目的:比较分析PLo S ALMs与Altmetrics评分、单篇论文学术评价指标之间的相关性及对单篇论文的评价效度。方法:以PLo S系列期刊PLo S Biology、PLo S Medicine为例,基于PLo S ALMs论文层面计量指标数据,分析比较其阅览量、下载量、讨论...目的:比较分析PLo S ALMs与Altmetrics评分、单篇论文学术评价指标之间的相关性及对单篇论文的评价效度。方法:以PLo S系列期刊PLo S Biology、PLo S Medicine为例,基于PLo S ALMs论文层面计量指标数据,分析比较其阅览量、下载量、讨论量、保存量、被引频次、推荐量与Altmetrics评分、h指数、学术迹T之间的相关性以及对单篇论文的评价效果。结果:阅览量、下载量、讨论量与被引频次、h指数有正相关性,推荐量与h指数、学术迹无关。Altmetrics评分与阅览量、下载量和讨论量呈中度相关性,与被引频次呈弱相关。结论:PLo S ALMs是一个多维评价,应该应用多指标测度,才能体现研究成果的综合实力。展开更多
Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen ism.Previous studies have shown that LHCGR is en riched in the ovar...Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen ism.Previous studies have shown that LHCGR is en riched in the ovary and LHCGR deficiency causes infertility without typical PCOS phenotypes.ALMS1 is implicated in obesity and hyperandrogenism,the common phenotypes among PCOS patients.Through whole-exome sequencing of 22 PCOS families and targeted candidate gene sequencing of additional 65 sporadic PCOS patients,we identified potential causative mutations in LHCGR and ALMS1 in a sibling-pair PCOS family and three sporadic PCOS patients.The expression of LHCGRL638 P in granulosa-like tumor cell line(KGN)cells promoted cyclic adenosine monophosphate production and granulosa cell proliferation,indicating that LHCGRL638 P is an activating mutation.Lhcgr~(L642 P/L642 P)mice showed an irregular estrous cycle,reduced follicles with dynamic folliculogenesis,and increased testosterone(T),estradiol(E2),and dehydroepiandrosterone.Lhcgr~(+/L642 P)AIms1~(+/PB)mice displayed increased T and E2 but decreased late secondary and preovulatory follicles.We showed that activating mutation of LHCGR likely plays important roles in the pathophysiology of PCOS involving abnormal reproductive physiology,whereas ALMS1 deficiency may promote anovulatory infertility via elevated androgens,suggesting that the disturbed LHCGR and ALMS1 cooperatively induce PCOS phenotypes,characterized as anovulation and hyperandrogenemia frequently observed in PCOS patients with obesity.展开更多
BACKGROUND Alström syndrome(AS,OMIM ID 203800)is a rare disease involving multiple organs in children and is mostly reported in non-Chinese patients.In the Chinese population,there are few reports on the clinical...BACKGROUND Alström syndrome(AS,OMIM ID 203800)is a rare disease involving multiple organs in children and is mostly reported in non-Chinese patients.In the Chinese population,there are few reports on the clinical manifestations and pathogenesis of AS.This is the first report on the association between AS and Graves’hyperthyroidism.CASE SUMMARY An 8-year-old Chinese girl was diagnosed with AS.Two years later,Graves’hyperthyroidism developed with progressive liver dysfunction.The patient’s clinical data were collected;DNA from peripheral blood of the proband,parents and sibling was collected for gene mutation detection using the second-generation sequencing method and gene panel for diabetes.The association between the patient’s genotype and clinical phenotype was analyzed.She carried the pathogenic compound heterozygous mutation of ALMS1(c.2296_2299del4 and c.11460C>A).These stop-gain mutations likely caused truncation of the ALMS1 protein.CONCLUSION The manifestation of hyperthyroidism may suggest rapid progression of AS.展开更多
人工智能(AI)技术的快速发展对高校毕业生就业产生了深远的影响。本文基于ALM(Advanced Language Models)模型,构建AI职业规划平台,通过分析学生能力、职业兴趣及企业需求,实现智能化的人岗精准匹配。平台有助于推动校企合作,优化教育内...人工智能(AI)技术的快速发展对高校毕业生就业产生了深远的影响。本文基于ALM(Advanced Language Models)模型,构建AI职业规划平台,通过分析学生能力、职业兴趣及企业需求,实现智能化的人岗精准匹配。平台有助于推动校企合作,优化教育内容,全面提升毕业生就业能力,同时帮助企业有效解决技能型人才短缺问题,促进教育体系与产业发展的深度融合。本研究成果为缓解就业压力提供了切实可行的路径,同时为劳动力市场优化和社会经济的可持续发展提供了重要的理论依据与实践支持。展开更多
2019年11月24日,2019/2020赛季ALMS亚洲勒芒系列赛(ASIAN LE MANS SERIES)迎来了上海揭幕战。2019/20赛季亚洲勒芒系列赛有着令人振奋的比赛阵容,也带来了精彩的演艺,而米其林作为该赛事的官方轮胎供应商以及技术合作伙伴,以米其林轮胎...2019年11月24日,2019/2020赛季ALMS亚洲勒芒系列赛(ASIAN LE MANS SERIES)迎来了上海揭幕战。2019/20赛季亚洲勒芒系列赛有着令人振奋的比赛阵容,也带来了精彩的演艺,而米其林作为该赛事的官方轮胎供应商以及技术合作伙伴,以米其林轮胎出色的性能表现为车手们护航,开启全新征程。展开更多
In this work,we propose a second-order model for image denoising by employing a novel potential function recently developed in Zhu(J Sci Comput 88:46,2021)for the design of a regularization term.Due to this new second...In this work,we propose a second-order model for image denoising by employing a novel potential function recently developed in Zhu(J Sci Comput 88:46,2021)for the design of a regularization term.Due to this new second-order derivative based regularizer,the model is able to alleviate the staircase effect and preserve image contrast.The augmented Lagrangian method(ALM)is utilized to minimize the associated functional and convergence analysis is established for the proposed algorithm.Numerical experiments are presented to demonstrate the features of the proposed model.展开更多
文摘目的:比较分析PLo S ALMs与Altmetrics评分、单篇论文学术评价指标之间的相关性及对单篇论文的评价效度。方法:以PLo S系列期刊PLo S Biology、PLo S Medicine为例,基于PLo S ALMs论文层面计量指标数据,分析比较其阅览量、下载量、讨论量、保存量、被引频次、推荐量与Altmetrics评分、h指数、学术迹T之间的相关性以及对单篇论文的评价效果。结果:阅览量、下载量、讨论量与被引频次、h指数有正相关性,推荐量与h指数、学术迹无关。Altmetrics评分与阅览量、下载量和讨论量呈中度相关性,与被引频次呈弱相关。结论:PLo S ALMs是一个多维评价,应该应用多指标测度,才能体现研究成果的综合实力。
基金jointly supported by the National Key Research and Development Program of China(2018YFC1002104 to L.W.,2018YFC1004904 to B.-L.W.and J.F.,2016YFC1000500 to H.Y.W.and W.F.T.)the National Natural Science Foundation of China([81930036,31521003,31771669]to H.Y.W.)+1 种基金the Commission for Science and Technology of Shanghai Municipality(17JC1400902to H.Y.W.)the MDA-CHB Research Grant to B.-L.W。
文摘Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen ism.Previous studies have shown that LHCGR is en riched in the ovary and LHCGR deficiency causes infertility without typical PCOS phenotypes.ALMS1 is implicated in obesity and hyperandrogenism,the common phenotypes among PCOS patients.Through whole-exome sequencing of 22 PCOS families and targeted candidate gene sequencing of additional 65 sporadic PCOS patients,we identified potential causative mutations in LHCGR and ALMS1 in a sibling-pair PCOS family and three sporadic PCOS patients.The expression of LHCGRL638 P in granulosa-like tumor cell line(KGN)cells promoted cyclic adenosine monophosphate production and granulosa cell proliferation,indicating that LHCGRL638 P is an activating mutation.Lhcgr~(L642 P/L642 P)mice showed an irregular estrous cycle,reduced follicles with dynamic folliculogenesis,and increased testosterone(T),estradiol(E2),and dehydroepiandrosterone.Lhcgr~(+/L642 P)AIms1~(+/PB)mice displayed increased T and E2 but decreased late secondary and preovulatory follicles.We showed that activating mutation of LHCGR likely plays important roles in the pathophysiology of PCOS involving abnormal reproductive physiology,whereas ALMS1 deficiency may promote anovulatory infertility via elevated androgens,suggesting that the disturbed LHCGR and ALMS1 cooperatively induce PCOS phenotypes,characterized as anovulation and hyperandrogenemia frequently observed in PCOS patients with obesity.
文摘BACKGROUND Alström syndrome(AS,OMIM ID 203800)is a rare disease involving multiple organs in children and is mostly reported in non-Chinese patients.In the Chinese population,there are few reports on the clinical manifestations and pathogenesis of AS.This is the first report on the association between AS and Graves’hyperthyroidism.CASE SUMMARY An 8-year-old Chinese girl was diagnosed with AS.Two years later,Graves’hyperthyroidism developed with progressive liver dysfunction.The patient’s clinical data were collected;DNA from peripheral blood of the proband,parents and sibling was collected for gene mutation detection using the second-generation sequencing method and gene panel for diabetes.The association between the patient’s genotype and clinical phenotype was analyzed.She carried the pathogenic compound heterozygous mutation of ALMS1(c.2296_2299del4 and c.11460C>A).These stop-gain mutations likely caused truncation of the ALMS1 protein.CONCLUSION The manifestation of hyperthyroidism may suggest rapid progression of AS.
文摘人工智能(AI)技术的快速发展对高校毕业生就业产生了深远的影响。本文基于ALM(Advanced Language Models)模型,构建AI职业规划平台,通过分析学生能力、职业兴趣及企业需求,实现智能化的人岗精准匹配。平台有助于推动校企合作,优化教育内容,全面提升毕业生就业能力,同时帮助企业有效解决技能型人才短缺问题,促进教育体系与产业发展的深度融合。本研究成果为缓解就业压力提供了切实可行的路径,同时为劳动力市场优化和社会经济的可持续发展提供了重要的理论依据与实践支持。
文摘2019年11月24日,2019/2020赛季ALMS亚洲勒芒系列赛(ASIAN LE MANS SERIES)迎来了上海揭幕战。2019/20赛季亚洲勒芒系列赛有着令人振奋的比赛阵容,也带来了精彩的演艺,而米其林作为该赛事的官方轮胎供应商以及技术合作伙伴,以米其林轮胎出色的性能表现为车手们护航,开启全新征程。
文摘In this work,we propose a second-order model for image denoising by employing a novel potential function recently developed in Zhu(J Sci Comput 88:46,2021)for the design of a regularization term.Due to this new second-order derivative based regularizer,the model is able to alleviate the staircase effect and preserve image contrast.The augmented Lagrangian method(ALM)is utilized to minimize the associated functional and convergence analysis is established for the proposed algorithm.Numerical experiments are presented to demonstrate the features of the proposed model.
