊断为免疫性血小板减少症(ITP)和自身免疫性溶血性贫血(AIHA)。全外显子基因测序显示LRBA复合杂合突变,诊断为LRBA缺陷伴自身免疫性淋巴细胞增生性综合征(ALPS)样表型。在皮质类固醇、新生儿样换血、利妥昔单抗、西罗莫司等治疗后ALPS样表型症状不能改善,且伴有肺部感染、巨细胞病毒血症,于出生后3个月行父亲单纯骨髓来源的单倍体造血干细胞移植(HSCT)。移植后,患儿血小板和粒细胞成功植入,感染得到控制,未出现严重并发症。移植后3个月患儿经历Ⅱ级皮肤移植物抗宿主病(GVHD),经治疗后完全缓解。目前患儿移植后8月余,健康存活,免疫功能恢复正常,ALPS样表型未复发。本文回顾性分析1例小年龄的LRBA缺陷伴ALPS样表型患儿,评估其接受携带突变的父亲骨髓来源造血干细胞治疗的有效性和安全性。研究表明,对于一线治疗无效的患儿,应尽早行HSCT。在无全相合供体时,单倍体供体和骨髓来源干细胞是可行的选择,可促进植入,降低GVHD和感染风险,提高移植成功率。未来需进一步研究优化治疗方案,以改善预后。 展开更多
关键词 LRBA缺陷 自身免疫性淋巴细胞增生性综合征样 骨髓移植 儿童
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DTI-ALPS指数和BG PVS-VF对阿尔茨海默病脑类淋巴系统改变的诊断价值
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作者 韩俊玲 焦欢静 +1 位作者 夏燕来 倪红艳 《天津医科大学学报》 2025年第3期274-279,共6页
目的:探究DTI-ALPS指数和基底节血管周围间隙体积分数(BG PVS-VF)对阿尔茨海默病(AD)的诊断价值。方法:纳入AD神经影像计划3队列的28例典型AD(AD)、36例轻度认知障碍(MCI)和67例认知正常(CN)受试者,分为AD、MCI和CN组。受试者均进行了... 目的:探究DTI-ALPS指数和基底节血管周围间隙体积分数(BG PVS-VF)对阿尔茨海默病(AD)的诊断价值。方法:纳入AD神经影像计划3队列的28例典型AD(AD)、36例轻度认知障碍(MCI)和67例认知正常(CN)受试者,分为AD、MCI和CN组。受试者均进行了扩散张量成像和三维T1加权磁共振扫描,计算DTI-ALPS指数、BG PVS-VF。进行3组间DTI-ALPS指数和BG PVS-VF的比较,分析DTI-ALPS指数和BG PVS-VF与临床数据,包括年龄、受教育年限、APOEε4携带状态的相关性,在控制年龄因素后,分析二者与简易精神状态量表(MMSE)评分的相关性。利用受试者工作特征(ROC)曲线评估DTI-ALPS指数、BG PVS-VF对AD的诊断效能。结果:与CN组和MCI组相比,AD组的DTI-ALPS指数均显著减低(95%CI:0.041~0.170和95%CI:0.005~0.150,均P<0.05)。3组间的BG PVS-VF未观察到显著差异(H=0.83,P=0.66)。DTI-ALPS指数与年龄(r=-0.20)、MMSE评分(r=0.27)显著相关(均P<0.05)。BG PVS-VF与年龄(r=0.34)、MMSE评分(r=0.19)显著相关(均P<0.05)。DTI-ALPS指数诊断MCI的曲线下面积(AUC)为0.59,无诊断价值(P>0.05);诊断AD的AUC更大,具有诊断价值(AUC=0.76,P<0.001)。结论:AD患者脑类淋巴系统活性降低和结构改变与认知障碍相关,DTI-ALPS指数对AD具有诊断价值。 展开更多
关键词 阿尔茨海默病 DTI-alps指数 血管周围间隙体积分数 脑类淋巴系统
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Early Paleozoic subduction initiation in the West Proto-Tethys Ocean: Insights from ophiolitic Speik Complex in the Eastern Alps
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作者 Qingbin Guan Yongjiang Liu +6 位作者 Franz Neubauer Johann Genser Ruihong Chang Boran Liu Sanzhong Li Qianwen Huang Sihua Yuan 《Geoscience Frontiers》 2025年第5期313-330,共18页
Subduction initiation is a critical part of the plate tectonic system,but its geodynamic process is still poorly understood due to the lack of well-preserved geological records.Based on new zircon U–Pb–Hf isotopic a... Subduction initiation is a critical part of the plate tectonic system,but its geodynamic process is still poorly understood due to the lack of well-preserved geological records.Based on new zircon U–Pb–Hf isotopic and whole-rock geochemical data,we report the first discovery of a latest Cambrian–Early Ordovician forearc-arc rock sequence in the Eastern Alps.This sequence includes granitic gneisses,amphibolites,and amphibole plagiogneisses from the ophiolitic Speik Complex and Gleinalpe Complex.These rocks exhibit geochemical affinities with typical oceanic plagiogranites,forearc basalts(FABs),and island arc basalts,respectively.The latest Cambrian plagiogranitic protoliths(491±2 Ma)are shearing-type plagiogranites that were formed in the tectonic setting of forearc spreading.The latest Cambrian FABs(496–489 Ma)have similar geochemical compositions and positiveεHf(t)values(+2.5 to+14.9)to the depleted mid-ocean ridge basalts.However,they show depletion in high field strength elements(HFSEs;e.g.,Nb,Ta,and Zr)and have relatively low Ti/V ratios.These features suggest that they were derived from a depleted mantle source modified by subducting slab-released components in a forearc environment.The Early Ordovician basaltic protoliths(476–472 Ma)of amphibole plagiogneisses show enrichment in large ion lithophile elements and depletion in HFSEs(e.g.Nb,Ta,Zr,and Hf),implying a mature island arc environment.These metaigneous rocks,along with the coeval boninite-like high-Mg amphibolites near the study area,form a typical rock sequence resembling that of the Izu–Bonin–Mariana(IBM)arc system.The Speik and Gleinalpe complexes document a complete magmatic evolution from subduction initiation to mature arc development within the West Proto-Tethys Ocean.Integrating our new data with published work,we reconstruct the late Ediacaran–early Paleozoic tectonic evolution of the northern Gondwana.During the late Ediacaran–early Cambrian,the rollback of the West Proto-Tethys oceanic plate triggered the separation of the Wechsel-Silvretta-Gleinalpe continental arc from the northern Gondwana.This process led to the formation of the Speik back-arc oceanic basin,a southwestern branch of the West Proto-Tethys Ocean.In the latest Cambrian–Early Ordovician,subduction initiation occurred in the Speik Ocean,which subsequently developed into an intra-oceanic arc system.During the Early Devonian,the Speik Ocean closed and the Wechsel-Silvretta-Gleinalpe continental arc reattached to the Gondwana,as evidenced by the metamorphic event at ca.400 Ma. 展开更多
关键词 Subduction initiation West Proto-Tethys Ocean Eastern alps Speik Complex Early Paleozoic
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Endoplasmic reticulum:Regulator of structural potentiation of dendritic spines
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作者 Philip J.Dittmer Mark L.Dell’Acqua 《Neural Regeneration Research》 2026年第3期1114-1115,共2页
Since the first electron micrograph of“lace-like structures”over 75 years ago,the endoplasmic reticulum(ER)is now viewed as a highly dynamic,constantly remodeling,continuous network of tubules and cisternae that pla... Since the first electron micrograph of“lace-like structures”over 75 years ago,the endoplasmic reticulum(ER)is now viewed as a highly dynamic,constantly remodeling,continuous network of tubules and cisternae that plays an important role in a broad range of cellular activities from calcium regulation to protein synthesis and trafficking.In neurons,the ER extends from the soma through the axon to presynaptic terminals,and throughout the dendritic arbor into as many as half of all postsynaptic dendritic spines at any given time(Falahati et al.,2022). 展开更多
关键词 calcium regulation endoplasmic reticulum er dendritic arbor TRAFFICKING tubules cisternae dendritic spines protein synthesis endoplasmic reticulum
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Synapses and dendritic spines are eliminated in the primary visual cortex of mice subjected to chronic intraocular pressure elevation
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作者 Xinyi Zhang Deling Li +6 位作者 Weiting Zeng Yiru Huang Zongyi Zhan Yuning Zhang Qinyuan Hu Lianyan Huang Minbin Yu 《Neural Regeneration Research》 2026年第3期1236-1248,共13页
Synaptic plasticity is essential for maintaining neuronal function in the central nervous system and serves as a critical indicator of the effects of neurodegenerative disease.Glaucoma directly impairs retinal ganglio... Synaptic plasticity is essential for maintaining neuronal function in the central nervous system and serves as a critical indicator of the effects of neurodegenerative disease.Glaucoma directly impairs retinal ganglion cells and their axons,leading to axonal transport dysfuntion,subsequently causing secondary damage to anterior or posterior ends of the visual system.Accordingly,recent evidence indicates that glaucoma is a degenerative disease of the central nervous system that causes damage throughout the visual pathway.However,the effects of glaucoma on synaptic plasticity in the primary visual cortex remain unclear.In this study,we established a mouse model of unilateral chronic ocular hypertension by injecting magnetic microbeads into the anterior chamber of one eye.We found that,after 4 weeks of chronic ocular hypertension,the neuronal somas were smaller in the superior colliculus and lateral geniculate body regions of the brain contralateral to the affected eye.This was accompanied by glial cell activation and increased expression of inflammatory factors.After 8 weeks of ocular hypertension,we observed a reduction in the number of excitatory and inhibitory synapses,dendritic spines,and activation of glial cells in the primary visual cortex contralateral to the affected eye.These findings suggest that glaucoma not only directly damages the retina but also induces alterations in synapses and dendritic spines in the primary visual cortex,providing new insights into the pathogenesis of glaucoma. 展开更多
关键词 chronic ocular hypertension dendritic spines GLAUCOMA glial cells NEUROINFLAMMATION NEURON retinal ganglion cells synaptic plasticity visual cortex visual pathway
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Specific dendritic spine modifications and dendritic transport:From in vitro to in vivo
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作者 Albert H.K.Fok Charlotte H.M.Lam Cora S.W.Lai 《Neural Regeneration Research》 2026年第2期665-666,共2页
Dendritic spines are small protrusions along dendrites that contain most of the excitatory synapses in principal neurons,playing a crucial role in neuronal function by creating a compartmentalized environment for sign... Dendritic spines are small protrusions along dendrites that contain most of the excitatory synapses in principal neurons,playing a crucial role in neuronal function by creating a compartmentalized environment for signal transduction.The plasticity of spine morphologies provides a tunable handle to regulate calcium signal dynamics,allowing rapid regulation of protein expression necessary to establish and maintain synapses(Cornejo et al.,2022).If excitatory inputs were to be located primarily on dendritic shafts,dendrites would frequently short-circuit,preventing voltage signals from propagating(Cornejo et al.,2022).It is thus not surprising that the structural plasticity of dendritic spines is closely linked to synaptic plasticity and memory formation(Berry and Nedivi,2017).While comprehensive in vitro studies have been conducted,in vivo studies that directly tackle the mechanism of dendritic transport and translation in regulating spine plasticity spatiotemporally are limited. 展开更多
关键词 excitatory synapses principal neuronsplaying compartmentalized environment establish maintain synapses cornejo dendritic spines regulate calcium signal dynamicsallowing regulation protein expression dendritic shaft
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法国阿尔卑斯山(Mt. Alps, France)溪流型喀斯特瀑布水生苔藓植物群落生态研究 被引量:9
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作者 张朝晖 陈家宽 艾伦.培特客斯 《中国岩溶》 CAS CSCD 北大核心 2007年第1期24-30,共7页
对法国阿尔卑斯山(Mt.Alps,France)6个溪流型喀斯特瀑布水生苔藓植物群落进行了研究。报道典型瀑布水生苔藓群落14个,苔藓植物种类由11科16属20种(含变种亚种)组成;生殖系统由雌雄异株(Dioecious,95%)和雌雄同株异苞(Autoecious,5%)两... 对法国阿尔卑斯山(Mt.Alps,France)6个溪流型喀斯特瀑布水生苔藓植物群落进行了研究。报道典型瀑布水生苔藓群落14个,苔藓植物种类由11科16属20种(含变种亚种)组成;生殖系统由雌雄异株(Dioecious,95%)和雌雄同株异苞(Autoecious,5%)两种类型构成,无性繁殖是繁殖的主要方式;区系地理成分含北温带分布(60%)、欧洲-北美分布(10%)、旧世界温带分布(5%)和世界广泛分布(25%)等4种成分;生活型含高丛集型(20%)、矮丛集型(10%)、交织型(60%)和平铺型(10%)4种类型。根据喀斯特沉积环境特征,划分瀑布水生苔藓群落为峡谷瀑布苔藓群落、温泉瀑布苔藓群落、瀑布水帘洞苔藓群落、悬崖瀑布苔藓群落和悬崖季节性瀑布苔藓群落等5种生态类型。法国阿尔卑斯山溪流型瀑布生物喀斯特沉积物具有分布广泛,但沉积规模较小的特点。 展开更多
关键词 苔藓植物 水生群落 溪流 喀斯特瀑布 法国阿尔卑斯山
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法国阿尔卑斯—罗讷(Rhone-Alps)岩溶洞穴弱光带苔藓植物群落研究 被引量:11
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作者 张朝晖 艾伦.培特客斯 《中国岩溶》 CAS CSCD 2001年第3期236-240,共5页
报道了法国阿尔卑斯 -罗讷 (Rhone- Alps)地区 3个岩溶洞穴苔藓植物群落研究结果。记载典型洞穴苔藓群落 11个 ,苔藓植物种类 8科 12属 15种 (含变种 ) ;区系地理成分含北温带分布 (4 6 .6 6 % )、温带欧洲分布 (6 .6 7% )、欧洲 -亚洲... 报道了法国阿尔卑斯 -罗讷 (Rhone- Alps)地区 3个岩溶洞穴苔藓植物群落研究结果。记载典型洞穴苔藓群落 11个 ,苔藓植物种类 8科 12属 15种 (含变种 ) ;区系地理成分含北温带分布 (4 6 .6 6 % )、温带欧洲分布 (6 .6 7% )、欧洲 -亚洲分布 (6 .6 7% )、欧洲 -北美分布 (13.33% )和世界广泛分布 (2 6 .6 7% ) 5种成分 ;生活型含高丛集型 (2 0 % )、矮丛集型 (33.33% )、交织型 (4 0 % )和平铺型 (6 .6 7% ) 4种类型。根据岩溶沉积环境特征 ,划分洞穴苔藓群落为钟乳石苔藓群落、洞壁钙华苔藓群落、洞底泉华苔藓群落和石灰土苔藓群落等 4种生态类型。 展开更多
关键词 岩溶 洞穴 苔藓植物群落 弱光带 法国 阿尔卑斯-罗讷地区 自然地理
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Genetic Variation and Differentiation of Larix decidua Populations in Swiss Alps
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作者 赵桂仿 Fran0is FELBER Philippe KPFER 《Acta Botanica Sinica》 CSCD 2001年第7期731-735,共5页
Genetic diversity within and among six subpopulations of Larix decidua Mill. from two altitudinal transects of Swiss Alps was investigated using 6 enzyme systems coding for 8 loci. Globally, the mean proportion of pol... Genetic diversity within and among six subpopulations of Larix decidua Mill. from two altitudinal transects of Swiss Alps was investigated using 6 enzyme systems coding for 8 loci. Globally, the mean proportion of polymorphic loci was 22.9%, the average number of alleles per locus was 1.3, and the mean expected heterozygosity was 0.095. Only 5.8% of the genetic variation resided among populations. The mean genetic distance was 0.006. Several significant differences of gene frequencies were found between different age classes. Positive values of the species mean fixation index observed in this study suggested a considerable deficit of heterozygotes in the populations of L. decidua of Swiss Alps. At one of the sites (Arpette), the highest subpopulation in elevation gave the lowest level of genetic diversity (as evidenced by the lowest proportion of polymorphic loci and the lowest mean expected heterozygosity) and the largest value of genetic distance when compared to other subpopulations. The genetic differences between the highest subpopulation and the other ones suggest that the founder effect may be an important factor influencing genetic differentiation of L. decidua populations at Arpette transect. 展开更多
关键词 Larix decidua Swiss alps allozyme variation genetic differentiation age classes
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颈椎前路减压植骨融合ALPS肽钢板内固定术的护理体会(摘要)
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作者 刘茂菊 焦绪美 《济宁医学院学报》 2001年第3期80-81,共2页
关键词 颈椎骨折 颈椎前路减压植骨融合 alps肽钢板 内固定术 护理
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HGSE教师教育资源ALPS的设计特点及启示
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作者 赖小琴 《广西教育学院学报》 2010年第1期147-149,共3页
学校的主动学习和实践项目ALPS是HGSE提供的教师教育资源之一,是一个致力于教育教学和实践改进的电子社团,其任务是为不同国家和地区的教师、管理者与HGSE的教育研究者、教授和课程设计者提供在线的合作环境和许多可供探索的教育学领域... 学校的主动学习和实践项目ALPS是HGSE提供的教师教育资源之一,是一个致力于教育教学和实践改进的电子社团,其任务是为不同国家和地区的教师、管理者与HGSE的教育研究者、教授和课程设计者提供在线的合作环境和许多可供探索的教育学领域,既有广度又有深度,设置的栏目主要有"看"、"反思"、"探索"、"建造"、"连接"、"学习"和"挑运"等,每个栏目都有自己的资源,用于培养教师的主动学习实践,操作者可以灵活进入和退出。ALPS设计的目的、内容和操作方式为我国基础教育课程改革的教师教育资源开发与设计提供了有益的启示。 展开更多
关键词 HGSE alps 教师教育资源 特点 启示
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The role of structural inheritance in continental break-up and exhumation of Alpine Tethyan mantle(Canavese Zone,Western Alps) 被引量:4
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作者 Andrea Festa Gianni Balestro +2 位作者 Alessandro Borghi Sara De Caroli Andrea Succo 《Geoscience Frontiers》 SCIE CAS CSCD 2020年第1期167-188,共22页
The Canavese Zone(CZ)in the Western Alps represents the remnant of the distal passive margin of the Adria microplate,which was stretched and thinned during the Jurassic opening of the Alpine Tethys.Through detailed ge... The Canavese Zone(CZ)in the Western Alps represents the remnant of the distal passive margin of the Adria microplate,which was stretched and thinned during the Jurassic opening of the Alpine Tethys.Through detailed geological mapping,stratigraphic and structural analyses,we document that the continental break-up of Pangea and tectonic dismemberment of the Adria distal margin,up to mantle rocks exhumation and oceanization,did not simply result from the syn-rift Jurassic extension but was strongly favored by older structu ral inheritances(the Proto-Canavese Shear Zone),which controlled earlier lithospheric weakness.Our findings allowed to redefine in detail(i)the tectono-stratigraphic setting of the Variscan metamorphic basement and the Late Carbonife rous to Early Cretaceous CZ succession,(ii)the role played by inherited Late Carboniferous to Early Triassic structures and(iii)the significance of the CZ in the geodynamic evolution of the Alpine Tethys.The large amount of extensional displacement and crustal thinning occurred during different pulses of Late Carbonife rous-Early Triassic strike-slip tectonics is wellconsistent with the role played by long-lived regional-scale wrench faults(e.g.,the East-Variscan Shear Zone),suggesting a re-discussion of models of mantle exhumation driven by low-angle detachment faults as unique efficient mechanism in stretching and thinning continental crust. 展开更多
关键词 alpine Tethys Western alps Jurassic ophiolite Structural inheritance Continental break-up Mantle exhumation
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Cambro-Silurian magmatisms at the northern Gondwana margin(Penninic basement of the Ligurian Alps) 被引量:3
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作者 Matteo Maino Laura Gaggero +2 位作者 Antonio Langone Silvio Seno Mark Fanning 《Geoscience Frontiers》 SCIE CAS CSCD 2019年第1期315-330,共16页
The Early Paleozoic evolution of the northern margin of Gondwana is characterized by several episodes of bimodal magmatism intruded or outpoured within thick sedimentary basins. These processes are well recorded in th... The Early Paleozoic evolution of the northern margin of Gondwana is characterized by several episodes of bimodal magmatism intruded or outpoured within thick sedimentary basins. These processes are well recorded in the Variscan blocks incorporated in the Ligurian Alps because they experienced low temperature Alpine metamorphism. During the Paleozoic, these blocks, together with the other Alpine basements, were placed between the Corsica-Sardinia and the Bohemian Massif along the northern margin of Gondwana. In this framework, they host several a variegated lithostratigraphy forming two main complexes(Complexs I and II) that can be distinguished by both the protoliths and their crosscutting relationships, which indicate that the acidic and mafic intrusives of Complex II cut an already folded sequence made of sediments, basalts and granitoids of Complex I. Both complexes were involved in the Variscan orogenic phases as highlighted by the pervasive eclogite-amphibolite facies schistosity(foliation II). However, rare relicts of a metamorphic foliation at amphibolite facies conditions(foliation I)is locally preserved only in the rocks of Complex I. It is debatable if this schistosity was produced during the early folding event e occurred between the emplacement of Complex I and II e rather than during an early stage of the Variscan metamorphic cycle.New SHRIMP and LA ICP-MS Ue Pb zircon dating integrated with literature data, provide emplacement ages of the several volcanic or intrusive bodies of both complexes. The igneous activity of Complex I is dated between 507 ± 15 Ma and 494 ± 5 Ma, while Complex II between 467 ± 12 Ma and 445.5 ± 12 Ma.The folding event recorded only by the Complex I should therefore have occurred between 494 ± 5 Ma and 467 ± 12 Ma. The Variscan eclogite-amphibolite facies metamorphism is instead constrained between ~420 Ma and ~300 Ma. These ages and the geochemical signature of these rocks allow constraining the Early Paleozoic tectono-magmatic evolution of the Ligurian blocks, from a middleeupper Cambrian rifting stage, through the formation of an Early Ordovician volcanic arc during the Rheic Ocean subduction, until a Late Ordovician extension related to the arc collapse and subsequent rifting of the PaleoThetys. Furthermore, the ~420-350 Ma ages from zircon rims testify to thermal perturbations that may be associated with the Silurian rifting-related magmatism, followed by the subduction-collisional phases of the Variscan orogeny. 展开更多
关键词 U-Pb zircon dating Early PALEOZOIC MAGMATISM Pre-alpine BASEMENTS GONDWANA margin Ligurian alps
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The role of a national park in classifying mountain tourism destinations: An exploratory study of the Italian Western Alps 被引量:1
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作者 DUGLIO Stefano LETEY Marilisa 《Journal of Mountain Science》 SCIE CSCD 2019年第7期1675-1690,共16页
Together with the main aim of preserving nature,national parks are also expected to play an important role for the local communities,driving economic activities toward the lens of sustainable development.This contribu... Together with the main aim of preserving nature,national parks are also expected to play an important role for the local communities,driving economic activities toward the lens of sustainable development.This contribution aims to present an exploratory study on the relationship between the presence of a protected mountain area,the Gran Paradiso National Park(GPNP),in the North West of the Italian Alps,and the classification of tourism destinations,according to Weaver model of destination management.Starting from the model,the authors provide a quantitative analysis using a set of variables and indicators to comprehensively assess the differing patterns assumed by the municipalities within the borders of the GPNP and those that are not.The provisional results illustrate that the municipalities within the border of a protected area are more likely to be grouped alongside the sustainable mountain destinations.Meanwhile,research outcomes confirm that a protected area does not necessarily contrast the tourism industry but instead may boost local development by driving it within the borders of the sustainable development,switching from the area’s only preservation function to a flywheel for the local communities. 展开更多
关键词 Mountain TOURISM Sustainable TOURISM DESTINATION management National park alps
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An integrated approach to investigate climate-driven rockfall occurrence in high alpine slopes: the Bessanese glacial basin, Western Italian Alps 被引量:3
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作者 VIANI Cristina CHIARLE Marta +4 位作者 PARANUNZIO Roberta MERLONE Andrea MUSACCHIO Chiara COPPA Graziano NIGRELLI Guido 《Journal of Mountain Science》 SCIE CSCD 2020年第11期2591-2610,共20页
Rockfalls are one of the most common instability processes in high mountains.They represent a relevant issue,both for the risks they represent for(infra)structures and frequentation,and for their potential role as ter... Rockfalls are one of the most common instability processes in high mountains.They represent a relevant issue,both for the risks they represent for(infra)structures and frequentation,and for their potential role as terrestrial indicators of climate change.This study aims to contribute to the growing topic of the relationship between climate change and slope instability at the basin scale.The selected study area is the Bessanese glacial basin(Western Italian Alps)which,since 2016,has been specifically equipped,monitored and investigated for this purpose.In order to provide a broader context for the interpretation of the recent rockfall events and associated climate conditions,a cross-temporal and integrated approach has been adopted.For this purpose,geomorphological investigations(last 100 years),local climate(last 30 years)and near-surface rock/air temperatures analyses,have been carried out.First research outcomes show that rockfalls occurred in two different geomorphological positions:on rock slopes in permafrost condition,facing from NW to NE and/or along the glacier margins,on rock slopes uncovered by the ice in the last decades.Seasonal thaw of the active layer and/or glacier debutressing can be deemed responsible for slope failure preparation.With regard to timing,almost all dated rock falls occurred in summer.For the July events,initiation may have been caused by a combination of rapid snow melt and enhanced seasonal thaw of the active layer due to anomalous high temperatures,and rainfall.August events are,instead,associated with a significant positive temperature anomaly on the quarterly scale,and they can be ascribed to the rapid and/or in depth thaw of the permafrost active layer.According to our findings,we can expect that in the Bessanese glacierized basin,as in similar high mountain areas,climate change will cause an increase of slope instability in the future.To fasten knowledge deepening,we highlight the need for a growth of a network of high elevation experimental sites at the basin scale,and the definition of shared methodological and measurement standards,that would allow a more rapid and effective comparison of data. 展开更多
关键词 ROCKFALLS Climate change Air and rock temperature Periglacial environment Western Italian alps
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1991-2020 climate normal in the European Alps:focus on high-elevation environments 被引量:1
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作者 NIGRELLI Guido CHIARLE Marta 《Journal of Mountain Science》 SCIE CSCD 2023年第8期2149-2163,共15页
Alps are an important geographical area of the European continent and,in this area,temperature increase is most evident.However,the 1991-2020 climate normal in the Alps has still not been thoroughly investigated.Aimin... Alps are an important geographical area of the European continent and,in this area,temperature increase is most evident.However,the 1991-2020 climate normal in the Alps has still not been thoroughly investigated.Aiming to fill this gap with a focus on high-elevation environments,minimum and maximum daily air temperature acquired by 23 automatic weather station were used.The results show that the mean annual values of minimum and maximum temperature for the 1991-2020 climate normal in the Alps are-2.4℃ and 4.4℃,respectively,with a warming rate of 0.5℃/10 years.The mean annual temperature comparison between 1961-1990 and 1971-2000,1961-1990 and 1981-2010,1961-1990 and 1991-2020 climate normal show an increase of 0.3℃,0.5℃ and 0.9℃,respectively.The results also confirm that seasonal and annual temperatures are rising through the whole Alpine arc,mainly in summer and autumn.This work highlights that annual minimum and maximum temperature do not seem to be affected by a positive elevation-dependent warming.Instead,a positive elevation-dependent warming in the maximum values of the annual minimum temperature was found.If anthropogenic emissions maintain the trend of the last decades,the expected mean annual temperature of the 2001-2030 climate normal is-0.2℃,with an increase of 0.5℃ if compared to the 1991-2020 climate normal and with an increase of 1.5℃ if compared to the 1961-1990 climate normal.This study highlights the warming rate that is now present in the European Alps,provides indications on the warming rate that will occur in the coming years and highlights the importance of carrying out investigations that consider not only the last 30-year climate normal,but also the most recent 30-year climate normal by comparing them with each other. 展开更多
关键词 Air temperature trend Climate normal Climate change High mountain climate alps
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Factors Controlling the Extent of Contact Metamorphic Aureoles as Deduced by Field Evidence in the Western Alps
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作者 Davide Zanoni 《地学前缘》 EI CAS CSCD 北大核心 2009年第S1期208-209,共2页
The shallow Biella and Traversella late-orogenic plutons are intruded in the Sesia Lanzo Zone(SLZ) the innermost structural element of the Western Alpine arc,a continental unit that records a pervasive metamorphic imp... The shallow Biella and Traversella late-orogenic plutons are intruded in the Sesia Lanzo Zone(SLZ) the innermost structural element of the Western Alpine arc,a continental unit that records a pervasive metamorphic imprint related to the Alpine subduction. The country rocks consist of metapelites with minor metagranitoids,meta-aplites,metabasites and marbles. The pre-intrusive pervasive metamorphic imprint developed under eclogite facies conditions. The ductile syn-metamorphic deformation 展开更多
关键词 WESTERN alps Sesia Lanzo Zone Biella and Traversella PLUTONS CONTACT METAMORPHISM
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Geomorphological mapping for the valorization of the alpine environment. A methodological proposal tested in the Loana Valley(Sesia Val Grande Geopark, Western Italian Alps) 被引量:3
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作者 Irene BOLLATI Beatrice CROSA LENZ +1 位作者 Enrico ZANOLETTI Manuela PELFINI 《Journal of Mountain Science》 SCIE CSCD 2017年第6期1023-1038,共16页
Geomorphological mapping plays a key role in landscape representation: it is the starting point for many applications and for the realization of thematic maps, such as hazard and risk maps, geoheritage and geotourism ... Geomorphological mapping plays a key role in landscape representation: it is the starting point for many applications and for the realization of thematic maps, such as hazard and risk maps, geoheritage and geotourism maps. Traditional geomorphological maps are useful for scientific purposes but they need to be simplified for different aims as management and education. In tourism valorization, mapping of geomorphological resources(i.e., geosites, and geomorphosites), and of geomorphic evidences of past hazardous geomorphological events, is important for increasing knowledge about landscape evolution and active processes, potentially involving geomorphosites and hiking trails. Active geomorphosites, as those widespread in mountain regions, testify the high dynamicity of geomorphic processes and their link with climatic conditions. In the present paper, we propose a method to produce and to update cartographic supports(Geomorphological Boxes)realized starting from a traditional geomorphological survey and mapping. The Geomorphological Boxes are geomorphological representation of single, composed or complex landforms drawn on satellite images, using the official Italian geomorphological legend(ISPRA symbols). Such cartographic representation is also addressed to the analysis(identification, evaluation and selection) of Potential Geomorphosites and Geotrails. The method has been tested in the upper portion of the Loana Valley(Western Italian Alps), located within the borders of the Sesia Val Grande Geopark, recognized by UNESCO in 2013. The area has a good potential for geotourism and for educational purposes. We identified 15 Potential Geomorphosites located along 2 Geotrails; they were ranked according to specific attributes also in relation with a Reference Geomorphosite located in the Loana hydrographic basin and inserted in official national and regional databases of geosites(ISPRA; Regione Piemonte). Finally, the ranking of Potential Geomorphosites allowed to select the most valuable ones for valorization or geoconservation purposes. In thisframework, examples of Geomorphological Boxes are proposed as supports to geo-risk education practices. 展开更多
关键词 Geomorphological mapping Geomorphological Boxes Mountain geomorphosites Geotrails GIS-Geographical Information Systems Loana Valley Western Italian alps
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Economic and Qualitative Traits of Italian Alps Saffron 被引量:1
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作者 Alessandra MANZO Sara PANSERI +1 位作者 Danilo BERTONI Annamaria GIORGI 《Journal of Mountain Science》 SCIE CSCD 2015年第6期1542-1550,共9页
Saffron, obtained from the flower stigmas of Crocus sativus L., is one of the most expensive food spices. The introduction of saffron in alpine areas could help to broaden and diversify the activities of mountain mult... Saffron, obtained from the flower stigmas of Crocus sativus L., is one of the most expensive food spices. The introduction of saffron in alpine areas could help to broaden and diversify the activities of mountain multifunctional farms, with a positive impact on economy and land management. According to ISO 3632(2010/2011), saffron can be classified into three categories of quality(I, II, III) depending on the concentration of the three main metabolites responsible for its characteristic colour, flavor and aroma: Crocin, Picrocrocin and Safranal. This study represents the first investigation of the quality of saffron produced in the Italian Alps evaluated with spectrophotometry, HPLC, solid-phase microextraction(SPME), and gas chromatographic analysis combined with mass spectrometry(GC/MS). The experiments used Crocus sativus stigmas produced in 2012-2013 in different areas of the Central Italian Alps were located at an altitude between 720 and 1200 m a.s.l.. Results obtained were compared to commercial saffron. The analyses confirmed that all samples can be classified in the first quality category according to the ISO classification. This high quality is also confirmed by HPLC analysis. Moreover, the SPME-GC/MS analysis identified some differences in the aromatic profile of saffron samples, in particular regarding safranal concentration. A preliminary assessment of the economic viability of high quality saffron production for local markets was also performed. Our study provides valid information regarding the quality and economic sustainability of saffron production in the alpine area confirming this crop as a good candidate for a new source of income for multifunctional farms in mountain areas. 展开更多
关键词 Crocus sativus L. alps ISO 3632 UV– Vis spectrophotometry SPME-GC/MS HPLC
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