Background: Flight and cabin crew are known to be at increased risk for atherosclerotic cardiovascular disease (ASCVD). However, ASCVD risks have not yet been compared in flight and cabin crew in low resource settings...Background: Flight and cabin crew are known to be at increased risk for atherosclerotic cardiovascular disease (ASCVD). However, ASCVD risks have not yet been compared in flight and cabin crew in low resource settings like sub-Saharan Africa. Objectives: To assess absolute ASCVD risk estimate and its clinical correlates among flight and cabin crew. Methods: From June 1st 2015 to December 30th 2015, 379 consecutive aviation navigants (Flight crew: 62.5%, pilots: 46.2%, women: 29.6%, Caucasians 23.2%) were enrolled in a cross-sectional survey of ASCVD risk estimate using the Framingham tools. They underwent a physical examination for either initial or renewal medical certificate Class 1 or 2 including blood chemistry, ECG, and echocardiogram as per International Civil Aviation Organization (ICAO) and Civil Aviation Authority (CAA-DRC) medical regulations. We modeled the risk of moderate and high ASCVD estimate in a stepwise logistic regression. Results: Low, moderate and high ASCVD risk estimates were observed respectively in 248 (65.4%), 64 (16.9%), and 67 (17.7%) navigants. Moderate and high ASCVD risk estimates predominated among flight than cabin crew (23.6% vs. 5.6%;p 0.0001 and 28.3% vs. null;p 0.001), low ASCVD risk estimate among cabin than flight crew (94.4% vs. 48.1%;p ≤ 0.001). Low ASCVD risk?estimates.展开更多
This study looks into the influence of cosmic radiation at high altitudes on human bodies. Results reveal that the cytokinesis-block micronuclei (CBMN) and conventional cultured micronuclei in peripheral blood lymphoc...This study looks into the influence of cosmic radiation at high altitudes on human bodies. Results reveal that the cytokinesis-block micronuclei (CBMN) and conventional cultured micronuclei in peripheral blood lymphocytes, serum levels of lipid peroxide, superoxide dismutase, and the total antioxidation capacity by chemical colorimetry all increased significantly in aircrew members. There exists a linear relationship between the CBMN and the average annual effective doses of radiation received or the average annual flying hours. With both of them, a trend shows that the serum lipid peroxide levels increase as well. Either the lipid peroxide or CBMN can sensitively reflect the recent changes in flight load. These findings indicate that cosmic radiation impairs the stability of chromosomes and genome, and induces lipid oxidative damage in aircrews; Lymphocyte CBMN and serum lipid peroxide can be used as monitoring indicators in the cosmic radiation protection for aircrew members.展开更多
目的探讨直升机飞行人员干眼症状和干眼患病情况,并分析干眼的影响因素。方法选取2024年1—9月于北戴河康复疗养中心行年度体检的636名直升机飞行人员为研究对象。采用眼表疾病指数(Ocular Surface Disease Index,OSDI)量表对其进行干...目的探讨直升机飞行人员干眼症状和干眼患病情况,并分析干眼的影响因素。方法选取2024年1—9月于北戴河康复疗养中心行年度体检的636名直升机飞行人员为研究对象。采用眼表疾病指数(Ocular Surface Disease Index,OSDI)量表对其进行干眼症状筛查,对筛查出有干眼症状的97例飞行人员通过Eye s i s DE V-1000眼表综合分析仪进行眼科检查,包括非侵入性泪膜破裂时间(non-invasive tear break-up time,NIBUT)、角结膜荧光素钠染色情况和睑板腺萎缩状态。根据眼科检查结果分为干眼组(n=97)和对照组(n=539),对OSDI量表结果与眼表综合分析仪检查结果进行一致性检验。通过入院体检病历获取研究对象的基本信息、血常规及血生化指标,采用多因素Logistic回归分析直升机飞行人员患干眼的影响因素。结果OSDI量表调查结果显示,15.25%(97/636)的直升机飞行人员存在不同程度的干眼症状,其中4.09%(26/636)为重度,5.50%(35/636)为中度,5.66%(36/636)为轻度;眼科检查结果显示,97例(194只眼)有干眼症状的直升机飞行人员,均有不同程度的NIBUT异常,均确诊为干眼,干眼组194只眼中有76.80%(149/194)为睑板腺萎缩。OSDI量表结果与眼表综合分析仪检查的结果具有良好的一致性(Kappa系数=0.748,95%CI:0.620~0.857)。多因素Logistic回归分析结果显示,甲状腺素(thyroxine,T4)升高(OR=0.969,95%CI:0.958~0.981)是患干眼的保护因素,间接胆红素(indirect bilirubin,IBIL)(OR=1.046,95%CI:1.012~1.081)和血清ALT升高(OR=1.014,95%CI:1.001~1.028)是患干眼的危险因素。结论直升机飞行人员的干眼患病率较高。OSDI量表与Eyesis DEV-1000眼表综合分析仪检查结果具有较好的一致性,OSDI量表可作为干眼常规筛查手段。T4、IBIL和ALT是干眼的影响因素。建议航空管理部门在飞行员健康管理中加入定期眼部检查,强化干眼的预防和治疗。展开更多
文摘Background: Flight and cabin crew are known to be at increased risk for atherosclerotic cardiovascular disease (ASCVD). However, ASCVD risks have not yet been compared in flight and cabin crew in low resource settings like sub-Saharan Africa. Objectives: To assess absolute ASCVD risk estimate and its clinical correlates among flight and cabin crew. Methods: From June 1st 2015 to December 30th 2015, 379 consecutive aviation navigants (Flight crew: 62.5%, pilots: 46.2%, women: 29.6%, Caucasians 23.2%) were enrolled in a cross-sectional survey of ASCVD risk estimate using the Framingham tools. They underwent a physical examination for either initial or renewal medical certificate Class 1 or 2 including blood chemistry, ECG, and echocardiogram as per International Civil Aviation Organization (ICAO) and Civil Aviation Authority (CAA-DRC) medical regulations. We modeled the risk of moderate and high ASCVD estimate in a stepwise logistic regression. Results: Low, moderate and high ASCVD risk estimates were observed respectively in 248 (65.4%), 64 (16.9%), and 67 (17.7%) navigants. Moderate and high ASCVD risk estimates predominated among flight than cabin crew (23.6% vs. 5.6%;p 0.0001 and 28.3% vs. null;p 0.001), low ASCVD risk estimate among cabin than flight crew (94.4% vs. 48.1%;p ≤ 0.001). Low ASCVD risk?estimates.
基金This work was supported by the Science Foundation of Civil Aviation Administration of China (Grant No. 99-3-3).
文摘This study looks into the influence of cosmic radiation at high altitudes on human bodies. Results reveal that the cytokinesis-block micronuclei (CBMN) and conventional cultured micronuclei in peripheral blood lymphocytes, serum levels of lipid peroxide, superoxide dismutase, and the total antioxidation capacity by chemical colorimetry all increased significantly in aircrew members. There exists a linear relationship between the CBMN and the average annual effective doses of radiation received or the average annual flying hours. With both of them, a trend shows that the serum lipid peroxide levels increase as well. Either the lipid peroxide or CBMN can sensitively reflect the recent changes in flight load. These findings indicate that cosmic radiation impairs the stability of chromosomes and genome, and induces lipid oxidative damage in aircrews; Lymphocyte CBMN and serum lipid peroxide can be used as monitoring indicators in the cosmic radiation protection for aircrew members.
文摘目的探讨直升机飞行人员干眼症状和干眼患病情况,并分析干眼的影响因素。方法选取2024年1—9月于北戴河康复疗养中心行年度体检的636名直升机飞行人员为研究对象。采用眼表疾病指数(Ocular Surface Disease Index,OSDI)量表对其进行干眼症状筛查,对筛查出有干眼症状的97例飞行人员通过Eye s i s DE V-1000眼表综合分析仪进行眼科检查,包括非侵入性泪膜破裂时间(non-invasive tear break-up time,NIBUT)、角结膜荧光素钠染色情况和睑板腺萎缩状态。根据眼科检查结果分为干眼组(n=97)和对照组(n=539),对OSDI量表结果与眼表综合分析仪检查结果进行一致性检验。通过入院体检病历获取研究对象的基本信息、血常规及血生化指标,采用多因素Logistic回归分析直升机飞行人员患干眼的影响因素。结果OSDI量表调查结果显示,15.25%(97/636)的直升机飞行人员存在不同程度的干眼症状,其中4.09%(26/636)为重度,5.50%(35/636)为中度,5.66%(36/636)为轻度;眼科检查结果显示,97例(194只眼)有干眼症状的直升机飞行人员,均有不同程度的NIBUT异常,均确诊为干眼,干眼组194只眼中有76.80%(149/194)为睑板腺萎缩。OSDI量表结果与眼表综合分析仪检查的结果具有良好的一致性(Kappa系数=0.748,95%CI:0.620~0.857)。多因素Logistic回归分析结果显示,甲状腺素(thyroxine,T4)升高(OR=0.969,95%CI:0.958~0.981)是患干眼的保护因素,间接胆红素(indirect bilirubin,IBIL)(OR=1.046,95%CI:1.012~1.081)和血清ALT升高(OR=1.014,95%CI:1.001~1.028)是患干眼的危险因素。结论直升机飞行人员的干眼患病率较高。OSDI量表与Eyesis DEV-1000眼表综合分析仪检查结果具有较好的一致性,OSDI量表可作为干眼常规筛查手段。T4、IBIL和ALT是干眼的影响因素。建议航空管理部门在飞行员健康管理中加入定期眼部检查,强化干眼的预防和治疗。
